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  1. Article ; Online: With Single Plasma Exchange, a Better Understanding of the Potential Clinical Effects of Albumin Replacement Is Required.

    Moranne, Olivier / Cristol, Jean-Paul

    Blood purification

    2023  Volume 52, Issue 9-10, Page(s) 844–846

    MeSH term(s) Humans ; Plasma Exchange ; Albumins/therapeutic use ; Plasmapheresis
    Chemical Substances Albumins
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000531186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Manipulating the complement system via Therapeutic plasmapheresis: Is there any therapeutic role?

    Ahmadpoor, Pedram / Moranne, Olivier

    Journal of clinical apheresis

    2022  Volume 37, Issue 5, Page(s) 529–530

    MeSH term(s) Complement System Proteins ; Humans ; Plasma Exchange ; Plasmapheresis
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Letter
    ZDB-ID 604912-6
    ISSN 1098-1101 ; 0733-2459
    ISSN (online) 1098-1101
    ISSN 0733-2459
    DOI 10.1002/jca.22001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Granulomatous interstitial nephritis following BRAF/MEK inhibitor treatment for metastatic melanoma.

    Garo, Florian / Reboul, Pascal / Gerbal, Marion / Moranne, Olivier

    Journal of nephrology

    2023  Volume 36, Issue 9, Page(s) 2649–2650

    MeSH term(s) Humans ; Melanoma/drug therapy ; Proto-Oncogene Proteins B-raf/genetics ; Nephritis, Interstitial/chemically induced ; Nephritis, Interstitial/diagnosis ; Granuloma ; Mitogen-Activated Protein Kinase Kinases
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; BRAF protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-08-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01736-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: REIN: a tool to evaluate pratices

    Kazes, Isabelle / Moranne, Olivier / Lassalle, Mathilde

    Nephrologie & therapeutique

    2023  Volume 18, Issue S2, Page(s) 46–49

    Abstract: On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of its role in practices evaluation, the ... ...

    Title translation REIN : un outil au service de l’évaluation des pratiques
    Abstract On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of its role in practices evaluation, the following key messages were retained. The evaluation of our practices allows improving them as proposed by the concept of the Edward Deming wheel (Plan, Do, Check, Act). Measurement also allows setting goals and targets. Where there are recommendations available, the REIN indicators allow comparison with the identified targets. The REIN registry is an interesting tool to observe the deployment and impact of the recommendations in dialysis units and to evaluate the professional practices taking into account the patients’ characteristics and the changes in the recommendations. Finally, the treatment indicators analysed using REIN data show the great diversity of practices from one region to another, the result of habits, training of nephrologists, the history of the care offered and sometimes the geography of the region and its population.
    MeSH term(s) Humans ; Kidney ; Nephrologists ; Professional Practice ; Registries
    Language French
    Publishing date 2023-08-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/S1769-7255(22)00567-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: REIN: a tool at the service of the elderly patients

    Moranne, Olivier / Béchade, Clémence / Couchoud, Cécile

    Nephrologie & therapeutique

    2023  Volume 18, Issue S2, Page(s) 65–69

    Abstract: On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of elderly CKD patients, the following key ... ...

    Title translation REIN : un outil au service des patients âgés
    Abstract On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of elderly CKD patients, the following key messages were retained. The population of elderly dialysis patients continues to grow. These patients have multiple comorbidities including pathologies specific to the elderly like undernutrition, walking and cognitive disorders. The data from the REIN registry has been the subject of numerous studies pertaining to this group showing heterogeneous prognosis and treatment, requiring to be better evaluated to target an individualised treatment. Decision support tools have been developed using the registry data to help nephrologists and patients in deciding whether to start replacement therapy and whether to refer elderly patients for assessment for a renal transplant. Finally, the risk-benefit evaluation of the different replacement therapies in this population should be monitored at the registry level and on a case-by-case basis in clinical practice.
    MeSH term(s) Aged ; Humans ; Kidney ; Kidney Transplantation ; Malnutrition/diagnosis ; Malnutrition/epidemiology ; Malnutrition/therapy ; Nephrologists ; Patients
    Language French
    Publishing date 2023-08-02
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/S1769-7255(22)00571-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: What does the French REIN registry tell us about Stage 4-5 CKD care in older adults?

    Moranne, Olivier / Hamroun, Aghilès / Couchoud, Cécile

    Frontiers in nephrology

    2023  Volume 2, Page(s) 1026874

    Abstract: The aim of this paper is to illustrate all the clinical epidemiology searches made within the French network REIN to improve CKD stage 4-5 care in older adults. We summarize various studies describing clinical practice, care organization, prognosis and ... ...

    Abstract The aim of this paper is to illustrate all the clinical epidemiology searches made within the French network REIN to improve CKD stage 4-5 care in older adults. We summarize various studies describing clinical practice, care organization, prognosis and health economics evaluation in order to develop personalized care plans and decision-making tools. In France, for 20 years now, various databases have been mobilized including the national REIN registry which includes all patients receiving dialysis or transplantation. REIN data are indirectly linked to the French administrative healthcare database. They are also pooled with data from the PSPA cohort, a multicenter prospective cohort study of patients aged 75 or over with advanced CKD, monitored for 5 years, and the CKD-REIN clinical-based prospective cohort which included 3033 patients with CKD stage 3-4 from 2013 to 2016. During our various research work, we identified heterogeneous trajectories specific to this growing older population, raising ethical, organizational and economic issues. Renal registries will help clinicians, health providers and policy-makers if suitable decision- making tools are developed and validated.
    Language English
    Publishing date 2023-01-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2813-0626
    ISSN (online) 2813-0626
    DOI 10.3389/fneph.2022.1026874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Treatment trajectories of patients with End Stage Kidney Disease

    Cremades, Adeline / Moranne, Olivier / Couchoud, Cécile

    Nephrologie & therapeutique

    2023  Volume 18, Issue S2, Page(s) 31–34

    Abstract: On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of trajectory of ESKD patients, the following ... ...

    Title translation Trajectoires des patients en suppléance
    Abstract On the occasion of the 20th anniversary of the REIN (French Renal Epidemiology and Information Network), a summary work on the contributions of the national French ESKD register was carried out. On the issue of trajectory of ESKD patients, the following key messages were retained. Apart from a few rare, absolute or relative contraindications, till date, there is no medical consensus on the indications of one treatment modality as compared to another, and therefore, no recommendations allowing defining criteria for guiding patients, based on their characteristics, to a technique/treatment modality. In addition, the patients’ choices and their changing needs over time must be taken into account. Thus, due to the limitations of each of these modalities, a good number of patients with stage 5 renal failure treated with kidney replacement therapy will move between these different modalities. For many years, the REIN registry has endeavoured to represent the patient flows between the different treatment modalities. In order to better understand and then optimise the trajectories followed by patients who have reached stage 5 of their chronic renal failure, it was necessary to develop tools to model these complex trajectories where the treatment modalities are considered as complementary.
    MeSH term(s) Humans ; Kidney Failure, Chronic/therapy ; Renal Insufficiency, Chronic ; Kidney ; Patient Selection ; Patients
    Language French
    Publishing date 2023-07-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/S1769-7255(22)00564-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Qualitative approach to better understand the trajectory of patients with early and moderate stage CKD.

    Engberink, Agnes Oude / Bourrel, Gerard / Moranne, Olivier

    Clinical kidney journal

    2022  Volume 15, Issue 11, Page(s) 2157–2158

    Language English
    Publishing date 2022-04-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfac106
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  9. Article ; Online: General practitioners' representation of early-stage CKD is a barrier to adequate management and patient empowerment: a phenomenological study.

    Oude Engberink, Agnès / Tessier, Guillaume / Kamil, Ilham / Bourrel, Gérard / Moranne, Olivier

    Journal of nephrology

    2024  Volume 37, Issue 2, Page(s) 379–390

    Abstract: Background: In high-income countries, chronic kidney disease (CKD) affects over 10% of the population. Identifying these patients early is a priority, especially as new treatments are available to reduce the risk of cardiovascular and renal morbidity. ... ...

    Abstract Background: In high-income countries, chronic kidney disease (CKD) affects over 10% of the population. Identifying these patients early is a priority, especially as new treatments are available to reduce the risk of cardiovascular and renal morbidity. We aimed at understanding the management and care pathway of patients with early-to-moderate CKD defined as an estimated glomerular filtration rate (eGFR) ≥ 45 mL/min/1.73 m
    Methods: This qualitative semiopragmatic phenomenological study analyzed in-depth interviews held with a purposive sample (age, gender, training, type of practice, rural/urban context) of 24 general practitioners, with triangulation of research until data saturation.
    Results: From diagnostic, etiological and prognostic viewpoints, the general practitioners enrolled in our study perceived CKD as a complex, poorly-defined clinical entity in asymptomatic and multimorbid patients. They distinguished it from a rare condition they considered as 'mainly renal'. The fact that they did not perceive early-stage CKD as a disease was a hindrance to patient care, which should protect the kidneys with a preventive approach. Indeed, general practitioners perceived CKD patient management as a pathway requiring a personalized, integrative model, common to all chronic diseases, without necessarily involving a nephrologist, at least in the early stages.
    Conclusions: This study shows how the general practitioners' representations influence their attitudes and interventions. Clarifying the concept of early-stage CKD by taking factors like age and etiology into account would facilitate personalized management of this heterogeneous, often multimorbid, population. Finally, organizational models to support patient empowerment in an integrative care pathway must be established and validated.
    MeSH term(s) Humans ; Female ; Male ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/psychology ; Middle Aged ; General Practitioners/psychology ; Adult ; Patient Participation ; Qualitative Research ; Attitude of Health Personnel ; Glomerular Filtration Rate ; Aged ; France ; Health Knowledge, Attitudes, Practice ; Interviews as Topic
    Language English
    Publishing date 2024-01-16
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01838-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Feasibility, Efficacy, and Safety of Peripheral Venous Access for Chronic Double-Filtration Plasmapheresis with Regional Citrate Anticoagulation.

    Cardinale, Antoine / Pambrun, Emilie / Prelipcean, Camelia / Messikh, Ziyad / Moranne, Olivier

    Blood purification

    2023  Volume 52, Issue 7-8, Page(s) 621–630

    Abstract: Introduction: Peripheral venous access (PVA) is recommended as a first-line vascular approach for therapeutic plasmapheresis with centrifugation methods but not filtration, which usually requires high blood flow. We evaluated the feasibility, efficacy, ... ...

    Abstract Introduction: Peripheral venous access (PVA) is recommended as a first-line vascular approach for therapeutic plasmapheresis with centrifugation methods but not filtration, which usually requires high blood flow. We evaluated the feasibility, efficacy, and safety of double-filtration plasmapheresis (DFPP) with PVA, using ultrasound guidance and regional citrate anticoagulation (RCA), i.e., PVA-RCA-DFPP in patients undergoing chronic DFPP. Secondly, we assessed the number of central venous catheters (CVCs) avoided.
    Methods: A single-center retrospective study evaluated 22 adult patients on chronic DFPP to perform PVA-RCA-DFPP. They were classified into 3 groups: successful (i.e., completion of sessions with PVA), primary failure (i.e., no sessions completed), secondary failure (i.e., ≥1 session with PVA completed but secondary return with CVC or arteriovenous fistula).
    Results: Among the 22 patients included (64% men), 7 patients (32%) were classified as primary failures (2 patient refusals, 5 inadequate PVAs), 1 patient (5%) as a secondary failure (due to uncomfortable venipunctures), and 14 patients (64%) as successful. In the successful group including 12 patients treated for chronic inflammatory demyelinating polyneuropathy (CIDP) and 2 patients for familial hypercholesterolemia (FH) (2 patients), 116 sessions were performed, with a median treated plasma volume of 4.3 L [IQR 3.6-4.6] (45 mL/kg) for a median duration of 134 min [IQR 122-144], and a median blood flow of 94 mL/min [IQR 87-103]. For the CIDP group, 90% of sessions achieved a plasma volume >1 TPV, and for the FH group 91% of sessions achieved an LDLc reduction >60%. Eleven sessions out of 116 (9%) were interrupted, mostly due to PVA dysfunction (5/11) and circuit clotting (4/11). Session interruptions decreased significantly between each patient's first and following sessions (29% to 7%, p = 0.009).
    Conclusion: Chronic PVA-RCA-DFPP can be performed safely and efficiently, avoiding the use of CVCs.
    MeSH term(s) Adult ; Male ; Humans ; Female ; Citric Acid ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating ; Feasibility Studies ; Retrospective Studies ; Plasmapheresis/methods ; Anticoagulants/therapeutic use
    Chemical Substances Citric Acid (2968PHW8QP) ; Anticoagulants
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 605548-5
    ISSN 1421-9735 ; 0253-5068
    ISSN (online) 1421-9735
    ISSN 0253-5068
    DOI 10.1159/000531688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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