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Article ; Online: Assessment of the impact of insulin resistance on pancreatic exocrine functions in obese patients

Betul Borku Uysal / Derya Argun

Medicine Science, Vol 10, Iss 3, Pp 998-

2021 Volume 1001

Abstract: We aimed to show whether insufficiency develops in pancreatic exocrine functions since the insulin resistance period or not. We measured the anthropometric parameters, blood glucose profile parameters and fecal elastase-1 (FE-1) levels of a total of 65 ... ...

Abstract	We aimed to show whether insufficiency develops in pancreatic exocrine functions since the insulin resistance period or not. We measured the anthropometric parameters, blood glucose profile parameters and fecal elastase-1 (FE-1) levels of a total of 65 obese patients with 35 insulin resistance and 30 without insulin resistance. Body mass indexes (BMI) and homeostasis of model assessment insulin resistance indexes (HOMA-IR) were calculated. Exocrine pancreatic insufficiency (EPI) was diagnosed with a FE-1of less than 200 mg/g (ELISA). A statistically significant difference was not observed between the mean FE-1 levels between the groups (p> 0.05). No statistically significant difference was observed between the distribution of mild and severe low FE-1 levels of the insulin resistant (IR) and Non-IR groups (p> 0.05). Our study revealed that the presence of insulin resistance does not cause any change in FE-1 levels in obese patients. [Med-Science 2021; 10(3.000): 998-1001]
Keywords	pancreatic exocrine function ; insulin resistance ; fecal elastase-1 ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
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Article ; Online: Angioedema after favipiravir treatment: Two cases.

Islamoglu, Mehmet Sami / Dokur, Mehmet / Borku Uysal, Betul / Onal, Burak

Journal of cosmetic dermatology

2022 Volume 21, Issue 9, Page(s) 3704–3706

Abstract: Drug-induced angioedema often affects elderly patients with chronic drug use. Proper diagnosis and prompt with effective treatment reduce mortality. With the increasing use of favipiravir, many side effects, especially increased alanine aminotransferase ( ...

Abstract	Drug-induced angioedema often affects elderly patients with chronic drug use. Proper diagnosis and prompt with effective treatment reduce mortality. With the increasing use of favipiravir, many side effects, especially increased alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels due to liver toxicity, and also skin lesions are reported. First patient oral favipiravir treatment on the second day was admitted to the hospital with rash and swelling on the eyelids. Second patient suffered from significant swelling on the upper lip and displayed angioedema. In this cases, angioedema findings regressed after rapid diagnosis and parenterally administered antihistamine and steroid treatment. Although there is no effective drug therapy in the treatment of COVID-19, favipiravir is also included in the treatment protocols in many countries. Clinicians should be careful about the side effects and possible skin manifestations, especially including angioedema, related to the use of favipiravir.
MeSH term(s)	Aged ; Alanine Transaminase ; Amides ; Angioedema/chemically induced ; Angioedema/diagnosis ; Aspartate Aminotransferases ; COVID-19/drug therapy ; Humans ; Pyrazines ; Steroids
Chemical Substances	Amides ; Pyrazines ; Steroids ; Aspartate Aminotransferases (EC 2.6.1.1) ; Alanine Transaminase (EC 2.6.1.2) ; favipiravir (EW5GL2X7E0)
Language	English
Publishing date	2022-01-30
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2280551-5
ISSN	1473-2165 ; 1473-2130
ISSN (online)	1473-2165
ISSN	1473-2130
DOI	10.1111/jocd.14790
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Article ; Online: Evaluation of salusin-α and salusin-β levels in patients with type 2 diabetes mellitus and determination of the impact of severity of hyperglycemia on salusin levels.

Argun, Derya / Argun, Ferit / Borku Uysal, Betul

Irish journal of medical science

2021 Volume 190, Issue 4, Page(s) 1403–1411

Abstract: Aims: To investigate the usefulness of salusin-α and salusin-β as biomarkers in patients with type 2 diabetes mellitus (T2DM) and to determine whether diabetes severity and obesity have an effect on the salusin levels in diabetic patients.: Methods: ... ...

Abstract	Aims: To investigate the usefulness of salusin-α and salusin-β as biomarkers in patients with type 2 diabetes mellitus (T2DM) and to determine whether diabetes severity and obesity have an effect on the salusin levels in diabetic patients. Methods: The study included a total of 90 patients, comprising 55 diagnosed with T2DM and 35 healthy volunteers with similar demographic characteristics. Salusins were assayed by a commercially available ELISA kit. Results: The salusin-β levels were found to be significantly higher in T2DM group compared to control group, while the salusin-α levels were lower (p < 0.05, for both). Furthermore, in patient group, Spearman analysis showed a statistically significant negative correlation between salusin-α and fasting glucose and glycated hemoglobin (HbA1c), whereas salusin-β had a statistically significant positive correlation with fasting glucose and HbA1c (p < 0.05, for both). When analyzed according to the HbA1c groups, the patients with HbA1c > 9% had significantly lower salusin-α and higher salusin-β levels levels compared to those with HbA1c < 9% (p < 0.05, for both). When examined according to body-mass-index groups, there was no significant difference in the salusin levels of the patient and control groups (p > 0.05). Conclusion: We demonstrated that the serum salusin-α level was decreased whereas the salusin-β level was increased in patients with T2DM compared to healthy subjects, and this was more pronounced as T2DM-deteriorated. We also showed that obesity had no effect on salusin levels among diabetics. This study may provide a basis for the availability of salusin-targeted therapies, especially in uncontrolled T2DM.
MeSH term(s)	Biomarkers ; Body Mass Index ; Diabetes Mellitus, Type 2/complications ; Glycated Hemoglobin A ; Humans ; Hyperglycemia ; Intercellular Signaling Peptides and Proteins
Chemical Substances	Biomarkers ; Glycated Hemoglobin A ; Intercellular Signaling Peptides and Proteins ; TOR2A protein, human
Language	English
Publishing date	2021-06-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-021-02674-4
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Article: Messenger ribonucleic acid vaccine-associated immune thrombocytopenia: A rare complication of vaccine.

Islamoglu, Mehmet Sami / Dokur, Mehmet / Uysal, Betul Borku / Gunduz, Mehmet

Turkish journal of emergency medicine

2022 Volume 22, Issue 2, Page(s) 111–113

Abstract: Coronavirus disease-2019 continues to have a serious impact in countries with the effect of new variant viruses emerging with mutations. While the effectiveness and protection of the vaccine have been determined all over the world, some vaccine-related ... ...

Abstract	Coronavirus disease-2019 continues to have a serious impact in countries with the effect of new variant viruses emerging with mutations. While the effectiveness and protection of the vaccine have been determined all over the world, some vaccine-related side effects can be detected in the form of cases. In our case, the patient was admitted to the emergency department of our hospital with complaints of weakness and progressive rash on his legs. Diffuse petechiae purpura on the legs of the patient was observed and complete blood count revealed thrombocytopenia. Peripheral blood smear supported the blood count test results with thrombocytopenia, secondary causes of thrombocytopenia were excluded, and the patient was diagnosed with vaccine-induced immune thrombocytopenia.
Language	English
Publishing date	2022-04-11
Publishing country	India
Document type	Case Reports
ISSN	2452-2473
ISSN	2452-2473
DOI	10.4103/2452-2473.342810
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Article ; Online: Measurement of antibody levels in patients with COVID-19 over time by immunofluorescence assay

Betul Borku Uysal / Serap Yavuzer / Mehmet Sami Islamoglu / Mahir Cengiz

Journal of International Medical Research, Vol

a longitudinal observational study

2022 Volume 50

Abstract: Background During the coronavirus disease 2019 (COVID-19) pandemic, antibody screening is a critical tool to assess anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. We examined variation in antibody titers associated with age ... ...

Abstract	Background During the coronavirus disease 2019 (COVID-19) pandemic, antibody screening is a critical tool to assess anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. We examined variation in antibody titers associated with age and sex among patients with confirmed COVID-19. Methods Blood IgG levels were tested in 1081 patients with positive SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (RT-qPCR) tests between 1 September and 31 December 2020. Patients who did not experience reinfection were identified. Serum IgG levels were measured by immunofluorescence assay. Antibody positivity and antibody titers were analyzed according to time since infection, sex, and age. Results The mean (standard deviation) age was 41.2 (14.2) years and 41.2% of patients were women. The lowest antibody positivity rate between the first and ninth month post-infection was detected in the sixth month. The lowest antibody titers among patients aged 20 to 80 years occurred in those aged 30 to 39 years. The IgG titer was positively correlated with age in years (r = 0.125) and decades (r = 0.126). Conclusions Six months after infection, anti-SARS-CoV-2 antibody titers increased. Anti-SARS-CoV-2 antibody titers also increased with age. Immunity and pathogenicity should be investigated in addition to antibody positivity rates and antibody titers.
Keywords	Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
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Article ; Online: SARS-CoV-2 antibody seroprevalence in healthcare personnel during the pandemic's peak

Mehmet Sami Islamoglu / Mahir Cengiz / Betul Borku Uysal / Serap Yavuzer

Medicine Science, Vol 11, Iss 1, Pp 154-

The experience of single hospital

2022 Volume 8

Abstract: Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies determination in healthcare personnels with a increased risk of infection is important for detecting asymptomatic coronavirus disease 2019 (COVID-19) and post-disease ... ...

Abstract	Serological severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies determination in healthcare personnels with a increased risk of infection is important for detecting asymptomatic coronavirus disease 2019 (COVID-19) and post-disease immunity. Purpose of study were to determine the seroprevelance of healthcare personnels with COVID-19 in university hospital. 439 healthcare personnels working at Biruni University Medical Faculty Hospital between March 2020 to January 2021 were included to the study. All participants were divided into groups based on the results of their immunoglobulin G (IgG) antibodies against novel coronavirus in blood test, collecting nasopharyngeal and oropharyngeal swabs reverse transcriptasepolymerase chain reaction (RT-PCR), and thorax computed tomography (CT). Group 1: Antibody positivity and RT- PCR negativity, Group 2: RT-PCR positivity without lung involvement, Group 3: RT-PCR positivity with lung involvement. The RT-PCR positivity was detected as 32.8 % (n=144) in all healthcare personnels, 68.8 % of RT-PCR positive healthcare personnels were symptomatic and 15.3 % of them had lung involvement. The IgG antibody positivity was detected as 41 % (n=180) in all healthcare personnels. The antibody positivity (p=0.353) and titers were similar in the healthcare personnels (p=0.361). Risk of COVID-19 and contagiousness is high in healthcare personnels under pandemic conditions. Additionally the antibody positivity and antibody titer are higher in those who have symptomatic disease compared to those who have asymptomatic. [Med-Science 2022; 11(1.000): 154-8]
Keywords	sars-cov-2 antibody ; healthcare personnel ; seroprevalence,covid-19 ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
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Article: Mad Honey Poisoning Case Series Presenting With ECG Findings Including Atrioventricular Complete Block and Symptomatic Hypotension.

Islamoglu, Mehmet Sami / Dokur, Mehmet / Talibli, Kanan / Borku Uysal, Betul / Ozdemir, Emrah

Cureus

2021 Volume 13, Issue 8, Page(s) e17165

Abstract: Plants belonging to the Ericaceae family, which grow endemically in some parts of the world, contain grayanotoxin, which causes fatal bradyarrhythmia and circulatory collapse. Mad honey, which comes from plants with grayanotoxin, has various uses, namely, ...

Abstract	Plants belonging to the Ericaceae family, which grow endemically in some parts of the world, contain grayanotoxin, which causes fatal bradyarrhythmia and circulatory collapse. Mad honey, which comes from plants with grayanotoxin, has various uses, namely, as an aphrodisiac, as an alternative therapy for GI disorders such as peptic ulcer, dyspepsia, and gastritis, and as a treatment for hypertension. However, GI, neurological and cardiac side effects may arise from its ingestion due to the grayanotoxin contained by this type of honey. Cardiac rhythm disturbances, sinus bradycardia, and other life-threatening side effects can occur, especially atrioventricular (AV) block and nodal rhythms. In this article, we present five honey poisoning cases involving adults who were admitted to our ED. Notably, one of the patients was unresponsive to atropine, so a temporary pacemaker was inserted, after which the patient was moved to the coronary ICU. Meanwhile, the cardiac rhythm of the other cases returned to normal in the follow-up after atropine administration.
Language	English
Publishing date	2021-08-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.17165
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Article ; Online: Measurement of antibody levels in patients with COVID-19 over time by immunofluorescence assay: a longitudinal observational study.

Uysal, Betul Borku / Yavuzer, Serap / Islamoglu, Mehmet Sami / Cengiz, Mahir

The Journal of international medical research

2021 Volume 50, Issue 1, Page(s) 3000605211069279

Abstract: Background: During the coronavirus disease 2019 (COVID-19) pandemic, antibody screening is a critical tool to assess anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. We examined variation in antibody titers associated with age ...

Abstract	Background: During the coronavirus disease 2019 (COVID-19) pandemic, antibody screening is a critical tool to assess anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity. We examined variation in antibody titers associated with age and sex among patients with confirmed COVID-19. Methods: Blood IgG levels were tested in 1081 patients with positive SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (RT-qPCR) tests between 1 September and 31 December 2020. Patients who did not experience reinfection were identified. Serum IgG levels were measured by immunofluorescence assay. Antibody positivity and antibody titers were analyzed according to time since infection, sex, and age. Results: The mean (standard deviation) age was 41.2 (14.2) years and 41.2% of patients were women. The lowest antibody positivity rate between the first and ninth month post-infection was detected in the sixth month. The lowest antibody titers among patients aged 20 to 80 years occurred in those aged 30 to 39 years. The IgG titer was positively correlated with age in years (r = 0.125) and decades (r = 0.126). Conclusions: Six months after infection, anti-SARS-CoV-2 antibody titers increased. Anti-SARS-CoV-2 antibody titers also increased with age. Immunity and pathogenicity should be investigated in addition to antibody positivity rates and antibody titers.
MeSH term(s)	Adult ; Antibodies, Viral ; COVID-19 ; Female ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin G ; Pandemics ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2021-12-04
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605211069279
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Article ; Online: Most notable 100 articles of COVID-19: an Altmetric study based on bibliometric analysis.

Borku Uysal, Betul / Islamoglu, Mehmet Sami / Koc, Suna / Karadag, Mehmet / Dokur, Mehmet

Irish journal of medical science

2021 Volume 190, Issue 4, Page(s) 1335–1341

Abstract: Objective: The purpose of this study is to guide researchers in the COVID-19 pandemic by evaluating the 100 most cited articles of COVID-19 in terms of bibliometric analysis, Altmetric scores, and dimension badges.: Methods: "COVID-19" was entered as ...

Abstract	Objective: The purpose of this study is to guide researchers in the COVID-19 pandemic by evaluating the 100 most cited articles of COVID-19 in terms of bibliometric analysis, Altmetric scores, and dimension badges. Methods: "COVID-19" was entered as the search term in Thomson Reuter's Web of Science database. The 100 most cited articles (T100) were analyzed bibliometrically. Altmetric attention scores (AASs) and dimension badge scores of the articles were evaluated. Results: T100 articles were published from January to September 2020. The average citation of the top 100 articles on COVID-19 was 320 ± 344.3 (143-2676). The language of all articles was English. The average Altmetric value of T100 is 3246 ± 3795 (85-16,548) and the mean dimension badge value was 670 ± 541.6 (176-4232). Epidemiological features (n = 22) and treatment (n = 21) were at the top of the main topics of T100 articles. Conclusion: The more citations an article is made, the more it indicates the contribution of that article to science. However, the number of citations is not always the only indicator of article quality. The existence of methods that measure the impact of the article outside the academia to measure the value of the article arises more in an issue that affects the whole world, such as the COVID-19 pandemic.
MeSH term(s)	Bibliometrics ; COVID-19 ; Humans ; Pandemics ; Publications ; SARS-CoV-2
Language	English
Publishing date	2021-01-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-020-02460-8
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Article ; Online: Case Report: Two Cases of Persistent Hiccups Complicating COVID-19.

Ikitimur, Hande / Borku Uysal, Betul / Ikitimur, Barıs / Umihanic, Sefika / Smajic, Jasmina / Jahic, Rahima / Olcay, Ayhan

The American journal of tropical medicine and hygiene

2021 Volume 104, Issue 5, Page(s) 1713–1715

Abstract: Two cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one during initial presentation and one 10 days after COVID-19 diagnosis. Hiccups in both patients were resistant to treatment and responded only to chlorpromazine. COVID-19 ... ...

Abstract	Two cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one during initial presentation and one 10 days after COVID-19 diagnosis. Hiccups in both patients were resistant to treatment and responded only to chlorpromazine. COVID-19 patients may present with hiccups and also may have hiccups after treatment. Resistant hiccups without any underlying disease other than COVID-19 should be considered in association with COVID-19 and may respond well to chlorpromazine.
MeSH term(s)	Aged ; COVID-19/complications ; Chlorpromazine/therapeutic use ; Hiccup/drug therapy ; Hiccup/etiology ; Humans ; Male ; Middle Aged ; SARS-CoV-2
Chemical Substances	Chlorpromazine (U42B7VYA4P)
Language	English
Publishing date	2021-04-01
Publishing country	United States
Document type	Case Reports
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.21-0190
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