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Article ; Online: What the Silent Retina Tells You: Serous Retinal Detachment in Waldenström's Macroglobulinemia.

Amaador, Karima / Diederen, Roselie / Coumou, Jeroen / Vos, Josephine

HemaSphere

2021 Volume 5, Issue 2, Page(s) e527

Language	English
Publishing date	2021-01-20
Publishing country	United States
Document type	Case Reports
ISSN	2572-9241
ISSN (online)	2572-9241
DOI	10.1097/HS9.0000000000000527
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chloroquine als mogelijke behandeling van COVID-19.

Coumou, Jeroen / de Vries, Peter J

Nederlands tijdschrift voor geneeskunde

2020 Volume 164

Abstract: Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2. Recently, the Dutch National Institute for Public Health and the Environment ... ...

Title translation	Chloroquine as a possible treatment for COVID-19.
Abstract	Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2. Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir. In this commentary, we provide a background and history of chloroquine, the evidence for antiviral efficacy of chloroquine and the arguments for off-label use of chloroquine in COVID-19.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Chloroquine/therapeutic use ; Coronavirus Infections/drug therapy ; Humans ; Lopinavir/therapeutic use ; Off-Label Use ; Pandemics ; Pneumonia, Viral/drug therapy ; Ritonavir/therapeutic use ; SARS-CoV-2 ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Lopinavir (2494G1JF75) ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Chloroquine (886U3H6UFF) ; Ritonavir (O3J8G9O825) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	Dutch
Publishing date	2020-03-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ua VI Zs.18: Show issues

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Article ; Online: Tranende ogen.

Hartong, Dyonne T / van der Meeren, Stijn W / Coumou, Adriaan D / Kloos, Roel J H M / Saeed, Peerooz

Nederlands tijdschrift voor geneeskunde

2023 Volume 167

Abstract: Tear complaints can arise from either an increased tear production or from a disturbed tear drainage. Increased tear production from the lacrimal gland is a neuroregulated response to a dried out or irritated ocular surface. Dryness often results from a ... ...

Title translation	Watery eyes: diagnostic and therapeutic considerations.
Abstract	Tear complaints can arise from either an increased tear production or from a disturbed tear drainage. Increased tear production from the lacrimal gland is a neuroregulated response to a dried out or irritated ocular surface. Dryness often results from a reduced quality of the tear film, but can also be caused by eyelid malposition with increased globe exposure. Impaired tear drainage usually occurs when the lacrimal drainage system is blocked at the level of the ductus nasolacrimalis, the canaliculi or the lacrimal punctae. Anatomical knowledge of the lacrimal system is necessary to distinguish between the different causes. Using cases and illustrations, we provide insight into the diagnostic considerations for a patient with a watery eye.
MeSH term(s)	Humans ; Lacrimal Apparatus Diseases/diagnosis ; Lacrimal Apparatus Diseases/therapy ; Lacrimal Apparatus ; Tears/physiology ; Eyelid Diseases
Language	Dutch
Publishing date	2023-10-25
Publishing country	Netherlands
Document type	English Abstract ; Journal Article
ZDB-ID	82073-8
ISSN	1876-8784 ; 0028-2162
ISSN (online)	1876-8784
ISSN	0028-2162
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.18: Show issues

Location:
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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Article ; Online: Persistent La Niñas drive joint soybean harvest failures in North and South America

R. Hamed / S. Vijverberg / A. F. Van Loon / J. Aerts / D. Coumou

Earth System Dynamics, Vol 14, Pp 255-

2023 Volume 272

Abstract: Around 80 % of global soybean supply is produced in southeast South America (SESA), central Brazil (CB) and the United States (US) alone. This concentration of production in few regions makes global soybean supply sensitive to spatially compounding ... ...

Abstract	Around 80 % of global soybean supply is produced in southeast South America (SESA), central Brazil (CB) and the United States (US) alone. This concentration of production in few regions makes global soybean supply sensitive to spatially compounding harvest failures. Weather variability is a key driver of soybean variability, with soybeans being especially vulnerable to hot and dry conditions during the reproductive growth stage in summer. El Niño–Southern Oscillation (ENSO) teleconnections can influence summer weather conditions across the Americas, presenting potential risks for spatially compounding harvest failures. Here, we develop causal structural models to quantify the influence of ENSO on soybean yields via mediating variables like local weather conditions and extratropical sea surface temperatures (SSTs). We show that soybean yields are predominately driven by soil moisture conditions in summer, explaining ∼50 %, 18 % and 40 % of yield variability in SESA, CB and the US respectively. Summer soil moisture is strongly driven by spring soil moisture, as well as by remote extratropical SST patterns in both hemispheres. Both of these soil moisture drivers are again influenced by ENSO. Our causal models show that persistent negative ENSO anomalies of −1.5 standard deviation (SD) lead to a −0.4 SD soybean reduction in the US and SESA. When spring soil moisture and extratropical SST precursors are pronouncedly negative ( −1.5 SD), then estimated soybean losses increase to −0.9 SD for the US and SESA. Thus, by influencing extratropical SSTs and spring soil moisture, persistent La Niñas can trigger substantial soybean losses in both the US and SESA, with only minor potential gains in CB. Our findings highlight the physical pathways by which ENSO conditions can drive spatially compounding events. Such information may increase preparedness against climate-related global soybean supply shocks.
Keywords	Science ; Q ; Geology ; QE1-996.5 ; Dynamic and structural geology ; QE500-639.5
Subject code	550
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Chloroquine as a possible treatment for COVID-19]

Coumou, Jeroen / de Vries, Peter J.

Ned Tijdschr Geneeskd

Abstract: Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2 Recently, the Dutch National Institute for Public Health and the Environment ... ...

Abstract	Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2 Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir In this commentary, we provide a background and history of chloroquine, the evidence for antiviral efficacy of chloroquine and the arguments for off-label use of chloroquine in COVID-19
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #242142
Database	COVID19

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Article: Chloroquine als mogelijke behandeling van COVID-19./ [Chloroquine as a possible treatment for COVID-19]

Coumou, Jeroen / de Vries, Peter J

Ned. tijdschr. geneeskd

Abstract	Since the outbreak of COVID-19, chloroquine has been mentioned as a possible treatment. In vitro studies have shown anti-viral activity of chloroquine against SARS-CoV-2. Recently, the Dutch National Institute for Public Health and the Environment published treatment options for antiviral treatment for COVID-19 where chloroquine was suggested as first choice for off-label treatment, beside remdesivir en lopinavir/ritonavir. In this commentary, we provide a background and history of chloroquine, the evidence for antiviral efficacy of chloroquine and the arguments for off-label use of chloroquine in COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32391999
Database	COVID19

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Article ; Online: Impacts of compound hot–dry extremes on US soybean yields

R. Hamed / A. F. Van Loon / J. Aerts / D. Coumou

Earth System Dynamics, Vol 12, Pp 1371-

2021 Volume 1391

Abstract: The US agriculture system supplies more than one-third of globally traded soybean, and with 90 % of US soybean produced under rainfed agriculture, soybean trade is particularly sensitive to weather and climate variability. Average growing season climate ... ...

Abstract	The US agriculture system supplies more than one-third of globally traded soybean, and with 90 % of US soybean produced under rainfed agriculture, soybean trade is particularly sensitive to weather and climate variability. Average growing season climate conditions can explain about one-third of US soybean yield variability. Additionally, crops can be sensitive to specific short-term weather extremes, occurring in isolation or compounding at key moments throughout crop development. Here, we identify the dominant within-season climate drivers that can explain soybean yield variability in the US, and we explore the synergistic effects between drivers that can lead to severe impacts. The study combines weather data from reanalysis and satellite-informed root zone soil moisture fields with subnational crop yields using statistical methods that account for interaction effects. On average, our models can explain about two-thirds of the year-to-year yield variability (70 % for all years and 60 % for out-of-sample predictions). The largest negative influence on soybean yields is driven by high temperature and low soil moisture during the summer crop reproductive period. Moreover, due to synergistic effects, heat is considerably more damaging to soybean crops during dry conditions and is less problematic during wet conditions. Compounding and interacting hot and dry (hot–dry) summer conditions (defined by the 95th and 5th percentiles of temperature and soil moisture respectively) reduce yields by 2 standard deviations. This sensitivity is 4 and 3 times larger than the sensitivity to hot or dry conditions alone respectively. Other relevant drivers of negative yield responses are lower temperatures early and late in the season, excessive precipitation in the early season, and dry conditions in the late season. We note that the sensitivity to the identified drivers varies across the spatial domain. Higher latitudes, and thus colder regions, are positively affected by high temperatures during the summer period. On the other hand, warmer southeastern regions are positively affected by low temperatures during the late season. Historic trends in identified drivers indicate that US soybean production has generally benefited from recent shifts in weather except for increasing rainfall in the early season. Overall, warming conditions have reduced the risk of frost in the early and late seasons and have potentially allowed for earlier sowing dates. More importantly, summers have been getting cooler and wetter over the eastern US. Nevertheless, despite these positive changes, we show that the frequency of compound hot–dry summer events has remained unchanged over the 1946–2016 period. In the longer term, climate models project substantially warmer summers for the continental US, although uncertainty remains as to whether this will be accompanied by drier conditions. This highlights a critical element to explore in future studies focused on US agricultural production risk under climate change.
Keywords	Science ; Q ; Geology ; QE1-996.5 ; Dynamic and structural geology ; QE500-639.5
Subject code	550
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The influence of mid-latitude storm tracks on hot, cold, dry and wet extremes.

Lehmann, Jascha / Coumou, Dim

Scientific reports

2015 Volume 5, Page(s) 17491

Abstract: Changes in mid-latitude circulation can strongly affect the number and intensity of extreme weather events. In particular, high-amplitude quasi-stationary planetary waves have been linked to prolonged weather extremes at the surface. In contrast, ... ...

Abstract	Changes in mid-latitude circulation can strongly affect the number and intensity of extreme weather events. In particular, high-amplitude quasi-stationary planetary waves have been linked to prolonged weather extremes at the surface. In contrast, analyses of fast-traveling synoptic-scale waves and their direct influence on heat and cold extremes are scarce though changes in such waves have been detected and are projected for the 21st century. Here we apply regression analyses of synoptic activity with surface temperature and precipitation in monthly gridded observational data. We show that over large parts of mid-latitude continental regions, summer heat extremes are associated with low storm track activity. In winter, the occurrence of cold spells is related to low storm track activity over parts of eastern North America, Europe, and central- to eastern Asia. Storm tracks thus have a moderating effect on continental temperatures. Pronounced storm track activity favors monthly rainfall extremes throughout the year, whereas dry spells are associated with a lack thereof. Trend analyses reveal significant regional changes in recent decades favoring the occurrence of cold spells in the eastern US, droughts in California and heat extremes over Eurasia.
Language	English
Publishing date	2015-12-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep17491
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Online: Modelled storm surge changes in a warmer world

Scussolini, Paolo / Dullaart, Job / Muis, Sanne / Rovere, Alessio / Bakker, Pepijn / Coumou, Dim / Renssen, Hans / Ward, Philip J. / Aerts, Jeroen C. J. H.

eISSN:

the Last Interglacial

2023

Abstract: The Last Interglacial (LIG; ca. 125 ka) is a period of interest for climate research as it is the most recent period of the Earth's history when the boreal climate was warmer than at present. Previous research, based on models and geological evidence, ... ...

Abstract	The Last Interglacial (LIG; ca. 125 ka) is a period of interest for climate research as it is the most recent period of the Earth's history when the boreal climate was warmer than at present. Previous research, based on models and geological evidence, suggests that the LIG may have featured enhanced patterns of ocean storminess, but this remains hotly debated. Here, we apply state-of-the-art climate and hydrodynamic modeling to simulate changes in sea level extremes caused by storm surges, under LIG and pre-industrial climate forcings. Significantly higher seasonal LIG sea level extremes emerge for coastlines along northern Australia, the Indonesian archipelago, much of northern and eastern Africa, the Mediterranean Sea, the Gulf of Saint Lawrence, the Arabian Sea, the east coast of North America, and islands of the Pacific Ocean and of the Caribbean. Lower seasonal LIG sea level extremes emerge for coastlines along the North Sea, the Bay of Bengal, China, Vietnam, and parts of Central America. Most of these anomalies are associated with anomalies in seasonal sea level pressure minima and in eddy kinetic energy calculated from near-surface wind fields, and therefore seem to originate from anomalies in the meridional position and intensity of the predominant wind bands. In a qualitative comparison, LIG sea level extremes seem generally higher than those projected for future warmer climates. These results help to constrain the interpretation of coastal archives of LIG sea level indicators.
Subject code	551
Language	English
Publishing date	2023-01-16
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Modeled storm surge changes in a warmer world

Scussolini, Paolo / Dullaart, Job / Muis, Sanne / Rovere, Alessio / Bakker, Pepijn / Coumou, Dim / Renssen, Hans / Ward, Philip J. / Aerts, Jeroen C. J. H.

eISSN: 1814-9332

the Last Interglacial

2023

Abstract	The Last Interglacial (LIG; ca. 125 ka) is a period of interest for climate research as it is the most recent period of the Earth's history when the boreal climate was warmer than at present. Previous research, based on models and geological evidence, suggests that the LIG may have featured enhanced patterns of ocean storminess, but this remains hotly debated. Here, we apply state-of-the-art climate and hydrodynamic modeling to simulate changes in sea level extremes caused by storm surges, under LIG and pre-industrial climate forcings. Significantly higher seasonal LIG sea level extremes emerge for coastlines along northern Australia, the Indonesian archipelago, much of northern and eastern Africa, the Mediterranean Sea, the Gulf of Saint Lawrence, the Arabian Sea, the east coast of North America, and islands of the Pacific Ocean and of the Caribbean. Lower seasonal LIG sea level extremes emerge for coastlines along the North Sea, the Bay of Bengal, China, Vietnam, and parts of Central America. Most of these anomalies are associated with anomalies in seasonal sea level pressure minima and in eddy kinetic energy calculated from near-surface wind fields, and therefore seem to originate from anomalies in the meridional position and intensity of the predominant wind bands. In a qualitative comparison, LIG sea level extremes seem generally higher than those projected for future warmer climates. These results help to constrain the interpretation of coastal archives of LIG sea level indicators.
Subject code	551
Language	English
Publishing date	2023-01-16
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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