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  1. Article ; Online: Loneliness and Dementia in Context.

    Bhardwaj, Twisha / Donovan, Nancy J

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2023  Volume 31, Issue 7, Page(s) 487–490

    MeSH term(s) Humans ; Loneliness ; Dementia ; Risk Factors
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Editorial
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2023.03.004
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    Zs.A 4443: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Timely Insights Into the Treatment of Social Disconnection in Lonely, Homebound Older Adults.

    Donovan, Nancy J

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2020  Volume 28, Issue 7, Page(s) 709–711

    MeSH term(s) Aged ; Homebound Persons ; Humans ; Loneliness ; Problem Solving
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2020.04.002
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  3. Article ; Online: Veterans Affairs' Whole Health System of Care for Transitioning Service Members and Veterans.

    Gantt, Cynthia J / Donovan, Nancy / Khung, Maureen

    Military medicine

    2023  Volume 188, Issue Suppl 5, Page(s) 28–32

    Abstract: The Department of Veterans Affairs (VA) has launched an organization-wide transformation to a Whole Health System of Care that will ideally begin at the time of transition from active duty through the end of a Veteran's life. A brief history and overview ...

    Abstract The Department of Veterans Affairs (VA) has launched an organization-wide transformation to a Whole Health System of Care that will ideally begin at the time of transition from active duty through the end of a Veteran's life. A brief history and overview of the Whole Health approach are provided along with selected evaluation results and planned initial actions as a result of the Total Force Fitness-Whole Health Summit held in March 2022. More work is required to strengthen the natural linkages between the Department of Defense's Total Force Fitness and Veterans Affairs' Whole Health approach to care. The Total Force Fitness-Whole Health collaboration is a model of whole-person care for the nation.
    MeSH term(s) United States ; Humans ; Veterans ; Exercise ; Government Programs ; Self Care ; United States Government Agencies
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usad047
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    Un I Zs.546: Show issues Location:
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  5. Article ; Online: Social Isolation and Loneliness in Older Adults: Review and Commentary of a National Academies Report.

    Donovan, Nancy J / Blazer, Dan

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    2020  Volume 28, Issue 12, Page(s) 1233–1244

    Abstract: The authors of this review both served on the National Academy of Science, Engineering, and Medicine Committee that produced the report, "Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System." In 2018, the AARP ... ...

    Abstract The authors of this review both served on the National Academy of Science, Engineering, and Medicine Committee that produced the report, "Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System." In 2018, the AARP Foundation commissioned the National Academies to establish a committee to research and develop a report on social isolation and loneliness in persons 50 years of age and older. Emphasis was placed upon the role of the healthcare system in addressing this fundamental public health problem. The committee released the report in February 2020 as the Corona Virus Disease 2019 pandemic was beginning to spread to North America. In this review, the authors share central findings and conclusions from the report as well as how these findings may be relevant to the care and well-being of older adults during this historic pandemic. The health protective benefits of social distancing must be balanced by the essential need for sustaining social relationships.
    MeSH term(s) Aged ; COVID-19 ; Humans ; Loneliness ; Pandemics ; SARS-CoV-2 ; Social Isolation
    Keywords covid19
    Language English
    Publishing date 2020-08-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1016/j.jagp.2020.08.005
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    Zs.A 4443: Show issues Location:
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  6. Article ; Online: Social activity mediates locus coeruleus tangle-related cognition in older adults.

    Zide, Benjamin S / Donovan, Nancy J / Lee, Soyoung / Nag, Sukriti / Bennett, David A / Jacobs, Heidi I L

    Molecular psychiatry

    2024  

    Abstract: The locus coeruleus-noradrenaline system regulates brain-wide neural activity involved in cognition and behavior. Integrity of this subcortical neuromodulatory system is proposed to be a substrate of cognitive reserve that may be strengthened by lifetime ...

    Abstract The locus coeruleus-noradrenaline system regulates brain-wide neural activity involved in cognition and behavior. Integrity of this subcortical neuromodulatory system is proposed to be a substrate of cognitive reserve that may be strengthened by lifetime cognitive and social activity. Conversely, accumulation of tau tangles in the brainstem locus coeruleus nuclei is recently studied as a very early marker of Alzheimer's disease (AD) pathogenesis and cognitive vulnerability, even among older adults without cognitive impairment or significant cerebral AD pathologies. This clinical-pathologic study examined whether locus coeruleus tangle density was cross-sectionally associated with lower antemortem cognitive performance and social activity among 142 cognitively unimpaired and impaired older adults and whether social activity, a putative reserve factor, mediated the association of tangle density and cognition. We found that greater locus coeruleus tangle density was associated with lower social activity for the whole sample and in the cognitively unimpaired group alone and these associations were independent of age, sex, education, depressive symptoms, and burden of cerebral amyloid and tau. The association of locus coeruleus tangle density with lower cognitive performance was partially mediated by level of social activity. These findings implicate the locus coeruleus-noradrenaline system in late-life social function and support that locus coeruleus tangle pathology is associated with lower levels of social activity, independent of cerebral AD pathologies, and specifically among older adults who are cognitively unimpaired. Early brainstem pathology may impact social function, and level of social function, in turn, influences cognition, prior to canonical stages of AD.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02467-y
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    Zs.A 4812: Show issues Location:
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  7. Article: Functional Organization of Auditory and Reward Systems in Aging.

    Belden, Alexander / Quinci, Milena Aiello / Geddes, Maiya / Donovan, Nancy J / Hanser, Suzanne B / Loui, Psyche

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The intrinsic organization of functional brain networks is known to change with age, and is affected by perceptual input and task conditions. Here, we compare functional activity and connectivity during music listening and rest between younger (N=24) and ...

    Abstract The intrinsic organization of functional brain networks is known to change with age, and is affected by perceptual input and task conditions. Here, we compare functional activity and connectivity during music listening and rest between younger (N=24) and older (N=24) adults, using whole brain regression, seed-based connectivity, and ROI-ROI connectivity analyses. As expected, activity and connectivity of auditory and reward networks scaled with liking during music listening in both groups. Younger adults show higher within-network connectivity of auditory and reward regions as compared to older adults, both at rest and during music listening, but this age-related difference at rest was reduced during music listening, especially in individuals who self-report high musical reward. Furthermore, younger adults showed higher functional connectivity between auditory network and medial prefrontal cortex (mPFC) that was specific to music listening, whereas older adults showed a more globally diffuse pattern of connectivity, including higher connectivity between auditory regions and bilateral lingual and inferior frontal gyri. Finally, connectivity between auditory and reward regions was higher when listening to music selected by the participant. These results highlight the roles of aging and reward sensitivity on auditory and reward networks. Results may inform the design of music- based interventions for older adults, and improve our understanding of functional network dynamics of the brain at rest and during a cognitively engaging task.
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.01.522417
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  8. Article ; Online: Functional Organization of Auditory and Reward Systems in Aging.

    Belden, Alexander / Quinci, Milena Aiello / Geddes, Maiya / Donovan, Nancy J / Hanser, Suzanne B / Loui, Psyche

    Journal of cognitive neuroscience

    2023  Volume 35, Issue 10, Page(s) 1570–1592

    Abstract: The intrinsic organization of functional brain networks is known to change with age, and is affected by perceptual input and task conditions. Here, we compare functional activity and connectivity during music listening and rest between younger (n = 24) ... ...

    Abstract The intrinsic organization of functional brain networks is known to change with age, and is affected by perceptual input and task conditions. Here, we compare functional activity and connectivity during music listening and rest between younger (n = 24) and older (n = 24) adults, using whole-brain regression, seed-based connectivity, and ROI-ROI connectivity analyses. As expected, activity and connectivity of auditory and reward networks scaled with liking during music listening in both groups. Younger adults show higher within-network connectivity of auditory and reward regions as compared with older adults, both at rest and during music listening, but this age-related difference at rest was reduced during music listening, especially in individuals who self-report high musical reward. Furthermore, younger adults showed higher functional connectivity between auditory network and medial prefrontal cortex that was specific to music listening, whereas older adults showed a more globally diffuse pattern of connectivity, including higher connectivity between auditory regions and bilateral lingual and inferior frontal gyri. Finally, connectivity between auditory and reward regions was higher when listening to music selected by the participant. These results highlight the roles of aging and reward sensitivity on auditory and reward networks. Results may inform the design of music-based interventions for older adults and improve our understanding of functional network dynamics of the brain at rest and during a cognitively engaging task.
    MeSH term(s) Humans ; Aged ; Magnetic Resonance Imaging ; Brain/diagnostic imaging ; Music ; Aging ; Brain Mapping/methods ; Reward ; Auditory Perception
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 1007410-7
    ISSN 1530-8898 ; 0898-929X ; 1096-8857
    ISSN (online) 1530-8898
    ISSN 0898-929X ; 1096-8857
    DOI 10.1162/jocn_a_02028
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    Zs.A 2623: Show issues Location:
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  9. Article ; Online: Non-Pharmacological Treatments of Neuropsychiatric Symptoms in Mild Cognitive Impairment.

    Thurin, Kristina / Daffner, Kirk / Gale, Seth / Donovan, Nancy J / Urizar, Juan Carlos

    Seminars in neurology

    2022  Volume 42, Issue 2, Page(s) 192–203

    Abstract: Mild cognitive impairment (MCI) is a syndrome defined by objective cognitive deficits that do not impact functional independence. Individuals with MCI develop dementia at an annual rate of 10 to 15%. Neuropsychiatric symptoms (NPS) are common non- ... ...

    Abstract Mild cognitive impairment (MCI) is a syndrome defined by objective cognitive deficits that do not impact functional independence. Individuals with MCI develop dementia at an annual rate of 10 to 15%. Neuropsychiatric symptoms (NPS) are common non-cognitive features of neurocognitive disorders and have a major impact on the wellbeing and quality of life of affected individuals and their families. Non-pharmacological interventions for NPS are considered the first-line treatment because of the limited efficacy and side-effect potential of current pharmacological agents. This article summarizes the literature on non-pharmacological treatments for NPS in MCI. The limited number of studies specific to individuals with MCI and its various etiologies, as well as the overall heterogeneity of research design and methodologies, make the evidence base inconclusive. Nevertheless, some studies support psychosocial interventions aimed at individuals with MCI and their caregivers.
    MeSH term(s) Cognition Disorders ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/therapy ; Humans ; Neuropsychological Tests ; Quality of Life
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0042-1742486
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    Zs.A 1737: Show issues Location:
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  10. Article: Social Isolation and Loneliness in Older Adults: Review and Commentary of a National Academies Report

    Donovan, Nancy J / Blazer, Dan

    Am J Geriatr Psychiatry

    Abstract: The authors of this review both served on the National Academy of Science, Engineering, and Medicine Committee that produced the report, "Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System." In 2018, the AARP ... ...

    Abstract The authors of this review both served on the National Academy of Science, Engineering, and Medicine Committee that produced the report, "Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System." In 2018, the AARP Foundation commissioned the National Academies to establish a committee to research and develop a report on social isolation and loneliness in persons 50 years of age and older. Emphasis was placed upon the role of the healthcare system in addressing this fundamental public health problem. The committee released the report in February 2020 as the Corona Virus Disease 2019 pandemic was beginning to spread to North America. In this review, the authors share central findings and conclusions from the report as well as how these findings may be relevant to the care and well-being of older adults during this historic pandemic. The health protective benefits of social distancing must be balanced by the essential need for sustaining social relationships.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #720581
    Database COVID19

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