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  1. Article: Nocardial Infection in the Early Period after Kidney Transplantation.

    Gupta, Sudeendra / Abdulbaki, Ammar / El Hajj, Sandra / Nusair, Ahmad / Mooty, Mohamad / Attallah, Nizar

    Case reports in infectious diseases

    2022  Volume 2022, Page(s) 2252825

    Abstract: Patients with solid organ transplant have weaker immune system and can develop opportunistic infections. Prophylactic antimicrobials can help lower that risk but do not prevent it completely. High index of suspicion increases the chance of diagnosing ... ...

    Abstract Patients with solid organ transplant have weaker immune system and can develop opportunistic infections. Prophylactic antimicrobials can help lower that risk but do not prevent it completely. High index of suspicion increases the chance of diagnosing rare opportunistic infections in immunocompromised patients and helps early and effective treatment. We present a unique case of a patient who developed pneumonia from
    Language English
    Publishing date 2022-08-12
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627642-2
    ISSN 2090-6633 ; 2090-6625
    ISSN (online) 2090-6633
    ISSN 2090-6625
    DOI 10.1155/2022/2252825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anticoagulation in COVID-19 patients requiring continuous renal replacement therapy.

    Attallah, Nizar / Gupta, Sudeendra / Madhyastha, Rakesh / El Nekidy, Wasim S / Mallat, Jihad

    Anaesthesia, critical care & pain medicine

    2021  Volume 40, Issue 3, Page(s) 100841

    MeSH term(s) Acute Kidney Injury/therapy ; Anticoagulants/administration & dosage ; COVID-19/blood ; COVID-19/complications ; Continuous Renal Replacement Therapy/instrumentation ; Female ; Filtration/instrumentation ; Heparin/administration & dosage ; Humans ; Male ; Middle Aged ; Prothrombin Time ; Retrospective Studies ; Thrombosis/prevention & control
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2021-03-19
    Publishing country France
    Document type Letter
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2021.100841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Tocilizumab Use in a Chronic Hemodialysis Patient for the Management of COVID-19-Associated Pneumonia and Acute Respiratory Distress Syndrome.

    Gupta, Sudeendra / Madhyastha, Rakesh / Hamed, Fadi / Balkis, Maher / El Nekidy, Wasim / Attallah, Nizar

    Case reports in nephrology

    2020  Volume 2020, Page(s) 8829309

    Abstract: Novel coronavirus disease 2019 (COVID-19) is a highly infectious, rapidly spreading viral disease. As of writing this article, there are over 4.4 million people affected by COVID-19, and unfortunately, 300,000 have succumbed to the infection. In this ... ...

    Abstract Novel coronavirus disease 2019 (COVID-19) is a highly infectious, rapidly spreading viral disease. As of writing this article, there are over 4.4 million people affected by COVID-19, and unfortunately, 300,000 have succumbed to the infection. In this article, we address a particularly more susceptible group of the population of end-stage renal disease (ESRD) patients on dialysis who may potentially benefit from being treated with tocilizumab. The use of tocilizumab has not been reported widely in ESRD patients on dialysis to treat COVID-19. In this case report, we describe a patient with ESRD on hemodialysis who was admitted to the intensive care unit, with severe pneumonia secondary to COVID-19 infection. This patient was treated with tocilizumab 400 mg intravenous and had a favorable outcome with no apparent adverse events.
    Language English
    Publishing date 2020-11-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2627652-5
    ISSN 2090-665X ; 2090-6641
    ISSN (online) 2090-665X
    ISSN 2090-6641
    DOI 10.1155/2020/8829309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bioadhesive vaginal tablets containing spray dried microspheres loaded with clotrimazole for treatment of vaginal candidiasis.

    Gupta, Naresh Vishal / Natasha, Shirodker / Getyala, Anil / Bhat, Ramnath Sudeendra

    Acta pharmaceutica (Zagreb, Croatia)

    2013  Volume 63, Issue 3, Page(s) 359–372

    Abstract: The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by ... ...

    Abstract The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal tablets containing clotrimazole loaded microspheres in order to provide long-term therapeutic activity at the site of infection. Tablets were prepared by incorporating drug loaded microspheres and using bioadhesive polymers hydroxypropylmethylcellulose, sodium carboxymethylcellulose and Carbopol. Microspheres were prepared by the spray drying technique using Eudragit RS-100 and Eudragit RL-100. Microspheres were characterized by SEM, DSC, FTIR, particle size analysis and evaluated for percentage yield, drug loading, encapsulation efficiency and in vitro drug release. To achieve bioadhesion to the mucosal tissue, optimized microspheres were incorporated into bioadhesive tablets and were evaluated for in vitro drug release, in vitro and in vivo mucoadhesion. FTIR and DSC studies showed that no chemical interaction occurred between the drug and polymers. The sphericity factor indicated that the prepared microspheres were spherical. Formulation Mt6 indicated a controlled in vitro drug release and good bioadhesive strength. The in vivo images confirmed the bioadhesion and retention property of tablets up to 24 h. The results indicated that this drug delivery system can be explored for controlled intravaginal drug release.
    MeSH term(s) Acrylic Resins/administration & dosage ; Acrylic Resins/chemistry ; Acrylic Resins/metabolism ; Administration, Intravaginal ; Animals ; Antifungal Agents/administration & dosage ; Antifungal Agents/chemistry ; Antifungal Agents/metabolism ; Candidiasis, Vulvovaginal/drug therapy ; Candidiasis, Vulvovaginal/metabolism ; Clotrimazole/administration & dosage ; Clotrimazole/chemistry ; Clotrimazole/metabolism ; Drug Carriers/administration & dosage ; Drug Carriers/chemistry ; Drug Carriers/metabolism ; Drug Delivery Systems/methods ; Female ; Microspheres ; Rabbits ; Sheep ; Tissue Adhesives/administration & dosage ; Tissue Adhesives/chemistry ; Tissue Adhesives/metabolism ; Treatment Outcome ; Vaginal Creams, Foams, and Jellies
    Chemical Substances Acrylic Resins ; Antifungal Agents ; Drug Carriers ; Tissue Adhesives ; Vaginal Creams, Foams, and Jellies ; Eudragit RS (33434-24-1) ; Clotrimazole (G07GZ97H65)
    Language English
    Publishing date 2013-09
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 1111806-4
    ISSN 1846-9558 ; 1330-0075
    ISSN (online) 1846-9558
    ISSN 1330-0075
    DOI 10.2478/acph-2013-0027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Comparison of Quality Requirements for Sterile Product Manufacture as per International Regulatory Agencies

    L. Aswani Nageen / Vishal Gupta / N.S. Natasha / R. Sudeendra Bhat / P. Yogita

    International Journal of Pharmaceutical and Phytopharmacological Research, Vol 1, Iss 4, Pp 208-

    2012  Volume 214

    Abstract: The present study deals with a brief overview of the quality requirements for sterile pharmaceutical product manufacture as per international regulatory requirements. The pharmaceutical companies are required to follow the quality management ... ...

    Abstract The present study deals with a brief overview of the quality requirements for sterile pharmaceutical product manufacture as per international regulatory requirements. The pharmaceutical companies are required to follow the quality management specifications as per different guidelines such as Indian GMP (Schedule M), WHO, US cGMP and MHRA. Parenteral products are intended to be non-pyrogenic too, additionally to the requirement to be sterile. Medicinal drug products that do not meet the requirement to be sterile, non-pyrogenic can otherwise cause severe harm to life, threatening health risk to patient. It is necessary to know the differences in the requirements of guidelines given by different international agencies. Knowledge of the differences in the requirements is important to guarantee the quality products and their supply in due time for the designated market.The main aim is to study the quality requirements for sterile pharmaceutical product manufacture and to list down the similarities and differences as per the international regulatory requirements. The aspects that are taken into consideration are environmental parameters, buildings and premises, personnel, sanitation, equipment and sterilization.These guidelines focus on the parameters to be stressed on while manufacturing sterile pharmaceutical product and when these guidelines were compared, certain similarities and differences were observed. The requirements were broadly similar, and the differences found are detailed in this study.
    Keywords Indian GMP ; Schedule M ; WHO ; US cGMP ; MHRA ; Pharmacy and materia medica ; RS1-441 ; Medicine ; R ; DOAJ:Pharmacy and materia medica ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 650 ; 670
    Language English
    Publishing date 2012-03-01T00:00:00Z
    Publisher International Journal of Pharmaceutical and Phytopharmacological Research
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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