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  1. Article ; Online: Current status of sinonasal cancer survivorship care.

    Han, Albert Y / Nader, Marc-Elie / Lam, Keng / Su, Shirley Y

    Head & neck

    2023  Volume 45, Issue 9, Page(s) 2458–2468

    Abstract: Sinonasal cancer is a heterogeneous orphan disease of diverse histologies, each with distinct clinical, oncologic, and toxicity profiles. Because of the comparative rarity of these cancers, sinonasal cancers are treated as a grouped diagnosis despite ... ...

    Abstract Sinonasal cancer is a heterogeneous orphan disease of diverse histologies, each with distinct clinical, oncologic, and toxicity profiles. Because of the comparative rarity of these cancers, sinonasal cancers are treated as a grouped diagnosis despite their clinical and biological heterogeneity. Multimodality treatment with a combination of surgery, chemotherapy, and/or radiotherapy is the standard-of-care for advanced-stage patients but there are few surveillance or follow-up practice guidelines or formalized survivorship care pathways. A scoping literature review was conducted via PubMed, EMBASE, and Google Scholar. A total of 112 studies were included, which were grouped along the following topics: surveillance, second primary tumors, quality of life, and symptom burden. Sinonasal cancer tends to exhibit a higher rate of local failure and occur in a delayed fashion compared to mucosal malignancies of the head and neck. Moreover, the site of failure and time-varying risk of recurrence is histology-specific. Following multimodality treatment of the skull base, patients may experience endocrine, visual, auditory, sinonasal, olfactory, and neurocognitive deficits, as well as psychosocial impairments that impact multiple physical and neuropsychological domains, resulting in diminished quality of life. Sinonasal cancer patients would benefit from tailored, histology-specific survivorship programs to address the recurrence, second primary, and functional impairments resulting from disease and treatment toxicity.
    MeSH term(s) Humans ; Survivorship ; Quality of Life ; Cancer Survivors ; Paranasal Sinus Neoplasms/pathology ; Combined Modality Therapy
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Speech and Swallowing Outcomes of Surgically Managed Cervical Chordoma: A Case Series.

    Yu, Alice C / Ko, Myungjun / Han, Albert Y / St John, Maie / Chhetri, Dinesh K

    The Laryngoscope

    2024  

    Abstract: Objectives: Cervical chordoma is a rare, low-grade primary bone tumor occurring in the axial skeleton. Due to challenges in surgical exposure caused by anatomic location, patients may experience dysfunction in speech and swallowing. The objective of ... ...

    Abstract Objectives: Cervical chordoma is a rare, low-grade primary bone tumor occurring in the axial skeleton. Due to challenges in surgical exposure caused by anatomic location, patients may experience dysfunction in speech and swallowing. The objective of this study was to characterize speech and swallowing outcomes for patients undergoing surgical resection of cervical chordoma. Moreover, we detail in-depth two cases with similar initial presentations to compare prognostic factors and management strategies.
    Methods: Eleven patients with histologically confirmed cervical chordoma treated between 1993 and 2020 were included in this retrospective case series. Outcomes measured included overall survival, disease-free survival, need for enteral feeds, as well as results of modified barium swallow study (MBSS) and fiberoptic laryngoscopy.
    Results: The mean age at diagnosis was 55.9 years. The patient population was 81.8% male. Mean survival after diagnosis was 96 months. Four (36.4%) patients required post-operative MBSS and demonstrated aspiration. All four of these patients presented with tumors in the superior cervical spine and received surgeries utilizing anterior approaches. Of the four, 2 required enteral feeds long-term. Four (36.4%) patients endorsed dysphonia. One patient developed post-operative right vocal fold paresis. The remaining three patients experienced stable dysphonia pre- and post-operatively. Additionally, three (27%) patients required tracheostomy placement, two of which remained in place long-term.
    Conclusions: Dysphagia is a common side effect of cervical chordoma resection. It is associated with the use of an anterior approach during resection and with tumors located in the superior cervical spine. Patients with postoperative dysphagia should receive early multidisciplinary swallow rehabilitation.
    Level of evidence: 4 Laryngoscope, 2024.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nasal Mass in a Middle-aged Woman With Multiple Myeloma and Recurrent Fungal Sinusitis.

    Yu, Alice C / Han, Albert Y / Sercarz, Joel A

    JAMA otolaryngology-- head & neck surgery

    2021  

    Language English
    Publishing date 2021-06-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2021.1142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Trends in Indications and Contraindications for Cervical Disk Arthroplasty from 2009 to 2019.

    Shafi, Karim / Du, Jerry Y / Blackburn, Collin W / Kim, Han Jo / Iyer, Sravisht / Qureshi, Sheeraz / Marcus, Randall E / Albert, Todd J

    Clinical spine surgery

    2024  

    Abstract: Study design: Cross-sectional study.: Objective: Assess trends of indications and contraindications for the use of Cervical Disk Arthroplasty (CDA).: Summary of background data: As spine surgeons become more familiar with CDA, there have been ... ...

    Abstract Study design: Cross-sectional study.
    Objective: Assess trends of indications and contraindications for the use of Cervical Disk Arthroplasty (CDA).
    Summary of background data: As spine surgeons become more familiar with CDA, there have been expansions in indications.
    Methods: The Medicare Provider Analysis and Review Limited Data Sets for 2009, 2014, and 2019 were utilized. Patients undergoing elective CDA were included. Diagnosis for index surgery and "contraindications" as defined by original CDA Investigative Device Exemption (IDE) criteria were assessed. Variables were identified by the International Classification of Diseases (ICD)-9 or ICD-10 diagnosis and procedural codes.
    Results: A total of 1067 elective CDA patients were included. There were 230 patients in 2009, 300 patients in 2014, and 537 patients in 2019. The proportion of patients aged >65 increased from 35% to 51% (P<0.001). Incidence of CDA for radiculopathy increased from 57% to 69% (P<0.001), myelopathy increased from 23% to 78% (P<0.001), and spondylosis without radiculopathy or myelopathy decreased from 19% to 3% (P<0.001). There were increased incidences of ankylosing spondylitis (0.4% to 2.8%, P=0.007), long-term steroid use (1% to 2%, P=0.039), morbid obesity (2% to 6%, P=0.019), and osteoporosis (1% to 5%, P=0.014). The incidence of hybrid CDA and anterior cervical discectomy and fusion (ACDF) decreased from 28% to 23% (P=0.007).
    Conclusion: From 2009 to 2019, the number of CDA performed in older patients increased. An increase in the use of CDA for the treatment of myelopathy and radiculopathy and a decrease in the treatment of isolated cervical spondylosis was observed. The proportion of CDA performed in patients with original IDE trial "contraindications" increased. Further research into the efficacy of CDA for patients with contraindications is warranted.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Rare Case of Laryngeal Non-IgM Lymphoplasmacytic Lymphoma.

    Hong, Michelle K / Han, Albert Y / Shiba, Travis L

    Cureus

    2022  Volume 14, Issue 9, Page(s) e29136

    Abstract: Laryngeal lymphoplasmacytic lymphoma has been previously reported only a handful of times in the literature. It can be difficult to diagnose without significant histologic workup and proper methodology. Here, we demonstrate the first known case of ... ...

    Abstract Laryngeal lymphoplasmacytic lymphoma has been previously reported only a handful of times in the literature. It can be difficult to diagnose without significant histologic workup and proper methodology. Here, we demonstrate the first known case of laryngeal lymphoplasmacytic lymphoma with non-immunoglobulin M (IgM) features. In this case report, a 79-year-old female with seropositive rheumatoid arthritis presented with five months of dysphonia and dyspnea on exertion. Lab studies revealed high levels of serum IgA and IgG. Flexible laryngoscopy and computed tomography of the neck showed a left supraglottic submucosal mass, which was surgically excised with a carbon dioxide laser. The histology of the mass confirmed the diagnosis of lymphoplasmacytic lymphoma. The patient was treated with 30.6 Gy of radiation therapy and eight cycles of rituximab with successful remission of her lymphoma and no evidence of disease recurrence six months after treatment completion. Lymphoplasmacytic lymphoma without corresponding IgM gammopathy is unusual and has been shown to have a higher frequency of extramedullary involvement. This is the first known manifestation of non-IgM lymphoplasmacytic lymphoma in the larynx.
    Language English
    Publishing date 2022-09-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.29136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Intractable Hiccups Caused by Diaphragmatic Eventration.

    Hong, Michelle K / Han, Albert Y / Long, Jennifer L

    Cureus

    2022  Volume 14, Issue 4, Page(s) e24430

    Abstract: Intractable hiccups are a rare yet debilitating pathology with a broad differential and often indicate a more serious underlying pathology, which can range from neoplasms to structural abnormalities. In this case report, we present a 64-year-old male ... ...

    Abstract Intractable hiccups are a rare yet debilitating pathology with a broad differential and often indicate a more serious underlying pathology, which can range from neoplasms to structural abnormalities. In this case report, we present a 64-year-old male with seven months of intractable hiccups determined to be caused by eventration of the right hemidiaphragm. The patient was treated with baclofen to treat the hiccups pharmacologically. He was also prescribed voice therapy to establish rescue breathing techniques and reduce laryngospasm. Finally, he was referred to thoracic surgery for further evaluation and potential surgical intervention should his diaphragmatic eventration worsen or cause hypoxemia. To our knowledge, this is the first reported case of an association between diaphragmatic eventration and intractable hiccups. It is important to highlight this addition to the broad differential of intractable hiccups and to emphasize an interdisciplinary approach to workup and treatment of intractable hiccups.
    Language English
    Publishing date 2022-04-24
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Predictors of Nodal Metastasis in Cutaneous Head and Neck Cancers.

    Han, Albert Y / John, Maie A St

    Current oncology reports

    2022  Volume 24, Issue 9, Page(s) 1145–1152

    Abstract: Purpose of review: The complex and varied drainage patterns in the head and neck present a challenge in the regional control of cutaneous neoplasms. Lymph node involvement significantly diminishes survival, often warranting more aggressive treatment. ... ...

    Abstract Purpose of review: The complex and varied drainage patterns in the head and neck present a challenge in the regional control of cutaneous neoplasms. Lymph node involvement significantly diminishes survival, often warranting more aggressive treatment. Here, we review the risk factors associated with lymphatic metastasis, in the context of the evolving role of sentinel lymph node biopsy.
    Recent findings: In cutaneous head and neck melanomas, tumor thickness, age, size, mitosis, ulceration, and specific histology have been associated with lymph node metastasis (LNM). In head and neck cutaneous squamous cell carcinomas, tumor thickness, size, perineural invasion, and immunosuppression are all risk factors for nodal metastasis. The risk factors for lymph node involvement in Merkel cell carcinoma are not yet fully defined, but emerging evidence indicates that tumor thickness and size may be  associated with regional metastasis. The specific factors that predict a greater risk of LNM for cutaneous head and neck cancers generally include depth of invasion, tumor size, mitotic rate, ulceration, immunosuppression, and other histopathological factors.
    MeSH term(s) Head and Neck Neoplasms/pathology ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Melanoma/pathology ; Retrospective Studies ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/pathology ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2022-04-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-022-01249-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Blue, Green, or Radioisotope: Which Modality Is Best for Head and Neck Melanoma SLN Identification?

    Wong, Emily C / Han, Albert Y / St John, Maie

    The Laryngoscope

    2021  Volume 132, Issue 2, Page(s) 253–254

    MeSH term(s) Coloring Agents ; Diagnostic Techniques, Radioisotope ; Head and Neck Neoplasms/diagnosis ; Humans ; Indocyanine Green ; Melanoma/diagnosis ; Sentinel Lymph Node
    Chemical Substances Coloring Agents ; Indocyanine Green (IX6J1063HV)
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.29510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Secondary syphilis of the oropharynx and cervical lymph nodes: a case report.

    Han, Albert Y / Wang, Jennifer N / Yu, Alice C / Shiba, Travis L

    Ear, nose, & throat journal

    2022  , Page(s) 1455613221095605

    Abstract: Secondary syphilis rarely affects the head and neck including the oropharynx and cervical lymph nodes. These patients present with throat pain, cystic/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be ... ...

    Abstract Secondary syphilis rarely affects the head and neck including the oropharynx and cervical lymph nodes. These patients present with throat pain, cystic/necrotic lymphadenopathy, and mucosal swelling. Sometimes this constellation of symptoms can be mistaken for head and neck cancer. We report a case of an enlarging throat and painless cystic neck mass in a transgender woman in her forties who was initially suspected to have oropharyngeal squamous cell carcinoma. A subsequent workup revealed the presence of spirochetes without cellular atypia consistent with secondary syphilis. We include the ultrasonography images as well as an endoscopic photograph of the oropharyngeal manifestation in this report.
    Language English
    Publishing date 2022-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 750153-5
    ISSN 1942-7522 ; 0145-5613
    ISSN (online) 1942-7522
    ISSN 0145-5613
    DOI 10.1177/01455613221095605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Does American Society of Anesthesiologist classification effect hospital course and postoperative complications following oral and maxillofacial surgical procedures?

    Kurnick, Benjamin / Madrigal, Josef / Han, Albert Y / Benharash, Peyman / St John, Maie A / Aghaloo, Tara

    Oral surgery, oral medicine, oral pathology and oral radiology

    2023  Volume 136, Issue 2, Page(s) 136–141

    Abstract: Objective: The purpose of the present study was to assess the duration of operative time and outcomes related to patients with an increased American Society of Anesthesiologists (ASA) Physical Status classification in the setting of hospital-based ... ...

    Abstract Objective: The purpose of the present study was to assess the duration of operative time and outcomes related to patients with an increased American Society of Anesthesiologists (ASA) Physical Status classification in the setting of hospital-based maxillofacial surgical procedures.
    Study design: The study was a retrospective multi-institutional cohort study using the American College of Surgeons National Surgical Quality Improvement Program database to enroll patients who underwent maxillofacial procedures between 2012 and 2019. The primary independent variable was ASA Physical Status Classification (I, II, III, IV). Descriptive, univariate, and multiple logistic regression statistics were used to evaluate the relationship between ASA classification, body mass index (BMI), operative time, and perioperative complications.
    Results: The study cohort was comprised of 1807 patients, with 946 males and 861 females. The ASA Physical Status Classification ranged from class I to IV. On bivariate analysis, patients classified as ASA III (286 [IQR 152-503], P < .001) and ASA IV (412 [IQR 156.5-547.5], P = .003) were associated with longer operative times. The risk of perioperative complications was 2.6% for ASA I patients (n = 19), 6.3% for ASA II (n = 48; P = .005), 24.5% for ASA III (n = 76; P < .001), and 55.0% for ASA IV (n = 11; P < .001). On multivariate-adjusted analysis, using ASA I as the reference, ASA III (β +53.2 minutes, 95% CI +28.6 to +77.8, P < .001) and ASA IV (β +81.5 minutes, 95% CI +21.0 to +141.9, P = .008) were variables associated with longer operative time.
    Conclusions: Increased ASA Physical Status Classification was associated with increased operative time and perioperative complications.
    MeSH term(s) Female ; Humans ; Male ; Anesthesiologists ; Cohort Studies ; Hospitals ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors ; United States
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2023.01.003
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