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  1. Article: New treatments of multidrug-resistant Gram-negative ventilator-associated pneumonia.

    Poulakou, Garyphallia / Lagou, Styliani / Karageorgopoulos, Drosos E / Dimopoulos, George

    Annals of translational medicine

    2018  Volume 6, Issue 21, Page(s) 423

    Abstract: Ventilator-associated pneumonia (VAP) remains an important clinical problem globally, being associated with significant morbidity and mortality. As management of VAP requires adequate and timely antibiotic administration, global emergence of ... ...

    Abstract Ventilator-associated pneumonia (VAP) remains an important clinical problem globally, being associated with significant morbidity and mortality. As management of VAP requires adequate and timely antibiotic administration, global emergence of antimicrobial resistance poses serious challenges over our ability to maintain this axiom. Development of antimicrobials against MDR Gram-negative pathogens has therefore emerged as a priority and some new antibiotics have been marketed or approach late stage of development. The aim of this review is to analyse new therapeutic options from the point view of potential treatment of VAP. Among recently developed antimicrobials presented herein, it is obvious that we will have promising therapeutic options against VAP caused by
    Language English
    Publishing date 2018-12-05
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2018.10.29
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A prospective observational study of chronic prostatitis with emphasis on epidemiological and microbiological features.

    Stamatiou, Konstantinos / Karageorgopoulos, Drosos E

    Urologia

    2013  Volume 80, Issue 3, Page(s) 225–232

    Abstract: Objectives: Despite the progress made in recent years in understanding and diagnosing chronic prostatitis (CP) many cases are still underdiagnosed and undertreated for unknown reasons. The purpose of this study is to investigate the epidemiological data ...

    Abstract Objectives: Despite the progress made in recent years in understanding and diagnosing chronic prostatitis (CP) many cases are still underdiagnosed and undertreated for unknown reasons. The purpose of this study is to investigate the epidemiological data of patients with symptoms of CP and to associate data from medical history and clinical examination with the results of laboratory tests.
    Methods: The study population consisted of individuals with reported pelvic discomfort and genital pain with or without lower urinary tract symptoms and sexual dysfunction visiting our department from 03/2009 to 03/2011. Patients underwent Meares-Stamey test (a few cases underwent the two-glass test). Depending on history and specific symptoms, urethral smear and sperm cultures were additionally obtained from several patients. The processes and reading of the samples were performed by a specialist microbiologist, who has not notified the patient record.
    Results: 114 out of 155 patients who finally enrolled into the study had a medical history, 69 had sexual behavior and 72 sexual habits that predispose to chronic prostatitis. The clinical examination was not diagnostic in 43.8% of cases. The urethral smear and sperm culture diagnosed coexistent urethral infection in 22 cases. 54 out of the 72 positive EPS/VB3/PPM cultures grew one, 11 two to three and 5 cultures grew more than three different organisms.
    Conclusions: Findings of this study debate some widely accepted considerations on the etiology and diagnosis of chronic prostatitis and highlight the uncertainties and controversies regarding chronic prostatitis etiology, pathophysiology, presentation and diagnosis.
    MeSH term(s) Adolescent ; Adult ; Aged ; Bacterial Infections ; Chronic Disease ; Humans ; Male ; Middle Aged ; Prospective Studies ; Prostatitis/epidemiology ; Prostatitis/microbiology ; Young Adult
    Language English
    Publishing date 2013-07
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 204043-8
    ISSN 1724-6075 ; 0391-5603 ; 0376-0057
    ISSN (online) 1724-6075
    ISSN 0391-5603 ; 0376-0057
    DOI 10.5301/urologia.5000024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lefamulin. Comment on: "Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms.

    Koulenti, Despoina / Xu, Elena / Yin Sum Mok, Isaac / Song, Andrew / Karageorgopoulos, Drosos E / Armaganidis, Apostolos / Lipman, Jeffrey / Tsiodras, Sotirios

    Microorganisms

    2019  Volume 7, Issue 10

    Abstract: On 18 August 2019, an article was published ... ...

    Abstract On 18 August 2019, an article was published in
    Language English
    Publishing date 2019-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7100386
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  4. Article: Emerging Treatment Options for Infections by Multidrug-Resistant Gram-Positive Microorganisms.

    Koulenti, Despoina / Xu, Elena / Song, Andrew / Sum Mok, Isaac Yin / Karageorgopoulos, Drosos E / Armaganidis, Apostolos / Tsiodras, Sotirios / Lipman, Jeffrey

    Microorganisms

    2020  Volume 8, Issue 2

    Abstract: Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug ... ...

    Abstract Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug resistance, leading to the persistence and spread of difficult-to-treat infections. Several current antibacterial agents active against Gram-positive bacteria will be rendered useless in the face of increasing resistance rates. There are several emerging antibiotics under development, some of which have been shown to be more effective with an improved safety profile than current treatment regimens against Gram-positive bacteria. We will extensively discuss these antibiotics under clinical development (phase I-III clinical trials) to combat Gram-positive bacteria, such as
    Language English
    Publishing date 2020-01-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8020191
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  5. Article: Hepatitis C in human immunodeficiency virus co-infected individuals: Is this still a "special population"?

    Karageorgopoulos, Drosos E / Allen, Joanna / Bhagani, Sanjay

    World journal of hepatology

    2015  Volume 7, Issue 15, Page(s) 1936–1952

    Abstract: A substantial proportion of individuals with chronic hepatitis C virus (HCV) are co-infected with human immunodeficiency virus (HIV). Co-infected individuals are traditionally considered as one of the "special populations" amongst those with chronic HCV, ...

    Abstract A substantial proportion of individuals with chronic hepatitis C virus (HCV) are co-infected with human immunodeficiency virus (HIV). Co-infected individuals are traditionally considered as one of the "special populations" amongst those with chronic HCV, mainly because of faster progression to end-stage liver disease and suboptimal responses to treatment with pegylated interferon alpha and ribavirin, the benefits of which are often outweighed by toxicity. The advent of the newer direct acting antivirals (DAAs) has given hope that the majority of co-infected individuals can clear HCV. However the "special population" designation may prove an obstacle for those with co-infection to gain access to the new agents, in terms of requirement for separate pre-licensing clinical trials and extensive drug-drug interaction studies. We review the global epidemiology, natural history and pathogenesis of chronic hepatitis C in HIV co-infection. The accelerated course of chronic hepatitis C in HIV co-infection is not adequately offset by successful combination antiretroviral therapy. We also review the treatment trials of chronic hepatitis C in HIV co-infected individuals with DAAs and compare them to trials in the HCV mono-infected. There is convincing evidence that HIV co-infection no longer diminishes the response to treatment against HCV in the new era of DAA-based therapy. The management of HCV co-infection should therefore become a priority in the care of HIV infected individuals, along with public health efforts to prevent new HCV infections, focusing particularly on specific patient groups at risk, such as men who have sex with men and injecting drug users.
    Language English
    Publishing date 2015-08-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573703-X
    ISSN 1948-5182
    ISSN 1948-5182
    DOI 10.4254/wjh.v7.i15.1936
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  6. Article ; Online: Adjustment of dosing of antimicrobial agents for bodyweight in adults.

    Falagas, Matthew E / Karageorgopoulos, Drosos E

    Lancet (London, England)

    2010  Volume 375, Issue 9710, Page(s) 248–251

    MeSH term(s) Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/pharmacokinetics ; Bacterial Infections/complications ; Bacterial Infections/drug therapy ; Body Weight ; Humans ; Kidney/metabolism ; Obesity/complications ; Obesity/metabolism
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2010-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(09)60743-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

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  7. Article ; Online: Emerging Treatment Options for Infections by Multidrug-Resistant Gram-Positive Microorganisms

    Despoina Koulenti / Elena Xu / Andrew Song / Isaac Yin Sum Mok / Drosos E. Karageorgopoulos / Apostolos Armaganidis / Sotirios Tsiodras / Jeffrey Lipman

    Microorganisms, Vol 8, Iss 2, p

    2020  Volume 191

    Abstract: Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug ... ...

    Abstract Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug resistance, leading to the persistence and spread of difficult-to-treat infections. Several current antibacterial agents active against Gram-positive bacteria will be rendered useless in the face of increasing resistance rates. There are several emerging antibiotics under development, some of which have been shown to be more effective with an improved safety profile than current treatment regimens against Gram-positive bacteria. We will extensively discuss these antibiotics under clinical development (phase I-III clinical trials) to combat Gram-positive bacteria, such as Staphylococcus aureus , Enterococcus faecium and Streptococcus pneumoniae . We will delve into the mechanism of actions, microbiological spectrum, and, where available, the pharmacokinetics, safety profile, and efficacy of these drugs, aiming to provide a comprehensive review to the involved stakeholders.
    Keywords emerging anti gram-positive antibiotics ; multi-drug resistance organisms ; clinical trials ; dihydrofolate reductase inhibitors ; ketolides ; oxazolidinones ; quinolones ; defensin mimetics ; β-lactams ; topoisomerase ii inhibitors ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms.

    Koulenti, Despoina / Xu, Elena / Mok, Isaac Yin Sum / Song, Andrew / Karageorgopoulos, Drosos E / Armaganidis, Apostolos / Lipman, Jeffrey / Tsiodras, Sotirios

    Microorganisms

    2019  Volume 7, Issue 8

    Abstract: Increasing multidrug-resistance to Gram-positive pathogens, particularly to staphylococci, enterococci and streptococci, is a major problem, resulting in significant morbidity, mortality and healthcare costs. In recent years, only a small number of novel ...

    Abstract Increasing multidrug-resistance to Gram-positive pathogens, particularly to staphylococci, enterococci and streptococci, is a major problem, resulting in significant morbidity, mortality and healthcare costs. In recent years, only a small number of novel antibiotics effective against Gram-positive bacteria has been approved. This review will discuss the current evidence for novel branded antibiotics that are highly effective in the treatment of multidrug-resistant infections by Gram-positive pathogens, namely ceftobiprole, ceftaroline, telavancin, oritavancin, dalbavancin, tedizolid, besifloxacin, delafloxacin, ozenoxacin, and omadacycline. The mechanism of action, pharmacokinetics, microbiological spectrum, efficacy and safety profile will be concisely presented. As for any emerging antibiotic agent, resistance is likely to develop against these highly effective antibiotics. Only through appropriate dosing, utilization and careful resistance development monitoring will these novel antibiotics continue to treat Gram-positive pathogens in the future.
    Language English
    Publishing date 2019-08-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms7080270
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  9. Article ; Online: Lefamulin. Comment on

    Despoina Koulenti / Elena Xu / Isaac Yin Sum Mok / Andrew Song / Drosos E. Karageorgopoulos / Apostolos Armaganidis / Jeffrey Lipman / Sotirios Tsiodras

    Microorganisms, Vol 7, Iss 10, p

    “Novel Antibiotics for Multidrug-Resistant Gram-Positive Microorganisms. Microorganisms , 2019, 7 , 270”

    2019  Volume 386

    Abstract: On 18 August 2019, an article was published in Microorganisms presenting novel, approved anti-Gram-positive antibiotics. On 19 August 2019, the U.S. Food and Drug Administration announced the approval of lefamulin, a representative of a new class of ... ...

    Abstract On 18 August 2019, an article was published in Microorganisms presenting novel, approved anti-Gram-positive antibiotics. On 19 August 2019, the U.S. Food and Drug Administration announced the approval of lefamulin, a representative of a new class of antibiotics, the pleuromutilins, for the treatment of adult community-acquired bacterial pneumonia. We present a brief description of lefamulin.
    Keywords multidrug-resistance ; Gram-positive pathogens ; novel antibiotics ; pleuromutilins ; lefamulin ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: continuous versus conventional infusion of amphotericin B deoxycholate: a meta-analysis.

    Falagas, Matthew E / Karageorgopoulos, Drosos E / Tansarli, Giannoula S

    PloS one

    2013  Volume 8, Issue 10, Page(s) e77075

    Abstract: Background: Treatment with Amphotericin B (AmB) deoxycholate, which is still used widely, particularly in low-resource countries, has been challenged due to nephrotoxicity. We sought to study whether continuous infusion of AmB deoxycholate reduces ... ...

    Abstract Background: Treatment with Amphotericin B (AmB) deoxycholate, which is still used widely, particularly in low-resource countries, has been challenged due to nephrotoxicity. We sought to study whether continuous infusion of AmB deoxycholate reduces nephrotoxicity retaining, however, the effectiveness of the drug.
    Methods: PubMed and Scopus databases were systematically searched to identify studies comparing the outcomes of patients receiving 24-h infusion of AmB ("continuous group") and those receiving 2-6-h infusion of AmB ("conventional group"). Nephrotoxicity and all-cause mortality were the primary outcomes of the review, while treatment failure was the secondary outcome.
    Results: Five studies met the inclusion criteria; one randomized controlled trial, two prospective cohort studies, and two retrospective cohort studies. The majority of patients were neutropenic with an underlying hematologic malignancy. All 5 studies (392 patients) provided data regarding the development of nephrotoxicity. A non-significant trend towards lower nephrotoxicity was observed for patients receiving continuous infusion of AmB compared with those receiving conventional infusion [RR = 0.61 (95% CI 0.36, 1.02)]. Four studies (365 patients) provided data regarding mortality; no relevant difference was detected between patients receiving continuous and those receiving conventional infusion of AmB [RR = 0.81 (95% CI 0.36, 1.83)]. Data on treatment failure of the two methods of administration was insufficient for meaningful conclusions.
    Conclusion: The available evidence from mainly non-randomized studies suggests that continuous infusion of AmB deoxycholate might offer an advantage over the conventional infusion regarding the development of nephrotoxicity, without compromising patient survival. Further randomized studies are needed to investigate this issue.
    MeSH term(s) Amphotericin B/administration & dosage ; Amphotericin B/adverse effects ; Amphotericin B/therapeutic use ; Antifungal Agents/administration & dosage ; Antifungal Agents/adverse effects ; Antifungal Agents/therapeutic use ; Deoxycholic Acid/administration & dosage ; Deoxycholic Acid/adverse effects ; Deoxycholic Acid/therapeutic use ; Drug Combinations ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Humans ; Infusions, Intravenous/methods ; Kidney Diseases/chemically induced ; Mycoses/complications ; Mycoses/drug therapy ; Neutropenia/chemically induced ; Prospective Studies ; Randomized Controlled Trials as Topic ; Retrospective Studies ; Risk Factors ; Treatment Outcome
    Chemical Substances Antifungal Agents ; Drug Combinations ; Deoxycholic Acid (005990WHZZ) ; Amphotericin B (7XU7A7DROE) ; amphotericin B, deoxycholate drug combination (87687-70-5)
    Language English
    Publishing date 2013-10-21
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0077075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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