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Article ; Online: Latarjet Procedure: Biomechanical Evaluation of 2 Screw Coracoid Fixation.

Chang, Kenny / Covarrubias, Oscar / Scott, Douglas / Paller, David / Green, Andrew

2024

Abstract: Background: Coracoid nonunion is a relevant complication following the Latarjet procedure and is influenced by multiple factors, including the method of graft fixation.: Aims: The purpose of this study was to evaluate and characterize the ... ...

Abstract	Background: Coracoid nonunion is a relevant complication following the Latarjet procedure and is influenced by multiple factors, including the method of graft fixation. Aims: The purpose of this study was to evaluate and characterize the biomechanical properties of various two-screw fixation constructs used for coracoid graft fixation in the Latarjet procedure. Methods: Forty model scapulae (Sawbones Inc., Vashon, WA, USA) were used for this study. A 15 percent anterior inferior glenoid bone defect was created. The coracoid was osteotomized at the juncture of the vertical and horizontal aspects, transferred to the anterior-inferior edge of the glenoid, and fixed with either two 3.5 mm fully threaded cannulated cortical screws (FTCS), two 3.5 mm fully threaded solid cortical screws (FTSS), two 3.5 mm partially threaded cannulated screws (PTCS), or two 4.5 mm partially threaded malleolar screws (MS). Biomechanical testing was performed with an Instron materials testing machine (Instron Corp., Norwood, MA) by applying loads to the lateral aspect of the transferred coracoid graft. The constructs were preconditioned with non-destructive cyclical loading (0-20N) to determine construct stiffness. After 100 cycles of dynamic loading, the construct was loaded to failure to determine ultimate failure load, yield displacement, and mode of failure. Results: All failures were associated with plastic deformation of the screws and coracoid graft fracture. There was a significantly lower initial stiffness for PTCS compared to MS (186±49.3 N/mm vs 280±65.5 N/mm, p=0.01) but no significant differences among the other constructs. There was no difference in ultimate failure load (p=0.18) or yield displacement (p=0.05) among constructs. Conclusion: Two screw coracoid fixation of the coracoid in a simulated classic Latarjet procedure with 3.5 mm fully threaded cortical and cannulated screws is comparable to 4.5 mm malleolar screws in strength, stiffness, and displacement at failure. On the other hand, partially threaded 3.5 mm cannulated screws provide inferior fixation stiffness and could potentially affect clinical outcomes.
Language	English
Publishing date	2024-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2024.03.035
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Article ; Online: The loss of antioxidant activities impairs intestinal epithelium homeostasis by altering lipid metabolism.

Ramos-León, Javier / Valencia, Concepción / Gutiérrez-Mariscal, Mariana / Rivera-Miranda, David-Alejandro / García-Meléndrez, Celina / Covarrubias, Luis

Experimental cell research

2024 Volume 437, Issue 1, Page(s) 113965

Abstract: Reactive oxygens species (ROS) are common byproducts of metabolic reactions and could be at the origin of many diseases of the elderly. Here we investigated the role of ROS in the renewal of the intestinal epithelium in mice lacking catalase (CAT) and/or ...

Abstract	Reactive oxygens species (ROS) are common byproducts of metabolic reactions and could be at the origin of many diseases of the elderly. Here we investigated the role of ROS in the renewal of the intestinal epithelium in mice lacking catalase (CAT) and/or nicotinamide nucleotide transhydrogenase (NNT) activities. Cat
MeSH term(s)	Humans ; Mice ; Animals ; Aged ; Lipid Metabolism/genetics ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Reactive Oxygen Species/metabolism ; Intestinal Mucosa/metabolism ; Homeostasis
Chemical Substances	Antioxidants ; Reactive Oxygen Species
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2024.113965
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Article: Novel Design Techniques for the Fermat Spiral in Antenna Arrays, for Maximum SLL Reduction.

Encino, Kleiverg / Panduro, Marco A / Reyna, Alberto / Covarrubias, David H

Micromachines

2022 Volume 13, Issue 11

Abstract: This paper presents novel design techniques for the Fermat spiral, considering a maximum side lobe level (SLL) reduction. The array system based on a Fermat spiral configuration considers techniques based on uniform and non-uniform amplitude excitation. ... ...

Abstract	This paper presents novel design techniques for the Fermat spiral, considering a maximum side lobe level (SLL) reduction. The array system based on a Fermat spiral configuration considers techniques based on uniform and non-uniform amplitude excitation. The cases of uniform amplitude excitation are the golden angle and the optimization of the angular separations. The cases of non-uniform amplitude excitations consider a raised cosine distribution and the optimization of the amplitude excitations through the Fermat spiral array. In this study, the method of genetic algorithms (GA) was used in the cases to find the values of the angular separations and the amplitude excitations of the Fermat spiral array. A performance evaluation was conducted for all these design cases, considering the Fermat spiral geometry. These design cases were validated using electromagnetic simulation to take mutual coupling into account and consider the effect of the antenna element pattern in each proposed design case.
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi13112000
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Article ; Online: The binding and mechanism of a positive allosteric modulator of Kv3 channels.

Liang, Qiansheng / Chi, Gamma / Cirqueira, Leonardo / Zhi, Lianteng / Marasco, Agostino / Pilati, Nadia / Gunthorpe, Martin J / Alvaro, Giuseppe / Large, Charles H / Sauer, David B / Treptow, Werner / Covarrubias, Manuel

Nature communications

2024 Volume 15, Issue 1, Page(s) 2533

Abstract: Small-molecule modulators of diverse voltage-gated ... ...

Abstract	Small-molecule modulators of diverse voltage-gated K
MeSH term(s)	Binding Sites ; Shaw Potassium Channels/metabolism
Chemical Substances	Shaw Potassium Channels
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-46813-8
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Article ; Online: Coherently Radiating Periodic Structures to Reduce the Number of Phase Shifters in a 2-D Phased Array.

Juárez, Elizvan / Panduro, Marco A / Covarrubias, David H / Reyna, Alberto

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 19

Abstract: This paper illustrates the application of CORPS (coherently radiating periodic structures) for feeding 2-D phased arrays with a reduced number of phase shifter (PS) devices. Three design configurations using CORPS are proposed for 2-D phased arrays. The ... ...

Abstract	This paper illustrates the application of CORPS (coherently radiating periodic structures) for feeding 2-D phased arrays with a reduced number of phase shifter (PS) devices. Three design configurations using CORPS are proposed for 2-D phased arrays. The design model of phased array for these configurations considers the cophasal excitation required for this structure to set a strategic way for feeding the antenna elements and reducing the number of PS devices. Blocks of 2 × 3 and 4 × 7 CORPS networks depending on the configuration in the 2-D phased array are set strategically in the feeding network to generate the cophasal excitation required in the antenna elements. These design configurations used for feeding the antenna elements in the planar array geometry provide several advantages with respect to others in the scanning capability and the reduction of the number of PS devices of the array system. The full-wave simulation results for the proposed configurations in 2-D phased arrays provide a reduction in the number of PSs of until 69% for a scanning range of ±25° in elevation and ±40° in azimuth. The application of the raised cosine amplitude distribution could generate radiation patterns with a SLL_PEAK ≈ -19 dB and SLL_PEAK ≈ -23 dB for the design proposed configurations in all the scanning range.
MeSH term(s)	Computer Simulation
Language	English
Publishing date	2021-10-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21196592
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Article ; Online: N

Garcias-Morales, David / Palomar, V Miguel / Charlot, Florence / Nogué, Fabien / Covarrubias, Alejandra A / Reyes, José L

The Plant journal : for cell and molecular biology

2023 Volume 114, Issue 1, Page(s) 7–22

Abstract: Plants colonized the land approximately 470 million years ago, coinciding with the development of apical cells that divide in three planes. The molecular mechanisms that underly the development of the 3D growth pattern are poorly understood, mainly ... ...

Abstract	Plants colonized the land approximately 470 million years ago, coinciding with the development of apical cells that divide in three planes. The molecular mechanisms that underly the development of the 3D growth pattern are poorly understood, mainly because 3D growth in seed plants starts during embryo development. In contrast, the transition from 2D to 3D growth in the moss Physcomitrium patens has been widely studied, and it involves a large turnover of the transcriptome to allow the establishment of stage-specific transcripts that facilitate this developmental transition. N
MeSH term(s)	RNA, Messenger/genetics ; Bryopsida/genetics ; Cell Proliferation ; Arabidopsis/genetics ; Transcriptome
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2023-03-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.16149
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Article ; Online: Coherently Radiating Periodic Structures for Feeding Concentric Rings Array with Reduced Number of Phase Shifters.

Sanchez, Brian / Panduro, Marco A / Covarrubias, David H / Reyna, Alberto / Juárez, Elizvan

Sensors (Basel, Switzerland)

2022 Volume 22, Issue 23

Abstract: This paper presents the application of CORPS (coherently radiating periodic structures) for feeding CRA (concentric rings array) with a reduced number of phase shifters. The proposed design technique for the structure of concentric rings provides a ... ...

Abstract	This paper presents the application of CORPS (coherently radiating periodic structures) for feeding CRA (concentric rings array) with a reduced number of phase shifters. The proposed design technique for the structure of concentric rings provides a better scanning capability with respect to other existing configurations. This design technique utilizes 2 × 3 or 4 × 7 CORPS networks depending on the configuration or the number of antenna elements in the phased array system. These CORPS networks are set strategically in the feeding network to provide several advantages with respect to others in the scanning capability and the reduction of the number of phase shifters of the array system. The contribution of this paper is the full antenna system design of phased CRA for analyzing scanning and the reduction of phase shifters. The proposed phased array reduces the number of phase shifter devices in CRA for a scanning range of ±25° in the elevation plane. Differential evolution (DE) was applied to optimize the amplitudes of the proposed system. Several design cases were analyzed using full-wave simulation results to verify the phased array model and to take mutual coupling into account. Full-wave simulation results provide radiation patterns with low SLL in all scanning directions. The proposed phased array was validated by experimental measurements of the full antenna system prototype.
Language	English
Publishing date	2022-12-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s22239528
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Article ; Online: Flood Mitigation in Urban Areas through Deep Aquifer Recharge: The Case of the Metropolitan Area of Guadalajara.

Vanegas-Espinosa, Luis Ignacio / Vargas-Del-Río, David / Ochoa-Covarrubias, Gabriela / Grindlay, Alejandro Luis

International journal of environmental research and public health

2022 Volume 19, Issue 6

Abstract: The Metropolitan Area of Guadalajara (MAG) experiences water shortage and overexploitation of aquifers. In addition, it suffers from seasonal flooding that is channeled towards inadequate sanitary drainage, creating a strong negative environmental impact. ...

Abstract	The Metropolitan Area of Guadalajara (MAG) experiences water shortage and overexploitation of aquifers. In addition, it suffers from seasonal flooding that is channeled towards inadequate sanitary drainage, creating a strong negative environmental impact. These problems are rooted in the waterproofing of the urban surface. Many cities around the world have used deep injection wells to recover aquifers and remove surface waters. Certain geohydrological conditions are required for the implementation of these deep injection wells, deeper than 30 m, such as significant surface runoff, acceptable water quality for infiltration, considerable depth in the phreatic levels, and good subsoil permeability. All of these conditions exist in the MAG or could be achieved without significant investment. An assessment is presented exploring the viability for a solution based on this technology, as a strategy to recover aquifers and reduce flooding. The first step was to identify, through map algebra, a micro-basin suitable for this technology. Then, mean runoff volumes were obtained and a stratigraphic profile was carried out based on 19 standard penetration tests (SPT). With these data, a numerical simulation of deep injection wells of different dimensions was performed, providing recommendations for a solution based on these calculations. The results show that both problems can be solved with this relatively simple and cheap technology supporting public health.
MeSH term(s)	Cities ; Floods ; Groundwater ; Water Quality
Language	English
Publishing date	2022-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19063160
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Article ; Online: Non-Uniform Concentric Rings Design for Ultra-Wideband Arrays.

Panduro, Marco A / Reyna, Alberto / Covarrubias, David H

Sensors (Basel, Switzerland)

2019 Volume 19, Issue 10

Abstract: This paper presents the design of aperiodic concentric ring arrays for ultra-wide bandwidths (UW-ACRA). This design of ultra-wideband arrays considers the synthesis of concentric rings in two cases: 1) non-uniform spacing between rings with non-uniform ... ...

Abstract	This paper presents the design of aperiodic concentric ring arrays for ultra-wide bandwidths (UW-ACRA). This design of ultra-wideband arrays considers the synthesis of concentric rings in two cases: 1) non-uniform spacing between rings with non-uniform spacing between antenna elements of the same ring (UW-ACRA
Language	English
Publishing date	2019-05-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s19102262
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Article ; Online: Alternative conformations of a group 4 Late Embryogenesis Abundant protein associated to its in vitro protective activity.

Rendón-Luna, David F / Arroyo-Mosso, Inti A / De Luna-Valenciano, Haydee / Campos, Francisco / Segovia, Lorenzo / Saab-Rincón, Gloria / Cuevas-Velazquez, Cesar L / Reyes, José Luis / Covarrubias, Alejandra A

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2770

Abstract: Late Embryogenesis Abundant (LEA) proteins are a group of intrinsically disordered proteins implicated in plant responses to water deficit. In vitro studies revealed that LEA proteins protect reporter enzymes from inactivation during low water ... ...

Abstract	Late Embryogenesis Abundant (LEA) proteins are a group of intrinsically disordered proteins implicated in plant responses to water deficit. In vitro studies revealed that LEA proteins protect reporter enzymes from inactivation during low water availability. Group 4 LEA proteins constitute a conserved protein family, displaying in vitro protective capabilities. Under water deficiency or macromolecular crowding, the N-terminal of these proteins adopts an alpha-helix conformation. This region has been identified as responsible for the protein in vitro protective activity. This study investigates whether the attainment of alpha-helix conformation and/or particular amino acid residues are required for the in vitro protective activity. The LEA4-5 protein from Arabidopsis thaliana was used to generate mutant proteins. The mutations altered conserved residues, deleted specific conserved regions, or introduced prolines to hinder alpha-helix formation. The results indicate that conserved residues are not essential for LEA4-5 protective function. Interestingly, the C-terminal region was found to contribute to this function. Moreover, alpha-helix conformation is necessary for the protective activity only when the C-terminal region is deleted. Overall, LEA4-5 shows the ability to adopt alternative functional conformations under the tested conditions. These findings shed light on the in vitro mechanisms by which LEA proteins protect against water deficit stress.
MeSH term(s)	Plant Proteins/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Arabidopsis/metabolism ; Water/metabolism ; Embryonic Development
Chemical Substances	Plant Proteins ; Arabidopsis Proteins ; Water (059QF0KO0R)
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53295-7
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