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  1. Article ; Online: Personalized Radiation Therapy-Spurning the "One Size Fits All" Approach.

    Verma, Vivek

    JAMA oncology

    2023  Volume 9, Issue 11, Page(s) 1534–1535

    MeSH term(s) Humans ; Precision Medicine ; Neoplasms/radiotherapy
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.3350
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  2. Article ; Online: Stereotactic radiotherapy for early-stage (T1-2N0) small cell lung cancer: Where are we now and where are we going?

    Verma, Vivek

    Lung cancer (Amsterdam, Netherlands)

    2021  Volume 160, Page(s) 187–189

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/pathology ; Humans ; Lung Neoplasms/pathology ; Neoplasm Staging ; Radiosurgery ; Small Cell Lung Carcinoma/radiotherapy ; Treatment Outcome
    Language English
    Publishing date 2021-08-03
    Publishing country Ireland
    Document type Editorial
    ZDB-ID 632771-0
    ISSN 1872-8332 ; 0169-5002
    ISSN (online) 1872-8332
    ISSN 0169-5002
    DOI 10.1016/j.lungcan.2021.07.019
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    Zs.A 2135: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 423: Show issues

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  3. Article ; Online: Comprehensive Study on the Age-Strengthened Mg-Zn-Mn-Ca/ZnO Composites for Fracture Fixation: Microstructure, Mechanical, and In Vitro Biocompatibility Evaluation.

    Verma, Vivek / Singh, Swati / Pal, Kaushik

    ACS applied bio materials

    2024  Volume 7, Issue 1, Page(s) 203–219

    Abstract: The present work investigates the use of age-strengthened Mg-Zn-Mn-Ca/ ...

    Abstract The present work investigates the use of age-strengthened Mg-Zn-Mn-Ca/
    MeSH term(s) Biocompatible Materials/chemistry ; Materials Testing ; Zinc Oxide ; Zinc/chemistry ; Fracture Fixation
    Chemical Substances Biocompatible Materials ; Zinc Oxide (SOI2LOH54Z) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.3c00813
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  4. Article: A Comprehensive Review of Extra Corporeal Membrane Oxygenation: The Lifeline in Critical Moments.

    Geetha, Sindhu / Verma, Neeta / Chakole, Vivek

    Cureus

    2024  Volume 16, Issue 1, Page(s) e53275

    Abstract: Extracorporeal membrane oxygenation (ECMO) has evolved into a pivotal intervention in critical care, offering a lifeline for patients facing severe respiratory or cardiac failure. This review provides a comprehensive exploration of ECMO, spanning its ... ...

    Abstract Extracorporeal membrane oxygenation (ECMO) has evolved into a pivotal intervention in critical care, offering a lifeline for patients facing severe respiratory or cardiac failure. This review provides a comprehensive exploration of ECMO, spanning its definition and historical background to its contemporary advancements and ongoing impact in critical care. The versatility of ECMO in addressing diverse critical conditions, careful patient selection criteria, and the nuanced management of complications are discussed. Advances in technology, including miniaturization, novel circuit designs, and the integration of remote monitoring, showcase the evolving landscape of ECMO. The review underscores the ongoing impact of ECMO in improving survival rates, enhancing mobility, and enabling remote expertise. As a symbol of hope and innovation, ECMO's lifesaving potential is evident in its ability to navigate the complexities of critical care and redefine the boundaries of life support interventions.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53275
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  5. Article ; Online: Halloysite nanoclay reinforced hydroxyapatite porous scaffold for hard tissue regeneration.

    Yadav, Umakant / Verma, Vivek

    Journal of the mechanical behavior of biomedical materials

    2023  Volume 140, Page(s) 105626

    Abstract: Hydroxyapatite (HAP), a natural constituent of bone tissue is commonly used for the clinical treatment of bone defects due to its similar structure with bone and excellent biocompatibility. However, the processing exertion, poor osteoinductive capability ...

    Abstract Hydroxyapatite (HAP), a natural constituent of bone tissue is commonly used for the clinical treatment of bone defects due to its similar structure with bone and excellent biocompatibility. However, the processing exertion, poor osteoinductive capability and poor mechanical strength of HAP needs further addressing for its immense implementation in tissue engineering. Different approaches have been reported to escalate the mechanical hardness and osteogenic potential of HAP. In the present work, halloysite nanoclay (HNC) and sericin protein were used for better mechanical and osteogenic properties, respectively. Halloysite nanoclay (HNC, 1.0-4.0%) was used to reinforce hydroxyapatite (HAP) and the mechanical strength of nanocomposite scaffolds were evaluated. After surface modification of nanocomposite scaffolds with 1.0% silk sericin protein; physical properties like microstructure, porosity, swelling ratio and degradation rate were evaluated. Cell morphology, cytocompatibility and alkaline phosphatase (ALP) activity were assessed using MG 63 osteoblast cell lines. HAP reinforced with 4% HNC (HAP@4) showed a significant increase (199 MPa) in young modulus as compared to pure HAP. HAP reinforced with 2% HNC (HAP@2) and 4% HNC (HAP@4) showed a significant decrease in porosity as well as degradation rate than pure HAP but no significant difference was observed in swelling ratio. The scanning electron microscope (SEM) images of the scaffolds showed porous architecture. Remarkably, the incorporation of HNC in HAP enhanced the cytocompatibility as well as ALP activity in comparison to pure HAP. Overall, these results suggested that halloysite nanoclay reinforced HAP scaffold could be an auspicious alternative for bone tissue regeneration.
    MeSH term(s) Durapatite/chemistry ; Tissue Scaffolds/chemistry ; Porosity ; Clay ; Sericins ; Tissue Engineering/methods ; Bone Regeneration
    Chemical Substances Durapatite (91D9GV0Z28) ; Clay (T1FAD4SS2M) ; Sericins
    Language English
    Publishing date 2023-01-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2378381-3
    ISSN 1878-0180 ; 1751-6161
    ISSN (online) 1878-0180
    ISSN 1751-6161
    DOI 10.1016/j.jmbbm.2022.105626
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  6. Article ; Online: Simulated Chronic Jet Lag Affects the Structural and Functional Complexity of Hippocampal Neurons in Mice.

    Kumari, Ruchika / Verma, Vivek / Singaravel, Muniyandi

    Neuroscience

    2024  Volume 543, Page(s) 1–12

    Abstract: There has been a long history that chronic circadian disruption such as jet lag or shift work negatively affects brain and body physiology. Studies have shown that circadian misalignment act as a risk factor for developing anxiety and mood-related ... ...

    Abstract There has been a long history that chronic circadian disruption such as jet lag or shift work negatively affects brain and body physiology. Studies have shown that circadian misalignment act as a risk factor for developing anxiety and mood-related depression-like behavior. Till date, most studies focused on simulating jet lag in model animals under laboratory conditions by repeated phase advances or phase delay only, while the real-life conditions may differ. In the present study, adult male mice were subjected to simulated chronic jet lag (CJL) by alternately advancing and delaying the ambient light-dark (LD) cycle by 9 h every 2 days, thereby covering a total of 24 days. The effect of CJL was then examined for a range of stress and depression-related behavioral and physiological responses. The results showed that mice exposed to CJL exhibited depression-like behavior, such as anhedonia. In the open field and elevated plus maze test, CJL-exposed mice showed increased anxiety behavior compared to LD control. In addition, CJL-exposed mice showed an increased level of serum corticosterone and proinflammatory cytokine, TNF-α in both serum and hippocampus. Moreover, CJL-exposed mice exhibited a reduction in structural complexity of hippocampal CA1 neurons along with decreased expression of neurotrophic growth factors, BDNF and NGF in the hippocampus compared to LD control. Taken together, our findings suggest that simulated chronic jet lag adversely affects structural and functional complexity in hippocampal neurons along with interrelated endocrine and inflammatory responses, ultimately leading to stress, anxiety, and depression-like behavior in mice.
    MeSH term(s) Mice ; Male ; Animals ; Jet Lag Syndrome/metabolism ; Circadian Rhythm/physiology ; Photoperiod ; Hippocampus/metabolism ; Neurons/metabolism
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2024.01.026
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Reconciling the discrepancies in randomized data of combining immunotherapy and radiation therapy: Not all radiotherapy is created equal.

    Chang, Joe Y / Verma, Vivek / Weichselbaum, Ralph R

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 201, Page(s) 113972

    Abstract: It remains highly unclear and debatable whether combining radiotherapy (RT) and immune checkpoint blocker (ICB) therapy yields improved outcomes compared to either modality alone. Whereas some randomized data have shown improved outcomes, others have not. ...

    Abstract It remains highly unclear and debatable whether combining radiotherapy (RT) and immune checkpoint blocker (ICB) therapy yields improved outcomes compared to either modality alone. Whereas some randomized data have shown improved outcomes, others have not. As a result of these conflicting data, it is essential to reconcile differences in the data and postulate reasons thereof. This work seeks to address these discrepancies, and uses the lessons learned from both positive and negative trials, including the most cutting-edge data available, in order to guide future clinical trial design and clarify the ideal/expected role of combinatorial therapy going forward. Because RT offers two distinct contributions (cytoreductive (local) effects & immune-stimulating (systemic) effects), RT should complement immunotherapy by addressing immunotherapy-resistant clones, and immunotherapy should complement RT by addressing RT-resistant or out-of-field clones. RT is not merely a single "drug", but rather a constellation of diverse "drugs" that can be varied based on dose regimens, previous systemic therapy regimens, number of irradiated sites, treatment intent/location/timing, tumor biology, and individual patient immunological circumstances. These factors are discussed as an important explanation for the discrepancies in results of various randomized trials in heterogeneous populations and clinical settings, and these discrepancies may continue until trials of more uniform circumstances are designed to use particular RT paradigms that meaningfully add value to systemic therapy.
    MeSH term(s) Humans ; Combined Modality Therapy ; Immunotherapy/methods ; Radiosurgery/methods
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.113972
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    Zs.A 456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 583: Show issues

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  8. Article ; Online: Economic sustainability of immune-checkpoint inhibitors: the looming threat.

    Verma, Vivek

    Nature reviews. Clinical oncology

    2018  Volume 15, Issue 12, Page(s) 721–722

    MeSH term(s) Cost-Benefit Analysis/economics ; Counseling/economics ; Humans ; Neoplasms/economics ; Neoplasms/immunology ; Neoplasms/therapy ; Patient Selection
    Language English
    Publishing date 2018-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-018-0086-z
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    Zs.A 6029: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 103: Show issues

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  9. Article ; Online: The Emerging Concern of Chronic Wasting Disease (CWD) in Humans.

    Verma, Amogh / Anand, Ayush / Satapathy, Prakasini / Gaidhane, Abhay M / Zahiruddin, Quazi Syed / Sanker, Vivek

    Asia-Pacific journal of public health

    2024  Volume 36, Issue 2-3, Page(s) 301–302

    MeSH term(s) Animals ; Humans ; Wasting Disease, Chronic
    Language English
    Publishing date 2024-02-14
    Publishing country China
    Document type Letter
    ZDB-ID 1025444-4
    ISSN 1941-2479 ; 1010-5395
    ISSN (online) 1941-2479
    ISSN 1010-5395
    DOI 10.1177/10105395241230753
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2802: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Microstructural Understanding of Hydroxyapatite Addition on Age Hardening, Internal Friction, and Mechanical and Electrochemical Response of Resorbable Magnesium Alloys with Good Cytocompatibility.

    Verma, Vivek / Singh, Swati / Pal, Kaushik

    ACS biomaterials science & engineering

    2023  Volume 9, Issue 5, Page(s) 2764–2779

    Abstract: The present work aims to assess the age hardening of microalloyed Mg-Zn-Mn alloy reinforced with ... ...

    Abstract The present work aims to assess the age hardening of microalloyed Mg-Zn-Mn alloy reinforced with Ca
    MeSH term(s) Durapatite/pharmacology ; Durapatite/chemistry ; Magnesium/pharmacology ; Magnesium/chemistry ; Materials Testing ; Alloys/pharmacology ; Alloys/chemistry ; Friction
    Chemical Substances Durapatite (91D9GV0Z28) ; Magnesium (I38ZP9992A) ; Alloys
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c01403
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