LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 524

Search options

  1. Article: Editorial: Hybrid or mixed myelodyplastic/myeloproliferative disorders: Current trends in diagnosis and treatment.

    Symeonidis, Argiris / Germing, Ulrich

    Frontiers in oncology

    2023  Volume 13, Page(s) 1166163

    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1166163
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: SARS-CoV-2 infection (COVID-19) and male fertility: Something we should be worried about?

    Zeginiadou, Theodosia / Symeonidis, Evangelos N / Symeonidis, Asterios / Vakalopoulos, Ioannis

    Urologia

    2023  Volume 90, Issue 4, Page(s) 726–734

    Abstract: As of 2021, roughly 5 million deaths were linked to SARS-CoV-2 infection based on World Health Organization estimates. The pandemic takes its staggering death toll, severely affecting the healthcare systems and leading to detrimental implications ... ...

    Abstract As of 2021, roughly 5 million deaths were linked to SARS-CoV-2 infection based on World Health Organization estimates. The pandemic takes its staggering death toll, severely affecting the healthcare systems and leading to detrimental implications globally. While the severe impact on the respiratory system is well-established, the exact effect on male reproduction is still largely uncharted territory. When it comes to gender, men appear more vulnerable compared to women. Increasing evidence suggests that COVID-19 adversely affects spermatogenesis and hormonal balance in diverse ways. Semen parameters seem to be compromised at least temporarily, while long-term worsening needs to be clarified in studies with extended follow-up. For the time being, no data support the adverse effect of COVID-19 vaccines on a male's reproductive health. In the present article, we examine the available literature and briefly discuss the impact of the virus on reproduction and fertility. We further provide a comprehensive overview of the current status of vaccination and its potential effect on male fertility. Ultimately, we address the need for future well-designed large-scale trials before drawing definite conclusions on the exact impact of the virus on a male's fecundity.
    MeSH term(s) Male ; Humans ; Female ; COVID-19 ; SARS-CoV-2 ; COVID-19 Vaccines ; Fertility ; Pandemics
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 204043-8
    ISSN 1724-6075 ; 0376-0057 ; 0391-5603
    ISSN (online) 1724-6075
    ISSN 0376-0057 ; 0391-5603
    DOI 10.1177/03915603231175941
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 891: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Dense Multi-Scale Graph Convolutional Network for Knee Joint Cartilage Segmentation.

    Chadoulos, Christos / Tsaopoulos, Dimitrios / Symeonidis, Andreas / Moustakidis, Serafeim / Theocharis, John

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 3

    Abstract: In this paper, we propose a dense multi-scale adaptive graph convolutional network ( ...

    Abstract In this paper, we propose a dense multi-scale adaptive graph convolutional network (
    Language English
    Publishing date 2024-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11030278
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Obstructive lower urinary tract symptoms (LUTS) as the initial presentation of penile paraffinoma: a case report and literature review.

    Symeonidis, Asterios / Symeonidis, Evangelos N / Toutziaris, Chrysovalantis / Dimitriadis, Georgios

    The Pan African medical journal

    2021  Volume 38, Page(s) 265

    Abstract: Penile paraffinoma is a rare condition after penile injection of liquid paraffin or other mineral oils, with well-documented debilitating complications. Nevertheless, such injections are still performed by people of Eastern European and Asian descent for ...

    Abstract Penile paraffinoma is a rare condition after penile injection of liquid paraffin or other mineral oils, with well-documented debilitating complications. Nevertheless, such injections are still performed by people of Eastern European and Asian descent for cosmetic penile augmentation. We report a case of penile paraffinoma in an otherwise healthy, 30-year-old male, with obstructive lower urinary tract symptoms (LUTS) as the sole complaint at presentation in the emergency department and a conservative approach. This case report describes an unusual presentation of penile paraffinoma in a young man and aims to raise public and physician awareness regarding disease manifestation to prevent high morbidity from delayed diagnosis and treatment.
    MeSH term(s) Adult ; Delayed Diagnosis ; Granuloma, Foreign-Body/diagnosis ; Granuloma, Foreign-Body/pathology ; Humans ; Lower Urinary Tract Symptoms/etiology ; Male ; Penile Diseases/diagnosis ; Penile Diseases/pathology
    Language English
    Publishing date 2021-03-15
    Publishing country Uganda
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2021.38.265.28084
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Autophagy and oxidative stress modulation mediate Bortezomib resistance in prostate cancer.

    Zafeiropoulou, Kalliopi / Kalampounias, Georgios / Alexis, Spyridon / Anastasopoulos, Daniil / Symeonidis, Argiris / Katsoris, Panagiotis

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0289904

    Abstract: Proteasome inhibitors such as Bortezomib represent an established type of targeted treatment for several types of hematological malignancies, including multiple myeloma, Waldenstrom's macroglobulinemia, and mantle cell lymphoma, based on the cancer cell' ... ...

    Abstract Proteasome inhibitors such as Bortezomib represent an established type of targeted treatment for several types of hematological malignancies, including multiple myeloma, Waldenstrom's macroglobulinemia, and mantle cell lymphoma, based on the cancer cell's susceptibility to impairment of the proteasome-ubiquitin system. However, a major problem limiting their efficacy is the emergence of resistance. Their application to solid tumors is currently being studied, while simultaneously, a wide spectrum of hematological cancers, such as Myelodysplastic Syndromes show minimal or no response to Bortezomib treatment. In this study, we utilize the prostate cancer cell line DU-145 to establish a model of Bortezomib resistance, studying the underlying mechanisms. Evaluating the resulting resistant cell line, we observed restoration of proteasome chymotrypsin-like activity, regardless of drug presence, an induction of pro-survival pathways, and the substitution of the Ubiquitin-Proteasome System role in proteostasis by induction of autophagy. Finally, an estimation of the oxidative condition of the cells indicated that the resistant clones reduce the generation of reactive oxygen species induced by Bortezomib to levels even lower than those induced in non-resistant cells. Our findings highlight the role of autophagy and oxidative stress regulation in Bortezomib resistance and elucidate key proteins of signaling pathways as potential pharmaceutical targets, which could increase the efficiency of proteasome-targeting therapies, thus expanding the group of molecular targets for neoplastic disorders.
    MeSH term(s) Humans ; Adult ; Male ; Bortezomib/pharmacology ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors/pharmacology ; Proteasome Inhibitors/therapeutic use ; Multiple Myeloma/drug therapy ; Hematologic Neoplasms/pathology ; Prostatic Neoplasms/drug therapy ; Oxidative Stress ; Autophagy ; Ubiquitins/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use
    Chemical Substances Bortezomib (69G8BD63PP) ; Proteasome Endopeptidase Complex (EC 3.4.25.1) ; Proteasome Inhibitors ; Ubiquitins ; Antineoplastic Agents
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0289904
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Contingent Synergistic Interactions between Non-Coding RNAs and DNA-Modifying Enzymes in Myelodysplastic Syndromes.

    Symeonidis, Argiris / Chatzilygeroudi, Theodora / Chondrou, Vasiliki / Sgourou, Argyro

    International journal of molecular sciences

    2022  Volume 23, Issue 24

    Abstract: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders with maturation and differentiation defects exhibiting morphological dysplasia in one or more hematopoietic cell lineages. They are associated with ... ...

    Abstract Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders with maturation and differentiation defects exhibiting morphological dysplasia in one or more hematopoietic cell lineages. They are associated with peripheral blood cytopenias and by increased risk for progression into acute myelogenous leukemia. Among their multifactorial pathogenesis, age-related epigenetic instability and the error-rate DNA methylation maintenance have been recognized as critical factors for both the initial steps of their pathogenesis and for disease progression. Although lower-risk MDS is associated with an inflammatory bone marrow microenvironment, higher-risk disease is delineated by immunosuppression and clonal expansion. "Epigenetics" is a multidimensional level of gene regulation that determines the specific gene networks expressed in tissues under physiological conditions and guides appropriate chromatin rearrangements upon influence of environmental stimulation. Regulation of this level consists of biochemical modifications in amino acid residues of the histone proteins' N-terminal tails and their concomitant effects on chromatin structure, DNA methylation patterns in CpG dinucleotides and the tissue-specific non-coding RNAs repertoire, which are directed against various gene targets. The role of epigenetic modifications is widely recognized as pivotal both in gene expression control and differential molecular response to drug therapies in humans. Insights to the potential of synergistic cooperations of epigenetic mechanisms provide new avenues for treatment development to comfort human diseases with a known epigenetic shift, such as MDS. Hypomethylating agents (HMAs), such as epigenetic modulating drugs, have been widely used in the past years as first line treatment for elderly higher-risk MDS patients; however, just half of them respond to therapy and are benefited. Rational outcome predictors following epigenetic therapy in MDS and biomarkers associated with disease relapse are of high importance to improve our efforts in developing patient-tailored clinical approaches.
    Language English
    Publishing date 2022-12-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232416069
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Juxta-Vesical Urinary Stones: An Extremely Rare Finding Secondary to Bladder Rupture and Squamous Cell Carcinoma in a Patient on Clean Intermittent Self-Catheterization.

    Tsikopoulos, Ioannis / Papadopoulos, Dimitrios / Symeonidis, Asterios / Katsimperis, Stamatios / Gkekas, Chrysovalantis

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38776

    Abstract: We present a rare case of juxta-vesical urinary stones in the lesser pelvis, incidentally diagnosed during the investigation of a urinary tract infection (UTI). The patient (male) had a history of neurogenic bladder and performed self-catheterizations. ... ...

    Abstract We present a rare case of juxta-vesical urinary stones in the lesser pelvis, incidentally diagnosed during the investigation of a urinary tract infection (UTI). The patient (male) had a history of neurogenic bladder and performed self-catheterizations. After the initial workup, the patient was admitted with a complicated UTI diagnosis. CT scan of the abdomen and pelvis depicted multiple bladder stones, some calculi lying juxta- and retro-vesically, an abscess cavity, and diffuse thickening of the bladder. The abscess was adherent to the bladder wall, containing calculi, too. We presumed that the patient self-inflicted a bladder rupture when performing clean intermittent self-catheterization (CISC) and stones dislodged in the pelvis due to his poor bladder sensation. Flexible cystoscopy was attempted but was not completed due to stone obstruction and poor bladder compliance. The patient underwent open surgical exploration. Several calculi were removed, the abscess was drained, and bladder wall biopsies were taken. Pathology results revealed invasive squamous bladder carcinoma; the patient was listed for radical cystectomy. We aim to familiarize the clinician with rare complications that should be taken into consideration when treating patients on CISC and present an extremely rare clinical finding of juxta-vesical lithiasis.
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38776
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Operational State Recognition of a DC Motor Using Edge Artificial Intelligence.

    Strantzalis, Konstantinos / Gioulekas, Fotios / Katsaros, Panagiotis / Symeonidis, Andreas

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 24

    Abstract: Edge artificial intelligence (EDGE-AI) refers to the execution of artificial intelligence algorithms on hardware devices while processing sensor data/signals in order to extract information and identify patterns, without utilizing the cloud. In the field ...

    Abstract Edge artificial intelligence (EDGE-AI) refers to the execution of artificial intelligence algorithms on hardware devices while processing sensor data/signals in order to extract information and identify patterns, without utilizing the cloud. In the field of predictive maintenance for industrial applications, EDGE-AI systems can provide operational state recognition for machines and production chains, almost in real time. This work presents two methodological approaches for the detection of the operational states of a DC motor, based on sound data. Initially, features were extracted using an audio dataset. Two different Convolutional Neural Network (CNN) models were trained for the particular classification problem. These two models are subject to post-training quantization and an appropriate conversion/compression in order to be deployed to microcontroller units (MCUs) through utilizing appropriate software tools. A real-time validation experiment was conducted, including the simulation of a custom stress test environment, to check the deployed models' performance on the recognition of the engine's operational states and the response time for the transition between the engine's states. Finally, the two implementations were compared in terms of classification accuracy, latency, and resource utilization, leading to promising results.
    Language English
    Publishing date 2022-12-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22249658
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Anthropometric measurements of the foot cannot predict the screw diameter for fifth metatarsal fractures intramedullary fixation.

    Symeonidis, Panagiotis D / Totlis, Trifon / Dermitzakis, Iasonas / Papachristodoulou, Athanasia / Giatas, Ioannis / Beris, Alexandros

    Surgical and radiologic anatomy : SRA

    2023  Volume 46, Issue 1, Page(s) 65–70

    Abstract: Purpose: The present study aimed to evaluate the accuracy of anthropometric foot measurements in predicting the diameter of the intramedullary screw for fifth metatarsal fracture fixation. Secondary aim was to identify whether the fifth metatarsal ... ...

    Abstract Purpose: The present study aimed to evaluate the accuracy of anthropometric foot measurements in predicting the diameter of the intramedullary screw for fifth metatarsal fracture fixation. Secondary aim was to identify whether the fifth metatarsal intramedullary canal diameter is correlated to the fifth metatarsal length and the foot dimensions.
    Methods: In 29 cadaveric feet, the maximum length of the plantar surface of the foot (PL) and the perimeter of the foot at the level of the fifth metatarsal base (PBFM) were measured using a measuring tape. Subsequently, the fifth metatarsal was excised. Using Computed Tomography scan, the metatarsal length (FML), and the horizontal (HDI) and vertical diameter (VDI) at the isthmus level were measured. The HDI values were grouped in 5 mm increments to correspond to the recommended screw diameter (RSD) for intramedullary fixation. A univariate linear regression analysis considered RSD and HDI as the dependent variables and FML, PL, PBFM as the independent variables. A multivariate regression analysis was performed to examine the predictive value of the two anthropometric measurements. A p-value < 0.05 was considered statistically significant.
    Results: All six univariate analyses revealed that the dependent variable was significantly correlated with the independent variable. However, the multivariate regression models showed that the anthropometric measurements were not significantly correlated with the RSD and HDI.
    Conclusion: The current study found an association between the fifth metatarsal intramedullary canal diameter and the fifth metatarsal length and foot anthropometric dimensions. However, the anthropometric measurements of the foot presented a low predictive value for the decision of an intramedullary screw diameter in the treatment of fractures of the base of the fifth metatarsal.
    MeSH term(s) Humans ; Metatarsal Bones/diagnostic imaging ; Metatarsal Bones/surgery ; Fracture Fixation, Internal/methods ; Fluorometholone ; Fractures, Bone/diagnostic imaging ; Fractures, Bone/surgery ; Foot Injuries/surgery ; Ankle Injuries ; Knee Injuries ; Bone Screws
    Chemical Substances Fluorometholone (SV0CSG527L)
    Language English
    Publishing date 2023-12-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 632839-8
    ISSN 1279-8517 ; 0930-312X ; 0930-1038
    ISSN (online) 1279-8517
    ISSN 0930-312X ; 0930-1038
    DOI 10.1007/s00276-023-03267-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Central Pancreatectomy: Balancing between the Favorable Functional Results and the Increased Associated Morbidity.

    Symeonidis, Dimitrios / Paraskeva, Ismini / Samara, Athina A / Kissa, Labrini / Valaroutsos, Alexandros / Petsa, Eleana / Tepetes, Konstantinos

    Surgery journal (New York, N.Y.)

    2024  Volume 10, Issue 1, Page(s) e20–e24

    Abstract: ... ...

    Abstract Introduction
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2864275-2
    ISSN 2378-5136 ; 2378-5128
    ISSN (online) 2378-5136
    ISSN 2378-5128
    DOI 10.1055/s-0044-1782655
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top