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  1. Article: Review the progression of ovarian clear cell carcinoma from the perspective of genomics and epigenomics.

    Tong, An / Di, Xiangjie / Zhao, Xia / Liang, Xiao

    Frontiers in genetics

    2023  Volume 14, Page(s) 952379

    Abstract: Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer with unique molecular characteristics, specific biological and clinical behavior, poor prognosis and high resistance to chemotherapy. Pushed by the development of genome- ... ...

    Abstract Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer with unique molecular characteristics, specific biological and clinical behavior, poor prognosis and high resistance to chemotherapy. Pushed by the development of genome-wide technologies, our knowledge about the molecular features of OCCC has been considerably advanced. Numerous studies are emerging as groundbreaking, and many of them are promising treatment strategies. In this article, we reviewed studies about the genomics and epigenetics of OCCC, including gene mutation, copy number variations, DNA methylation and histone modifications.
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2023.952379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nailfold capillary abnormalities: A predictor of psoriatic arthritis?

    Wang, Yifei / Song, Zexing / Gao, Yaoying / Yin, Yue / An, Xiangjie / Yang, Jing / Tao, Juan

    The Journal of dermatology

    2022  Volume 50, Issue 5, Page(s) e166–e167

    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnosis ; Nails/blood supply ; Capillaries ; Microscopic Angioscopy
    Language English
    Publishing date 2022-12-29
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1950: Show issues Location:
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  3. Article ; Online: To resume noninvasive imaging detection safely after peak period of COVID-19: Experiences from Wuhan China.

    An, Xiangjie / Song, Zexing / Gao, Yaoying / Tao, Juan / Yang, Jing

    Dermatologic therapy

    2020  Volume 33, Issue 5, Page(s) e13590

    MeSH term(s) COVID-19 ; China ; Coronavirus ; Dermoscopy ; Humans ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13590
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    Zs.A 5181: Show issues Location:
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  4. Article ; Online: Construction of V

    Chen, Xiangjie / Kong, Qingquan / Wu, Xiaoqiang / An, Xuguang / Zhang, Jing / Wang, Qingyuan / Yao, Weitang

    Journal of colloid and interface science

    2022  Volume 625, Page(s) 1002–1011

    Abstract: Aqueous zinc-ion batteries (AZIBs) have become a focus due to their high safety, low cost, and environmental protection. Vanadium-based materials are commonly used as cathodes in AZIBs. As technology improves, more types of vanadium-based materials are ... ...

    Abstract Aqueous zinc-ion batteries (AZIBs) have become a focus due to their high safety, low cost, and environmental protection. Vanadium-based materials are commonly used as cathodes in AZIBs. As technology improves, more types of vanadium-based materials are successfully synthesized and applied. To find more suitable cathode materials, we first investigated the utility of V
    Language English
    Publishing date 2022-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2022.06.110
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    In stock of ZB MED Bonn / Germany

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  5. Article: Rapid azoospermia classification by stimulated Raman scattering and second harmonic generation microscopy.

    Huang, Jie / Tang, Xiaobin / Chen, Zhicong / Li, Xiaomin / Zhang, Yongqing / Huang, Xiangjie / Zhang, Delong / An, Geng / Lee, Hyeon Jeong

    Biomedical optics express

    2023  Volume 14, Issue 11, Page(s) 5569–5582

    Abstract: Disease diagnosis and classification pose significant challenges due to the limited capabilities of traditional methods to obtain molecular information with spatial distribution. Optical imaging techniques, utilizing (auto)fluorescence and nonlinear ... ...

    Abstract Disease diagnosis and classification pose significant challenges due to the limited capabilities of traditional methods to obtain molecular information with spatial distribution. Optical imaging techniques, utilizing (auto)fluorescence and nonlinear optical signals, introduce new dimensions for biomarkers exploration that can improve diagnosis and classification. Nevertheless, these signals often cover only a limited number of species, impeding a comprehensive assessment of the tissue microenvironment, which is crucial for effective disease diagnosis and therapy. To address this challenge, we developed a multimodal platform, termed stimulated Raman scattering and second harmonic generation microscopy (SRASH), capable of simultaneously providing both chemical bonds and structural information of tissues. Applying SRASH imaging to azoospermia patient samples, we successfully identified lipids, protein, and collagen contrasts, unveiling molecular and structural signatures for non-obstructive azoospermia. This achievement is facilitated by LiteBlendNet-Dx (LBNet-Dx), our diagnostic algorithm, which achieved an outstanding 100% sample-level accuracy in classifying azoospermia, surpassing conventional imaging modalities. As a label-free technique, SRASH imaging eliminates the requirement for sample pre-treatment, demonstrating great potential for clinical translation and enabling molecular imaging-based diagnosis and therapy.
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.501623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Molecular Cloning and Expression Profile of Class

    Liu, Zhuoxing / Zhang, Dasheng / Zhang, Weiwei / Xiong, Lei / Liu, Qingqing / Liu, Fengluan / Li, Hanchun / An, Xiangjie / Cui, Lijie / Tian, Daike

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 8

    Abstract: The lotus ( ...

    Abstract The lotus (
    Language English
    Publishing date 2021-08-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10081629
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  7. Article ; Online: Transcription factor ELK1 regulates the expression of histone 3 lysine 9 to affect developmental potential of porcine preimplantation embryos.

    Zhao, Yuanshen / Zhai, Yanhui / Fu, Cong / Shi, Lijing / Kong, Xiangjie / Li, Qi / Yu, Hao / An, Xinglan / Zhang, Sheng / Li, Ziyi

    Theriogenology

    2023  Volume 206, Page(s) 170–180

    Abstract: A series of changes occur in the early embryo that are critical for subsequent development, and the pig is an excellent animal model of human disease, so understanding the regulatory mechanisms of early embryonic development in the pig is of very ... ...

    Abstract A series of changes occur in the early embryo that are critical for subsequent development, and the pig is an excellent animal model of human disease, so understanding the regulatory mechanisms of early embryonic development in the pig is of very importance. To find key transcription factors regulating pig early embryonic development, we first profiled the transcriptome of pig early embryos, and confirmed that zygotic gene activation (ZGA) in porcine embryos starts from 4 cell stage. Subsequent enrichment analysis of up-regulated gene motifs during ZGA revealed that the transcription factor ELK1 ranked first. The expression pattern of ELK1 in porcine early embryos was analyzed by immunofluorescence staining and qPCR, and the results showed that the transcript level of ELK1 reached the highest at the 8 cell stage, while the protein level reached the highest at 4 cell stage. To further investigate the effect of ELK1 on early embryo development in pigs, we silenced ELK1 in zygotes and showed that ELK1 silencing significantly reduced cleavage rate, blastocyst rate as well as blastocyst quality. A significant decrease in the expression of the pluripotency gene Oct4 was also observed in blastocysts from the ELK1 silenced group by immunofluorescence staining. Silencing of ELK1 also resulted in decreased H3K9Ac modification and increased H3K9me3 modification at 4 cell stage. To investigate the effect of ELK1 on ZGA, we analyzed transcriptome changes in 4 cell embryos after ELK1 silencing by RNA seq, which revealed that ELK1 silencing resulted in significant differences in the expression of a total of 1953 genes at the 4 cell stage compared with their normal counterparts, including 1106 genes that were significantly upregulated and 847 genes that were significantly downregulated. Through GO and KEGG enrichment, we found that the functions and pathways of down-regulated genes were concentrated in protein synthesis, processing, cell cycle regulation, etc., while the functions of up-regulated genes were focused on aerobic respiration process. In conclusion, this study demonstrates that the transcription factor ELK1 plays an important role in regulation of preimplantation embryo development of pigs and deficiency of ELK1 leads to abnormal epigenetic reprogramming as well as zygotic genome activation, thus adversely affecting embryonic development. This study will provide important reference for the regulation of transcription factors in porcine embryo development.
    MeSH term(s) Pregnancy ; Female ; Swine ; Humans ; Animals ; Histones/genetics ; Histones/metabolism ; Lysine/metabolism ; ets-Domain Protein Elk-1/genetics ; ets-Domain Protein Elk-1/metabolism ; ets-Domain Protein Elk-1/pharmacology ; Blastocyst ; Embryonic Development ; Transcription Factors/metabolism ; Gene Expression Regulation, Developmental
    Chemical Substances Histones ; Lysine (K3Z4F929H6) ; ets-Domain Protein Elk-1 ; Transcription Factors ; ELK1 protein, human
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2023.05.018
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Observation and consideration on using of JAKi in clinical trials in times of COVID-19.

    Yang, Jing / Al-Muriesh, Maher / Yan, Li / An, Xiangjie / Tao, Juan

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e13831

    MeSH term(s) Adult ; Alopecia Areata/drug therapy ; COVID-19 ; Humans ; Janus Kinase Inhibitors/administration & dosage ; Janus Kinase Inhibitors/adverse effects ; Middle Aged
    Chemical Substances Janus Kinase Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-07-13
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13831
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: To resume noninvasive imaging detection safely after peak period of COVID ‐19

    An, Xiangjie / Song, Zexing / Gao, Yaoying / Tao, Juan / Yang, Jing

    Dermatologic Therapy

    Experiences from Wuhan China

    2020  Volume 33, Issue 5

    Keywords Dermatology ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13590
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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