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Article ; Online: Diabetes and the risk of cirrhosis and HCC: An analysis of the UK Biobank.

Ye, Fangzhou / Chen, Liangkai / Zheng, Xin

Hepatology communications

2023 Volume 7, Issue 11

Abstract: Background: Diabetes increases the risk of cirrhosis and HCC. We aimed to assess such associations given different diabetes statuses.: Methods: We included 449,497 participants in the UK Biobank cohort (mean age 56.7±8.0 y; 45.5% male) and assessed ... ...

Abstract	Background: Diabetes increases the risk of cirrhosis and HCC. We aimed to assess such associations given different diabetes statuses. Methods: We included 449,497 participants in the UK Biobank cohort (mean age 56.7±8.0 y; 45.5% male) and assessed the association between preclinical diabetes (prediabetes, having a high risk of diabetes), clinical diabetes (presence, duration, or glycemic control of type 2 diabetes), and incident liver cirrhosis and HCC by the Cox regression. Liver diseases were ascertained through inpatient records and national death registration. Gene-environment interaction was examined using the polygenic risk scores of cirrhosis and HCC. Results: Compared with normoglycemia, having <5 years,≥5 years of diabetes showed adjusted HRs (aHRs) of cirrhosis as 2.85 (2.45-3.32) and 3.43 (2.92-4.02), respectively, which was similarly observed in HCC. In diabetes, a level of hemoglobin A1c ≥ 7.5% showed aHRs of 1.37 (1.07-1.76) and 1.89 (1.10-3.25) for cirrhosis and HCC, respectively, compared with hemoglobin A1c < 6.5%. In non-diabetes, prediabetes presented aHRs of 1.41 (1.14-1.73) and 1.80 (1.06-3.04) of cirrhosis and HCC, respectively. Participants with a high risk of diabetes at baseline showed an aHR of 3.31 (2.65-4.13) for cirrhosis and 2.09 (1.15-3.80) for HCC. In those with a high genetic risk of HCC, having an increased risk of diabetes posed a significantly higher risk of HCC (aHR: 1.93, 1.45-2.58, Pinteraction=0.005), compared with those without a high genetic risk of HCC. Conclusions: Not only diabetes but preclinical diabetes, longer diabetes duration, and higher baseline hemoglobin A1c were associated with an increased risk of incident cirrhosis and HCC in the general population.
MeSH term(s)	Humans ; Male ; Middle Aged ; Female ; Carcinoma, Hepatocellular/epidemiology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/complications ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/complications ; Liver Neoplasms/epidemiology ; Liver Neoplasms/genetics ; Liver Neoplasms/complications ; Glycated Hemoglobin ; Prediabetic State/complications ; Biological Specimen Banks ; Liver Cirrhosis/complications ; United Kingdom/epidemiology
Chemical Substances	Glycated Hemoglobin
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ISSN	2471-254X
ISSN (online)	2471-254X
DOI	10.1097/HC9.0000000000000280
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Report and literature review of four cases of EWSR1::NFATC2 round cell sarcoma.

Liu, Lili / Li, Lan / Ding, Yi / Kong, Fangzhou / Mo, Wenfa / Ye, Hongtao / Shen, Danhua

Diagnostic pathology

2024 Volume 19, Issue 1, Page(s) 19

Abstract: Background: EWSR1::NFATC2 rearranged sarcomas are a group of rare round, undifferentiated sarcomas with clinicopathological features different from those of Ewing's sarcoma (ES) family and other non-ES sarcomas. We report 4 cases of this rare sarcoma ... ...

Abstract	Background: EWSR1::NFATC2 rearranged sarcomas are a group of rare round, undifferentiated sarcomas with clinicopathological features different from those of Ewing's sarcoma (ES) family and other non-ES sarcomas. We report 4 cases of this rare sarcoma and review their features. Materials and methods: Four cases of EWSR1::NFATC2 rearranged round cell sarcoma of the bone from the Pathology Department of Peking University People's Hospital were retrospectively studied. Clinical and pathological data were summarized, and immunohistochemical staining, fluorescence in situ hybridization (FISH), and Next-generation sequencing (NGS) were performed. Relevant literature reports were also reviewed. Results: Among the four cases of EWSR1::NFATC2 rearranged round cell sarcoma, three were male, and one was female, with the age ranged from 14 to 34 years old at diagnosis (mean age: 27.5 years). All tumors were located in the femur and ranged in size from 4 to 8cm (mean 6cm), involving the surrounding soft tissues. All four patients underwent surgical treatment, and three received chemotherapy and radiotherapy postoperatively. Follow-up results showed that all four patients were alive. Histologically, the tumors exhibited small round cell sarcoma phenotype, with the stroma rich in mucin or exhibiting a glassy appearance. The tumor cells diffusely expressed CD99, NKX2.2, NKX3.1 and focal expression of CK and EMA was observed. FISH analysis showed that EWSR1 gene rearrangement was detected in all 4 cases, accompanied by 5' locus amplification. EWSR1::NFATC2 fusion probe demonstrated multi yellow fusion signals. NGS identified EWSR1::NFATC2 breakpoints in exon 9 and exon 3 in all 4 cases. The average follow-up duration of the study group was 88 months (range from 26-180 months). One case experienced both local recurrence and metastasis to the lung and chest wall. One case presented with local recurrence. The remaining two cases did not have the recurrence or metastasis. Conclusion: Although the disease can locally recur and metastasize to the lungs, its mortality rate is significantly lower than that of Ewing sarcoma and other high-grade small round cell undifferentiated sarcomas. Therefore, it supports to classify this tumor as a separate subtype of small round cell sarcoma.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Male ; Young Adult ; Exons ; In Situ Hybridization, Fluorescence ; Neuroectodermal Tumors, Primitive, Peripheral ; NFATC Transcription Factors/genetics ; Retrospective Studies ; RNA-Binding Protein EWS/genetics ; Sarcoma ; Sarcoma, Ewing ; Soft Tissue Neoplasms ; Oncogene Proteins, Fusion
Chemical Substances	EWSR1 protein, human ; NFATC Transcription Factors ; NFATC2 protein, human ; RNA-Binding Protein EWS ; NFATc2-EWSR1 fusion protein, human ; Oncogene Proteins, Fusion
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2210518-9
ISSN	1746-1596 ; 1746-1596
ISSN (online)	1746-1596
ISSN	1746-1596
DOI	10.1186/s13000-024-01443-y
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Article ; Online: Novel nomograms based on microvascular invasion grade for early-stage hepatocellular carcinoma after curative hepatectomy.

Chen, Hengkai / Ye, Honghao / Ye, Linfang / Lin, Fangzhou / Shi, Yingjun / Zhong, Aoxue / Guan, Guoxian / Zhuang, Jinfu

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3470

Abstract: Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). This study aimed to firstly develop and validate nomograms based on MVI grade for predicting recurrence, especially early recurrence, ... ...

Abstract	Microvascular invasion (MVI) is a critical risk factor for postoperative recurrence of hepatocellular carcinoma (HCC). This study aimed to firstly develop and validate nomograms based on MVI grade for predicting recurrence, especially early recurrence, and overall survival in patients with early-stage HCC after curative resection. We retrospectively reviewed the data of patients with early-stage HCC who underwent curative hepatectomy in the First Affiliated Hospital of Fujian Medical University (FHFU) and Mengchao Hepatobiliary Hospital of Fujian Medical University (MHH). Kaplan-Meier curves and Cox proportional hazards regression models were used to analyse disease-free survival (DFS) and overall survival (OS). Nomogram models were constructed on the datasets from the 70% samples of and FHFU, which were validated using bootstrap resampling with 30% samples as internal validation and data of patients from MHH as external validation. A total of 703 patients with early-stage HCC were included to create a nomogram for predicting recurrence or metastasis (DFS nomogram) and a nomogram for predicting survival (OS nomogram). The concordance indexes and calibration curves in the training and validation cohorts showed optimal agreement between the predicted and observed DFS and OS rates. The predictive accuracy was significantly better than that of the classic HCC staging systems.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/pathology ; Nomograms ; Liver Neoplasms/pathology ; Retrospective Studies ; Hepatectomy ; Prognosis
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54260-0
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Article: Indocyanine green angiography for lower incidence of anastomotic leakage after transanal total mesorectal excision: a propensity score-matched cohort study.

Chen, Hengkai / Ye, Linfang / Huang, Changyu / Shi, Yingjun / Lin, Fangzhou / Ye, Honghao / Huang, Yongjian

Frontiers in oncology

2023 Volume 13, Page(s) 1134723

Abstract: Background: Anastomotic leakage (AL) is the most serious complication that can arise during colorectal surgery. Indocyanine green (ICG) angiography offers an intraoperative assessment of colonic vascular perfusion in real time. We aimed to assess ICG's ... ...

Abstract	Background: Anastomotic leakage (AL) is the most serious complication that can arise during colorectal surgery. Indocyanine green (ICG) angiography offers an intraoperative assessment of colonic vascular perfusion in real time. We aimed to assess ICG's effects on the AL rate in patients who have undergone transanal total mesorectal excision (TaTME) for rectal cancer. Methods: This retrospective cohort study was conducted at our center from October 2018 to March 2022 to analyze the clinical data of patients with rectal cancer who have undergone TaTME after propensity score matching (PSM). The primary outcome was the proximal colonic transection line modification and clinical AL rate. Results: A total of 143 patients in the non-ICG group and 143 patients in the ICG group were included after PSM. The proximal colonic transection line of seven patients in the non-ICG group was modified, while 18 were in the ICG group (4.9% Conclusions: ICG angiography is a safe and feasible method to help surgeons identify potentially poor colonic vascular perfusion and modify the proximal colonic transection line, resulting in a significant reduction in AL and hospital readmission rates.
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1134723
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Article ; Online: Exemplar-Based 3D Portrait Stylization.

Han, Fangzhou / Ye, Shuquan / He, Mingming / Chai, Menglei / Liao, Jing

IEEE transactions on visualization and computer graphics

2022 Volume 29, Issue 2, Page(s) 1371–1383

Abstract: Exemplar-based portrait stylization is widely attractive and highly desired. Despite recent successes, it remains challenging, especially when considering both texture and geometric styles. In this article, we present the first framework for one-shot 3D ... ...

Abstract	Exemplar-based portrait stylization is widely attractive and highly desired. Despite recent successes, it remains challenging, especially when considering both texture and geometric styles. In this article, we present the first framework for one-shot 3D portrait style transfer, which can generate 3D face models with both the geometry exaggerated and the texture stylized while preserving the identity from the original content. It requires only one arbitrary style image instead of a large set of training examples for a particular style, provides geometry and texture outputs that are fully parameterized and disentangled, and enables further graphics applications with the 3D representations. The framework consists of two stages. In the first geometric style transfer stage, we use facial landmark translation to capture the coarse geometry style and guide the deformation of the dense 3D face geometry. In the second texture style transfer stage, we focus on performing style transfer on the canonical texture by adopting a differentiable renderer to optimize the texture in a multi-view framework. Experiments show that our method achieves robustly good results on different artistic styles and outperforms existing methods. We also demonstrate the advantages of our method via various 2D and 3D graphics applications.
Language	English
Publishing date	2022-12-29
Publishing country	United States
Document type	Journal Article
ISSN	1941-0506
ISSN (online)	1941-0506
DOI	10.1109/TVCG.2021.3114308
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Article ; Online: BEFP

Ting Lyu / Liang Liu / Fangzhou Zhu / Simin Hu / Renjun Ye

Security and Communication Networks, Vol

An Extension Recognition System Based on Behavioral and Environmental Fingerprinting

2022 Volume 2022

Abstract: Browser extensions are third-party applications that can customize the browsing experience. Previous studies have shown that browser extension fingerprinting can be used to track users and reveal users’ privacy information by obtaining the browser ... ...

Abstract	Browser extensions are third-party applications that can customize the browsing experience. Previous studies have shown that browser extension fingerprinting can be used to track users and reveal users’ privacy information by obtaining the browser extension list. However, the proposal of various defense measures weakens the effectiveness of the existing extension fingerprinting technologies. In this paper, we first propose two extension fingerprinting technologies: JavaScript-based environmental fingerprinting and DOM-based behavioral fingerprinting. They, respectively, capture the operation behaviors of extensions on JavaScript properties and webpage’s DOM. Second, we design BEFP, an extension recognition system which comprehensively utilizes the above two technologies to improve the uniqueness of the extension fingerprint. Finally, we collect the latest data set and carry out experiments on the actual scenario where users install multiple extensions. The results show that the true positive rate of extension recognition is as high as 96.3%. And the extension’s detectable rate of BEFP is superior to the existing technologies. Moreover, it is proved that the JavaScript-based environmental fingerprinting can complement the DOM-based fingerprinting to distinguish the extensions with the same DOM modification.
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	004
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
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Article ; Online: Learning Curves of Flexible Ureteroscopy (275 Cases) and Prone Percutaneous Nephrolithotomy (73 Cases) in Pediatric Stones: Data from 348 Children.

Wang, Xiaochuan / Zhang, Yu / Zhao, Fangzhou / Ji, Zhengguo / Yang, Peiqian / Li, Jun / Tian, Ye

Journal of endourology

2022 Volume 36, Issue 11, Page(s) 1502–1508

Abstract: Objectives: ...

Abstract	Objectives:
MeSH term(s)	Adult ; Humans ; Child ; Nephrolithotomy, Percutaneous/methods ; Ureteroscopy/methods ; Learning Curve ; Treatment Outcome ; Ureteroscopes ; Kidney Calculi/surgery ; Retrospective Studies
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2021.0757
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.

Li, Jian / Zhang, Yaqiong / Ye, Fangzhou / Qian, Peiyu / Qin, Zhe / Li, Deming / Ye, Li / Feng, Li

Cancers

2023 Volume 15, Issue 19

Abstract: Chemotherapy is a classical method of cancer treatment. Cisplatin-based chemotherapy is a traditional and essential therapeutic approach in gastric cancer treatment. However, the development of drug resistance during treatment is a major obstacle that ... ...

Abstract	Chemotherapy is a classical method of cancer treatment. Cisplatin-based chemotherapy is a traditional and essential therapeutic approach in gastric cancer treatment. However, the development of drug resistance during treatment is a major obstacle that limits their further application, and molecular changes have occurred in the development of drug resistance. Here, we found that Dickkopf-related protein 1 (DKK1) is highly expressed in gastric cancer and related to poor prognosis in gastric cancer patients through public database mining. Next, we also identified that DKK1 is highly expressed in CDDP-resistant gastric cancer cell lines, supporting the notion that DKK1 is a necessary regulator of CDDP resistance. In terms of mechanistic research, our data reveal that DKK1 was able to activate the PI3K/AKT pathway and affect epithelial-to-mesenchymal transition, further contributing to CDDP resistance. Genetic knockdown and pharmacological inhibition of DKK1 recovered CDDP sensitivity both in vitro and in vivo. Therefore, our study highlights the potential of targeted inhibition of DKK1 to reverse CDDP resistance and alleviate metastatic properties in gastric cancer.
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15194756
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Article ; Online: Breast cancer brain metastasis: insight into molecular mechanisms and therapeutic strategies.

Wang, Yajie / Ye, Fangzhou / Liang, Yiran / Yang, Qifeng

British journal of cancer

2021 Volume 125, Issue 8, Page(s) 1056–1067

Abstract: Breast cancer is one of the most prevalent malignancies in women worldwide. Early-stage breast cancer is considered a curable disease; however, once distant metastasis occurs, the 5-year overall survival rate of patients becomes significantly reduced. ... ...

Abstract	Breast cancer is one of the most prevalent malignancies in women worldwide. Early-stage breast cancer is considered a curable disease; however, once distant metastasis occurs, the 5-year overall survival rate of patients becomes significantly reduced. There are four distinct metastatic patterns in breast cancer: bone, lung, liver and brain. Among these, breast cancer brain metastasis (BCBM) is the leading cause of death; it is highly associated with impaired quality of life and poor prognosis due to the limited permeability of the blood-brain barrier and consequent lack of effective treatments. Although the sequence of events in BCBM is universally accepted, the underlying mechanisms have not yet been fully elucidated. In this review, we outline progress surrounding the molecular mechanisms involved in BCBM as well as experimental methods and research models to better understand the process. We further discuss the challenges in the management of brain metastases, as well as providing an overview of current therapies and highlighting innovative research towards developing novel efficacious targeted therapies.
MeSH term(s)	Animals ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Female ; Gene Regulatory Networks/drug effects ; Humans ; Immunotherapy ; Molecular Targeted Therapy ; Prognosis ; Survival Analysis
Language	English
Publishing date	2021-07-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-021-01424-8
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Uh III Zs.142: Show issues

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Article ; Online: Outcomes of retrograde ureteroscopy in Chinese infants and toddlers under 3 years old with ureteric stones from a single center.

Zhao, Youquan / Wang, Xiaochuan / Zhao, Fangzhou / Yang, Boyu / Tian, Ye / Li, Jun

Journal of pediatric urology

2023

Abstract: Introduction: Pediatric urolithiasis is a less common disease with a steadily increasing incidence of 10.6 % per year. The comprehensive management of pediatric urolithiasis is more challenging than in adults, and published studies of endourological ... ...

Abstract	Introduction: Pediatric urolithiasis is a less common disease with a steadily increasing incidence of 10.6 % per year. The comprehensive management of pediatric urolithiasis is more challenging than in adults, and published studies of endourological treatment in children have small sample sizes and older mean ages, which may not be representative of the overall pediatric population, especially in infants and toddlers. This study aimed to report results of retrograde ureteroscopy for treating pediatric ureteral stones in infants and toddlers (<3 years) from a single center in China. Methods: Demographic and surgical data of infants and toddlers with ureteral stones who underwent retrograde URS were retrospectively analyzed from January 2015 to September 2022. Results: The mean age of 100 infants (73 boys and 27 girls) was 19.6 ± 7.6 months and stone burden was 0.27 (0.11-0.52) cm³. 111 procedures were performed for all children due to 11 patients with bilateral ureteric stones were simultaneously treated. Among them, 70.3 % were semi-rigid URS, 12.6 % were Micro-URS and 17.1 % were flexible URS. SFR was up to 96 %, the median operation time and hospitalization days were 35.0 (25.0-50.0) minutes and 6.0 (5.0-6.0) days, respectively. 15 (15.0 %) infants had postoperative fever (Grade I), and complications above grade I were not observed. Discussions: This research reported the largest sample size of infant and toddler ureteric stones (under 3 years old) and shared optimal management strategies for these special populations. Compared to other related studies, we had a higher SFR due to diverse management strategies and reasonable application of pre-operative ureteric stents. The most important potential reason why our complication rate was relatively higher might be the younger population under 3 years old. In additionally, the reason of long hospitalization was maybe some patients underwent staged surgeries during one hospitalization. Those results indicated the robust effectiveness of URS for infants. This study has limitations, including its retrospective single-center design, absence of long-term follow-up data, and potential variability in surgical outcomes due to differences in surgeons' experience. Conclusions: The experience of endourologic procedures for 100 infant and toddler patients with ureteric stones from a Chinese single center was reported. And URS showed its effectiveness and safety for those special populations based on its high SFR and low complication rate.
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2237683-5
ISSN	1873-4898 ; 1477-5131
ISSN (online)	1873-4898
ISSN	1477-5131
DOI	10.1016/j.jpurol.2023.12.003
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