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  1. Article ; Online: The authors reply.

    Sharif, Sameer / Rochwerg, Bram

    Critical care medicine

    2022  Volume 50, Issue 12, Page(s) e810–e811

    Language English
    Publishing date 2022-11-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tocilizumab did not reduce hypoxemic respiratory failure or death in hospitalized patients with COVID-19.

    Sharif, Sameer / Rochwerg, Bram

    Annals of internal medicine

    2021  Volume 174, Issue 2, Page(s) JC16

    Abstract: Source citation: Stone JH, Frigault MJ, Serling-Boyd NJ, et al. ...

    Abstract Source citation: Stone JH, Frigault MJ, Serling-Boyd NJ, et al.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal, Humanized/therapeutic use ; COVID-19/drug therapy ; COVID-19/mortality ; Female ; Humans ; Male ; Middle Aged ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic ; Respiratory Insufficiency/drug therapy ; Respiratory Insufficiency/mortality ; Respiratory Insufficiency/virology ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/ACPJ202102160-016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comment on "Labia minora tourniquet syndrome in an adult resulting from erotic dancing".

    Chan, Kathryn / Cook-Chaimowitz, Lauren / Sharif, Sameer

    CJEM

    2021  Volume 23, Issue 3, Page(s) 415

    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Letter
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-020-00003-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: Is dexamethasone an effective treatment for severe COVID‑19 patients: Journal Club review.

    Chan, Kathryn / Sharif, Sameer / Rochwerg, Bram

    CJEM

    2021  Volume 23, Issue 3, Page(s) 412

    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Published Erratum
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-021-00091-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: VICE raises the GRADE: recommendations for CAEP clinical practice guidelines.

    Upadhye, Suneel / Sharif, Sameer / Lang, Eddy / Rochwerg, Bram

    CJEM

    2021  Volume 23, Issue 4, Page(s) 427–431

    MeSH term(s) Emergency Medicine ; Humans
    Language English
    Publishing date 2021-04-20
    Publishing country England
    Document type Editorial
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-021-00133-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comparative Effectiveness of Ketorolac Dosing Strategies for Emergency Department Patients With Acute Pain.

    Forestell, Ben / Sabbineni, Monica / Sharif, Sameer / Chao, Jennifer / Eltorki, Mohamed

    Annals of emergency medicine

    2023  Volume 82, Issue 5, Page(s) 615–623

    Abstract: Study objectives: Ketorolac is a commonly used nonopioid parenteral analgesic for treating emergency department (ED) patients with acute pain. Our systematic review aims to summarize the available evidence by comparing the efficacy and safety of ... ...

    Abstract Study objectives: Ketorolac is a commonly used nonopioid parenteral analgesic for treating emergency department (ED) patients with acute pain. Our systematic review aims to summarize the available evidence by comparing the efficacy and safety of differing ketorolac dosing strategies for acute pain relief in the ED.
    Methods: The review was registered on PROSPERO (CRD42022310062). We searched MEDLINE, PubMed, EMBASE, and unpublished sources from inception through December 9, 2022. We included randomized control trials of patients presenting with acute pain to the ED, comparing ketorolac doses less than 30 mg (low dose) to ketorolac doses more than or equal to 30 mg (high dose) for the outcomes of pain scores after treatment need for rescue analgesia, and incidence of adverse events. We excluded patients in non-ED settings, including postoperative settings. We extracted data independently and in duplicate and pooled them using a random-effects model. We assessed the risk of bias using the Cochrane Risk of Bias 2 tool and the overall certainty of the evidence for each outcome using the Grading Recommendations Assessment, Development, and Evaluation approach.
    Results: This review included 5 randomized controlled trials (n=627 patients). Low-dose parenteral ketorolac (15 to 20 mg), as compared to high-dose ketorolac (≥30 mg), probably has no effect on pain scores (mean difference 0.05 mm lower on 100 mm visual analog scale, 95% confidence interval [CI] -4.91 mm to +5.01 mm; moderate certainty). Further, low-dose ketorolac at 10 mg may have no effect on pain scores compared to high-dose ketorolac (mean difference 1.58 mm lower on 100 mm visual analog scale, 95% CI -8.86 mm to +5.71 mm; low certainty). Low-dose ketorolac may increase the need for rescue analgesia (risk ratio 1.27, 95% CI 0.86 to 1.87; low certainty) and may have no difference on rates of adverse events (risk ratio 0.84, 95% CI 0.54 to 1.33; low certainty).
    Conclusion: In adult ED patients with acute pain, parenteral ketorolac given at doses of 10 mg to 20 mg is probably as effective in relieving pain as doses of 30 mg or higher. Low-dose ketorolac may have no effect on adverse events, but these patients may require more rescue analgesia. This evidence is limited by imprecision and is not generalizable to children or those at higher risk of adverse events.
    Language English
    Publishing date 2023-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603080-4
    ISSN 1097-6760 ; 0196-0644
    ISSN (online) 1097-6760
    ISSN 0196-0644
    DOI 10.1016/j.annemergmed.2023.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Does hypothermia versus normothermia after out-of-hospital cardiac arrest improve patient-oriented outcomes?

    Greer, Alisha / Rochwerg, Bram / Sharif, Sameer

    CJEM

    2021  Volume 23, Issue 6, Page(s) 755–757

    MeSH term(s) Cardiopulmonary Resuscitation ; Humans ; Hypothermia ; Hypothermia, Induced ; Out-of-Hospital Cardiac Arrest/therapy
    Language English
    Publishing date 2021-10-05
    Publishing country England
    Document type Editorial ; Comment
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-021-00211-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: VDI pacing with temporary esophageal and transvenous pacemaker leads to treat post-cardiac surgery cardiogenic shock.

    Sharif, Sameer / Dyub, Adel / Ainsworth, Craig

    Journal of cardiothoracic surgery

    2022  Volume 17, Issue 1, Page(s) 101

    Abstract: Background: Post-operative atrio-ventricular (AV) block after cardiac surgery is not uncommon in high-risk patients.: Case presentation: Our case highlights the management of a 62-year-old female with cardiogenic shock post-cardiac surgery with ... ...

    Abstract Background: Post-operative atrio-ventricular (AV) block after cardiac surgery is not uncommon in high-risk patients.
    Case presentation: Our case highlights the management of a 62-year-old female with cardiogenic shock post-cardiac surgery with concomitant complete heart block. With VVI pacing proving ineffective, it was postulated that the patient may benefit hemodynamically from AV sequential pacing, re-establishing her atrial kick. We describe a novel technique of attaching a temporary pacemaker wire to an orogastric tube to sense atrial p-waves and pace the ventricle transvenously to perform AV sequential pacing. This was done temporarily to stabilize the patient's hemodynamic status while awaiting a permanent pacemaker implantation.
    Conclusions: In hemodynamically unstable post-cardiac surgery patients with complete heart block in whom VVI pacing fails to improve their clinical status, clinicians should consider VDI pacing with an orogastric atrial sensing pacemaker lead, in consultation with the cardiac surgeon and the electrophysiology team. Of note, the patient needs to have underlying organized atrial activity for this setup to work.
    MeSH term(s) Atrioventricular Block ; Cardiac Pacing, Artificial/methods ; Cardiac Surgical Procedures ; Female ; Humans ; Middle Aged ; Pacemaker, Artificial/adverse effects ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/surgery
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2227224-0
    ISSN 1749-8090 ; 1749-8090
    ISSN (online) 1749-8090
    ISSN 1749-8090
    DOI 10.1186/s13019-022-01849-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Is dexamethasone an effective treatment for severe COVID-19 patients: Journal Club review.

    Chan, Kathryn / Sharif, Sameer / Rochwerg, Bram

    CJEM

    2021  Volume 23, Issue 2, Page(s) 159–161

    MeSH term(s) COVID-19/drug therapy ; COVID-19/epidemiology ; Dexamethasone/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Pandemics ; SARS-CoV-2 ; Treatment Outcome
    Chemical Substances Glucocorticoids ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Editorial
    ISSN 1481-8043
    ISSN (online) 1481-8043
    DOI 10.1007/s43678-020-00033-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pandemics and Innovation: How Medical Education Programs Can Adapt Extraclinical Teaching to Maintain Social Distancing.

    Sharif, Sameer / Sherbino, Jonathan / Centofanti, John / Karachi, Tim

    ATS scholar

    2020  Volume 1, Issue 4, Page(s) 344–347

    Language English
    Publishing date 2020-08-04
    Document type Journal Article
    ISSN 2690-7097
    ISSN (online) 2690-7097
    DOI 10.34197/ats-scholar.2020-0084CM
    Database MEDical Literature Analysis and Retrieval System OnLINE

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