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Article ; Online: Upregulation of CENPM promotes breast carcinogenesis by altering immune infiltration.

Tong, Yanchu / Zhou, Tongzhou / Wang, Xiaokun / Deng, Shun / Qin, Lu

2024 Volume 24, Issue 1, Page(s) 54

Abstract: Background: The involvement of centromere protein M (CENPM) in various types of cancer has been established, however, its impact on breast cancer and immune infiltration remains unknown.: Methods: We examined the expression of CENPM in different ... ...

Abstract	Background: The involvement of centromere protein M (CENPM) in various types of cancer has been established, however, its impact on breast cancer and immune infiltration remains unknown. Methods: We examined the expression of CENPM in different cancer types by utilizing the Cancer Genome Atlas (TCGA) and Genotype Tissue Expression Pan-Cancer (GEO) databases. Using data from the TCGA, we examined the correlation between the expression of CENPM, the prognosis, and the clinicopathological features of individuals diagnosed with breast cancer. We conducted an enrichment analysis of CENPM using the clusterProfiler R software tool, utilizing data obtained from breast cancer patients and specimens at our institution. In addition to examining the correlation between CENPM expression and genes associated with immune checkpoints, the TIDE algorithm was employed to explore the potential of CENPM as a biomarker for immunotherapy in breast cancer. The impact of CENPM on the growth of breast cancer cells was evaluated through the utilization of the CCK8 test and the colony formation assay. The effect of CENPM on the migration of breast cancer cells was assessed using scratch and transwell assays. Results: Research findings indicate that elevated levels of CENPM are linked to patient outcomes in breast cancer and various clinicopathological features. Furthermore, elevated levels of CENPM expression correlated with decreased levels of CD8 + T cells and mast cells, increased levels of Tregs and Th2, and reduced levels of CD8 + T cells. Additionally, the coexpression of CENPM with the majority of genes related to immune checkpoints indicates its potential to forecast the effectiveness of treatment in breast cancer. Suppression of CENPM hampers the growth and movement of breast tumor cells. Conclusions: In summary, our study findings indicate that CENPM may serve as a cancer-causing gene in breast cancer and also as a biomarker for predicting the efficacy of immunotherapy. The oncogene CENPM is associated with breast cancer and is involved in cell proliferation and immune infiltration.
MeSH term(s)	Female ; Humans ; Biomarkers ; Breast Neoplasms/genetics ; Cell Transformation, Neoplastic ; Oncogenes ; Up-Regulation
Chemical Substances	Biomarkers ; CENPM protein, human
Language	English
Publishing date	2024-01-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11808-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Embedding Quantum Many-Body Scars into Decoherence-Free Subspaces.

Wang, He-Ran / Yuan, Dong / Zhang, Shun-Yao / Wang, Zhong / Deng, Dong-Ling / Duan, L-M

Physical review letters

2024 Volume 132, Issue 15, Page(s) 150401

Abstract: Quantum many-body scars are nonthermal excited eigenstates of nonintegrable Hamiltonians, which could support coherent revival dynamics from special initial states when scars form an equally spaced tower in the energy spectrum. For open quantum systems, ... ...

Abstract	Quantum many-body scars are nonthermal excited eigenstates of nonintegrable Hamiltonians, which could support coherent revival dynamics from special initial states when scars form an equally spaced tower in the energy spectrum. For open quantum systems, engineering many-body scarred dynamics by a controlled coupling to the environment remains largely unexplored. Here, we provide a general framework to exactly embed quantum many-body scars into the decoherence-free subspaces of Lindblad master equations. The dissipative scarred dynamics manifest persistent periodic oscillations for generic initial states, and can be practically utilized to prepare scar states with potential quantum metrology applications. We construct the Liouvillian dissipators with the local projectors that annihilate the whole scar towers, and utilize the Hamiltonian part to rotate the undesired states out of the null space of dissipators. We demonstrate our protocol through several typical models hosting many-body scar towers and propose an experimental scheme to observe the dissipative scarred dynamics based on digital quantum simulations and resetting ancilla qubits.
Language	English
Publishing date	2024-04-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.150401
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Article ; Online: Efficacy of antioxidant supplementation in improving endocrine, hormonal, inflammatory, and metabolic statuses of PCOS: a meta-analysis and systematic review.

He, Junhui / Deng, Renhe / Wei, Yanhong / Zhang, Shun / Su, Mingxuan / Tang, Masong / Wang, Jinyuan / Nong, Weihua / Lei, Xiaocan

Food & function

2024 Volume 15, Issue 4, Page(s) 1779–1802

Abstract: Background and ... ...

Abstract	Background and aim
MeSH term(s)	Female ; Humans ; Antioxidants/therapeutic use ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/metabolism ; Dietary Supplements ; Lipoproteins, LDL ; Cholesterol
Chemical Substances	Antioxidants ; Lipoproteins, LDL ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo02824k
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Article ; Online: Effects of different wall-breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion.

Qi, Yaoyao / Zhong, Shun / Pan, Feng / Zhou, Junfu / Wang, Zhiyu / Deng, Zeyuan / Li, Hongyan

Journal of the science of food and agriculture

2024

Abstract: Background: The hard double-walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP. In this study, the wall of GLSP was broken by mechanical milling at room ... ...

Abstract	Background: The hard double-walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP. In this study, the wall of GLSP was broken by mechanical milling at room temperature (MM-R) and ultra-fine grinding at low temperature (UFG-L), respectively. Results: Compared with MM-R, UFG-L could better retain the sporangium powder's morphological and structural integrity. During in vitro digestion, compared with unbroken GLSP, the released amounts of polysaccharides and triterpenes from broken GLSP were significantly increased, and they increased with the increase of specific surface area. The bioaccessibility of polysaccharide and triterpene from unbroken GLSP after the intestinal stage were 29.52% and 5.37%, respectively. The bioaccessibility of polysaccharides and triterpene from broken GLSP by MM-R after the intestinal phase were 39.73-72.45% and 16.44-24.97%, while those by UFG-L were 44.53-104.18% and 12.96-32.90%, respectively. Conclusion: The active ingredients of broken GLSP showed better digestion and absorption abilities than unbroken GLSP. Moreover, the specific surface area of GLSP by UFG-L was lower than that by MM-R, and the bioaccessibility of GLSP by UFG-L was higher than that by MM-R. © 2024 Society of Chemical Industry.
Language	English
Publishing date	2024-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.13490
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Article ; Online: Metasurface-Based Solid Poincaré Sphere Polarizer.

Wang, Shuai / Wen, Shun / Deng, Zi-Lan / Li, Xiangping / Yang, Yuanmu

Physical review letters

2023 Volume 130, Issue 12, Page(s) 123801

Abstract: The combination of conventional polarization optical elements, such as linear polarizers and waveplates, is widely adopted to tailor light's state of polarization (SOP). Meanwhile, less attention has been given to the manipulation of light's degree of ... ...

Abstract	The combination of conventional polarization optical elements, such as linear polarizers and waveplates, is widely adopted to tailor light's state of polarization (SOP). Meanwhile, less attention has been given to the manipulation of light's degree of polarization (DOP). Here, we propose metasurface-based polarizers that can filter unpolarized incident light to light with any prescribed SOP and DOP, corresponding to arbitrary points located both at the surface and within the solid Poincaré sphere. The Jones matrix elements of the metasurface are inverse-designed via the adjoint method. As prototypes, we experimentally demonstrated metasurface-based polarizers in near-infrared frequencies that can convert unpolarized light into linear, elliptical, or circular polarizations with varying DOPs of 1, 0.7, and 0.4, respectively. Our Letter unlocks a new degree of freedom for metasurface polarization optics and may break new ground for a variety of DOP-related applications, such as polarization calibration and quantum state tomography.
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.130.123801
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Article ; Online: External Field-Responsive Ternary Non-Noble Metal Oxygen Electrocatalyst for Rechargeable Zinc-Air Batteries.

Gu, Fan / Guo, Wengai / Yuan, Yifei / Deng, Ya-Ping / Jin, Huile / Wang, Jichang / Chen, Zhongwei / Pan, Shuang / Chen, Yihuang / Wang, Shun

Advanced materials (Deerfield Beach, Fla.)

2024 , Page(s) e2313096

Abstract: Despite the increasing effort in advancing oxygen electrocatalysts for zinc-air batteries (ZABs), the performance development gradually reaches a plateau via only ameliorating the electrocatalyst materials. Herein, a new class of external field- ... ...

Abstract	Despite the increasing effort in advancing oxygen electrocatalysts for zinc-air batteries (ZABs), the performance development gradually reaches a plateau via only ameliorating the electrocatalyst materials. Herein, a new class of external field-responsive electrocatalyst comprising Ni
Language	English
Publishing date	2024-02-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202313096
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Article ; Online: Multiple beneficial outcomes of medication therapy management interventions in randomized control trials and non-randomized control trials: A protocol for systematic review and meta-analysis.

Deng, Zhi-Jie / Ding, Yu-Feng / Peng, Shun-Shun / Wang, Lu / Wei, An-Hua

Medicine

2022 Volume 101, Issue 43, Page(s) e31491

Abstract: Background: Medication therapy management (MTM) service is an effective method to reduce medication-related problems and improve patients' multiple kinds of outcomes. However, the lack of comprehensive review for MTM services has hindered its ... ...

Abstract	Background: Medication therapy management (MTM) service is an effective method to reduce medication-related problems and improve patients' multiple kinds of outcomes. However, the lack of comprehensive review for MTM services has hindered its development. As a result, we are aiming to evaluate the current benefits of MTM services with multiple outcomes. Method: An electronic search will be performed for randomized controlled trials (RCTs) or non-randomized control trials (NRCTs) that reported MTM services or pharmaceutical services as interventions from PubMed, The Cochrane Library, Embase, and ClinicalTrial. gov. The odds ratios, mean differences, and standard mean differences and their 95% confidence intervals (95% confidence intervals) will be calculated with fixed or random effect models. Results: This study will evaluate the multiple benefits of MTM services in clinical endpoints, quality of life, economy, and drug-related problems. Conclusion: The results will review eligible studies released in the past twenty years and provide more comprehensive evidence of the efficacy of MTM services. Ethics and dissemination: Ethical approval is not applicable for this study.
MeSH term(s)	Humans ; Medication Therapy Management ; Meta-Analysis as Topic ; Pharmaceutical Services ; Quality of Life ; Systematic Reviews as Topic/methods ; Controlled Clinical Trials as Topic
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000031491
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dramatic improvement in the mechanical properties of polydopamine/polyacrylamide hydrogel mediated human amniotic membrane.

Peng, Lin / Liang, Yufei / Yue, Jianling / Li, Hanmei / Deng, Aimin / Xie, Shun / Tang, Xiu-Zhi / Wang, Jing / Mao, Zenghui

RSC advances

2023 Volume 13, Issue 6, Page(s) 3635–3642

Abstract: Human amniotic membrane (hAM) is a promising material for tissue engineering due to several benefits, including desirable biocompatibility, stem cell source, antibacterial activity, ...

Abstract	Human amniotic membrane (hAM) is a promising material for tissue engineering due to several benefits, including desirable biocompatibility, stem cell source, antibacterial activity,
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d2ra07622e
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Article ; Online: Short and long term curative efficacy of CABG, MVP combined operation in patients with coronary heart disease with moderate ischemic mitral regurgitation

Yu-guang GE / Hui-shan WANG / Hui JIANG / Deng-shun TAO / Yan JIN / Ke-yan ZHAO / Yan YU / Huai LAN

Medical Journal of Chinese People's Liberation Army, Vol 44, Iss 5, Pp 418-

2019 Volume 422

Abstract: Objective To observe the short and long term efficacy of coronary artery bypass grafting (CABG), mitral valve annuloplasty (MVP) combined operation in patients with coronary heart disease with moderate ischemic mitral regurgitation comparing with simple ... ...

Abstract	Objective To observe the short and long term efficacy of coronary artery bypass grafting (CABG), mitral valve annuloplasty (MVP) combined operation in patients with coronary heart disease with moderate ischemic mitral regurgitation comparing with simple CABG operation, and explore the best treatment and provide reference for clinical treatment. Method 115 patients with coronary heart disease complicated with moderate ischemic mitral regurgitation, admitted from September 2010 to September 2017 in General Hospital of Northern Theater Command, of PLA, were enrolled in present study. Of the 115 patients, 69 underwent coronary artery bypass grafting surgery (CABG group), and 46 underwent coronary artery bypass grafting and mitral valve annuloplasty combined surgery (CABG+MVP group). The short and long term outcomes of the two groups were compared and analyzed. The short term outcomes included clinical indicators [left atrium diameter (LAD), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), systolic pulmonary artery pressure (sPAP), mitral regurgitation area, NYHA cardiac function classification) and the incidence of perioperative events. The long term outcomes included the cumulative survival rate and the exemption rate of cardiovascular and cerebrovascular events. Results The operation was successful in both groups. Perioperative mortality was 8 cases, including 4 cases in CABG group (5.7%) and 4 cases in CABG+MVP group (8.6%). There was no significant difference between the two groups (P>0.05). LVESD (P=0.009), mitral regurgitation (P<0.05) and NYHA cardiac function classification index (P<0.05) in CABG+MVP group were better than those in CABG group. The patients were followed up for 2 to 96 months (39.9±20.7). There were 11 deaths, 7 in CABG group (11.1%) and 4 in CABG+MVP group (9.7%). There was no significant difference between the two groups (P>0.05). The cumulative survival rate (P=0.205) and the exemption rate of cardiovascular and cerebrovascular events (P=0.535) had no significant difference between the two groups. Conclusions For treatment of coronary heart disease with moderate ischemic mitral regurgitation, the CABG+MVP group was superior to the CABG group, but not on long term efficacy, which can effectively improve the mitral regurgitation and NYHA cardiac function classification of patients. However, follow-up observation was still needed. DOI:10.11855/j.issn.0577-7402.2019.05.10
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	Chinese
Publishing date	2019-05-01T00:00:00Z
Publisher	Editorial Board of Medical Journal of Chinese People's Liberation Army
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Smoking and outcomes following personalized antiplatelet therapy in chronic coronary syndrome patients: A substudy from the randomized PATH-PCI trial.

Pan, Ying / Wu, Ting-Ting / Deng, Chang-Jiang / Yang, Yi / Hou, Xian-Geng / Yan, Tuo / Wang, Shun / Zheng, Ying-Ying / Xie, Xiang

Clinical cardiology

2024 Volume 47, Issue 3, Page(s) e24214

Abstract: Background: This is a sub-analysis of the Personalized Antithrombotic Therapy for Coronary Heart Disease after PCI (PATH-PCI) trial in China to explore the relationship between smoking and outcomes following personalized antiplatelet therapy (PAT) in ... ...

Abstract	Background: This is a sub-analysis of the Personalized Antithrombotic Therapy for Coronary Heart Disease after PCI (PATH-PCI) trial in China to explore the relationship between smoking and outcomes following personalized antiplatelet therapy (PAT) in chronic coronary syndrome (CCS) patients undergoing percutaneous coronary intervention (PCI). Methods: As a single-center, prospective, randomized controlled and open-label trial, the PATH-PCI trial randomized CCS patients undergoing PCI into standard group or personalized group guided by a novel platelet function test (PFT), from December 2016 to February 2018. All patients were divided into smokers and nonsmokers according to their smoking status. Subsequently, we underwent a 180-day follow-up evaluation. The primary endpoint was the net adverse clinical events (NACE). Results: Regardless of smoking status, in the incidence of NACE, there was a reduction with PAT but that the reductions are not statistically significant. In the incidence of bleeding events, we found no statistically significant difference between two groups (smokers: 2.0% vs. 1.4%, HR = 1.455, 95% confidence interval [CI]: 0.595-3.559, p = .412; nonsmokers: 2.2% vs. 1.8%, HR = 1.228, 95% CI: 0.530-2.842, p = .632). In smokers, PAT reduced major adverse cardiac and cerebrovascular events (MACCE) by 48.7% (3.0% vs. 5.9%, HR = 0.513, 95% CI: 0.290-0.908, p = .022), compared with standard antiplatelet therapy (SAT). PAT also reduced the major adverse cardiovascular events (MACE) but there was no statistically difference in the reductions (p > .05). In nonsmokers, PAT reduced MACCE and MACE by 51.5% (3.3% vs. 6.7%, HR = 0.485, 95% CI: 0.277-0.849, p = .011) and 63.5% (1.8% vs. 4.9%, HR = 0.365, 95% CI: 0.178-0.752, p = .006), respectively. When testing p-values for interaction, we found there was no significant interaction of smoking status with treatment effects of PAT (p Conclusion: Regardless of smoking, PAT reduced the MACE and MACCE, with no significant difference in bleeding. This suggests that PAT was an recommendable regimen to CCS patients after PCI, taking into consideration both ischemic and bleeding risk.
MeSH term(s)	Humans ; Platelet Aggregation Inhibitors/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Prospective Studies ; Hemorrhage/chemically induced ; Smoking ; Treatment Outcome ; Acute Coronary Syndrome/therapy
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	391935-3
ISSN	1932-8737 ; 0160-9289
ISSN (online)	1932-8737
ISSN	0160-9289
DOI	10.1002/clc.24214
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