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Article ; Online: Prevalence and predictors of depressive symptoms among caregivers of patients with epilepsy in Hong Kong.

Lou, Vivian W Q / Chung, Ho-Fung / Leung, William C Y / Chang, Richard Shek-Kwan / Tsaw, Meagan / Lo, Cheuk Nam Rachel / Chiu, Annie Ting-Gee

Epilepsy & behavior : E&B

2023 Volume 147, Page(s) 109411

Abstract: Study aim: To estimate the prevalence of high caregiving burden and depressive symptoms among caregivers (CG) of patients with epilepsy (PWEs) in Hong Kong and identify risk and protective factors for both outcomes after the Model of Stress and Carer ... ...

Abstract	Study aim: To estimate the prevalence of high caregiving burden and depressive symptoms among caregivers (CG) of patients with epilepsy (PWEs) in Hong Kong and identify risk and protective factors for both outcomes after the Model of Stress and Carer Burden (MSCB). Methods: This cross-sectional study recruited participants from local epilepsy clinics to complete a 15-minute survey on a tablet. Caregiving burden (CB) was assessed using the 4-item Zarit Caregiver Burden Interview. Depressive symptoms were assessed using the 2-item Patient Health Questionnaire. Family functioning was assessed using the Short-Form Family Assessment Device General Functioning Subscale. Sociodemographic data of the caregivers and clinical data of the PWE they cared for were described. Hierarchical logistic regression models were used to analyze the factors associated with the outcomes. Results: A hundred and fifty-one CGs of PWEs were recruited for this study. The prevalence of high caregiving burden (ZBI-4 > 7) for CGs of PWEs was 58.9% (n = 89), whereas the prevalence of high depressive symptoms (PHQ2 > 2) was 23.8% (n = 36). Hierarchical logistic regression analysis revealed that entering patient characteristics and care situations did not enhance the model's predictability. In the full model, a high perceived CB was a risk factor for elevated depressive symptoms. Good physical health protects against depressive symptoms. Conclusions: Among caregivers of PWE in Hong Kong, a high perceived caregiving burden was a risk factor for elevated depressive symptoms; however, the clinical characteristics of the PWEs were not. Self-reported physical health is a protective factor against increased depressive symptoms.
Language	English
Publishing date	2023-09-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2023.109411
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Article ; Online: Volatilised pyrene: A phase 1 study demonstrating a new method of visualising fingermarks with comparisons to iodine fuming.

Chang, Ingram / Stone, Ashton C A / Hanney, Oliver C / Gee, William J

Forensic science international

2019 Volume 305, Page(s) 109996

Abstract: Pyrene is a fluorescent polycyclic aromatic hydrocarbon that can be volatilised under mild conditions. When fumed, pyrene is rapidly absorbed into the sebaceous residues of fingermarks, enabling their fluorescent visualisation upon excitation with ... ...

Abstract	Pyrene is a fluorescent polycyclic aromatic hydrocarbon that can be volatilised under mild conditions. When fumed, pyrene is rapidly absorbed into the sebaceous residues of fingermarks, enabling their fluorescent visualisation upon excitation with ultraviolet radiation. This new means of fluorescent fingermark detection is more sensitive than the non-fluorescent iodine fuming approach for nonporous surfaces. This is demonstrated here in a phase 1 study using split-print comparisons on metal and glass surfaces. Pyrene-treated fingermarks also retain the volatile fluorophore for comparably long time periods relative to iodine fuming (in the order of hours). The phase 1 study comprised four donors, and 80 natural fingermarks that were grouped into two time periods; aged 24h and 1 week. Iodine fuming was chosen as a reference to showcase the effectiveness of pyrene given it is the most closely-related chemical fuming method in routine use. This study demonstrates that pyrene fuming increases the quantity and quality of fingermark visualisations relative to iodine fuming, and is free of many of the latter method's drawbacks. Preliminary results shown here also show the effectiveness of pyrene fuming on highly patterned surfaces, and its compatibility with the use of gelatine lifters. Pyrene fuming is thus easy to effect, low-cost, and shows great promise as a new means of visualising fingermarks on non-porous surfaces.
Language	English
Publishing date	2019-10-21
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2019.109996
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Article ; Online: Adolescent civic engagement: Lessons from Black Lives Matter.

Baskin-Sommers, Arielle / Simmons, Cortney / Conley, May / Chang, Shou-An / Estrada, Suzanne / Collins, Meghan / Pelham, William / Beckford, Emil / Mitchell-Adams, Haley / Berrian, Nia / Tapert, Susan F / Gee, Dylan G / Casey, B J

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 41

Abstract: In 2020, individuals of all ages engaged in demonstrations condemning police brutality and supporting the Black Lives Matter (BLM) movement. Research that used parent reports and trends commented on in popular media suggested that adolescents under 18 ... ...

Abstract	In 2020, individuals of all ages engaged in demonstrations condemning police brutality and supporting the Black Lives Matter (BLM) movement. Research that used parent reports and trends commented on in popular media suggested that adolescents under 18 had become increasingly involved in this movement. In the first large-scale quantitative survey of adolescents' exposure to BLM demonstrations, 4,970 youth (mean
MeSH term(s)	Adolescent ; African Americans/psychology ; Child ; Emotions ; Exposure to Violence/psychology ; Female ; Humans ; Male ; Mass Gatherings ; Police ; Politics ; Social Media/statistics & numerical data ; Social Participation/psychology ; Surveys and Questionnaires ; United States
Language	English
Publishing date	2021-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2109860118
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Article: Volatilised pyrene: A phase 1 study demonstrating a new method of visualising fingermarks with comparisons to iodine fuming

Chang, Ingram / Gee, William J / Hanney, Oliver C / Stone, Ashton C.A

Forensic science international. 2019 Dec., v. 305

2019

Abstract	Pyrene is a fluorescent polycyclic aromatic hydrocarbon that can be volatilised under mild conditions. When fumed, pyrene is rapidly absorbed into the sebaceous residues of fingermarks, enabling their fluorescent visualisation upon excitation with ultraviolet radiation. This new means of fluorescent fingermark detection is more sensitive than the non-fluorescent iodine fuming approach for nonporous surfaces. This is demonstrated here in a phase 1 study using split-print comparisons on metal and glass surfaces. Pyrene-treated fingermarks also retain the volatile fluorophore for comparably long time periods relative to iodine fuming (in the order of hours). The phase 1 study comprised four donors, and 80 natural fingermarks that were grouped into two time periods; aged 24h and 1 week. Iodine fuming was chosen as a reference to showcase the effectiveness of pyrene given it is the most closely-related chemical fuming method in routine use. This study demonstrates that pyrene fuming increases the quantity and quality of fingermark visualisations relative to iodine fuming, and is free of many of the latter method’s drawbacks. Preliminary results shown here also show the effectiveness of pyrene fuming on highly patterned surfaces, and its compatibility with the use of gelatine lifters. Pyrene fuming is thus easy to effect, low-cost, and shows great promise as a new means of visualising fingermarks on non-porous surfaces.
Keywords	fluorescence ; fluorescent dyes ; gelatin ; glass ; iodine ; polycyclic aromatic hydrocarbons ; ultraviolet radiation ; volatilization
Language	English
Dates of publication	2019-12
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	424042-x
ISSN	1872-6283 ; 0379-0738
ISSN (online)	1872-6283
ISSN	0379-0738
DOI	10.1016/j.forsciint.2019.109996
Database	NAL-Catalogue (AGRICOLA)

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Article: Changes in pediatric seizure-related emergency department attendances during COVID-19 - A territory-wide observational study.

Chiu, Ting Gee Annie / Leung, William C Y / Zhang, Qiqi / Lau, Eric H Y / Ho, Ryan Wui-Hang / Chan, Hoi-Shan Sophelia / Chang, Richard Shek-Kwan

Journal of the Formosan Medical Association = Taiwan yi zhi

2020 Volume 120, Issue 8, Page(s) 1647–1651

Abstract: A territory-wide retrospective observational study was conducted in Hong Kong between January 23 to April 22, 2020 to demonstrate changes in pediatric seizure-related accident and emergency department (A&E) visits during the COVID-19 pandemic. Parallel ... ...

Abstract	A territory-wide retrospective observational study was conducted in Hong Kong between January 23 to April 22, 2020 to demonstrate changes in pediatric seizure-related accident and emergency department (A&E) visits during the COVID-19 pandemic. Parallel periods from 2015 to 2019 were used as control. All-cause A&E attendances in all paediatric age groups decreased significantly during the study period. Seizure-related attendances decreased across all pediatric age-groups in 2020 (RR 0.379, 95% CI 0.245-0.588), with a disproportionately large decrease in the 0-6 years age group (RR 0.303, 95% CI 0.174-0.526) compared with the 7-18 years age group (RR 0.534, 95% CI 0.393-0.719). Decrease in RTI-related A&E attendances was also more drastic in the 0-6 age group. The two time trends are congruent in the 0-6 years but not the 7-18 years age group. Such a trend is suggestive of the usefulness of infection control measures in seizure prevention, especially amongst young children.
MeSH term(s)	Adolescent ; COVID-19 ; Child ; Child, Preschool ; Emergency Service, Hospital ; Humans ; Infant ; Infant, Newborn ; Pandemics ; SARS-CoV-2 ; Seizures/epidemiology
Language	English
Publishing date	2020-11-21
Publishing country	Singapore
Document type	Journal Article ; Observational Study
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2020.11.006
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Article ; Online: Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke.

Mac Grory, Brian / Holmes, DaJuanicia N / Matsouaka, Roland A / Shah, Shreyansh / Chang, Cherylee W J / Rison, Richard / Jindal, Jenelle / Holmstedt, Christine / Logan, William R / Corral, Candy / Mackey, Jason S / Gee, Joey R / Bonovich, David / Walker, James / Gropen, Toby / Benesch, Curtis / Dissin, Jonathan / Pandey, Hemant / Wang, David /

Unverdorben, Martin / Hernandez, Adrian F / Reeves, Mathew / Smith, Eric E / Schwamm, Lee H / Bhatt, Deepak L / Saver, Jeffrey L / Fonarow, Gregg C / Peterson, Eric D / Xian, Ying

JAMA

2023 Volume 329, Issue 23, Page(s) 2038–2049

Abstract: Importance: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications.: Objective: To determine the association ...

Abstract	Importance: Use of oral vitamin K antagonists (VKAs) may place patients undergoing endovascular thrombectomy (EVT) for acute ischemic stroke caused by large vessel occlusion at increased risk of complications. Objective: To determine the association between recent use of a VKA and outcomes among patients selected to undergo EVT in clinical practice. Design, setting, and participants: Retrospective, observational cohort study based on the American Heart Association's Get With the Guidelines-Stroke Program between October 2015 and March 2020. From 594 participating hospitals in the US, 32 715 patients with acute ischemic stroke selected to undergo EVT within 6 hours of time last known to be well were included. Exposure: VKA use within the 7 days prior to hospital arrival. Main outcome and measures: The primary end point was symptomatic intracranial hemorrhage (sICH). Secondary end points included life-threatening systemic hemorrhage, another serious complication, any complications of reperfusion therapy, in-hospital mortality, and in-hospital mortality or discharge to hospice. Results: Of 32 715 patients (median age, 72 years; 50.7% female), 3087 (9.4%) had used a VKA (median international normalized ratio [INR], 1.5 [IQR, 1.2-1.9]) and 29 628 had not used a VKA prior to hospital presentation. Overall, prior VKA use was not significantly associated with an increased risk of sICH (211/3087 patients [6.8%] taking a VKA compared with 1904/29 628 patients [6.4%] not taking a VKA; adjusted odds ratio [OR], 1.12 [95% CI, 0.94-1.35]; adjusted risk difference, 0.69% [95% CI, -0.39% to 1.77%]). Among 830 patients taking a VKA with an INR greater than 1.7, sICH risk was significantly higher than in those not taking a VKA (8.3% vs 6.4%; adjusted OR, 1.88 [95% CI, 1.33-2.65]; adjusted risk difference, 4.03% [95% CI, 1.53%-6.53%]), while those with an INR of 1.7 or lower (n = 1585) had no significant difference in the risk of sICH (6.7% vs 6.4%; adjusted OR, 1.24 [95% CI, 0.87-1.76]; adjusted risk difference, 1.13% [95% CI, -0.79% to 3.04%]). Of 5 prespecified secondary end points, none showed a significant difference across VKA-exposed vs VKA-unexposed groups. Conclusions and relevance: Among patients with acute ischemic stroke selected to receive EVT, VKA use within the preceding 7 days was not associated with a significantly increased risk of sICH overall. However, recent VKA use with a presenting INR greater than 1.7 was associated with a significantly increased risk of sICH compared with no use of anticoagulants.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Brain Ischemia/drug therapy ; Brain Ischemia/mortality ; Brain Ischemia/surgery ; Endovascular Procedures/adverse effects ; Endovascular Procedures/methods ; Endovascular Procedures/mortality ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/adverse effects ; Fibrinolytic Agents/therapeutic use ; Hemorrhage/chemically induced ; Intracranial Hemorrhages/chemically induced ; Intracranial Hemorrhages/etiology ; Ischemic Stroke/drug therapy ; Ischemic Stroke/mortality ; Ischemic Stroke/surgery ; Retrospective Studies ; Thrombectomy/adverse effects ; Thrombectomy/methods ; Thrombectomy/mortality ; Treatment Outcome ; Vitamin K/antagonists & inhibitors ; Administration, Oral ; Hospital Mortality ; International Normalized Ratio
Chemical Substances	Anticoagulants ; Fibrinolytic Agents ; Vitamin K (12001-79-5)
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2023.8073
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Article ; Online: Changes in pediatric seizure-related emergency department attendances during COVID-19 – A territory-wide observational study

Ting Gee Annie Chiu / William C.Y. Leung / Qiqi Zhang / Eric H.Y. Lau / Ryan Wui-hang Ho / Hoi-Shan Sophelia Chan / Richard Shek-kwan Chang

Journal of the Formosan Medical Association, Vol 120, Iss 8, Pp 1647-

2021 Volume 1651

Abstract	A territory-wide retrospective observational study was conducted in Hong Kong between January 23 to April 22, 2020 to demonstrate changes in pediatric seizure-related accident and emergency department (A&E) visits during the COVID-19 pandemic. Parallel periods from 2015 to 2019 were used as control.All-cause A&E attendances in all paediatric age groups decreased significantly during the study period. Seizure-related attendances decreased across all pediatric age-groups in 2020 (RR 0.379, 95% CI 0.245–0.588), with a disproportionately large decrease in the 0–6 years age group (RR 0.303, 95% CI 0.174–0.526) compared with the 7–18 years age group (RR 0.534, 95% CI 0.393–0.719). Decrease in RTI-related A&E attendances was also more drastic in the 0–6 age group. The two time trends are congruent in the 0–6 years but not the 7–18 years age group. Such a trend is suggestive of the usefulness of infection control measures in seizure prevention, especially amongst young children.
Keywords	COVID19 ; Epilepsy ; Respiratory tract infections ; Medical help seek-behaviour ; Febrile seizures ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Mitigating exhalation puffs during oxygen therapy for respiratory disease.

Kudrolli, Arshad / Chang, Brian / Consalvi, Jade / Deti, Anton / Frechette, Christopher / Scoville, Helen / Sheinfeld, Geoffrey R / McGee, William T

Physics of fluids (Woodbury, N.Y. : 1994)

2021 Volume 33, Issue 8, Page(s) 81903

Abstract: We investigate the dispersal of exhalations corresponding to a patient experiencing shortness of breath while being treated for a respiratory disease with oxygen therapy. Respiration through a nasal cannula and a simple ... ...

Abstract	We investigate the dispersal of exhalations corresponding to a patient experiencing shortness of breath while being treated for a respiratory disease with oxygen therapy. Respiration through a nasal cannula and a simple O
Language	English
Publishing date	2021-08-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1472743-2
ISSN	1089-7666 ; 1070-6631
ISSN (online)	1089-7666
ISSN	1070-6631
DOI	10.1063/5.0057227
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Article ; Online: Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.

Chang, William Gee / Fornoni, Alessia / Tietjen, Gregory / Mendez, Julio J / Niklason, Laura E / Saltzman, W Mark / Pober, Jordan S

Tissue engineering. Part A

2015 Volume 21, Issue 21-22, Page(s) 2673–2679

Abstract: Kidney transplantation is often the most effective therapy for end-stage renal disease, but there are not enough donor organs to meet the rising demand. Tissue engineering of kidneys is a potential solution to this organ shortage. Achieving microvascular ...

Abstract	Kidney transplantation is often the most effective therapy for end-stage renal disease, but there are not enough donor organs to meet the rising demand. Tissue engineering of kidneys is a potential solution to this organ shortage. Achieving microvascular perfusion has been a major barrier to engineering tissues beyond thin muscularized sheets such as the bladder wall. Our laboratory has previously reported that human umbilical vein endothelial cells (ECs) transduced with the antiapoptotic protein Bcl-2 will spontaneously organize into perfused microvessels within type I collagen gels when implanted in immunodeficient mice. To test if this system can be used to perfuse more complex structures, we combined Bcl-2-transduced ECs (Bcl-2-ECs) with renal glomeruli, the specialized vascular filtration units of the kidney. Microdissected green fluorescent protein-expressing rat glomeruli suspended in type I collagen gels were implanted within immunodeficient mice with or without the inclusion of Bcl-2-ECs. Survival of rat glomeruli was enhanced by coimplantation with Bcl-2-ECs. Intravital rhodamine dextran injections demonstrated that surviving glomeruli were perfused through Bcl-2-EC-derived microvessels. Perfused glomeruli maintained podocin staining, but transmission electron microscopy revealed endothelial swelling and podocyte foot process effacement. Anastomosis of microvessels derived from Bcl-2-ECs with glomerular capillaries provides proof of concept that self-assembled microvessels can perfuse specialized organ structures such as glomeruli, but that perfusion alone may be insufficient to maintain normal structure.
MeSH term(s)	Animals ; Cells, Cultured ; Endothelial Cells/cytology ; Endothelial Cells/physiology ; Endothelial Cells/transplantation ; Female ; Humans ; In Vitro Techniques ; Kidney Glomerulus/blood supply ; Kidney Glomerulus/physiology ; Kidney Glomerulus/surgery ; Mice, Inbred C57BL ; Microvessels/cytology ; Microvessels/growth & development ; Rats ; Rats, Transgenic ; Reperfusion/methods ; Tissue Engineering/methods ; Umbilical Veins/cytology
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2420582-5
ISSN	1937-335X ; 1937-3341
ISSN (online)	1937-335X
ISSN	1937-3341
DOI	10.1089/ten.TEA.2015.0060
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Article: Optical and Scanning Probe Identification of Electronic Structure and Phases in CH3NH3PbBr3 Crystal

Jung, Hye Ri / Ahn Chang Won / Cho Shinuk / Jin Hye-Jin / Jo William / Kim Gee Yeong / Kim Ill Won / Nguyen Bich Phuong / Thu Nguyen Trang Thi / Woo Won Seok / Yoon Seokhyun

The Journal of Physical Chemistry C. 2017 Oct. 12, v. 121, no. 40

2017

Abstract: Hybrid lead halide perovskite possesses attractive properties and outstanding performance. The electronic structure of hybrid lead halide perovskite single crystal can be used to comprehend its intrinsic properties. In this study, the crystal structure ... ...

Abstract	Hybrid lead halide perovskite possesses attractive properties and outstanding performance. The electronic structure of hybrid lead halide perovskite single crystal can be used to comprehend its intrinsic properties. In this study, the crystal structure of CH3NH3PbBr3 perovskite crystal was elucidated by transmission electron microscopy. Phonon modes and CH3NH3+ rocking modes were analyzed. Band gaps of the crystal were obtained by temperature-dependent Raman scattering spectroscopy and photoluminescence measurement. Surface potential measurement for a (001) plane exhibited a work function of the material and other phases of PbBr2 and CH3NH3Br. From experimentally determined values, an electronic structure of CH3NH3PbBr3 was built. It showed a p-type characteristic.
Keywords	crystal structure ; lead ; photoluminescence ; Raman spectroscopy ; transmission electron microscopy
Language	English
Dates of publication	2017-1012
Size	p. 21930-21934.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021%2Facs.jpcc.7b06765
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