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  1. Article: Debridement von Verbrennungen - enzymatisch-operativ. Burn debridement - enzymatic debridement compared to tangential excision

    Schiefer, J. L. / Fuchs, P. C.

    Chirurgische Praxis

    2021  Volume 88, Issue 4, Page(s) 587

    Language German
    Document type Article
    ZDB-ID 500633-8
    ISSN 0009-4846
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: How to evaluate scar colour after burn injuries - A clinical comparison of the Mexameter® and the subjective scar assessment (POSAS/VSS).

    Bagheri, M / von Kohout, M / Fuchs, P C / Seyhan, H / Stromps, J P / Lefering, R / Opländer, C / Schiefer, J L

    Burns : journal of the International Society for Burn Injuries

    2023  Volume 50, Issue 3, Page(s) 691–701

    Abstract: Introduction: Scarring after burn injuries remains one of the major challenges in burn medicine and is the subject of current research. Accurate and high-quality assessment of scars is needed to enable exact outcome evaluation of different treatments. ... ...

    Abstract Introduction: Scarring after burn injuries remains one of the major challenges in burn medicine and is the subject of current research. Accurate and high-quality assessment of scars is needed to enable exact outcome evaluation of different treatments. Our aim was to evaluate the most common subjective scar evaluation scores-the POSAS (Patient and Observer Scar Assessment Scale) and VSS (Vancouver Scar Scale)-in comparison with the objective device Mexameter® for colour evaluation.
    Methods: A prospective monocentre study was performed, which included 120 examined scar areas of 60 patients with third degree burns who had received skin grafts between 1975 and 2018 with a total burned surface area (TBSA) > 2%. Two different scar areas in comparison with one healthy skin area concerning 'colour', 'pigmentation', and 'vascularization' were evaluated by the Mexameter® MX 18, the OSAS, and the VSS by the same examiner, as well as the PSAS by the patient.
    Results: The mean TBSA of the 60 patients was 24.3%. In the OSAS, 61% of the scars were evaluated as 'hyper-', 19% as 'hypo-', and 19% as 'mix-pigmented'. Furthermore, 65% of the scars were estimated as highly vascularized. In the Mexameter®, the melanin index values of the scar areas compared to the healthy skin areas showed a small difference of 12 (p < 0.05). The mean difference of erythema between the scar and the healthy skin areas was 84 (p < 0.001). For the Mexameter®, moderate correlations were found when comparing 'erythema' with the OSAS category 'vascularization' (r = 0.33, p < 0.05) and 'melanin' with the OSAS parameter 'pigmentation' (r = 0.28, p < 0.05). When comparing the Mexameter® measurements to the OSAS questionnaire, 27% of the scars were wrongly evaluated as 'hyperpigmented' by the observer and 21% as 'hypervascularized', while showing low measurements in the device. Additionally, a novel Mexameter® ordinal scare scale was calculated.
    Conclusion: In this study, we were able to show on a relatively large patient population that with the Mexameter®, the subjectivity of the scar colour assessment by examiner/patient can be overcome, but precise differentiation can still be ensured with subjective evaluation tools. We further introduced a novel Mexameter® Scar Scale. It is necessary to further investigate the vast range of objective devices and develop scar panels for with an incorporation of objective and subjective devices to further improve reliability with reduced bias in terms of scar assessment.
    MeSH term(s) Humans ; Cicatrix/etiology ; Cicatrix/pathology ; Prospective Studies ; Reproducibility of Results ; Color ; Burns/complications ; Burns/therapy ; Erythema/etiology ; Melanins ; Sleep Apnea, Obstructive
    Chemical Substances Melanins
    Language English
    Publishing date 2023-11-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2023.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1250: Show issues Location:
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  3. Article: Can Cold Atmospheric Plasma Be Used for Infection Control in Burns? A Preclinical Evaluation.

    Bagheri, Mahsa / von Kohout, Maria / Zoric, Andreas / Fuchs, Paul C / Schiefer, Jennifer L / Opländer, Christian

    Biomedicines

    2023  Volume 11, Issue 5

    Abstract: Wound infection with Pseudomonas aeruginosa (PA) is a serious complication and is responsible for higher rates of mortality in burn patients. Because of the resistance of PA to many antibiotics and antiseptics, an effective treatment is difficult. As a ... ...

    Abstract Wound infection with Pseudomonas aeruginosa (PA) is a serious complication and is responsible for higher rates of mortality in burn patients. Because of the resistance of PA to many antibiotics and antiseptics, an effective treatment is difficult. As a possible alternative, cold atmospheric plasma (CAP) can be considered for treatment, as antibacterial effects are known from some types of CAP. Hence, we preclinically tested the CAP device PlasmaOne and found that CAP was effective against PA in various test systems. CAP induced an accumulation of nitrite, nitrate, and hydrogen peroxide, combined with a decrease in pH in agar and solutions, which could be responsible for the antibacterial effects. In an ex vivo contamination wound model using human skin, a reduction in microbial load of about 1 log
    Language English
    Publishing date 2023-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11051239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Our Initial Experience In The Customized Treatment Of Donor Site And Burn Wounds With A New Nanofibrous Temporary Epidermal Layer.

    Schulz, A / Fuchs, P C / Heitzmann, W / Kanho, C H / Schiefer, J L

    Annals of burns and fire disasters

    2021  Volume 34, Issue 1, Page(s) 58–66

    Abstract: Recently, electrospinning technology has gained increasing attention for wound care. SpinCare™ electrospun polymer nanofibrous temporary epidermal layer is one of the latest developments in the market. Our objective was to explore the potential use of ... ...

    Abstract Recently, electrospinning technology has gained increasing attention for wound care. SpinCare™ electrospun polymer nanofibrous temporary epidermal layer is one of the latest developments in the market. Our objective was to explore the potential use of the new SpinCare™ system for treating burns and wounds. We conducted a single-center prospective observational trial, treating 10 patients with superficial to partial thickness wounds including burn wounds with a nanofibrous dressing. Treatment was evaluated, including procedures, place of injury, treatment times, ease of use etc. Ten superficial to deep dermal wounds were treated successfully. Inexperienced users learned the handling of the device quickly. Covering difficult-to-access wound surfaces was challenging. One leading problem is that the product is nearly opaque once applied on the moist wound. We introduced a standardized 3-day treatment protocol. After application, wounds were covered with a silicon layer for 2 days. The nanofibrous dressing appeared to be suitable following enzymatic debridement in burn wounds. Because there is a risk of wounds drying out under the dressing, the application should probably be limited to superficial and partial thickness wounds if not combined with other treatment options. The electrospun polymer nanofibrous temporary epidermal layer shows promising results in the treatment of superficial to partial thickness wounds including burns. However, minor improvements might help to optimize its usage and thus take full advantage of all existing treatment options.
    Language English
    Publishing date 2021-05-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2106850-1
    ISSN 1592-9566 ; 1592-9558
    ISSN (online) 1592-9566
    ISSN 1592-9558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Does Platelet-Rich Fibrin Enhance Healing Of Burn Wounds? Our First Experiences And Main Pitfalls.

    Schulz, A / Schiefer, J L / Fuchs, P C / Kanho, C H / Nourah, N / Heitzmann, W

    Annals of burns and fire disasters

    2021  Volume 34, Issue 1, Page(s) 42–52

    Abstract: Recent research found that enzymatic debridement clearly improves long-term scarring in burns. By reducing the spontaneous wound-healing period, scarring might be optimized. The latest publications show that wound healing can be accelerated by the ... ...

    Abstract Recent research found that enzymatic debridement clearly improves long-term scarring in burns. By reducing the spontaneous wound-healing period, scarring might be optimized. The latest publications show that wound healing can be accelerated by the application of platelet-rich fibrin (PRF). However to date no study that evaluates PRF treatment in burn wounds following enzymatic debridement has been published. We conducted a single-center prospective observational trial treating ten patients with partial thickness to deep dermal burns after enzymatic debridement with PRF. After wound treatment, the dressing remained untouched for five days. For wound healing, we compared different dressings and treatment options. Minimum pain and no signs of infection were observed during any of the treatments. Physicians were able to learn the manufacture of PRF quickly. For two early treatments, skin grafting was required. In one case, the dressing was removed too early. In a second case, the wait for spontaneous wound healing was not long enough. After a standardized treatment procedure was set, we found that results were clearly improving. Mean healing time of seven wounds treated with Suprathel® dressing was 18 days (min 9 days, max 21 days). PRF application might be useful to reduce healing time in partial thickness to deep dermal burn wounds that heal spontaneously after enzymatic debridement. Thus, scarring can be improved.
    Language English
    Publishing date 2021-05-22
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2106850-1
    ISSN 1592-9566 ; 1592-9558
    ISSN (online) 1592-9566
    ISSN 1592-9558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The BUrn Mortality Prediction (BUMP) Score - An improved mortality prediction score based on data of the German burn registry.

    Bagheri, M / Fuchs, P C / Lefering, R / Daniels, M / Schulz, A / The German Burn Registry / Schiefer, J L

    Burns : journal of the International Society for Burn Injuries

    2022  

    Abstract: Background: Burn injuries constitute the fourth most common injuries globally. Patient outcomes must be currently assessed to provide appropriate patient care with high quality standards. However, existing mortality prediction scoring methods have been ... ...

    Abstract Background: Burn injuries constitute the fourth most common injuries globally. Patient outcomes must be currently assessed to provide appropriate patient care with high quality standards. However, existing mortality prediction scoring methods have been shown to lack accuracy in current burn patient populations. Therefore, this study aimed to validate existing scores using current patient data and assess whether new prediction parameters can provide better accuracy.
    Methods: A retrospective analysis of the patient data from the German Burn Registry between 2016 and 2019 was performed to evaluate all Abbreviated Burn Severity Index (ABSI) score parameters. All patients over 16 years of age who received intensive care were included. Descriptive statistics and logistic regression analysis were used to identify novel prediction parameters based on the parameters documented at admission and establish a new prediction score, the BUrn Mortality Prediction (BUMP) score. The quality of the new score was subsequently compared to that of the original ABSI, modified ABSI, Galeiras, Revised Baux score and TIMM. The new prediction score was then validated using patient data collected in the German Burn Registry in 2020.
    Results: In total, 7276 patients were included. Age; the presence of at least two comorbidities; burn injuries caused by work-related accidents, traffic accidents and suicide attempts; total burn surface area; inhalation trauma and full-thickness burns were identified as independent significant predictors of mortality (p < 0.001). Additionally, we evaluated new age groups to improve prediction accuracy. The number of comorbidities (p < 0.001) and the aetiology (burns occurring at work [p = 0.028], burns caused by traffic accidents [p < 0.001] or burns due to attempted suicide [p < 0.001]) had a significant influence on mortality. The BUMP score, which was developed based on these parameters, showed the best fitness and showed more accurate mortality prediction than all the above-mentioned scores (area under the receiver operating characteristic curve: 0.947 [0.939-0.954] compared to 0.926 [0.915-0.936], 0.928 [0.918-0.939], 0.937 [0.928-0.947], 0.939 [0.930-0.948], 0.940 [0.932-0.949] respectively).
    Conclusions: A novel score (BUMP score) was developed for the purpose of external quality assessment of burn centres participating in the German burn registry, where observed and expected outcomes are compared on a hospital level, and for scientifically applications. The clinical impact of this score and its generalisability to other patient populations needs to be evaluated.
    Language English
    Publishing date 2022-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2022.02.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1250: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Schlaf und Epilepsie. Sleep and epilepsy

    Schiefer, J.

    Zeitschrift für Epileptologie

    2018  Volume 31, Issue 1, Page(s) 12

    Language German
    Document type Article
    ZDB-ID 2049814-7
    ISSN 1617-6782
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2440: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Low-Dose Blue Light (420 nm) Reduces Metabolic Activity and Inhibits Proliferation of Human Dermal Fibroblasts.

    Brüning, Anne K E / Schiefer, Jennifer L / Fuchs, Paul C / Petzsch, Patrick / Köhrer, Karl / Suschek, Christoph V / Stürmer, Ewa K / Opländer, Christian

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Hypertrophic scarring in burn wounds is caused by overactive fibroblasts and myofibroblasts. Blue light reveals wavelength- and dose-dependent antibacterial and antiproliferative effects and may serve as a therapeutic option against wound infection and ... ...

    Abstract Hypertrophic scarring in burn wounds is caused by overactive fibroblasts and myofibroblasts. Blue light reveals wavelength- and dose-dependent antibacterial and antiproliferative effects and may serve as a therapeutic option against wound infection and fibrotic conditions. Therefore, we evaluated in this study the effects of single and multiple irradiations with blue light at 420 nm (BL
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020331
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Re: "Letter to the editor Joppich et al. which was a comment on our paper entitled "Patients' satisfaction with anesthesia in enzymatic debridement from a surgical perspective".

    Schiefer, J L / Lipensky, A / Fuchs, P C / Heitzmann, W / Schulz, A

    Burns : journal of the International Society for Burn Injuries

    2020  Volume 47, Issue 7, Page(s) 1688–1690

    MeSH term(s) Anesthesia ; Anesthesiology ; Burns ; Debridement ; Humans ; Patient Satisfaction
    Language English
    Publishing date 2020-12-22
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 197308-3
    ISSN 1879-1409 ; 0305-4179
    ISSN (online) 1879-1409
    ISSN 0305-4179
    DOI 10.1016/j.burns.2020.11.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: A laboratory-based predictive pathway for the development of

    Balthazar, Jacqueline T / Golparian, Daniel / Unemo, Magnus / Read, Timothy D / Grosse, Miriam / Stadler, Marc / Pfarr, Kenneth / Schiefer, Andrea / Hoerauf, Achim / Edwards, Jennifer L / Vassylyev, Dmitry G / Shafer, William M

    Microbiology spectrum

    2024  , Page(s) e0056024

    Abstract: The continued emergence of : Importance: The continued emergence of multi-antibiotic-resistant strains ... ...

    Abstract The continued emergence of
    Importance: The continued emergence of multi-antibiotic-resistant strains of
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00560-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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