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  1. Article: Remdesivir in the Management of COVID-19! Is there a Way Out of the Predicament?

    Kaur, Onkardeep / Singh, Pawan Kumar / Chaudhry, Dhruva

    The Journal of the Association of Physicians of India

    2023  Volume 71, Issue 8, Page(s) 11–12

    MeSH term(s) Humans ; COVID-19 ; COVID-19 Drug Treatment ; Alanine/therapeutic use
    Chemical Substances remdesivir (3QKI37EEHE) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2023-08-31
    Publishing country India
    Document type Letter ; Comment
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: In Response to: Corticosteroids in Non-severe COVID-19: Finding Window of Opportunity.

    Nasa, Prashant / Chaudhry, Dhruva

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2022  Volume 26, Issue 3, Page(s) 405

    Abstract: Nasa P, Chaudhry D. In Response to: Corticosteroids in Non-severe COVID-19: Finding Window ...

    Abstract Nasa P, Chaudhry D. In Response to: Corticosteroids in Non-severe COVID-19: Finding Window of Opportunity. Indian J Crit Care 2022;26(3):405.
    Language English
    Publishing date 2022-04-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24139
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Stridor in a Patient with Uncontrolled Diabetes: An Uncommon Adversary, Successfully Managed with Bronchoscopy.

    Gulia, Kuldeep / Singhal, Suresh / Jain, Promil / Chaudhry, Dhruva / Ahuja, Aman / Singh, Pawan Kumar

    Tuberculosis and respiratory diseases

    2023  Volume 86, Issue 4, Page(s) 319–321

    Language English
    Publishing date 2023-07-17
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2161256-0
    ISSN 1738-3536 ; 0378-0066
    ISSN 1738-3536 ; 0378-0066
    DOI 10.4046/trd.2023.0074
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  4. Article ; Online: Comprehensive diagnostic evaluation of palpatory method of blood pressure measurement.

    Kumar, Yogita / Singh, Pawan Kumar / Chaudhry, Dhruva / Sharma, Amit / Yadav, Pooja

    European journal of internal medicine

    2023  Volume 115, Page(s) 154–156

    MeSH term(s) Humans ; Blood Pressure ; Blood Pressure Determination ; Hypertension/diagnosis
    Language English
    Publishing date 2023-06-01
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.05.028
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  5. Article: Tuberculosis in Intensive Care Unit.

    Chaudhry, Dhruva / Tyagi, Diksha

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2021  Volume 25, Issue Suppl 2, Page(s) S150–S154

    Abstract: About 3.4% of the hospitalized tubercular patients need admission to the intensive care unit (ICU). Patients requiring ICU admission had a poor prognosis and high mortality rate (60 vs 25%) as compared to other causes of severe pneumonia. The most common ...

    Abstract About 3.4% of the hospitalized tubercular patients need admission to the intensive care unit (ICU). Patients requiring ICU admission had a poor prognosis and high mortality rate (60 vs 25%) as compared to other causes of severe pneumonia. The most common indication for tuberculosis-related ICU admission is acute respiratory failure due to pneumonia or acute respiratory distress syndrome (ARDS) (with or without miliary tuberculosis) followed by septic shock with multiple organ dysfunction, adrenal insufficiency, and neurological involvement, especially tubercular meningitis. Tuberculosis patients who require admission to ICU are mostly immunocompromised [human immunodeficiency virus (HIV) coinfection] and have underlying miliary tuberculosis or disseminated tuberculosis. Pulmonary tuberculosis presenting as ARDS is a rare phenomenon, but a most common cause of admission of tuberculosis patients to ICU. Tuberculous meningitis is the most severe form of tuberculosis with mortality more than 60% and residual neurological disability in 25% cases. Tuberculosis-related septic shock has been found in only 1% of all septic shock patients admitted to ICU. Patients with tuberculosis with refractory shock should be suspected for adrenal insufficiency. A trial of physiologic stress replacement dose of hydrocortisone (200-300 mg) should be given to all critically ill patients with vasopressor-dependent shock after correcting other causes. Diagnosis and treatment of tuberculosis in critically ill patients has various challenges, namely appropriate sample collection, issues with the route of administration, drug absorption, bioavailability, dose modification in hepatic and renal dysfunction, and interaction with other drugs.
    Language English
    Publishing date 2021-07-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23872
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  6. Article: Epidemiology of Intensive Care Unit-acquired Infections in a Tertiary Care Hospital of North India.

    Kumar, Amit / Chaudhry, Dhruva / Goel, Nidhi / Tanwar, Shweta

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2022  Volume 25, Issue 12, Page(s) 1427–1433

    Abstract: ... of the development of ICU-acquired infection.: How to cite this article: Kumar A, Chaudhry D, Goel N, Tanwar S ...

    Abstract Background: The majority of nosocomial infections in the hospital setting are found in intensive care units (ICUs). The present study was undertaken to determine the incidence, risk factors, causative microorganisms, and outcome of various ICU-acquired infections.
    Materials and methods: The patients admitted to the ICU of a teaching hospital in North India were prospectively studied. Detailed history, clinical examination, acute physiology and chronic health evaluation score II, simplified acute physiology score II, sequential organ failure assessment score, and baseline investigations were recorded. Patients were assessed daily till 14th day for nosocomial infection as per Centers for Disease Control and Prevention (CDC) guidelines and were followed till death or discharge. Incidence, risk factors, and outcome parameters were calculated using Student
    Results: The overall incidence rate of ICU infections was 27.9%. The most common ICU-acquired infection was ventilator-associated pneumonia followed by catheter-related bloodstream infection and catheter-associated urinary tract infection.
    Conclusion: Ventilator-associated pneumonia was the most common nosocomial infection in our study. Gram-negative microorganisms were the predominant causative agents for various ICU-acquired infections. Mortality was not found to be affected but ICU LOS was significantly prolonged as a consequence of the development of ICU-acquired infection.
    How to cite this article: Kumar A, Chaudhry D, Goel N, Tanwar S. Epidemiology of Intensive Care Unit-acquired Infections in a Tertiary Care Hospital of North India. Indian J Crit Care Med 2021;25(12):1427-1433.
    Language English
    Publishing date 2022-01-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24058
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  7. Article: Tocilizumab and COVID-19.

    Chaudhry, Dhruva / Singh, Pawan K

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2020  Volume 24, Issue 9, Page(s) 741–743

    Abstract: The number of cases in COVID-19 pandemic is rising rapidly. There has not been a single effective proven medication for COVID-19 disease. Highest mortality has been reported among subjects who develop acute respiratory disease (ARDS). The ... ...

    Abstract The number of cases in COVID-19 pandemic is rising rapidly. There has not been a single effective proven medication for COVID-19 disease. Highest mortality has been reported among subjects who develop acute respiratory disease (ARDS). The histopathological analysis of lung specimens has given rise to theories that propose the major role of cytokine release syndrome in the development of ARDS. IL-6 has often been found to be raised in subjects having severe disease. Tocilizumab is a selective inhibitor of the IL-6 pathway and has been approved for various rheumatological diseases. Its use in COVID-19 has been evaluated following the success of other immunosuppressive drugs like steroids. The data in support of against its use in COVID19 are lacking. Similarly, the risk of early- and late-onset infections after tocilizumab in COVID-19 remains unknown. The study by Nasa et al. is a valuable addition to the evidence concerning its use. Despite multiple articles, its safety and efficacy in COVID-19 remain unknown. Caution must be used about its timing and role of IL-6 levels for disease monitoring.
    Keywords covid19
    Language English
    Publishing date 2020-10-24
    Publishing country India
    Document type Editorial
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23608
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  8. Article ; Online: Prevalence of long COVID symptoms in Haryana, India: a cross-sectional follow-up study.

    Chaudhry, Dhruva / Khandelwal, Shweta / Bahadur, Chandrika / Daniels, Benjamin / Bhattacharyya, Malay / Gangakhedkar, Raman / Desai, Sapna / Das, Jishnu

    The Lancet regional health. Southeast Asia

    2024  Volume 25, Page(s) 100395

    Abstract: Background: Emerging research indicates growing concern over long COVID globally, although there have been limited studies that estimate population burden. We aimed to estimate the burden of long COVID in three districts of Haryana, India, using an ... ...

    Abstract Background: Emerging research indicates growing concern over long COVID globally, although there have been limited studies that estimate population burden. We aimed to estimate the burden of long COVID in three districts of Haryana, India, using an opportunity to link a seroprevalence study to follow-up survey of symptoms associated with long COVID.
    Methods: We used a population-based seroprevalence survey for COVID-19 conducted in September 2021 across Haryana, India. Adults from three purposively selected districts (Rohtak, Gurugram, and Jhajjar) were eligible to participate; 2205 of 3213 consented to participate in a survey on health status. Trained investigators administered a structured questionnaire that included demographic characteristics, self-reported symptoms of illness in the last six months before the survey, mental health, and history of COVID-19.
    Findings: Unadjusted regression estimates indicated positive correlations between symptomatic complaints and COVID-19 exposure, suggesting lingering effects of COVID-19 in this population. The overall physical morbidity index was higher among those who tested positive for COVID-19, as was the incidence of new cases. However, both morbidity and incidence became statistically insignificant after adjustment for multiple comparisons. Cough emerged as the only statistically significant individual persistent symptom. Sex-stratified analyses indicated significant estimates only for physical morbidity in women.
    Interpretation: This study is one of the first from India that uses a large population-based sample to examine longer term repercussions of COVID infections. The burden of long COVID should primarily be addressed in clinical settings, where specialised treatment for individual cases continues to evolve. Our analyses also provide insight into the size and nature of studies required to assess the population-level burden of long COVID.
    Funding: This paper was produced under the auspices of the Lancet COVID 19 Commission India Task Force, which was supported financially by the Reliance Foundation. The Lancet COVID 19 Commission was set up in July 2020 and submitted its final report by October 2022. This report by the India Task Force was prepared during the same period.
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Journal Article
    ISSN 2772-3682
    ISSN (online) 2772-3682
    DOI 10.1016/j.lansea.2024.100395
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  9. Article ; Online: Dynamic assessment of oropharynx with ultrasonography as a screening tool for obstructive sleep apnea.

    Govindagoudar, Manjunath B / Lalwani, Lokesh Kumar / Singh, Pawan Kumar / Sen, Jyotsna / Chaudhry, Dhruva

    Journal of sleep research

    2022  Volume 32, Issue 1, Page(s) e13712

    Abstract: Ultrasonography is an easily available and portable tool to assess the dynamic changes in the upper airway and surrounding soft tissue. This study aimed to evaluate the utility of oropharynx ultrasonography as a screening tool for obstructive sleep apnea ...

    Abstract Ultrasonography is an easily available and portable tool to assess the dynamic changes in the upper airway and surrounding soft tissue. This study aimed to evaluate the utility of oropharynx ultrasonography as a screening tool for obstructive sleep apnea (OSA). The study sequentially enrolled overweight individuals (body mass index >25 kg/m
    MeSH term(s) Humans ; Overweight ; Oropharynx/diagnostic imaging ; Sleep Apnea, Obstructive/diagnostic imaging ; Polysomnography ; Ultrasonography ; Surveys and Questionnaires ; Mass Screening
    Language English
    Publishing date 2022-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.13712
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  10. Article: Impact of Educational and Training Programs on Knowledge of Healthcare Students Regarding Nosocomial Infections, Standard Precautions and Hand Hygiene: A Study at Tertiary Care Hospital.

    Goyal, Mohit / Chaudhry, Dhruva

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2019  Volume 23, Issue 5, Page(s) 227–231

    Abstract: ... hand hygiene.: How to cite this article: Goyal M, Chaudhry D. Impact of Educational and Training Programs ...

    Abstract Background and objectives: Nosocomial infections are significant public health problems in developed as well as developing countries. To tackle this problem, it is vital to sensitize healthcare students (HCSs) at early period of their clinical practise. Thus, this study was conducted to access the existing knowledge among HCSs and determine the impact of educational and training programs regarding nosocomial infections, standard precautions, and hand hygiene.
    Methods: This was a cross-sectional cum interventional, questionnaire based, single center study. Total 728 MBBS, BDS and BSC nursing students were targeted for workshop on nosocomial infections, standard precautions, and hand hygiene based on the Centers for Disease Control and prevention (CDC) and World Health Organization (WHO) guidelines. Infection control standardized questionnaire (ICSQ) was administered as a pretest and posttest. Results were analyzed by SPSS software.
    Results: A paired-samples t-test was conducted to access the impact of educational and training programs on knowledge of HCS. There was a significant difference in the scores of pretests (M = 37.30, SD = 4.81) and posttests (M = 42.03, SD = 4.55); t (727) = 22.162,
    Conclusion: This study highlighted the need for regular educational and training programs in primary training time for retention of knowledge regarding nosocomial infections and reinforcement of the principals of standard precautions and hand hygiene.
    How to cite this article: Goyal M, Chaudhry D. Impact of Educational and Training Programs on Knowledge of Healthcare Students Regarding Nosocomial Infections, Standard Precautions and Hand Hygiene: A Study at Tertiary Care Hospital. Indian J Crit Care Med 2019;23(2):227-231.
    Language English
    Publishing date 2019-06-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23166
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