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Article: Concerns and expectations in women with polycystic ovary syndrome vary across age and ethnicity: findings from PCOS Pearls Study.

Elghobashy, Mirna / Lau, Gar Mun / Davitadze, Meri / Gillett, Caroline D T / O'Reilly, Michael W / Arlt, Wiebke / Lindenmeyer, Antje / Kempegowda, Punith

Frontiers in endocrinology

2023 Volume 14, Page(s) 1175548

Abstract: Objective: To understand and explore the perceptions and opinions of women with polycystic ovary syndrome (PCOS) and further delineate the variations across age and ethnicity.: Design: Qualitative survey focussed on lived experiences of people with ... ...

Abstract	Objective: To understand and explore the perceptions and opinions of women with polycystic ovary syndrome (PCOS) and further delineate the variations across age and ethnicity. Design: Qualitative survey focussed on lived experiences of people with PCOS. Participants could share their views either as written text or as voice note audio recording(s) on WhatsApp. The data from the audio were transcribed verbatim. Responses were coded by two study members independently, using a thematic inductive method with NVivo 12. Two senior study members then reviewed these codes to identify common themes. Subjects: Women with PCOS aged 18-60 years. Results: 43 of 45 participants had a formal diagnosis of PCOS, the remaining two had suspected PCOS which was under investigation. Four participants opted to share their views as voice note recordings. Poor mental health was the most reported (83.3% of participants), followed by dermatological (81.0%) and menstrual issues (76.2%). Participants were generally dissatisfied with the care they received (88.1%). A lengthy diagnostic journey was reported in 35.7% of cases. 52.6% felt less feminine, particularly regarding weight gain and infertility. As part of the recommendations by participants, it was emphasised that others with the condition should educate themselves and be proactive in their management. 46.3% reported that being more enlightened regarding their condition improved their health outcomes and enabled them to advocate for their own care. Women in their 20s expressed distress due to poor mental health, needing a longer time to get the diagnosis, and having weight and eating concerns. While women with PCOS in their 30s discussed their menstrual irregularities and fertility issues, those in their 40s expressed their concerns about the societal expectations of women when diagnosed with PCOS. The concerns varied across ethnicities as well. Conclusion: PCOS has wide-ranging consequences for women living with the condition, with many dissatisfied with the clinical support they currently receive. The concerns and expectations vary across ages and ethnicities. Therefore, we propose involving women with PCOS to co-create clinical and educational resources informed by lived experiences to provide end-user-informed services.
MeSH term(s)	Humans ; Female ; Ethnicity ; Motivation ; Polycystic Ovary Syndrome ; Emotions ; Infertility
Language	English
Publishing date	2023-08-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1175548
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Article ; Online: Avoid the Trap: Nonexpanding Lung.

Gillett, Dan / Mitchell, Michael A / Dhaliwal, Inderdeep

Chest

2021 Volume 160, Issue 3, Page(s) 1131–1136

Abstract: Nonexpanding lung is a mechanical complication in which part of the lung is unable to expand to the chest wall, preventing apposition of the visceral and parietal pleura. This can result from various visceral pleural disease processes, including ... ...

Abstract	Nonexpanding lung is a mechanical complication in which part of the lung is unable to expand to the chest wall, preventing apposition of the visceral and parietal pleura. This can result from various visceral pleural disease processes, including malignant pleural effusion and empyema. Nonexpanding lung can be referred to as trapped lung or lung entrapment, both with distinct clinical features and management strategies. Early evaluation of pleural effusions is important to address underlying causes of pleural inflammation and to prevent the progression from lung entrapment to trapped lung. Some patients with trapped lung will not experience symptomatic relief with pleural fluid removal. Therefore, misrecognition of trapped lung can result in patients undergoing unnecessary procedures with significant cost and morbidity. We reviewed the current understanding of nonexpanding lung, which included causes, common presentations, preventative strategies, and recommendations for clinical care.
MeSH term(s)	Early Medical Intervention ; Humans ; Pleural Diseases/complications ; Pleural Diseases/diagnosis ; Pleural Diseases/therapy ; Pulmonary Atelectasis/diagnosis ; Pulmonary Atelectasis/etiology ; Pulmonary Atelectasis/physiopathology ; Pulmonary Atelectasis/prevention & control ; Time-to-Treatment
Language	English
Publishing date	2021-04-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2021.04.025
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Article ; Online: Celiac Disease Management in the United Kingdom Specialist Pediatric Gastroenterology Centers-A Service Survey.

Paul, Siba Prosad / Balakumar, Varathagini / Gillett, Peter Michael

Journal of pediatric gastroenterology and nutrition

2021 Volume 72, Issue 6, Page(s) e149–e153

Abstract: ... Most centers (n = 23) waited 6-12 months post-diagnosis to start gluten-free oats. Routine vitamin D ...

Abstract	Objectives: The 2012 European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines on celiac disease (CD) recommended a no-biopsy pathway (NBP) for symptomatic children with high immunoglobin A (IgA)-based anti-tissue transglutaminase (TGA-IgA) titers, positive anti-endomysial antibody and human leukocyte antigen (HLA)-DQ2/DQ8 status. We aimed to understand variations in practice amongst specialist pediatric gastroenterology centers (SPGIC) in the United Kingdom (UK). Methods: A survey questionnaire was sent to all UK SPGIC (n = 29) providing endoscopy services for CD diagnosis. It was divided into four main subgroups: analyzing diagnosis of CD through adherence to the ESPGHAN (2012) guidelines, post-diagnosis care and long-term follow-up and discharge from pediatric services. Results: All 29 responded. NBP was implemented in 28 of 29 centers. Five of 29 centers had already stopped HLA-DQ2/DQ8 testing for NBP diagnosis. Twenty six of 29 centers were performing endoscopy on screening-identified children (mostly asymptomatic, "at-risk" patients). Diagnosis was communicated by a doctor in 65% SPGIC (n = 19). Most centers (n = 23) waited 6-12 months post-diagnosis to start gluten-free oats. Routine vitamin D supplementation was commenced by 4 of 29 centers. All centers repeated TGA-IgA to assess normalization but at varying times post-GFD. Follow-up was with a combination of doctors/dieticians (n = 26). Eleven of 29 centers discharged their patient to primary care. Conclusions: There was excellent uptake of ESPGHAN guidelines (2012) in the UK and adherence to guidelines is generally good. Despite published evidence and pragmatic advice from the British Society of Paediatric Gastroenterology Hepatology and Nutrition and National Institute for Health and Care Excellence, significant differences remain in diagnostic and ongoing management practice and are opportunities for research and directive evidence-based follow-up guidance.
MeSH term(s)	Celiac Disease/diagnosis ; Celiac Disease/therapy ; Child ; Disease Management ; Gastroenterology ; Humans ; Surveys and Questionnaires ; Transglutaminases ; United Kingdom
Chemical Substances	Transglutaminases (EC 2.3.2.13)
Language	English
Publishing date	2021-04-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000003126
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Article ; Online: Measurement of Eosinophil Kinetics In Vivo.

Farahi, Neda / Gillett, Daniel / Loutsios, Chrystalla / Peters, A Michael / Summers, Charlotte / Chilvers, Edwin R

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2241, Page(s) 183–191

Abstract: Radiolabeled leukocyte scans are used in nuclear medicine to detect sites of infection and inflammation. We have previously demonstrated the use of clinical grade immunomagnetic beads to isolate autologous eosinophils and image their distribution in ... ...

Abstract	Radiolabeled leukocyte scans are used in nuclear medicine to detect sites of infection and inflammation. We have previously demonstrated the use of clinical grade immunomagnetic beads to isolate autologous eosinophils and image their distribution in healthy volunteers. Here we describe the use of radiolabeled eosinophils coupled to single-photon emission computed tomography (SPECT) to quantify eosinophil uptake in the lungs of healthy volunteers, patients with asthma, and patients with focal eosinophilic inflammation.
MeSH term(s)	Asthma/diagnostic imaging ; Asthma/immunology ; Eosinophilia/diagnostic imaging ; Eosinophils/physiology ; Humans ; Immunomagnetic Separation/methods ; Inflammation/diagnostic imaging ; Inflammation/immunology ; Kinetics ; Leukocyte Count ; Radioimmunodetection/methods ; Tomography, Emission-Computed, Single-Photon/methods
Language	English
Publishing date	2021-01-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1095-4_15
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Article: A systematic review of lived experiences of people with polycystic ovary syndrome highlights the need for holistic care and co-creation of educational resources.

Lau, Gar Mun / Elghobashy, Mirna / Thanki, Mansi / Ibegbulam, Shirley / Latthe, Pallavi / Gillett, Caroline D T / O'Reilly, Michael W / Arlt, Wiebke / Lindenmeyer, Antje / Kempegowda, Punith

Frontiers in endocrinology

2022 Volume 13, Page(s) 1064937

Abstract: Introduction: PCOS-related literature is mostly dominated by the medical perspective. However, the condition's lifelong, far reaching, and multifaceted impacts highlight the importance to gain the perspectives from those with PCOS. Therefore, we ... ...

Abstract	Introduction: PCOS-related literature is mostly dominated by the medical perspective. However, the condition's lifelong, far reaching, and multifaceted impacts highlight the importance to gain the perspectives from those with PCOS. Therefore, we performed a systematic review to explore the current literatures and gaps around the experiences and perceptions of those living with PCOS. Method: A comprehensive search of seven electronic databases was conducted between July and October 2021. A total 34 from 1615 screened articles were included in this systematic review and subsequently coded using NVivo 12 software. The quality of individual studies was assessed by adaptation to the Critical Appraisal Skills Program (CASP) quality assessment tool. Results: Five domains were generated from the data: Signs/Symptoms, Diagnosis, Management, Perceptions, Resources and Improving Outcomes. Dissatisfaction surrounding the experience of diagnosis was common. Concerns surrounded perceived lack of knowledge from healthcare professionals and delays in diagnosis. Individual studies on adults and adolescents shared similar feelings. The consensus was found to be that current management was vague and generalised. Symptoms such as hirsutism, obesity, irregular menstruation challenge personal and societal expectations of femininity. Online PCOS resources are popular amongst those with PCOS but most of them lack evidence. A call for more culturally specific resources was found to be common ground amongst those with PCOS. Conclusion: Overall dissatisfaction amongst adults and adolescents regarding their diagnostic journey of PCOS. Tailored and culturally specific PCOS advice and management is necessary and can be achieved through co-creation of resources between healthcare professionals and those with PCOS. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42021272371.
MeSH term(s)	Adult ; Adolescent ; Female ; Humans ; Polycystic Ovary Syndrome/therapy ; Polycystic Ovary Syndrome/diagnosis ; Hirsutism/diagnosis ; Menstruation Disturbances/diagnosis ; Behavior Therapy
Language	English
Publishing date	2022-12-02
Publishing country	Switzerland
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1064937
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Article ; Online: Evaluation of venous thromboembolism risk assessment models for hospital inpatients: the VTEAM evidence synthesis.

Horner, Daniel Edward / Davis, Sarah / Pandor, Abdullah / Shulver, Helen / Goodacre, Steve / Hind, Daniel / Rex, Saleema / Gillett, Michael / Bursnall, Matthew / Griffin, Xavier / Holland, Mark / Hunt, Beverley Jane / de Wit, Kerstin / Bennett, Shan / Pierce-Williams, Robin

Health technology assessment (Winchester, England)

2024 Volume 28, Issue 20, Page(s) 1–166

Abstract: Background: Pharmacological prophylaxis during hospital admission can reduce the risk of acquired blood clots (venous thromboembolism) but may cause complications, such as bleeding. Using a risk assessment model to predict the risk of blood clots could ... ...

Abstract	Background: Pharmacological prophylaxis during hospital admission can reduce the risk of acquired blood clots (venous thromboembolism) but may cause complications, such as bleeding. Using a risk assessment model to predict the risk of blood clots could facilitate selection of patients for prophylaxis and optimise the balance of benefits, risks and costs. Objectives: We aimed to identify validated risk assessment models and estimate their prognostic accuracy, evaluate the cost-effectiveness of different strategies for selecting hospitalised patients for prophylaxis, assess the feasibility of using efficient research methods and estimate key parameters for future research. Design: We undertook a systematic review, decision-analytic modelling and observational cohort study conducted in accordance with Enhancing the QUAlity and Transparency Of health Research (EQUATOR) guidelines. Setting: NHS hospitals, with primary data collection at four sites. Participants: Medical and surgical hospital inpatients, excluding paediatric, critical care and pregnancy-related admissions. Interventions: Prophylaxis for all patients, none and according to selected risk assessment models. Main outcome measures: Model accuracy for predicting blood clots, lifetime costs and quality-adjusted life-years associated with alternative strategies, accuracy of efficient methods for identifying key outcomes and proportion of inpatients recommended prophylaxis using different models. Results: We identified 24 validated risk assessment models, but low-quality heterogeneous data suggested weak accuracy for prediction of blood clots and generally high risk of bias in all studies. Decision-analytic modelling showed that pharmacological prophylaxis for all eligible is generally more cost-effective than model-based strategies for both medical and surgical inpatients, when valuing a quality-adjusted life-year at £20,000. The findings were more sensitive to uncertainties in the surgical population; strategies using risk assessment models were more cost-effective if the model was assumed to have a very high sensitivity, or the long-term risks of post-thrombotic complications were lower. Efficient methods using routine data did not accurately identify blood clots or bleeding events and several pre-specified feasibility criteria were not met. Theoretical prophylaxis rates across an inpatient cohort based on existing risk assessment models ranged from 13% to 91%. Limitations: Existing studies may underestimate the accuracy of risk assessment models, leading to underestimation of their cost-effectiveness. The cost-effectiveness findings do not apply to patients with an increased risk of bleeding. Mechanical thromboprophylaxis options were excluded from the modelling. Primary data collection was predominately retrospective, risking case ascertainment bias. Conclusions: Thromboprophylaxis for all patients appears to be generally more cost-effective than using a risk assessment model, in hospitalised patients at low risk of bleeding. To be cost-effective, any risk assessment model would need to be highly sensitive. Current evidence on risk assessment models is at high risk of bias and our findings should be interpreted in this context. We were unable to demonstrate the feasibility of using efficient methods to accurately detect relevant outcomes for future research. Future work: Further research should evaluate routine prophylaxis strategies for all eligible hospitalised patients. Models that could accurately identify individuals at very low risk of blood clots (who could discontinue prophylaxis) warrant further evaluation. Study registration: This study is registered as PROSPERO CRD42020165778 and Researchregistry5216. Funding: This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: NIHR127454) and will be published in full in
MeSH term(s)	Female ; Pregnancy ; Humans ; Child ; Inpatients ; Anticoagulants ; Retrospective Studies ; Venous Thromboembolism ; Risk Assessment ; Thrombosis ; Cost-Benefit Analysis ; Observational Studies as Topic
Chemical Substances	Anticoagulants
Language	English
Publishing date	2024-04-18
Publishing country	England
Document type	Systematic Review
ZDB-ID	2006765-3
ISSN	2046-4924 ; 1366-5278
ISSN (online)	2046-4924
ISSN	1366-5278
DOI	10.3310/AWTW6200
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Article ; Online: Improved technical success and radiation safety of adrenal vein sampling using rapid, semi-quantitative point-of-care cortisol measurement.

Page, Michael M / Taranto, Mario / Ramsay, Duncan / van Schie, Greg / Glendenning, Paul / Gillett, Melissa J / Vasikaran, Samuel D

Annals of clinical biochemistry

2018 Volume 55, Issue 5, Page(s) 588–592

Abstract: Objective Primary aldosteronism is a curable cause of hypertension which can be treated surgically or medically depending on the findings of adrenal vein sampling studies. Adrenal vein sampling studies are technically demanding with a high failure rate ... ...

Abstract	Objective Primary aldosteronism is a curable cause of hypertension which can be treated surgically or medically depending on the findings of adrenal vein sampling studies. Adrenal vein sampling studies are technically demanding with a high failure rate in many centres. The use of intraprocedural cortisol measurement could improve the success rates of adrenal vein sampling but may be impracticable due to cost and effects on procedural duration. Design Retrospective review of the results of adrenal vein sampling procedures since commencement of point-of-care cortisol measurement using a novel single-use semi-quantitative measuring device for cortisol, the adrenal vein sampling Accuracy Kit. Measurements: Success rate and complications of adrenal vein sampling procedures before and after use of the adrenal vein sampling Accuracy Kit. Routine use of the adrenal vein sampling Accuracy Kit device for intraprocedural measurement of cortisol commenced in 2016. Results Technical success rate of adrenal vein sampling increased from 63% of 99 procedures to 90% of 48 procedures ( P = 0.0007) after implementation of the adrenal vein sampling Accuracy Kit. Failure of right adrenal vein cannulation was the main reason for an unsuccessful study. Radiation dose decreased from 34.2 Gy.cm
MeSH term(s)	Adrenal Glands/chemistry ; Blood Specimen Collection/methods ; Blood Specimen Collection/trends ; Humans ; Hydrocortisone/analysis ; Point-of-Care Systems/trends ; Radiation Dosage ; Retrospective Studies ; Time Factors ; Veins
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2018-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1177/0004563218760352
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Article: Is a cleft lip and palate a serious "handicap"? Jepson v Chief Constable of West Mercia--a legal and ethical critique.

Morrison, Michael / Gillett, Grant

Journal of law and medicine

2014 Volume 22, Issue 2, Page(s) 290–301

Abstract: ... that a cleft lip and palate should be regarded as a serious "handicap" for the purposes of s 1(1)(d ...

Abstract	This column considers the legal and ethical dimensions of the controversial case of Jepson v Chief Constable of West Mercia. The purpose of bringing legal proceedings was to judicially review the notion that a cleft lip and palate should be regarded as a serious "handicap" for the purposes of s 1(1)(d) of the Abortion Act 1967 (UK). The Column argues that while Parliament failed to provide a sufficiently precise definition of "seriously handicapped", it is clear that it never intended and positively rejected the notion that a cleft lip and palate was a serious enough condition to warrant the lawful termination of a pregnancy. In determining what constitutes a sufficiently serious disability, the column critiques the medical model of disability and proposes a remedy model in its place. Finally, it argues that an attentive and responsive moral framework is fundamental to any substantial narrative ethics, and it suggests that a life with a disability can generate meaningful stories and that when there is a network of support and relationships around the person living that life, that human life is not only viable but also, in its own way, fulfilling, even if not ordinary.
MeSH term(s)	Abortion, Eugenic/ethics ; Abortion, Eugenic/legislation & jurisprudence ; Cleft Lip ; Cleft Palate ; Female ; Humans ; Pregnancy ; United Kingdom
Language	English
Publishing date	2014-12
Publishing country	Australia
Document type	Journal Article ; Legal Cases
ZDB-ID	1236328-5
ISSN	1320-159X
ISSN	1320-159X
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Article ; Online: MultiPole pacing in non-responders to cardiac resynchronization therapy: Results from the QP ExCELs/MPP sub-study.

Drucker, Michael N / Manyam, Harish / Singh, Gurjit / Glascock, Dennis N / Gillett, Shane / Miller, Crystal / Sharmin, Kazi / Parks, Kimberly A

Pacing and clinical electrophysiology : PACE

2021 Volume 44, Issue 10, Page(s) 1683–1690

Abstract: ... feature in CRT non-responder patients.: Methods and results: CRT non-responders with a standard CRT-D ...

Abstract	Background: Multisite LV stimulation therapy allows for stimulation of two different left ventricular pacing vectors within a single LV lead and may improve responsiveness to cardiac resynchronization therapy (CRT). This study prospectively evaluated the safety and efficacy of the MultiPole Pacing (MPP) feature in CRT non-responder patients. Methods and results: CRT non-responders with a standard CRT-D indication were eligible for enrollment into the MPP Sub-Study. Patient status, NYHA classification, Patient Global Assessment (PGA), and adverse events were collected at follow-up. A clinical composite score (CCS) was determined at the 6 month follow-up visit. The primary objective was defined as the proportion of patients with an improved CCS. Safety was evaluated as freedom from MPP system related adverse events requiring additional invasive intervention to resolve. A total of 53 patients were enrolled across 26 U.S. centers. The cumulative follow-up duration was 24.1 years. CCS was improved in 35.6% of patients (p < .0001 when compared to a performance goal of 3%) after 6 months of MPP therapy. When incorporating patient feedback into a modified CCS, 60.0% of patients showed an improvement. Three patients (5.7%) experienced hospitalization for heart failure, and three patient deaths occurred over the follow-up period. No MPP system-related events were reported for an AE-free rate of 100% (95% CI 93.28% to 100.0%). Conclusions: The results of this small, non-randomized study suggest that the MPP feature is safe, and may be effective at converting a percentage of CRT non-responders to responders. Larger, randomized studies are needed to confirm this result.
MeSH term(s)	Aged ; Cardiac Resynchronization Therapy/methods ; Cardiac Resynchronization Therapy Devices ; Female ; Heart Failure/physiopathology ; Heart Failure/therapy ; Heart Ventricles/physiopathology ; Humans ; Male ; Prospective Studies ; United States
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14339
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Article ; Online: EPIDEMIOLOGY OF CHLAMYDIA-INDUCED REPRODUCTIVE DISEASE IN MALE KOALAS (

Hulse, Lyndal S / Beagley, Kenneth / Ellis, William / Fitzgibbon, Sean / Gillett, Amber / Barth, Ben / Robbins, Amy / Pyne, Michael / Larkin, Rebecca / Johnston, Stephen D

Journal of wildlife diseases

2019 Volume 56, Issue 1, Page(s) 82–92

Abstract: Declining population sizes of koalas ( ...

Abstract	Declining population sizes of koalas (
MeSH term(s)	Animals ; Chlamydia/isolation & purification ; Chlamydia Infections/epidemiology ; Chlamydia Infections/microbiology ; Chlamydia Infections/veterinary ; Male ; Phascolarctidae/microbiology ; Queensland/epidemiology ; Semen/microbiology ; Sexually Transmitted Diseases, Bacterial/microbiology ; Sexually Transmitted Diseases, Bacterial/veterinary ; Urethra/microbiology
Language	English
Publishing date	2019-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410709-3
ISSN	1943-3700 ; 0090-3558
ISSN (online)	1943-3700
ISSN	0090-3558
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