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Article ; Online: Uterine necrosis during pregnancy following exploratory laparotomy.

Hirsch, Anna / Newman, Rachel / Naqvi, Mariam

BMJ case reports

2022 Volume 15, Issue 11

Abstract: Uterine necrosis is an infrequent event and is most commonly reported as a complication of interventions for postpartum haemorrhage management. Cases of uterine necrosis in pregnancy are rare. The mainstay of treatment for uterine necrosis is ... ...

Abstract	Uterine necrosis is an infrequent event and is most commonly reported as a complication of interventions for postpartum haemorrhage management. Cases of uterine necrosis in pregnancy are rare. The mainstay of treatment for uterine necrosis is hysterectomy, and the data regarding conservative management are limited. A gravida 3, para 2 presented at 33 weeks gestation with ovarian torsion and underwent an exploratory laparotomy with ovarian cystectomy. The surgery was complicated by excess bleeding, which was controlled with the placement of sutures along the uterine body. She had multiple subsequent presentations for severe abdominal pain without clear aetiology. Four weeks after the initial surgery, she underwent caesarean delivery, at which time uterine necrosis was diagnosed. Her uterus was preserved. She received postoperative intravenous antibiotics and was closely observed. She continued to do well 10 months postpartum. In patients with uterine necrosis during pregnancy who are haemodynamically stable, conservative management may be an option.
MeSH term(s)	Pregnancy ; Female ; Humans ; Laparotomy ; Uterus/surgery ; Postpartum Hemorrhage/surgery ; Sutures ; Necrosis/surgery
Language	English
Publishing date	2022-11-01
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-252273
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Article: Antifungal Activity of

Naqvi, Syeda Itrat Zahra / Kausar, Humera / Afzal, Arooj / Hashim, Mariam / Mujahid, Huma / Javed, Maryam / Hano, Christophe / Anjum, Sumaira

Journal of functional biomaterials

2023 Volume 14, Issue 4

Abstract: Aflatoxins produced by some species ... ...

Abstract	Aflatoxins produced by some species of
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb14040221
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Article ; Online: Risk of Preterm Delivery in Very Advanced Maternal Age Parturients Utilizing In Vitro Fertilization.

Newman, Rachel A / Naqvi, Mariam / Levian, Candace / Smithson, Sarah D / Esakoff, Tania

American journal of perinatology

2023

Abstract: Objective: Among patients ≥45 years, the birth rate in the United States continues to increase. As fertility declines with age, this cohort often utilizes assisted reproductive technology, specifically in vitro fertilization (IVF). While both advancing ...

Abstract	Objective: Among patients ≥45 years, the birth rate in the United States continues to increase. As fertility declines with age, this cohort often utilizes assisted reproductive technology, specifically in vitro fertilization (IVF). While both advancing maternal age and IVF are independently associated with adverse maternal outcomes, data regarding their additive effect are scant. This article aims to determine if patients who conceive via IVF are at increased risk for preterm birth (PTB) compared to patients with non-IVF pregnancies in a very advanced maternal age (vAMA) cohort (≥45 years). Study design: Retrospective cohort study of all pregnant patients ≥45 years old who delivered at a single institution (2014-2021). Those with incomplete delivery/neonatal records or multiples beyond twins were excluded. We compared individuals who conceived via IVF to those who conceived without IVF. The primary outcome was preterm delivery <37 weeks gestation. Secondary outcomes included other adverse perinatal outcomes. Using multivariable logistic regression, we adjusted for multiple gestation as well as confounders found to be significantly different in the univariable analysis and other known risk factors for PTB. Results: In our study cohort of 420 vAMA patients, individuals who underwent IVF were more likely to be older, privately insured, nulliparous, and with a twin gestation. The PTB rate in vAMA patients who underwent IVF was 24.4 compared to 8.4% in patients who did not use IVF ( Conclusion: In the vAMA population, conception via IVF is associated with an increased risk of PTB <37 weeks. Key points: · This study examines IVF as an independent risk factor for PTB in patients ≥45 years at delivery, which has not been specifically addressed in prior studies.. · In vAMA patients, use of IVF is associated with an increased risk of PTB <37 weeks. These patients also have higher rates of cesarean delivery. Neonates from IVF pregnancies are more likely to be very low birth weight or low birth weight.. · Bodies of research exist for both advanced maternal age and assisted reproductive technology, there is a paucity of data specifically in parturients of vAMA who conceive via IVF..
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/a-2157-3106
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Article ; Online: Association between acceptance of routine pregnancy vaccinations and COVID-19 vaccine uptake in pregnant patients.

Ha, Laura / Levian, Candace / Greene, Naomi / Goldfarb, Ilona / Hirsch, Anna / Naqvi, Mariam

The Journal of infection

2023 Volume 87, Issue 6, Page(s) 551–555

Abstract: Objective: COVID-19 vaccination is a key approach to reduce morbidity and mortality in pregnant patients and their newborns. Anti-vaccine sentiment has recently increased with unclear impact on pregnant patients. We examined the association between ... ...

Abstract	Objective: COVID-19 vaccination is a key approach to reduce morbidity and mortality in pregnant patients and their newborns. Anti-vaccine sentiment has recently increased with unclear impact on pregnant patients. We examined the association between acceptance of tetanus-diphtheria-acellular pertussis (Tdap) and influenza vaccines, considered to be routine pregnancy vaccines, and COVID-19 vaccine acceptance. Secondarily, we identified other predictors of COVID-19 vaccine uptake and described pregnancy outcomes in patients who were and were not vaccinated during pregnancy. Methods: A retrospective cohort study of all patients who delivered at a single site from December 2020 - March 2022. Demographic, pregnancy, neonatal, and vaccination data were abstracted from the electronic medical record, which imports vaccine history from the California Immunization Registry. The relationship between influenza and Tdap vaccine acceptance, other baseline characteristics, and COVID-19 vaccine uptake was assessed using univariable and multivariable regression analysis. Results: Of the 7857 patients who delivered during the study period, 4410 (56.1%) accepted the COVID-19 vaccine. Of those who received the COVID-19 vaccine, 3363 (97.6%) and 3049 (88.5%) received influenza and Tdap vaccines, respectively. Patients were more likely to receive the COVID-19 vaccine if they had advanced maternal age, obesity, Asian race, and private insurance. After adjustment for baseline differences, COVID vaccine acceptance was associated with receipt of Tdap (aOR 2.10, 95% CI 1.90-2.33) and influenza vaccines (aOR 2.83, 95% CI 2.55-3.14). There were no differences in preterm birth, low birthweight, and NICU admission between patients who received and did not receive the COVID-19 vaccine. Conclusion: Patients were more likely to accept COVID-19 vaccination if they received Tdap or influenza vaccinations. Older age, obesity, Asian race, and private insurance were independent predictors of vaccine uptake. Disparities in COVID-19 vaccination uptake bear further exploration to guide efforts in equitable and widespread vaccine distribution.
MeSH term(s)	Female ; Humans ; Infant, Newborn ; Pregnancy ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/adverse effects ; Diphtheria-Tetanus-acellular Pertussis Vaccines/administration & dosage ; Influenza Vaccines/administration & dosage ; Influenza, Human ; Obesity ; Premature Birth ; Retrospective Studies ; Vaccination ; Whooping Cough
Chemical Substances	COVID-19 Vaccines ; Diphtheria-Tetanus-acellular Pertussis Vaccines ; Influenza Vaccines
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2023.10.010
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Article: COVID-19 related risk perception and altruistic response amongst undergraduates on reopening of educational institutes.

Rabbani, Bushra / Ahmed, Faisal / Saeed, Ammarah / Zulfiqar Hyder Naqvi, Syed Muhammad / Tariq, Mariam / Umar, Mehrunnisa

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73, Issue 2, Page(s) 284–289

Abstract: Objective: To determine the coronavirus disease-2019-related risk perception and altruistic response among undergraduate medical students post-lockdown.: Methods: The analytical cross-sectional study was conducted from October 1, 2020, to March 31, ... ...

Abstract	Objective: To determine the coronavirus disease-2019-related risk perception and altruistic response among undergraduate medical students post-lockdown. Methods: The analytical cross-sectional study was conducted from October 1, 2020, to March 31, 2021, at the Baqai Medical University, Karachi, and comprised undergraduates aged 16 and above, studying in medical, dental, physiotherapy, pharmacy and Information technology departments. Data was collected using a structured and standardised online questionnaire. Positive responses led to a perceived risk score ranging 0-9, with a higher score indicating a greater perception of risk. The score was corelated with demographic variables. Data was analysed using SPSS 21. Results: Of the 743 subjects, 472(63.5%) were females. The overall mean age of the sample was 21.34±1.8 years. The mean risk perception score was 3.8±2.5, and it was significantly associated with disease exposure (p<0.001). Altruism had a strong association with the perceived risk score (p<0.001), indicating lower risk perception. Conclusion: The risk perception among the students was low, pointing towards a need of psychological assistance programme for the students.
MeSH term(s)	Female ; Humans ; Young Adult ; Adult ; Male ; Altruism ; Cross-Sectional Studies ; COVID-19/epidemiology ; Communicable Disease Control ; Students, Medical ; Perception
Language	English
Publishing date	2023-02-17
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.5633
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Article: Risk of Preterm Delivery in Very Advanced Maternal Age Parturients Utilizing In Vitro Fertilization

Newman, Rachel A. / Naqvi, Mariam / Levian, Candace / Smithson, Sarah D. / Esakoff, Tania

American Journal of Perinatology

2023

Abstract	Objective: Among patients ≥45 years, the birth rate in the United States continues to increase. As fertility declines with age, this cohort often utilizes assisted reproductive technology, specifically in vitro fertilization (IVF). While both advancing maternal age and IVF are independently associated with adverse maternal outcomes, data regarding their additive effect are scant. This article aims to determine if patients who conceive via IVF are at increased risk for preterm birth (PTB) compared to patients with non-IVF pregnancies in a very advanced maternal age (vAMA) cohort (≥45 years). Study Design: Retrospective cohort study of all pregnant patients ≥45 years old who delivered at a single institution (2014–2021). Those with incomplete delivery/neonatal records or multiples beyond twins were excluded. We compared individuals who conceived via IVF to those who conceived without IVF. The primary outcome was preterm delivery <37 weeks gestation. Secondary outcomes included other adverse perinatal outcomes. Using multivariable logistic regression, we adjusted for multiple gestation as well as confounders found to be significantly different in the univariable analysis and other known risk factors for PTB. Results: In our study cohort of 420 vAMA patients, individuals who underwent IVF were more likely to be older, privately insured, nulliparous, and with a twin gestation. The PTB rate in vAMA patients who underwent IVF was 24.4 compared to 8.4% in patients who did not use IVF ( p < 0.001). After adjusting for confounders, IVF was an independent risk factor for PTB <37 weeks in vAMA patients (adjusted odds ratio {aOR] = 4.3, 95% confidence interval [CI]: 1.7–10.4, p = 0.001). In vitro fertilization was also associated with a composite of adverse maternal outcomes (hypertensive disorder of pregnancy, postpartum hemorrhage, blood transfusion, and unplanned hysterectomy) (aOR 1.7, 95% CI [1.1–2.9], p = 0.03). Conclusion: In the vAMA population, conception via IVF is associated with an increased risk of PTB <37 weeks. Key Points: This study examines IVF as an independent risk factor for PTB in patients ≥45 years at delivery, which has not been specifically addressed in prior studies. In vAMA patients, use of IVF is associated with an increased risk of PTB <37 weeks. These patients also have higher rates of cesarean delivery. Neonates from IVF pregnancies are more likely to be very low birth weight or low birth weight. Bodies of research exist for both advanced maternal age and assisted reproductive technology, there is a paucity of data specifically in parturients of vAMA who conceive via IVF.
Keywords	advanced maternal age ; assisted reproductive technology ; in vitro fertilization ; preterm birth ; very advanced maternal age
Language	English
Publishing date	2023-08-21
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	605671-4
ISSN	1098-8785 ; 0735-1631
ISSN (online)	1098-8785
ISSN	0735-1631
DOI	10.1055/a-2157-3106
Database	Thieme publisher's database

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Article ; Online: Emergency Cerclage: Outcomes, Patient Selection, and Operative Considerations.

Naqvi, Mariam / Barth, William H

Clinical obstetrics and gynecology

2016 Volume 59, Issue 2, Page(s) 286–294

Abstract: Emergency cerclage refers to a cerclage placed during the second trimester in a woman noted to have painless cervical dilation. Although randomized-controlled trials are limited, observational studies suggest an improvement in neonatal outcomes in ... ...

Abstract	Emergency cerclage refers to a cerclage placed during the second trimester in a woman noted to have painless cervical dilation. Although randomized-controlled trials are limited, observational studies suggest an improvement in neonatal outcomes in selected patients undergoing an emergency cerclage. Labor and chorioamniontis are contraindications for cerclage placement. Advanced dilation (>3 to 4 cm) and a later gestational age (22 to 24 wk) are associated with poorer outcomes. This chapter reviews the indications, outcomes and perioperative management strategies for cerclage placement in this setting.
MeSH term(s)	Amniocentesis ; Anti-Bacterial Agents/therapeutic use ; Cerclage, Cervical/adverse effects ; Cerclage, Cervical/methods ; Emergencies ; Female ; Humans ; Patient Selection ; Perioperative Care ; Physical Examination ; Pregnancy ; Pregnancy Trimester, Second ; Sutures ; Tocolytic Agents/therapeutic use ; Ultrasonography ; Uterine Cervical Incompetence/surgery
Chemical Substances	Anti-Bacterial Agents ; Tocolytic Agents
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391207-3
ISSN	1532-5520 ; 0009-9201
ISSN (online)	1532-5520
ISSN	0009-9201
DOI	10.1097/GRF.0000000000000197
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Article ; Online: Incorporating personal-device-based point-of-care ultrasound into obstetric care: a validation study.

Leggett, Cecilia B / Naqvi, Mariam / Esakoff, Tania F / Diniz, Marcio A / Wong, Melissa S

American journal of obstetrics and gynecology

2021 Volume 226, Issue 4, Page(s) 552.e1–552.e6

Abstract: Background: Personal-device-based point-of-care-ultrasound (P-POCUS) probes plug directly into a cell phone or tablet to function as its display, creating the potential to increase access to obstetric ultrasonography in complex healthcare settings ( ... ...

Abstract	Background: Personal-device-based point-of-care-ultrasound (P-POCUS) probes plug directly into a cell phone or tablet to function as its display, creating the potential to increase access to obstetric ultrasonography in complex healthcare settings (COVID units, low resource settings); however, new technology must be proven to be reliable in the obstetric setting before integrating into practice. Objective: To evaluate the intraclass correlation (reliability) of personal-device-based-point-of-care-ultrasound devices as compared with standard ultrasound machines in obstetrics. Study design: This was a prospective, observational study of patients between 19-39 weeks gestation in an urban, prenatal ultrasound diagnosis center. Each patient underwent assessment by an expert sonographer using standard ultrasound machines and personal-device-based-point-of-care-ultrasound devices to determine estimated fetal weight. The statistical reliability and agreement between the estimated fetal weights was assessed through intraclass correlation coefficients, Bland-Altman plots, and Pearson correlation coefficients. Results: 100 paired sets of scans were performed from October 2020 to December 2020. For the estimated fetal weights, there was near-perfect agreement, with an intraclass correlation coefficient of 0.99 (P<.0001). Bland-Altman analysis showed an average difference of 53 grams, with 95% limit of agreement between -178 grams and 283 grams. Pearson correlation showed near-perfect correlation between the measurements (r=0.99, P<.0001). Conclusion: personal-device-based point-of-care-ultrasound devices are reliable tools for performing basic obstetrical ultrasound and have the potential to increase access to obstetrical ultrasound worldwide.
MeSH term(s)	COVID-19 ; Female ; Humans ; Point-of-Care Systems ; Pregnancy ; Prospective Studies ; Reproducibility of Results ; Ultrasonography ; Ultrasonography, Prenatal
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	80016-8
ISSN	1097-6868 ; 0002-9378
ISSN (online)	1097-6868
ISSN	0002-9378
DOI	10.1016/j.ajog.2021.11.031
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Article ; Online: Monoclonal Antibodies Casirivimab and Imdevimab in Pregnancy for Coronavirus Disease 2019 (COVID-19).

Mayer, Christopher / VanHise, Katherine / Caskey, Rachel / Naqvi, Mariam / Burwick, Richard M

Obstetrics and gynecology

2021 Volume 138, Issue 6, Page(s) 937–939

Abstract: Background: For unvaccinated individuals with mild-to-moderate coronavirus disease 2019 (COVID-19), monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decrease the risk of severe disease and hospitalization. We ... ...

Abstract	Background: For unvaccinated individuals with mild-to-moderate coronavirus disease 2019 (COVID-19), monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decrease the risk of severe disease and hospitalization. We describe the use of the monoclonal antibodies casirivimab and imdevimab for COVID-19 in pregnancy. Case: Two unvaccinated pregnant individuals presented with moderate COVID-19, one in the second trimester and one in third trimester; both met criteria for outpatient management. To decrease the risk for severe disease, they were treated with casirivimab and imdevimab. Neither experienced an adverse drug reaction, and neither progressed to severe disease. Conclusion: Monoclonal antibodies such as casirivimab and imdevimab, approved under an emergency use authorization, should be considered in unvaccinated pregnant individuals with mild-to-moderate COVID-19 to decrease the risk of severe disease.
MeSH term(s)	Adult ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Neutralizing/therapeutic use ; Antiviral Agents/therapeutic use ; Drug Combinations ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antiviral Agents ; Drug Combinations ; casirivimab and imdevimab drug combination
Language	English
Publishing date	2021-09-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000004603
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Article ; Online: Adnexal masses in pregnancy.

Naqvi, Mariam / Kaimal, Anjali

Clinical obstetrics and gynecology

2015 Volume 58, Issue 1, Page(s) 93–101

Abstract: With the advent of routine obstetrical ultrasound, the diagnosis of an adnexal mass in pregnancy has become increasingly common. Although the reported incidence and expected clinical course varies based on the gestational age at the time of diagnosis and ...

Abstract	With the advent of routine obstetrical ultrasound, the diagnosis of an adnexal mass in pregnancy has become increasingly common. Although the reported incidence and expected clinical course varies based on the gestational age at the time of diagnosis and the criteria used to define an adnexal mass, the majority of adnexal masses diagnosed in pregnancy are benign and are likely to resolve without complication or intervention. This review will discuss the epidemiology of adnexal masses in pregnancy, diagnostic tools, potential complications, and management options during pregnancy.
MeSH term(s)	Adnexal Diseases/diagnosis ; Adnexal Diseases/epidemiology ; Adnexal Diseases/therapy ; Biomarkers, Tumor/blood ; Female ; Humans ; Laparoscopy ; Magnetic Resonance Imaging ; Ovarian Cysts/diagnosis ; Ovarian Cysts/epidemiology ; Ovarian Cysts/therapy ; Pregnancy ; Pregnancy Complications/diagnosis ; Pregnancy Complications/epidemiology ; Pregnancy Complications/therapy ; Pregnancy Complications, Neoplastic/diagnosis ; Pregnancy Complications, Neoplastic/epidemiology ; Pregnancy Complications, Neoplastic/therapy ; Torsion Abnormality/diagnosis ; Torsion Abnormality/epidemiology ; Torsion Abnormality/therapy ; Ultrasonography ; Watchful Waiting
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391207-3
ISSN	1532-5520 ; 0009-9201
ISSN (online)	1532-5520
ISSN	0009-9201
DOI	10.1097/GRF.0000000000000088
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