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Article ; Online: Treatment of experimental aneurysms with a new liquid embolic agent and a retrievable stent: proof of concept and feasibility study.

Berenstein, Alejandro

2016 Volume 8, Issue 9, Page(s) 934–939

Abstract: Background: Occlusion of canine bifurcation and sidewall aneurysms was undertaken with a new liquid embolic agent (PHIL 35) assisted by a high-density partially retrievable stent (FRED) with preservation of the carotid artery.: Methods: Three dogs ... ...

Abstract	Background: Occlusion of canine bifurcation and sidewall aneurysms was undertaken with a new liquid embolic agent (PHIL 35) assisted by a high-density partially retrievable stent (FRED) with preservation of the carotid artery. Methods: Three dogs were used as acute preparations for development of the technique and two were used for chronic studies lasting 90 days. In one animal we intentionally did not completely fill the aneurysm to determine the long-term results of incomplete treatment. The degree of occlusion, carotid artery compromise, and dislodgement and/or migration of embolic material in treated aneurysms were assessed. Results: All aneurysms planned for complete obliteration were totally occluded successfully. By design, we partially occluded one aneurysm. In this aneurysm, angiography performed at 30 days revealed less filling, but at 90 days it had persistent small residual filling. We did not detect any distal embolization during the injection and no angiographic occlusions, change in configuration, or delayed migration of the embolic material were found. In the inspected stent, no foreign material was noted. In four animals we successfully removed the stent with preservation of the integrity of the carotid artery. In the fifth we intentionally left both stents deployed. Conclusions: We have developed a new treatment for cerebral aneurysms using a combination of a retrievable stent and a new liquid embolic agent.
MeSH term(s)	Aneurysm/diagnostic imaging ; Aneurysm/therapy ; Animals ; Carotid Artery Diseases/diagnostic imaging ; Carotid Artery Diseases/therapy ; Cerebral Angiography ; Combined Modality Therapy ; Dimethyl Sulfoxide ; Disease Models, Animal ; Dogs ; Embolization, Therapeutic/methods ; Feasibility Studies ; Female ; Polymers/administration & dosage ; Stents ; Treatment Outcome
Chemical Substances	Polymers ; Dimethyl Sulfoxide (YOW8V9698H)
Keywords	covid19
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2015-011930
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Article ; Online: Advances and innovations in vascular neurosurgery: Foreword: Part II.

Berenstein, Alejandro

Neurosurgery

2014 Volume 74 Suppl 1, Page(s) S3–4

MeSH term(s)	Humans ; Neurosurgery/trends ; Neurosurgical Procedures ; Vascular Surgical Procedures
Language	English
Publishing date	2014-02
Publishing country	United States
Document type	Introductory Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/NEU.0000000000000246
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Zs.A 1424: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Machine vision-based automatic lamb identification and drinking activity in a commercial farm.

Alon, A / Shimshoni, I / Godo, A / Berenstein, R / Lepar, J / Bergman, N / Halachmi, I

Animal : an international journal of animal bioscience

2023 Volume 17, Issue 9, Page(s) 100923

Abstract: Using ear tags, farmers can track specific data for individual lambs such as age, medical records, body condition scores, genetic abnormalities; to make data-based decisions. However, automatic reading of ear tags using Radio Frequency Identification ... ...

Abstract	Using ear tags, farmers can track specific data for individual lambs such as age, medical records, body condition scores, genetic abnormalities; to make data-based decisions. However, automatic reading of ear tags using Radio Frequency Identification requires (a) an antenna, (b) a reader, (c) comparable reading standards; consequently, such a system can be expensive and impractical for a large group of lambs, especially in situations where animals are not required to have a compulsory Electronic identification, contrary to the case in Europe, where it is mandatory. Therefore, this paper proposes a machine vision system for indoor animals to identify individual lambs using existing ear tags. Using a camera that is installed such that the trough is visible, the drinking behaviour of the lambs can be automatically monitored. Data from different lamb groups in two different pens were collected. The identification algorithm includes a number of steps: (1) Detecting the lambs' face, and its ear tags in each image; (2) Cropping each ear tag image and discerning the digits on it to obtain the tag number; (3) Tracking each lamb throughout the visit using a tracking algorithm; (4) Recovering the ear tag number using an algorithm that incorporates a list of the ear tag numbers of the lambs in each pen, and the predictions for each lamb in each frame. The You Only Look Once deep learning object detection algorithm was applied to locate and localise the lamb's face and the digits in an image. The models' datasets contained 1 160 and 2 165 images for the training set, and 325 and 616 images for the validation set, respectively. The algorithm output includes the identity of each lamb that came to drink, and its duration. The identification system resulted in a total accuracy of 93% for the data tested, which consisted of approximately 900 visits to the drinking stations, and was collected in real time in a natural environment. The ground truth of each video of a visit was obtained by human observation by studying the video. We checked if there was indeed a visit to the water trough and if so we registered the ear tag number of each lamb whose head was above the water trough. Thus, identifying lambs in a commercial pen using a relatively inexpensive and easily installed system consisting of a RGB camera and a computer vision-based algorithm has potential for farm management.
MeSH term(s)	Humans ; Sheep ; Animals ; Farms ; Sheep, Domestic ; Farmers ; Algorithms ; Databases, Factual
Language	English
Publishing date	2023-07-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2023.100923
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Article ; Online: Fine, Vascular Network Formation in Patients with Vein of Galen Aneurysmal Malformation.

Shigematsu, T / Bazil, M J / Fifi, J T / Berenstein, A

AJNR. American journal of neuroradiology

2022 Volume 43, Issue 10, Page(s) 1481–1487

Abstract: Background and purpose: A vein of Galen aneurysmal malformation is known to present with recruitment of dural feeders and, in our cohort, a fine, vascular network formation. The vessels we have observed differ from dural vascular recruitment in that ... ...

Abstract	Background and purpose: A vein of Galen aneurysmal malformation is known to present with recruitment of dural feeders and, in our cohort, a fine, vascular network formation. The vessels we have observed differ from dural vascular recruitment in that they produce a hairlike, collateral network of vessels. We reviewed treatment courses of vein of Galen aneurysmal malformation treatments in a series of 36 cases that displayed a fine, vascular network formation. Materials and methods: We retrospectively analyzed 36 cases of vein of Galen aneurysmal malformation, including tectal/thalamic AVMs, treated at our center from January 2004 to September 2021, and reviewed fine, vascular network formations in the subarachnoid space and subependymal zone alongside the vein of Galen aneurysmal malformation. Results: Patients at first endovascular treatment ranged from neonates to 157 months (median age, 4.3 months). Patients with preinterventional fine, vascular network formations were significantly older at the initial angiogram than patients with postinterventional fine, vascular network formations ( Conclusions: Development of a fine, vascular network formation is an acquired and reversible phenomenon that differs from typical dural vessel recruitment, given the hairlike nature of the network and its rapid onset postinterventionally. It typically resolves after completion of treatment, and this resolution correlates with closure of the vein. We recommend that neurointerventionalists avoid delays in treatment wherever possible to reduce the likelihood of a fine, vascular network formation.
MeSH term(s)	Infant, Newborn ; Humans ; Infant ; Cerebral Veins/diagnostic imaging ; Cerebral Veins/abnormalities ; Vein of Galen Malformations/diagnostic imaging ; Vein of Galen Malformations/therapy ; Retrospective Studies ; Embolization, Therapeutic ; Cerebral Angiography
Language	English
Publishing date	2022-09-22
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	603808-6
ISSN	1936-959X ; 0195-6108
ISSN (online)	1936-959X
ISSN	0195-6108
DOI	10.3174/ajnr.A7649
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Article ; Online: Clinical and Simulated Experiences With the Bendit Articulating/Steerable Microcatheter in Endovascular Treatment: 2-Dimensional Operative Video.

Berenstein, Alejandro / Chapot, Rene / Orion, David / Barr, John D / Cabiri, Oz / Killer-Oberpfalzer, Monika

Operative neurosurgery (Hagerstown, Md.)

2023 Volume 25, Issue 1, Page(s) e36–e37

MeSH term(s)	Humans ; Catheterization/methods ; Catheters
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Video-Audio Media ; Journal Article
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1227/ons.0000000000000679
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Article ; Online: Distal Microcatheter Placement Using the ASAHI CHIKAI 008 Microguidewire for Liquid Embolic Material Delivery.

Furtado, Sunil V / Berenstein, Alejandro

World neurosurgery

2019 Volume 124, Page(s) 36–43

Abstract: Background: Management of vascular malformations requires microcatheter manipulation through distal tortuous arterial feeders <1 mm in diameter to permit safe and effective embolization at the fistula or nidus location. The ASAHI CHIKAI 008 ... ...

Abstract	Background: Management of vascular malformations requires microcatheter manipulation through distal tortuous arterial feeders <1 mm in diameter to permit safe and effective embolization at the fistula or nidus location. The ASAHI CHIKAI 008 microguidewire (ACM) recently introduced in the United States was used to evaluate microcatheter torque, support, and safety in distal microcatheter navigation. Methods: The use of the ACM in conjunction with flow-directed and over-the-wire microcatheters was evaluated in 25 neuroendovascular cases performed by a single operator for endovascular microcatheter embolization of intracranial vascular malformations over a 1-year period. The study evaluated angiographic evidence of distal microcatheter positioning, subsequent obliteration of the fistula at the location, and any complications. Results: The microguidewire was used in microcatheter embolization of 10 vein of Galen malformations, 11 brain and head and neck arteriovenous malformations, 2 spinal dural arteriovenous fistulas, and 2 cranial dural arteriovenous fistulas. Good flow-directed and over-the-wire microcatheter placement using the ACM was possible across the spectrum of cases achieving optimal catheterization and safe embolization in all. There were no microguidewire- or microcatheter-related vessel spasms, dissections, or perforations during combined or individual manipulation and no contrast or embolic extravasation on fluoroscopy or postembolization angiography. Conclusions: The ACM is a safe, sturdy microguidewire that provides good torque in distal arterial anatomy, while providing microcatheter support and maintaining tip configuration on repeated use.
Language	English
Publishing date	2019-01-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2018.12.132
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Zs.A 1159: Show issues

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Article ; Online: Infantile dural sinus malformation: curative embolization in two stages with the Scepter mini balloon microcatheter.

Matsoukas, Stavros / Rossitto, Christina P / Berenstein, Alejandro / Fifi, Johanna T

Journal of neurointerventional surgery

2022

Abstract: Endovascular embolization is the mainstay for treatment of infantile dural sinus malformations.1 2 Distal access and flow control are limiting factors in controlled embolization.3-6 The Scepter mini catheter (Microvention, Aliso Viejo, California, USA) ... ...

Abstract	Endovascular embolization is the mainstay for treatment of infantile dural sinus malformations.1 2 Distal access and flow control are limiting factors in controlled embolization.3-6 The Scepter mini catheter (Microvention, Aliso Viejo, California, USA) is a low-profile, dual-lumen balloon microcatheter designed to provide navigability in small-caliber, tortuous intracranial vessels. In this technical video, we demonstrate the staged embolization of a dural sinus malformation with multiple arteriovenous fistulae using the Scepter mini catheter (video 1). In the newborn patient, embolizations were performed through the parietal branches of the left and right middle meningeal arteries. The catheter easily navigated into the small feeding arteries. No neurological complications occurred due to the procedures. Post-embolization injections demonstrated significant flow reduction into the malformation. Three-month follow-up angiography illustrated resolution of the previously dilated left transverse sinus. Complete obliteration of the dural sinus malformation was achieved in the newborn patient.neurintsurg;neurintsurg-2021-018608v1/V1F1V1Video 1.
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2021-018608
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Article ; Online: Short Communication: The effect of age on young sheep biometric identification.

Hitelman, A / Edan, Y / Godo, A / Berenstein, R / Lepar, J / Halachmi, I

Animal : an international journal of animal bioscience

2022 Volume 16, Issue 2, Page(s) 100452

Abstract: Biometric identification provides an important tool for precision livestock farming. This study investigates the effect of weight gain and sheep maturation on recognition performance. Sheep facial identification was implemented using two convolutional ... ...

Abstract	Biometric identification provides an important tool for precision livestock farming. This study investigates the effect of weight gain and sheep maturation on recognition performance. Sheep facial identification was implemented using two convolutional neural network (CNN) called Faster R-CNN, and ResNet50V2, equipped with the state-of-art Additive Angular Margin (ArcFace) loss function. The identification model was tested on 47 young sheep at different stages, during a 3-month growth period, when they were between 2 and 5 months old, throughout which the sheep gained approximately 30 kilograms in weight. Results revealed that when the model was trained and tested on images of sheep aged 2 months, the average accuracy of the group was 95.4%, compared with 91.3% when trained on images of sheep aged 2 months but tested on images of sheep aged 5 months.
MeSH term(s)	Aging ; Animals ; Biometric Identification ; Neural Networks, Computer ; Sheep
Language	English
Publishing date	2022-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2257920-5
ISSN	1751-732X ; 1751-7311
ISSN (online)	1751-732X
ISSN	1751-7311
DOI	10.1016/j.animal.2021.100452
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Article ; Online: Commentary: Vein of Galen Malformations: The Texas Children's Hospital Experience in the Modern Endovascular Era.

Berenstein, Alejandro / Shigematsu, Tomoyoshi

Operative neurosurgery (Hagerstown, Md.)

2018 Volume 17, Issue 3, Page(s) E98–E99

MeSH term(s)	Child ; Embolization, Therapeutic ; Humans ; Texas ; Vein of Galen Malformations
Language	English
Publishing date	2018-12-12
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2767575-0
ISSN	2332-4260 ; 2332-4252
ISSN (online)	2332-4260
ISSN	2332-4252
DOI	10.1093/ons/opy374
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Article ; Online: De novo brain AVM following radiotherapy for cerebral cavernous malformation in a child: A 15-year clinical course.

Matsoukas, Stavros / Bageac, Devin V / DeLeacy, Reade / Berenstein, Alejandro / Fifi, Johanna T

The neuroradiology journal

2022 Volume 35, Issue 4, Page(s) 533–538

Abstract: Multiple de novo brain arteriovenous malformations (bAVM) have been reported in the literature, raising questions about the contended purely congenital nature of these lesions. We present the 15-year course of a pediatric patient, who initially presented ...

Abstract	Multiple de novo brain arteriovenous malformations (bAVM) have been reported in the literature, raising questions about the contended purely congenital nature of these lesions. We present the 15-year course of a pediatric patient, who initially presented at age 5 with a thalamic cavernous malformation and was treated with radiosurgery, and then subsequently developed a thalamic de novo bAVM immediately adjacent to the initial lesion location, discovered 2 years later. Treatment of the bAVM entailed two transarterial embolizations and one radiosurgery session which ultimately led to complete angiographic resolution. Finally, this patient's course was complicated by intraparenchymal hemorrhage and acute obstructive hydrocephalus, and further imaging revealed two newly formed cavernous malformations, also associated with the initial lesion's location, that have remained stable since their formation. This case likely represents the second-hit model for the formation of vascular malformations, as sparsely supported by the current literature. According to this, genetically aberrant, yet quiescent, brain areas might promote the de novo formation of vascular malformations after brain injury, including radiation.
MeSH term(s)	Child ; Child, Preschool ; Hemangioma, Cavernous, Central Nervous System ; Humans ; Hydrocephalus ; Intracranial Arteriovenous Malformations ; Radiosurgery ; Thalamus
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/19714009211059115
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