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  1. Article ; Online: Acute kidney injury or acute kidney disease: is it time to change endpoints in studies relying on intensive nephrology care?

    Faguer, Stanislas / Schanstra, Joost P

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 39, Issue 3, Page(s) 385–386

    MeSH term(s) Humans ; Nephrology ; Acute Kidney Injury/therapy ; Critical Care ; Acute Disease
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad236
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  2. Article ; Online: Plasma cell-directed therapy for rituximab-refractory PLA2R+ membranous nephropathy.

    Salhi, Sofiane / Ribes, David / Fortenfant, Françoise / Faguer, Stanislas

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2023  Volume 38, Issue 12, Page(s) 2851–2853

    MeSH term(s) Humans ; Rituximab/therapeutic use ; Glomerulonephritis, Membranous/drug therapy ; Plasma Cells ; Autoantibodies ; Receptors, Phospholipase A2
    Chemical Substances Rituximab (4F4X42SYQ6) ; Autoantibodies ; Receptors, Phospholipase A2
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfad135
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  3. Article ; Online: IL-4Rα Inhibition for Severe "Eosinophilic Gastroenteritis, Allergy, and Anaphylaxis" Syndrome due to a Gain-of-Function Variant in STAT6.

    Faguer, Stanislas / Delabesse, Eric / Paul, Carle / Pasquet, Marlène

    Journal of clinical immunology

    2023  Volume 44, Issue 1, Page(s) 29

    MeSH term(s) Humans ; Anaphylaxis/diagnosis ; Enteritis ; Eosinophilia/diagnosis ; Gain of Function Mutation ; STAT6 Transcription Factor/genetics ; STAT6 Transcription Factor/metabolism
    Chemical Substances STAT6 protein, human ; STAT6 Transcription Factor
    Language English
    Publishing date 2023-12-22
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-023-01639-9
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    Zs.A 1640: Show issues Location:
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  4. Article ; Online: Early use of eculizumab for catastrophic antiphospholipid syndrome.

    Faguer, Stanislas / Ribes, David

    British journal of haematology

    2021  Volume 196, Issue 2, Page(s) e12–e14

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Antiphospholipid Syndrome/drug therapy ; Humans ; Recurrence
    Chemical Substances Antibodies, Monoclonal, Humanized ; eculizumab (A3ULP0F556)
    Language English
    Publishing date 2021-08-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17783
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  5. Article ; Online: HRCT imaging of pulmonary involvement in granulomatosis with polyangiitis and microscopic polyangiitis at disease onset and during follow-up.

    Villeneuve, Thomas / Faguer, Stanislas / Collot, Samia / Pugnet, Grégory / Prévot, Grégoire

    Seminars in arthritis and rheumatism

    2023  Volume 63, Page(s) 152307

    Abstract: Background: The pulmonary involvement in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) is well known at disease onset but data during follow-up (after the induction regimen and when the first relapse occurs) are ...

    Abstract Background: The pulmonary involvement in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) is well known at disease onset but data during follow-up (after the induction regimen and when the first relapse occurs) are limited. Our goal was to analyze chest high-resolution computed tomography (HRCT) findings of (ANCA)-associated vasculitis patients.
    Method: All consecutive unselected AAV patients over eighteen with positive ANCA status and with HRCT chest performed at the diagnosis were retrospectively enrolled between 2004 and 2019 at the Toulouse University Hospital (France). Two experienced pulmonologists and one expert respiratory radiologist reviewed independently HRCT chest scans.
    Results: A total of 157 AAV patients were included in the study. Two-thirds of AAV patients had pulmonary involvement at diagnosis. Diffuse alveolar hemorrhage (DAH) was observed in 31.2 % of cases, nodules and masses in 18.5 %, bronchial airway involvement in 13.4 %, and interstitial involvement in 12.7 %. Following the induction regimen, chest HRCT scans over a two-year period demonstrated significant improvement in DAH and nodular manifestations, whereas bronchial airway involvement exhibited variability and half of cases of interstitial lung disease (ILD) had progressive course. Outcomes and survival rates are better for nodular and bronchial involvement. DAH was the most frequent cause of deaths. Progressive fibrotic changes in ILD over time could impact prognosis despite AAV remission.
    Conclusion: Employing a pattern-based approach with HRCT chest scans to assess lung involvement could be valuable in predicting treatment response, relapse, mortality, and could improved the management of AAV patients.
    MeSH term(s) Humans ; Microscopic Polyangiitis/complications ; Microscopic Polyangiitis/diagnostic imaging ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnostic imaging ; Antibodies, Antineutrophil Cytoplasmic ; Retrospective Studies ; Follow-Up Studies ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/complications ; Lung Diseases, Interstitial/complications ; Hemorrhage ; Recurrence
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2023-11-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2023.152307
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    Zs.A 790: Show issues Location:
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  6. Article: Role of bronchoscopy for respiratory involvement in granulomatosis with polyangiitis and microscopic polyangiitis.

    Villeneuve, Thomas / Prévot, Grégoire / Pugnet, Grégory / Plat, Gavin / Héluain, Valentin / Faguer, Stanislas / Guibert, Nicolas

    ERJ open research

    2023  Volume 9, Issue 5

    Abstract: Objectives: This study describes data from bronchoscopy performed at the diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).: Methods: We conducted a retrospective study between 2004 and 2019 in patients aged >18 ... ...

    Abstract Objectives: This study describes data from bronchoscopy performed at the diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
    Methods: We conducted a retrospective study between 2004 and 2019 in patients aged >18 years with a diagnosis of microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) who underwent bronchoscopy at onset of the disease. We collected bronchoalveolar lavage (BAL) and histological findings obtained during bronchoscopy.
    Results: 274 patients with AAV were identified. Among 92 bronchoscopies, 62 were performed at diagnosis, and 58 procedures were finally analysed. Cough was more frequent in patients with MPA than GPA (p=0.02). The presence of endobronchial lesions (24.1%) was found to be significantly associated with GPA (p<0.0001) and proteinase 3-ANCA (p=0.01). The most frequent endobronchial lesions were inflammation and hyperaemia of the bronchial mucosa (50%), followed by stenoses (28%), ulcerations (21%) and mass-like granulomatosis (7%). The diagnostic yield of bronchial biopsies was useful for visible lesions (66.6%
    Conclusion: Bronchoscopy is an informative procedure at the onset of AAV disease in patients with respiratory manifestations. Endobronchial lesions are more frequently found in GPA and should be biopsied. BAL can be used to confirm DAH or diagnose superadded infection.
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00141-2023
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  7. Article ; Online: Acetate-Free Biofiltration Versus Online Acetate-Free Hemodiafiltration in Patients at High Risk of Hemodialysis Intolerance.

    Apter, Clara / Seigneuric, Bruno / Darres, Amandine / Longlune, Nathalie / Kamar, Nassim / Cointault, Olivier / Faguer, Stanislas

    Kidney international reports

    2022  Volume 7, Issue 5, Page(s) 1108–1111

    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2022.01.1056
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  8. Article ; Online: Bortezomib plus dexamethasone for rituximab-resistant PLA2R

    Salhi, Sofiane / Ribes, David / Colombat, Magali / Fortenfant, Françoise / Faguer, Stanislas

    Kidney international

    2021  Volume 100, Issue 3, Page(s) 708–709

    MeSH term(s) Bortezomib ; Dexamethasone ; Glomerulonephritis, Membranous/drug therapy ; Humans ; Rituximab
    Chemical Substances Rituximab (4F4X42SYQ6) ; Bortezomib (69G8BD63PP) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.04.011
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    Zs.A 797: Show issues Location:
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  9. Article ; Online: Role of bronchoscopy for respiratory involvement in granulomatosis with polyangiitis and microscopic polyangiitis

    Thomas Villeneuve / Grégoire Prévot / Grégory Pugnet / Gavin Plat / Valentin Héluain / Stanislas Faguer / Nicolas Guibert

    ERJ Open Research, Vol 9, Iss

    2023  Volume 5

    Abstract: Objectives This study describes data from bronchoscopy performed at the diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods We conducted a retrospective study between 2004 and 2019 in patients aged >18 years with ...

    Abstract Objectives This study describes data from bronchoscopy performed at the diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods We conducted a retrospective study between 2004 and 2019 in patients aged >18 years with a diagnosis of microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) who underwent bronchoscopy at onset of the disease. We collected bronchoalveolar lavage (BAL) and histological findings obtained during bronchoscopy. Results 274 patients with AAV were identified. Among 92 bronchoscopies, 62 were performed at diagnosis, and 58 procedures were finally analysed. Cough was more frequent in patients with MPA than GPA (p=0.02). The presence of endobronchial lesions (24.1%) was found to be significantly associated with GPA (p<0.0001) and proteinase 3-ANCA (p=0.01). The most frequent endobronchial lesions were inflammation and hyperaemia of the bronchial mucosa (50%), followed by stenoses (28%), ulcerations (21%) and mass-like granulomatosis (7%). The diagnostic yield of bronchial biopsies was useful for visible lesions (66.6% versus 0%; p=0.006). On BAL, diffuse alveolar haemorrhage (DAH) was detected in 31 (53.4%) patients and was more frequent in MPA patients (70.4% versus 38.7%; p=0.016). In 16.1% of DAH cases, BAL confirmed the diagnosis despite the absence of clinical or biological arguments. The incidence of microbial infections on BAL (38%) was similar between MPA and GPA (p=0.54). Conclusion Bronchoscopy is an informative procedure at the onset of AAV disease in patients with respiratory manifestations. Endobronchial lesions are more frequently found in GPA and should be biopsied. BAL can be used to confirm DAH or diagnose superadded infection.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: JAK inhibition for CD3

    Faguer, Stanislas / Groh, Matthieu / Vergez, François / Hunault-Berger, Mathilde / Duployez, Nicolas / Renaudineau, Yves / Paul, Carle / Lefevre, Guillaume / Kahn, Jean-Emmanuel

    Clinical immunology (Orlando, Fla.)

    2023  Volume 251, Page(s) 109275

    Abstract: Alternatives are urgently needed in patients with ... ...

    Abstract Alternatives are urgently needed in patients with CD3
    MeSH term(s) Humans ; Prednisone/therapeutic use ; Prospective Studies ; CD3 Complex ; Hypereosinophilic Syndrome/drug therapy ; CD4-Positive T-Lymphocytes
    Chemical Substances ruxolitinib (82S8X8XX8H) ; Prednisone (VB0R961HZT) ; CD3 Complex
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109275
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    Zs.A 880: Show issues Location:
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