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  1. Article ; Online: Tolerability of immune checkpoint inhibitors in patients with cancer and pre-existing multiple sclerosis.

    Chavaz, L / Guyon, D / Boespflug, A / Cauquil, C / Michot, J M

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 189, Page(s) 112928

    MeSH term(s) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Multiple Sclerosis/drug therapy ; Neoplasms/drug therapy ; Antineoplastic Agents, Immunological/adverse effects
    Chemical Substances Immune Checkpoint Inhibitors ; Antineoplastic Agents, Immunological
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sensitivity, specificity, and accuracy of molecular profiling on circulating cell-free DNA in refractory or relapsed multiple myeloma patients, results of MM-EP1 study.

    Quivoron, C / Michot, J-M / Danu, A / Lecourt, H / Saada, V / Saleh, K / Vergé, V / Cotteret, S / Bernard, O A / Ribrag, V

    Leukemia & lymphoma

    2024  , Page(s) 1–11

    Abstract: As a promising alternative to bone marrow aspiration (BMA), mutational profiling on blood-derived circulating cell-free tumor DNA (cfDNA) is a harmless and simple technique to monitor molecular response and treatment resistance of patients with ... ...

    Abstract As a promising alternative to bone marrow aspiration (BMA), mutational profiling on blood-derived circulating cell-free tumor DNA (cfDNA) is a harmless and simple technique to monitor molecular response and treatment resistance of patients with refractory/relapsed multiple myeloma (R/R MM). We evaluated the sensitivity and specificity of cfDNA compared to BMA CD138 positive myeloma plasma cells (PCs) in a series of 45 R/R MM patients using the 29-gene targeted panel (AmpliSeq) NGS.
    Language English
    Publishing date 2024-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2024.2320258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: High levels of TNFα in patients with COVID-19 refractory to tocilizumab.

    Danlos, F X / Ackermann, F / Rohmer, J / Roumier, M / Marabelle, A / Michot, J M

    European journal of cancer (Oxford, England : 1990)

    2021  Volume 149, Page(s) 102–104

    MeSH term(s) Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Humans ; SARS-CoV-2 ; Tumor Necrosis Factor-alpha
    Chemical Substances Antibodies, Monoclonal, Humanized ; Tumor Necrosis Factor-alpha ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2021-03-20
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2021.01.056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effects of CGRP-Primed Dental Pulp Stem Cells on Trigeminal Sensory Neurons.

    Michot, B / Casey, S M / Gibbs, J L

    Journal of dental research

    2021  Volume 100, Issue 11, Page(s) 1273–1280

    Abstract: Dental pulp stem cells (DPSCs) are important in tooth physiology, contributing to development, repair, regeneration, and immunomodulatory processes. However, their role in inflammatory mechanisms underlying pulpitis is not well understood. We evaluated ... ...

    Abstract Dental pulp stem cells (DPSCs) are important in tooth physiology, contributing to development, repair, regeneration, and immunomodulatory processes. However, their role in inflammatory mechanisms underlying pulpitis is not well understood. We evaluated the influence of DPSCs stimulated with calcitonin gene-related peptide (CGRP), a proinflammatory neuropeptide, on the expression of mediators released from DPSCs and the effect of these mediators on sensory neuron activity. Human DPSCs were treated with either control media or media containing CGRP (10
    MeSH term(s) Animals ; Calcitonin ; Calcitonin Gene-Related Peptide ; Cell Differentiation ; Cells, Cultured ; Dental Pulp ; Mice ; Sensory Receptor Cells ; Stem Cells
    Chemical Substances Calcitonin (9007-12-9) ; Calcitonin Gene-Related Peptide (JHB2QIZ69Z)
    Language English
    Publishing date 2021-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345211004872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Incidence, characteristics, management and outcome of patients with follicular lymphoma with tumor epidural compression, a study on 22 cases.

    Gueiderikh, A / Ung, M / Lazarovici, J / Danu, A / Ghez, D / Saleh, K / Dragani, M / Noël, N / Bigenwald, C / Willekens, C / Ribrag, V / Michot, J-M / Martin, V

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2023  Volume 27, Issue 5, Page(s) 370–375

    Abstract: Purpose: Follicular lymphoma (FL) is one of the most common lymphoma. Occasionally, FL is associated with tumoral epidural compression and management of these patients remain poorly codified. This study aims to report incidence, clinical characteristics, ...

    Abstract Purpose: Follicular lymphoma (FL) is one of the most common lymphoma. Occasionally, FL is associated with tumoral epidural compression and management of these patients remain poorly codified. This study aims to report incidence, clinical characteristics, management and outcomes of patients with FL and tumoral epidural compression.
    Material and methods: Observational, retrospective cohort study of adult patients with FL and epidural tumor compression, treated in a French Institute over the last 20 years (2000-2021).
    Results: Between 2000 and 2021, 1382 patients with FL were followed by the haematological department. Of them, 22 (1.6%) patients (16 men and 6 women) had follicular lymphoma with epidural tumor compression. At epidural tumor compression occurrence, 8/22 (36%) patients had a neurological clinical deficit (motor, sensory or sphincter function) and 14/22 (64%) had tumor pain. All patients were treated with immuno-chemotherapy; the main regimen being used was R-CHOP plus high dose IV methotrexate in 16/22 (73%) patients. Radiotherapy for tumor epidural compression was performed in 19/22 (86%) patients. With a median follow-up of 60 months (range=[1-216]), 5 year local tumor relapse free survival was achieved in 65% (95% CI 47-90%) of patients. The median PFS was of 36 months (95% CI 24-NA) and 5 years OS estimate was 79% (95% CI 62-100%). Two patients developed a relapse at a second epidural site.
    Conclusion: FL with tumoral epidural compression reached 1.6% of all FL patients. Management based on immuno-chemotherapy with radiotherapy appeared to produce comparable outcomes with the general FL population.
    MeSH term(s) Adult ; Female ; Humans ; Male ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Doxorubicin ; Epidural Neoplasms/drug therapy ; Incidence ; Lymphoma, Follicular/radiotherapy ; Neoplasm Recurrence, Local/drug therapy ; Retrospective Studies ; Rituximab/therapeutic use ; Treatment Outcome
    Chemical Substances Doxorubicin (80168379AG) ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-05-06
    Publishing country France
    Document type Journal Article ; Observational Study
    ZDB-ID 1397169-4
    ISSN 1769-6658 ; 1278-3218
    ISSN (online) 1769-6658
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2023.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Analysis of the Peritumoral Tissue Unveils Cellular Changes Associated with a High Risk of Recurrence.

    Michot, Audrey / Lagarde, Pauline / Lesluyes, Tom / Darbo, Elodie / Neuville, Agnès / Baud, Jessica / Perot, Gaëlle / Bonomo, Iris / Maire, Mathilde / Michot, Maxime / Coindre, Jean-Michel / Le Loarer, François / Chibon, Frédéric

    Cancers

    2023  Volume 15, Issue 13

    Abstract: Background: The management of soft-tissue sarcoma (STS) relies on a multidisciplinary approach involving specialized oncological surgery combined with other adjuvant therapies to achieve optimal local disease control. Purpose and Results: Genomic and ... ...

    Abstract Background: The management of soft-tissue sarcoma (STS) relies on a multidisciplinary approach involving specialized oncological surgery combined with other adjuvant therapies to achieve optimal local disease control. Purpose and Results: Genomic and transcriptomic pseudocapsules of 20 prospective sarcomas were analyzed and revealed to be correlated with a higher risk of recurrence after surgery.
    Conclusions: A peritumoral environment that has been remodeled and infiltrated by M2 macrophages, and is less expressive of healthy tissue, would pose a significant risk of relapse and require more aggressive treatment strategies.
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15133450
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Systemic Hemodynamics, Cardiac Mechanics, and Signaling Pathways Induced by Extracorporeal Membrane Oxygenation in a Cardiogenic Shock Model.

    Beurton, Antoine / Michot, Maxime / Hérion, François-Xavier / Rienzo, Mario / Oddos, Claire / Couffinhal, Thierry / Imbault, Julien / Ouattara, Alexandre

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2024  Volume 70, Issue 3, Page(s) 177–184

    Abstract: Peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used in patients suffering from refractory cardiogenic shock (CS). Although considered life-saving, peripheral VA-ECMO may also be responsible for intracardiac ... ...

    Abstract Peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used in patients suffering from refractory cardiogenic shock (CS). Although considered life-saving, peripheral VA-ECMO may also be responsible for intracardiac hemodynamic changes, including left ventricular overload and dysfunction. Venoarterial extracorporeal membrane oxygenation may also increase myocardial wall stress and stroke work, possibly affecting the cellular cardioprotective and apoptosis signaling pathways, and thus the infarct size. To test this hypothesis, we investigated the effects of increasing the peripheral VA-ECMO blood flow (25-100% of the baseline cardiac output) on systemic and cardiac hemodynamics in a closed-chest CS model. Upon completion of the experiment, the hearts were removed for assessment of infarct size, histology, apoptosis measurements, and phosphorylation statuses of p38 and protein Kinase B (Akt), and extracellular signal-regulated kinase mitogen-activated protein kinases (ERK-MAPK). Peripheral VA-ECMO restored systemic perfusion but induced a significant and blood flow-dependent increase in left ventricular preload and afterload. Venoarterial extracorporeal membrane oxygenation did not affect infarct size but significantly decreased p38-MAPK phosphorylation and cardiac myocyte apoptosis in the border zone.
    MeSH term(s) Humans ; Shock, Cardiogenic/therapy ; Extracorporeal Membrane Oxygenation ; Hemodynamics ; Myocardium ; Signal Transduction
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000002139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Belantamab Mafotodin-Induced Epithelial Keratopathy Masquerading Myopic Surgery.

    Rousseau, Antoine / Michot, Jean-Marie / Labetoulle, Marc

    Ophthalmology

    2020  Volume 127, Issue 12, Page(s) 1626

    MeSH term(s) Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; Corneal Opacity/chemically induced ; Corneal Opacity/diagnosis ; Corneal Topography ; Diagnosis, Differential ; Epithelium, Corneal/drug effects ; Female ; Humans ; Hyperopia/chemically induced ; Hyperopia/diagnosis ; Microscopy, Confocal ; Multiple Myeloma/drug therapy ; Myopia/diagnosis ; Myopia/surgery ; Tomography, Optical Coherence
    Chemical Substances Antibodies, Monoclonal, Humanized ; belantamab mafodotin (DB1041CXDG)
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2020.07.047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Crystalline restacking of 2D-materials from their nanosheets suspensions.

    Cherni, Lina / El Rifaii, Karin / Wensink, Henricus H / Chevrier, Sarah M / Goldmann, Claire / Michot, Laurent J / Davidson, Patrick / Gabriel, Jean-Christophe P

    Nanoscale

    2023  Volume 15, Issue 45, Page(s) 18359–18367

    Abstract: We report here the highly ordered restacking of the layered phosphatoantimonic dielectric materials ... ...

    Abstract We report here the highly ordered restacking of the layered phosphatoantimonic dielectric materials H
    Language English
    Publishing date 2023-11-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr04885c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Infections occurring following IL6 blockade for the management of cytokine release syndrome in onco-hematology patients.

    Valery, M / Saleh, K / Ecea, R / Michot, J M / Ribrag, V / Fizazi, K / Hollebecque, A / Lecesne, A / Ponce, S / Loriot, Y / Champiat, S / Baldini, C / Sarkozy, C / Castilla-Llorente, C

    Cancer chemotherapy and pharmacology

    2023  Volume 92, Issue 3, Page(s) 229–233

    Abstract: Background: Cytokine release syndrome (CRS) is a common adverse event of CAR T cell or bispecific antibody (bsAb) therapy. Anti-IL6/IL6R drugs are used in the management of auto-immune diseases. Some reports showed increased risk of bacterial infection ... ...

    Abstract Background: Cytokine release syndrome (CRS) is a common adverse event of CAR T cell or bispecific antibody (bsAb) therapy. Anti-IL6/IL6R drugs are used in the management of auto-immune diseases. Some reports showed increased risk of bacterial infection in this context. In onco-hematology, there are few data about the occurrence of infection after administration of an anti-IL6/IL6R for CRS.
    Methods: We retrospectively reviewed all consecutive patients treated in Gustave Roussy Cancer Campus between 2018 and 2021, who received anti-IL6/IL6R for CRS due to bsAb in phase I clinical trials or adoptive cellular therapy (ACT). We constituted a control group including all the patients treated in the same clinical trials or standard of care ACT, naïve of anti-IL6/IL6R.
    Results: Fifty-two patients have been included. In the anti-IL6/IL6R group (n = 26), five patients developed a grade 2 to 5 infection within a month after anti-IL6/IL6R treatment, including two grade 5 infections. In the control group (n = 26), only one patient had a grade 3 infection. The two patients who had grade 5 infections were treated for diffuse large B cell lymphoma (DLBCL), one with bsAb and the other with CAR T cell. Fifty percent (3/6) of DLBCL patients who received an anti-IL6/IL6R presented an infection, one of which was a grade 5. In solid tumor patients treated with bsAb and anti-IL6/IL6R, only one patient (/9, 11%) developed a grade 2 viral infection.
    Conclusion: It seems that the use of anti-IL6/IL6R in CRS secondary to bsAb administration in solid tumors patients does not significantly increase the risk of infection, as opposed to DLBCL patients where secondary infection might be a concern.
    MeSH term(s) Humans ; Cytokine Release Syndrome/chemically induced ; Retrospective Studies ; Antibodies, Bispecific ; Lymphoma, Large B-Cell, Diffuse/drug therapy
    Chemical Substances Antibodies, Bispecific
    Language English
    Publishing date 2023-06-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6820-2
    ISSN 1432-0843 ; 0344-5704 ; 0943-9404
    ISSN (online) 1432-0843
    ISSN 0344-5704 ; 0943-9404
    DOI 10.1007/s00280-023-04551-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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