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  1. Article ; Online: Psychosocial Functioning in Transgender Youth after Hormones.

    Jorgensen, Sarah C J

    The New England journal of medicine

    2023  Volume 389, Issue 16, Page(s) 1537–1538

    MeSH term(s) Humans ; Adolescent ; Transgender Persons/psychology ; Psychosocial Functioning ; Hormones ; Gender Identity
    Chemical Substances Hormones
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2302030
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  2. Article ; Online: Iatrogenic Harm in Gender Medicine.

    Jorgensen, Sarah C J

    Journal of sex & marital therapy

    2023  Volume 49, Issue 8, Page(s) 939–944

    Abstract: Although transition regret and detransition are often dismissed as rare, the increasing number of young detransitioners who have come forward in recent years to publicly share their experiences suggests that there are cracks in the gender-affirmation ... ...

    Abstract Although transition regret and detransition are often dismissed as rare, the increasing number of young detransitioners who have come forward in recent years to publicly share their experiences suggests that there are cracks in the gender-affirmation model of care that can no longer be ignored. In this commentary, I argue that the medical community must find ways to have more open discussions and commit to research and clinical collaboration so that regret and detransition really are vanishingly rare outcomes. Moving forward, we must recognize detransitioners as survivors of iatrogenic harm and provide them with the personalized medicine and supports they require.
    MeSH term(s) Humans ; Emotions ; Iatrogenic Disease ; Gender Identity
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 752393-2
    ISSN 1521-0715 ; 0092-623X
    ISSN (online) 1521-0715
    ISSN 0092-623X
    DOI 10.1080/0092623X.2023.2224320
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    Zs.A 1317: Show issues Location:
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  3. Article ; Online: Nirsevimab: review of pharmacology, antiviral activity and emerging clinical experience for respiratory syncytial virus infection in infants.

    Jorgensen, Sarah C J

    The Journal of antimicrobial chemotherapy

    2023  Volume 78, Issue 5, Page(s) 1143–1149

    Abstract: Respiratory syncytial virus (RSV) is a leading cause of hospitalization and infant mortality worldwide. There are currently no approved vaccines against RSV, and immunoprophylaxis with the mAb palivizumab is limited to extremely vulnerable infants in ... ...

    Abstract Respiratory syncytial virus (RSV) is a leading cause of hospitalization and infant mortality worldwide. There are currently no approved vaccines against RSV, and immunoprophylaxis with the mAb palivizumab is limited to extremely vulnerable infants in resource-rich settings due to its high cost and the need for monthly injections throughout the RSV season. Nirsevimab (formerly MEDI8897) is a highly potent, long-acting, human, recombinant mAb that received approval for the prevention of RSV infection in newborns and infants during their first RSV season from the EMA and the UK's Medicines and Healthcare products Regulatory Agency in November 2022 based on positive results in Phase 2b and 3 clinical trials. Nirsevimab targets the highly conserved site Ø of the prefusion conformation of the RSV fusion (F) protein and contains a triple amino acid substitution in the Fc domain that extends its half-life, allowing for a single dose to cover a typical RSV season in regions with temperate climates. In this article I review key attributes of nirsevimab with an emphasis on pharmacology, pharmacokinetics, antiviral activity, and the potential for resistance and escape variants. I also summarize current progress in clinical trials and consider future research priorities.
    MeSH term(s) Humans ; Infant, Newborn ; Infant ; Antiviral Agents/therapeutic use ; Respiratory Syncytial Virus Infections/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Respiratory Syncytial Virus, Human/genetics
    Chemical Substances Antiviral Agents ; nirsevimab (VRN8S9CW5V) ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkad076
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    Zs.MO 124: Show issues

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  4. Article ; Online: Transition Regret and Detransition: Meanings and Uncertainties.

    Jorgensen, Sarah C J

    Archives of sexual behavior

    2023  Volume 52, Issue 5, Page(s) 2173–2184

    Abstract: Gender transition is undertaken to improve the well-being of people suffering from gender dysphoria. However, some have argued that the evidence supporting medical interventions for gender transition (e.g., hormonal therapies and surgery) is weak and ... ...

    Abstract Gender transition is undertaken to improve the well-being of people suffering from gender dysphoria. However, some have argued that the evidence supporting medical interventions for gender transition (e.g., hormonal therapies and surgery) is weak and inconclusive, and an increasing number of people have come forward recently to share their experiences of transition regret and detransition. In this essay, I discuss emerging clinical and research issues related to transition regret and detransition with the aim of arming clinicians with the latest information so they can support patients navigating the challenges of regret and detransition. I begin by describing recent changes in the epidemiology of gender dysphoria, conceptualization of transgender identification, and models of care. I then discuss the potential impact of these changes on regret and detransition; the prevalence of desistance, regret, and detransition; reasons for detransition; and medical and mental healthcare needs of detransitioners. Although recent data have shed light on a complex range of experiences that lead people to detransition, research remains very much in its infancy. Little is known about the medical and mental healthcare needs of these patients, and there is currently no guidance on best practices for clinicians involved in their care. Moreover, the term detransition can hold a wide array of possible meanings for transgender-identifying people, detransitioners, and researchers, leading to inconsistences in its usage. Moving forward, minimizing harm will require conducting robust research, challenging fundamental assumptions, scrutinizing of practice patterns, and embracing debate.
    MeSH term(s) Humans ; Transgender Persons ; Transsexualism/therapy ; Gender Identity ; Uncertainty ; Gender Dysphoria ; Emotions
    Language English
    Publishing date 2023-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-023-02626-2
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    Zs.A 1106: Show issues Location:
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  5. Article ; Online: Delving Deeper Into Maternal COVID-19 Vaccination and Neonatal Outcomes-Reply.

    Jorgensen, Sarah C J / Fell, Deshayne B / Kwong, Jeffrey C

    JAMA pediatrics

    2024  Volume 178, Issue 4, Page(s) 419–420

    MeSH term(s) Infant, Newborn ; Humans ; Pregnancy ; Female ; COVID-19/prevention & control ; COVID-19 Vaccines ; Vaccination ; Pregnancy Outcome
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2023.6683
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    Um IV Zs.74: Show issues Location:
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  6. Article ; Online: Puberty Suppression for Pediatric Gender Dysphoria and the Child's Right to an Open Future.

    Jorgensen, Sarah C J / Athéa, Nicole / Masson, Céline

    Archives of sexual behavior

    2024  Volume 53, Issue 5, Page(s) 1941–1956

    Abstract: In this essay, we consider the clinical and ethical implications of puberty blockers for pediatric gender dysphoria through the lens of "the child's right to an open future," which refers to rights that children do not have the capacity to exercise as ... ...

    Abstract In this essay, we consider the clinical and ethical implications of puberty blockers for pediatric gender dysphoria through the lens of "the child's right to an open future," which refers to rights that children do not have the capacity to exercise as minors, but that must be protected, so they can exercise them in the future as autonomous adults. We contrast the open future principle with the beliefs underpinning the gender affirming care model and discuss implications for consent. We evaluate claims that puberty blockers are reversible, discuss the scientific uncertainty about long-term benefits and harms, summarize international developments, and examine how suicide has been used to frame puberty suppression as a medically necessary, lifesaving treatment. In discussing these issues, we include relevant empirical evidence and raise questions for clinicians and researchers. We conclude that treatment pathways that delay decisions about medical transition until the child has had the chance to grow and mature into an autonomous adulthood would be most consistent with the open future principle.
    MeSH term(s) Humans ; Gender Dysphoria/psychology ; Gender Dysphoria/therapy ; Puberty/psychology ; Female ; Child ; Male ; Adolescent ; Puberty Suppression
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 184221-3
    ISSN 1573-2800 ; 0004-0002
    ISSN (online) 1573-2800
    ISSN 0004-0002
    DOI 10.1007/s10508-024-02850-4
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    Zs.A 1106: Show issues Location:
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  7. Article ; Online: Comment on: Antibiotic use during pregnancy and the risk of preterm birth: a population-based Swedish cohort study.

    Jorgensen, Sarah C J / Burry, Lisa

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 7, Page(s) 2040–2041

    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Cohort Studies ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Outcome ; Premature Birth/epidemiology ; Risk Factors ; Sweden/epidemiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-03-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac113
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    Zs.MO 124: Show issues

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  8. Article ; Online: The case for 'conservative pharmacotherapy'-authors' response.

    Dalton, Bruce R / Stewart, Jackson J / Jorgensen, Sarah C J

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue 9, Page(s) 2491–2492

    Language English
    Publishing date 2021-07-10
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab234
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  9. Article ; Online: The case for 'conservative pharmacotherapy'-authors' response.

    Jorgensen, Sarah C J / Stewart, Jackson J / Dalton, Bruce R

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue 7, Page(s) 1952–1953

    Language English
    Publishing date 2021-05-16
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab148
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  10. Article ; Online: Vancomycin Therapeutic Drug Monitoring: A Cross-Sectional Survey of Canadian Hospitals.

    Jorgensen, Sarah C J / McIntyre, Mark / Curran, Jennifer / So, Miranda

    The Canadian journal of hospital pharmacy

    2023  Volume 76, Issue 3, Page(s) 203–208

    Abstract: Background: Little is known about the current landscape of vancomycin therapeutic drug monitoring (TDM) in Canadian hospitals, which operate within publicly funded health care systems.: Objectives: To determine current TDM practices for vancomycin ... ...

    Abstract Background: Little is known about the current landscape of vancomycin therapeutic drug monitoring (TDM) in Canadian hospitals, which operate within publicly funded health care systems.
    Objectives: To determine current TDM practices for vancomycin and associated challenges and to gather perceptions about TDM based on area under the concentration-time curve (AUC) in Canadian hospitals.
    Methods: An electronic survey was distributed to hospital pharmacists in spring 2021 through multiple national and provincial antimicrobial stewardship, public health, and pharmacy organizations. The survey gathered data about hospital characteristics, TDM methods, inclusion criteria for patient selection, pharmacokinetic and pharmacodynamic targets, vancomycin susceptibility testing and reporting, and perceived barriers and challenges.
    Results: In total, 120 pharmacists from 10 of the 13 provincial and territorial jurisdictions in Canada, representing 12.5% of Canadian acute care hospitals (
    Conclusions: This survey represents a first step in developing evidence-based, standardized best practices for vancomycin TDM that are uniquely suited to the Canadian health care system.
    Language English
    Publishing date 2023-07-05
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 413450-3
    ISSN 1920-2903 ; 0008-4123
    ISSN (online) 1920-2903
    ISSN 0008-4123
    DOI 10.4212/cjhp.3337
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