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  1. Article ; Online: Right heart function during and after pregnancy in women with pulmonary arterial hypertension.

    Olsson, Karen M / Fuge, Jan / Park, Da-Hee / Kamp, Jan C / Berliner, Dominik / von Kaisenberg, Constantin / Hoeper, Marius M

    The European respiratory journal

    2024  

    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00179-2024
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    Zs.A 2322: Show issues Location:
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  2. Article ; Online: Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension.

    Olsson, Karen M / Fuge, Jan / Park, Da-Hee / Kamp, Jan C / Brod, Torben / Harrigfeld, Britta / Schupp, Jonas C / Hoeper, Marius M

    The European respiratory journal

    2023  Volume 62, Issue 2

    MeSH term(s) Humans ; Pulmonary Arterial Hypertension ; Lung ; Recombinant Fusion Proteins ; Familial Primary Pulmonary Hypertension ; Gases
    Chemical Substances ACE-011 ; Recombinant Fusion Proteins ; Gases
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01070-2023
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  3. Article ; Online: Pregnancy in PAH: Reality is changing.

    Olsson, Karen M / Kamp, Jan C / Hoeper, Marius M

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2021  Volume 40, Issue 5, Page(s) 395–396

    MeSH term(s) Emotions ; Female ; Humans ; Hypertension, Pulmonary/diagnosis ; Pregnancy ; Pregnancy Complications, Cardiovascular
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2021.02.001
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    Zs.A 2056: Show issues Location:
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  4. Article ; Online: Fibre intake for optimal health: how can healthcare professionals support people to reach dietary recommendations?

    McKeown, Nicola M / Fahey, George C / Slavin, Joanne / van der Kamp, Jan-Willem

    BMJ (Clinical research ed.)

    2022  Volume 378, Page(s) e054370

    MeSH term(s) Delivery of Health Care ; Diet ; Dietary Fiber ; Humans
    Chemical Substances Dietary Fiber
    Language English
    Publishing date 2022-07-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj-2020-054370
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  5. Article ; Online: COVID-19 in lung transplant recipients-Risk prediction and outcomes.

    Kamp, Jan C / Hinrichs, Jan B / Fuge, Jan / Ewen, Raphael / Gottlieb, Jens

    PloS one

    2021  Volume 16, Issue 10, Page(s) e0257807

    Abstract: Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk ... ...

    Abstract Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was performed in a German high-volume lung transplant center between 19th March 2020 and 18th May 2021. Impact of COVID-19 on physical and psychological health, clinical outcomes, and mortality were analyzed including follow-up visits up to 12 weeks after infection in survivors. Predictive parameters on survival were assessed using univariate and multivariate proportional hazards regression models. Out of 1,046 patients in follow-up, 31 acquired COVID-19 during the pandemic. 12 of 31 (39%) died and 26 (84%) were hospitalized. In survivors a significant decline in exercise capacity (p = 0.034), TLC (p = 0.02), and DLCO (p = 0.007) was observed at follow-up after 3 months. Anxiety, depression, and self-assessed quality of life remained stable. Charlson comorbidity index predicted mortality (HR 1.5, 1.1-2.2; p = 0.023). In recipients with pre-existing CLAD, mortality and clinical outcomes were inferior. However, pre-existing CLAD did not predict mortality. COVID-19 remains a life-threatening disease for lung transplant recipients, particularly in case comorbidities. Further studies on long term outcomes and impact on pre-existing CLAD are needed.
    MeSH term(s) Adult ; COVID-19/epidemiology ; Female ; Hospitalization ; Humans ; Lung Transplantation/statistics & numerical data ; Male ; Middle Aged ; Quality of Life ; Retrospective Studies ; Risk Assessment ; Transplant Recipients/statistics & numerical data
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0257807
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  6. Article ; Online: Refined risk stratification in pulmonary arterial hypertension and timing of lung transplantation.

    Olsson, Karen M / Richter, Manuel J / Kamp, Jan C / Gall, Henning / Ghofrani, Hossein-Ardeshir / Fuge, Jan / Ewert, Ralf / Hoeper, Marius M

    The European respiratory journal

    2022  Volume 60, Issue 2

    MeSH term(s) Familial Primary Pulmonary Hypertension ; Humans ; Lung Transplantation ; Pulmonary Arterial Hypertension ; Risk Assessment
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.03087-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2322: Show issues Location:
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  7. Article ; Online: COVID-19 in lung transplant recipients-Risk prediction and outcomes.

    Jan C Kamp / Jan B Hinrichs / Jan Fuge / Raphael Ewen / Jens Gottlieb

    PLoS ONE, Vol 16, Iss 10, p e

    2021  Volume 0257807

    Abstract: Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk ... ...

    Abstract Patients after lung transplantation are at risk for life-threatening infections. Recently, several publications on COVID-19 outcomes in this patient population appeared, but knowledge on optimal treatment, mortality, outcomes, and appropriate risk predictors is limited. A retrospective analysis was performed in a German high-volume lung transplant center between 19th March 2020 and 18th May 2021. Impact of COVID-19 on physical and psychological health, clinical outcomes, and mortality were analyzed including follow-up visits up to 12 weeks after infection in survivors. Predictive parameters on survival were assessed using univariate and multivariate proportional hazards regression models. Out of 1,046 patients in follow-up, 31 acquired COVID-19 during the pandemic. 12 of 31 (39%) died and 26 (84%) were hospitalized. In survivors a significant decline in exercise capacity (p = 0.034), TLC (p = 0.02), and DLCO (p = 0.007) was observed at follow-up after 3 months. Anxiety, depression, and self-assessed quality of life remained stable. Charlson comorbidity index predicted mortality (HR 1.5, 1.1-2.2; p = 0.023). In recipients with pre-existing CLAD, mortality and clinical outcomes were inferior. However, pre-existing CLAD did not predict mortality. COVID-19 remains a life-threatening disease for lung transplant recipients, particularly in case comorbidities. Further studies on long term outcomes and impact on pre-existing CLAD are needed.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Human lung virtual histology by multi-scale x-ray phase-contrast computed tomography.

    Reichmann, Jakob / Verleden, Stijn E / Kühnel, Mark / Kamp, Jan C / Werlein, Christopher / Neubert, Lavinia / Müller, Jan-Hendrik / Bui, Thanh Quynh / Ackermann, Maximilian / Jonigk, Danny / Salditt, Tim

    Physics in medicine and biology

    2023  Volume 68, Issue 11

    Abstract: Objectives. ...

    Abstract Objectives.
    MeSH term(s) Infant, Newborn ; Humans ; X-Rays ; Imaging, Three-Dimensional/methods ; Lung/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Persistent Fetal Circulation Syndrome ; Synchrotrons ; X-Ray Microtomography/methods
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acd48d
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    Zs.A 199: Show issues Location:
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  9. Article ; Online: Pulmonary hypertension associated with lung disease: new insights into pathomechanisms, diagnosis, and management.

    Olsson, Karen M / Corte, Tamera J / Kamp, Jan C / Montani, David / Nathan, Steven D / Neubert, Lavinia / Price, Laura C / Kiely, David G

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 9, Page(s) 820–835

    Abstract: Patients with chronic lung diseases, particularly interstitial lung disease and chronic obstructive pulmonary disease, frequently develop pulmonary hypertension, which results in clinical deterioration, worsening of oxygen uptake, and an increased ... ...

    Abstract Patients with chronic lung diseases, particularly interstitial lung disease and chronic obstructive pulmonary disease, frequently develop pulmonary hypertension, which results in clinical deterioration, worsening of oxygen uptake, and an increased mortality risk. Pulmonary hypertension can develop and progress independently from the underlying lung disease. The pulmonary vasculopathy is distinct from that of other forms of pulmonary hypertension, with vascular ablation due to loss of small pulmonary vessels being a key feature. Long-term tobacco exposure might contribute to this type of pulmonary vascular remodelling. The distinct pathomechanisms together with the underlying lung disease might explain why treatment options for this condition remain scarce. Most drugs approved for pulmonary arterial hypertension have shown no or sometimes harmful effects in pulmonary hypertension associated with lung disease. An exception is inhaled treprostinil, which improves exercise capacity in patients with interstitial lung disease and pulmonary hypertension. There is a pressing need for safe, effective treatment options and for reliable, non-invasive diagnostic tools to detect and characterise pulmonary hypertension in patients with chronic lung disease.
    MeSH term(s) Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Pulmonary Disease, Chronic Obstructive ; Pulmonary Arterial Hypertension ; Familial Primary Pulmonary Hypertension ; Clinical Deterioration
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00259-X
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    Zs.A 7041: Show issues Location:
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  10. Article: Health Disparities and Differences in Health-Care-Utilization in Patients With Pulmonary Arterial Hypertension.

    Park, Da-Hee / Meltendorf, Tanja / Kahl, Kai G / Kamp, Jan C / Richter, Manuel J / Hoeper, Marius M / Olsson, Karen M / Fuge, Jan

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 813506

    Abstract: Introduction: Mental disorders are common in patients with pulmonary arterial hypertension (PAH) and contribute to impaired quality of life (QoL). The impact of mental disorders on access to health care, differences in clinical parameters and treatment ... ...

    Abstract Introduction: Mental disorders are common in patients with pulmonary arterial hypertension (PAH) and contribute to impaired quality of life (QoL). The impact of mental disorders on access to health care, differences in clinical parameters and treatment in patients with PAH is unclear. In this study we sought to assess the impact of mental disorders and other health disparities on health-care-utilization in patients with PAH.
    Methods: In a cross-sectional observational study of patients with PAH, mental disorders were characterized using a structed clinical interview. In addition, patients completed a self-administered questionnaire to assess QoL, symptoms of anxiety and depression, lifestyle-factors and educational status. Number of outpatient visits and communication events per year were calculated as a surrogate for health-care-utilization and were compared by the presence of mental disorder. Linear regression analysis was conducted to assess the impact on health-care-utilization.
    Results: 117 patients with PAH participated in this study (70% female, median age 59 (interquartile range, 49-70) years). Significant differences between patients with or without mental disorders were found in anxiety, depression and QoL. There were no significant differences in clinical parameters. Patients with mental disorders had higher rates of outpatient visits and communication events than patients without mental disorders. Linear regression revealed a gain of 2.2 communication events per year in the presence of any mental disorders.
    Conclusion: Mental disorders in patients with PAH are common and significantly affect health-care-utilization. This higher demand in patients with mental disorder needs to be addressed by physicians, psychiatrists and specialized nurses offering therapeutic strategies.
    Language English
    Publishing date 2022-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.813506
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