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  1. Article ; Online: APOL1 Risk Alleles and Outcomes in Kidney Transplantation: Enter the Recipient.

    Kant, Sam / Brennan, Daniel C

    Transplantation

    2023  Volume 107, Issue 12, Page(s) 2462–2463

    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Alleles ; Apolipoprotein L1/genetics ; Genotype ; Apolipoproteins/genetics ; Genetic Predisposition to Disease
    Chemical Substances Apolipoprotein L1 ; Apolipoproteins ; APOL1 protein, human
    Language English
    Publishing date 2023-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  2. Article ; Online: Nephrology Picture. Infected Liver Cyst in a Kidney Transplant Recipient with ADPKD.

    Alotaibi, Manal / Kant, Sam

    Journal of nephrology

    2023  Volume 36, Issue 4, Page(s) 1187–1188

    MeSH term(s) Humans ; Polycystic Kidney, Autosomal Dominant/complications ; Polycystic Kidney, Autosomal Dominant/surgery ; Kidney Transplantation/adverse effects ; Nephrology ; Liver ; Cysts/diagnostic imaging ; Cysts/etiology
    Language English
    Publishing date 2023-05-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01648-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article: Pathophysiology of Rejection in Kidney Transplantation.

    Tamargo, Christina L / Kant, Sam

    Journal of clinical medicine

    2023  Volume 12, Issue 12

    Abstract: Kidney transplantation has been the optimal treatment for end-stage kidney disease for almost 70 years, with increasing frequency over this period. Despite the prevalence of the procedure, allograft rejection continues to impact transplant recipients, ... ...

    Abstract Kidney transplantation has been the optimal treatment for end-stage kidney disease for almost 70 years, with increasing frequency over this period. Despite the prevalence of the procedure, allograft rejection continues to impact transplant recipients, with consequences ranging from hospitalization to allograft failure. Rates of rejection have declined over time, which has been largely attributed to developments in immunosuppressive therapy, understanding of the immune system, and monitoring. Developments in these therapies, as well as an improved understanding of rejection risk and the epidemiology of rejection, are dependent on a foundational understanding of the pathophysiology of rejection. This review explains the interconnected mechanisms behind antibody-mediated and T-cell-mediated rejection and highlights how these processes contribute to outcomes and can inform future progress.
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12124130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Management of kidney transplant recipients for primary care practitioners.

    Alotaibi, Manal / Trollinger, Brandon / Kant, Sam

    BMC nephrology

    2024  Volume 25, Issue 1, Page(s) 102

    Abstract: Patients with kidney transplants have a significant co-morbidity index, due to a high number of pre-existing conditions and use of immunosuppression medications. These patients are at higher risk of developing conditions such as hypertension, ... ...

    Abstract Patients with kidney transplants have a significant co-morbidity index, due to a high number of pre-existing conditions and use of immunosuppression medications. These patients are at higher risk of developing conditions such as hypertension, dyslipidemia, post-transplant diabetes, cardiovascular events, and anemia. Moreover, they are particularly susceptible to infections such as urinary tract infections or pyelonephritis, cancers, and gastrointestinal complications such as diarrhea, which in turn may be attributed to medication adverse effects or infectious causes. Along with these concerns, meticulous management of electrolytes and allograft function is essential. Prior to prescribing any new medications, it is imperative to exercise caution in identifying potential interactions with immunosuppression drugs. This review aims to equip primary care practitioners to address these complex issues and appropriate methods of delivering care to this rapidly growing highly susceptible group.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Diabetes Mellitus/etiology ; Transplantation, Homologous ; Hypertension/etiology ; Primary Health Care ; Transplant Recipients
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-024-03504-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pathophysiology of Rejection in Kidney Transplantation

    Christina L. Tamargo / Sam Kant

    Journal of Clinical Medicine, Vol 12, Iss 4130, p

    2023  Volume 4130

    Abstract: Kidney transplantation has been the optimal treatment for end-stage kidney disease for almost 70 years, with increasing frequency over this period. Despite the prevalence of the procedure, allograft rejection continues to impact transplant recipients, ... ...

    Abstract Kidney transplantation has been the optimal treatment for end-stage kidney disease for almost 70 years, with increasing frequency over this period. Despite the prevalence of the procedure, allograft rejection continues to impact transplant recipients, with consequences ranging from hospitalization to allograft failure. Rates of rejection have declined over time, which has been largely attributed to developments in immunosuppressive therapy, understanding of the immune system, and monitoring. Developments in these therapies, as well as an improved understanding of rejection risk and the epidemiology of rejection, are dependent on a foundational understanding of the pathophysiology of rejection. This review explains the interconnected mechanisms behind antibody-mediated and T-cell-mediated rejection and highlights how these processes contribute to outcomes and can inform future progress.
    Keywords allograft rejection ; antibody-mediated rejection ; kidney transplant ; T-cell-mediated rejection ; transplant immunology ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Donor Derived Cell Free DNA in Kidney Transplantation: The Circa 2020-2021 Update.

    Kant, Sam / Brennan, Daniel C

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10448

    Abstract: The routine surveillance of kidney transplant allografts has relied on imperfect non-invasive biomarkers such as creatinine and urinary indices, while the gold standard allograft biopsy is associated with risk of bleeding, organ injury and sampling ... ...

    Abstract The routine surveillance of kidney transplant allografts has relied on imperfect non-invasive biomarkers such as creatinine and urinary indices, while the gold standard allograft biopsy is associated with risk of bleeding, organ injury and sampling errors. Donor derived cell free DNA (dd-cfDNA) is being employed as a biomarker that addresses limitations of these surveillance methods, albeit has inherent drawbacks. This review provides an update on the enhanced understanding of dd-cfDNA and its expanded use beyond the conventional indication of detecting allograft rejection.
    MeSH term(s) Biomarkers ; Cell-Free Nucleic Acids ; Graft Rejection/diagnosis ; Humans ; Kidney Transplantation/adverse effects ; Tissue Donors
    Chemical Substances Biomarkers ; Cell-Free Nucleic Acids
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2358: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Outcomes and management of kidney transplant recipients with Fabry disease: a review.

    Yu, Bo / Atta, Mohamed G / Brennan, Daniel C / Kant, Sam

    Journal of nephrology

    2024  

    Abstract: Fabry disease is an X-linked inheritable lysosomal storage disease caused by various mutations of the galactosidase α gene resulting in α-galactosidase deficiency. Chronic kidney disease (CKD) is one of the most significant consequences of Fabry disease,  ...

    Abstract Fabry disease is an X-linked inheritable lysosomal storage disease caused by various mutations of the galactosidase α gene resulting in α-galactosidase deficiency. Chronic kidney disease (CKD) is one of the most significant consequences of Fabry disease, with risk of end-stage kidney disease (ESKD) in this population. Like for other patients with ESKD, kidney transplant is the optimal treatment for Fabry disease patients with ESKD. However, enzyme replacement therapy and newer Fabry disease treatments remain important to mitigate other end organ damage such as cardiomyopathy post transplantation. This review is a primer on Fabry disease, which examines the outcomes of disease in the context of kidney transplant prior to, and during, the enzyme replacement treatment era, medical treatment of kidney transplant recipients with Fabry disease, and progress in screening studies.
    Language English
    Publishing date 2024-01-16
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01853-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Nephrology picture: C4d positive tubules in severe BK virus nephropathy.

    Haq, Kanza / Malvica, Silvia / Rosenberg, Avi / Kant, Sam

    Journal of nephrology

    2023  Volume 37, Issue 2, Page(s) 501–503

    MeSH term(s) Humans ; BK Virus/pathogenicity ; Polyomavirus Infections ; Tumor Virus Infections ; Kidney Tubules ; Male ; Peptide Fragments/blood ; Severity of Illness Index ; Kidney Diseases/virology ; Middle Aged
    Chemical Substances Peptide Fragments
    Language English
    Publishing date 2023-10-25
    Publishing country Italy
    Document type Journal Article ; Case Reports
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01797-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3369: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Measures to Increase Immunogenicity of SARS-CoV-2 Vaccines in Solid Organ Transplant Recipients: A Narrative Review.

    Yu, Bo / Tamargo, Christina / Brennan, Daniel C / Kant, Sam

    Vaccines

    2023  Volume 11, Issue 12

    Abstract: Purpose of review: ...

    Abstract Purpose of review:
    Language English
    Publishing date 2023-11-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11121755
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Combining Clinical and Genetic Factors to Predict Tacrolimus Levels in Pediatric Solid Organ Transplants: Problem Solved?

    Kant, Sam / Brennan, Daniel C

    Transplantation

    2021  Volume 106, Issue 3, Page(s) 449–450

    MeSH term(s) Child ; Humans ; Immunosuppressive Agents/adverse effects ; Organ Transplantation/adverse effects ; Tacrolimus/therapeutic use
    Chemical Substances Immunosuppressive Agents ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000003701
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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