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  1. Article: Editorial: From mechanosensing to signalling and cell response: The ion channel force.

    Gkika, Dimitra / Schwab, Albrecht

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1183726

    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1183726
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial

    Dimitra Gkika / Albrecht Schwab

    Frontiers in Cell and Developmental Biology, Vol

    From mechanosensing to signalling and cell response: The ion channel force

    2023  Volume 11

    Keywords piezo ; force-from-tethering gating ; cancer microenvironment ; osteoarthritis ; macrophage ; dendritic cell ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: TRP Channels: The Neglected Culprits in Breast Cancer Chemotherapy Resistance?

    Soussi, Mayar / Hasselsweiller, Alice / Gkika, Dimitra

    Membranes

    2023  Volume 13, Issue 9

    Abstract: Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly ... ...

    Abstract Breast cancer is a major health concern worldwide, and resistance to therapies remains a significant challenge in treating this disease. In breast cancer, Transient Receptor Potential (TRP) channels are well studied and constitute key players in nearly all carcinogenesis hallmarks. Recently, they have also emerged as important actors in resistance to therapy by modulating the response to various pharmaceutical agents. Targeting TRP channels may represent a promising approach to overcome resistance to therapies in breast cancer patients.
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes13090788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Membranes Coated with Graphene-Based Materials: A Review.

    Gkika, Despina A / Karmali, Vasiliki / Lambropoulou, Dimitra A / Mitropoulos, Athanasios C / Kyzas, George Z

    Membranes

    2023  Volume 13, Issue 2

    Abstract: Graphene is a popular material with outstanding properties due to its single layer. Graphene and its oxide have been put to the test as nano-sized building components for separation membranes with distinctive structures and adjustable physicochemical ... ...

    Abstract Graphene is a popular material with outstanding properties due to its single layer. Graphene and its oxide have been put to the test as nano-sized building components for separation membranes with distinctive structures and adjustable physicochemical attributes. Graphene-based membranes have exhibited excellent water and gas purification abilities, which have garnered the spotlight over the past decade. This work aims to examine the most recent science and engineering cutting-edge advances of graphene-based membranes in regard to design, production and use. Additional effort will be directed towards the breakthroughs in synthesizing graphene and its composites to create various forms of membranes, such as nanoporous layers, laminates and graphene-based compounds. Their efficiency in separating and decontaminating water via different techniques such as cross-linking, layer by layer and coating will also be explored. This review intends to offer comprehensive, up-to-date information that will be useful to scientists of multiple disciplines interested in graphene-based membranes.
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes13020127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The Two-Way Relationship Between Calcium and Metabolism in Cancer.

    Dejos, Camille / Gkika, Dimitra / Cantelmo, Anna Rita

    Frontiers in cell and developmental biology

    2020  Volume 8, Page(s) 573747

    Abstract: Calcium ion ( ... ...

    Abstract Calcium ion (Ca
    Language English
    Publishing date 2020-11-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2020.573747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: TRP Channels in Brain Tumors.

    Chinigò, Giorgia / Castel, Hélène / Chever, Oana / Gkika, Dimitra

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 617801

    Abstract: Malignant glioma including glioblastoma (GBM) is the most common group of primary brain tumors. Despite standard optimized treatment consisting of extensive resection followed by radiotherapy/concomitant and adjuvant therapy, GBM remains one of the most ... ...

    Abstract Malignant glioma including glioblastoma (GBM) is the most common group of primary brain tumors. Despite standard optimized treatment consisting of extensive resection followed by radiotherapy/concomitant and adjuvant therapy, GBM remains one of the most aggressive human cancers. GBM is a typical example of intra-heterogeneity modeled by different micro-environmental situations, one of the main causes of resistance to conventional treatments. The resistance to treatment is associated with angiogenesis, hypoxic and necrotic tumor areas while heterogeneity would accumulate during glioma cell invasion, supporting recurrence. These complex mechanisms require a focus on potential new molecular actors to consider new treatment options for gliomas. Among emerging and underexplored targets, transient receptor potential (TRP) channels belonging to a superfamily of non-selective cation channels which play critical roles in the responses to a number of external stimuli from the external environment were found to be related to cancer development, including glioma. Here, we discuss the potential as biological markers of diagnosis and prognosis of TRPC6, TRPM8, TRPV4, or TRPV1/V2 being associated with glioma patient overall survival. TRPs-inducing common or distinct mechanisms associated with their Ca
    Language English
    Publishing date 2021-04-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.617801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening.

    Farfariello, Valerio / Prevarskaya, Natalia / Gkika, Dimitra

    Reviews of physiology, biochemistry and pharmacology

    2021  Volume 181, Page(s) 39–56

    Abstract: In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate carcinogenesis, including cell proliferation, apoptosis, migration, and angiogenesis. The changes in the expression of individual ... ...

    Abstract In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate carcinogenesis, including cell proliferation, apoptosis, migration, and angiogenesis. The changes in the expression of individual ion channels show a specific profile, making these proteins promising clinical biomarkers that may enable better molecular subtyping of the disease and lead to more rapid and accurate clinical decision-making. Expression profiles and channel function are mainly based on the tumoral tissue itself, in this case, the epithelial cancer cell population. To date, little data on the ion channel profile of the cancerous prostate stroma are available, even though tumor interactions with the microenvironment are crucial in carcinogenesis and each distinct population plays a specific role in tumor progression. In this review, we describe ion channel expression profiles specific for the distinct cell population of the tumor microenvironment (stromal, endothelial, neuronal, and neuroendocrine cell populations) and the technical approaches used for efficient separation and screening of these cell populations.
    MeSH term(s) Carcinogenesis ; Early Detection of Cancer ; Humans ; Ion Channels ; Male ; Prostatic Neoplasms/diagnosis ; Tumor Microenvironment
    Chemical Substances Ion Channels
    Language English
    Publishing date 2021-12-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125106-5
    ISSN 1617-5786 ; 0303-4240
    ISSN (online) 1617-5786
    ISSN 0303-4240
    DOI 10.1007/112_2020_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs 90: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Ca2+ Channel Toolkit in Neuroendocrine Tumors.

    Fiorio Pla, Alessandra / Gkika, Dimitra

    Neuroendocrinology

    2019  Volume 110, Issue 1-2, Page(s) 147–154

    Abstract: Neuroendocrine tumors (NET) constitute a heterogeneous group of malignancies with various clinical presentations and growth rates but a common origin in neuroendocrine cells located all over the body. NET are a relatively low-frequency disease mostly ... ...

    Abstract Neuroendocrine tumors (NET) constitute a heterogeneous group of malignancies with various clinical presentations and growth rates but a common origin in neuroendocrine cells located all over the body. NET are a relatively low-frequency disease mostly represented by gastroenteropancreatic (GEP) and bronchopulmonary tumors (pNET); on the other hand, an increasing frequency and prevalence have been associated with NET. Despite great efforts in recent years, the management of NET is still a critical unmet need due to the lack of knowledge of the biology of the disease, the lack of adequate biomarkers, late presentation, the relative insensitivity of imaging modalities, and a paucity of predictably effective treatment options. In this context Ca2+ signals, being pivotal molecular devices in sensing and integrating signals from the microenvironment, are emerging to be particularly relevant in cancer, where they mediate interactions between tumor cells and the tumor microenvironment to drive different aspects of neoplastic progression (e.g., cell proliferation and survival, cell invasiveness, and proangiogenetic programs). Indeed, ion channels represent good potential pharmacological targets due to their location on the plasma membrane, where they can be easily accessed by drugs. The present review aims to provide a critical and up-to-date overview of NET development integrating Ca2+ signal involvement. In this perspective, we first give an introduction to NET and Ca2+ channels and then describe the different families of Ca2+ channels implicated in NET, i.e., ionotropic receptors, voltage-dependent Ca2+ channels, and transient receptor potential channels, as well as intracellular Ca2+ channels and their signaling molecules.
    MeSH term(s) Calcium Channels/metabolism ; Calcium Signaling ; Humans ; Neuroendocrine Tumors/metabolism
    Chemical Substances Calcium Channels
    Language English
    Publishing date 2019-06-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 123303-8
    ISSN 1423-0194 ; 0028-3835
    ISSN (online) 1423-0194
    ISSN 0028-3835
    DOI 10.1159/000501397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 531: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: TRP Channels and Small GTPases Interplay in the Main Hallmarks of Metastatic Cancer.

    Chinigò, Giorgia / Fiorio Pla, Alessandra / Gkika, Dimitra

    Frontiers in pharmacology

    2020  Volume 11, Page(s) 581455

    Abstract: Transient Receptor Potential (TRP) cations channels, as key regulators of intracellular calcium homeostasis, play a central role in the essential hallmarks of cancer. Among the multiple pathways in which TRPs may be involved, here we focus our attention ... ...

    Abstract Transient Receptor Potential (TRP) cations channels, as key regulators of intracellular calcium homeostasis, play a central role in the essential hallmarks of cancer. Among the multiple pathways in which TRPs may be involved, here we focus our attention on the ones involving small guanosine triphosphatases (GTPases), summarizing the main processes associated with the metastatic cascade, such as migration, invasion and tumor vascularization. In the last decade, several studies have highlighted a bidirectional interplay between TRPs and small GTPases in cancer progression: TRP channels may affect small GTPases activity
    Language English
    Publishing date 2020-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2020.581455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: TRP Channels in Brain Tumors

    Giorgia Chinigò / Hélène Castel / Oana Chever / Dimitra Gkika

    Frontiers in Cell and Developmental Biology, Vol

    2021  Volume 9

    Abstract: Malignant glioma including glioblastoma (GBM) is the most common group of primary brain tumors. Despite standard optimized treatment consisting of extensive resection followed by radiotherapy/concomitant and adjuvant therapy, GBM remains one of the most ... ...

    Abstract Malignant glioma including glioblastoma (GBM) is the most common group of primary brain tumors. Despite standard optimized treatment consisting of extensive resection followed by radiotherapy/concomitant and adjuvant therapy, GBM remains one of the most aggressive human cancers. GBM is a typical example of intra-heterogeneity modeled by different micro-environmental situations, one of the main causes of resistance to conventional treatments. The resistance to treatment is associated with angiogenesis, hypoxic and necrotic tumor areas while heterogeneity would accumulate during glioma cell invasion, supporting recurrence. These complex mechanisms require a focus on potential new molecular actors to consider new treatment options for gliomas. Among emerging and underexplored targets, transient receptor potential (TRP) channels belonging to a superfamily of non-selective cation channels which play critical roles in the responses to a number of external stimuli from the external environment were found to be related to cancer development, including glioma. Here, we discuss the potential as biological markers of diagnosis and prognosis of TRPC6, TRPM8, TRPV4, or TRPV1/V2 being associated with glioma patient overall survival. TRPs-inducing common or distinct mechanisms associated with their Ca2+-channel permeability and/or kinase function were detailed as involving miRNA or secondary effector signaling cascades in turn controlling proliferation, cell cycle, apoptotic pathways, DNA repair, resistance to treatment as well as migration/invasion. These recent observations of the key role played by TRPs such as TRPC6 in GBM growth and invasiveness, TRPV2 in proliferation and glioma-stem cell differentiation and TRPM2 as channel carriers of cytotoxic chemotherapy within glioma cells, should offer new directions for innovation in treatment strategies of high-grade glioma as GBM to overcome high resistance and recurrence.
    Keywords ion channel ; TRP channel ; brain tumor ; glioma ; glioblastoma ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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