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Article ; Online: Post-COVID-19 syndrome in everyday clinical practice: interdisciplinary expert position statement endorsed by the Polish Society of Civilization Diseases.

Tomasiewicz, Krzysztof / Woron, Jaroslaw / Kobayashi, Adam / Krasinski, Zbigniew / Rydzewska, Grażyna / Szymanski, Filip M

Polish archives of internal medicine

2024

Abstract: Post-COVID-19 syndrome, also known as long-COVID-19 syndrome, is a complex set of symptoms that persist for weeks or months after recovery from the acute phase of COVID-19. These symptoms can affect various body systems, including the respiratory, ... ...

Abstract	Post-COVID-19 syndrome, also known as long-COVID-19 syndrome, is a complex set of symptoms that persist for weeks or months after recovery from the acute phase of COVID-19. These symptoms can affect various body systems, including the respiratory, nervous, cardiovascular, and digestive systems. The most common complaints are fatigue, shortness of breath, joint pain, taste and smell disorders, as well as problems with memory and concentration. The pathogenesis of the post-COVID-19 syndrome is complicated and not fully understood, but it is likely related to an overactive immune system, disturbances in the intestinal microbiome, and cell and tissue damage caused by the virus. Incorporating a multidisciplinary approach to treating and rehabilitating patients and further research into this syndrome's underlying mechanisms and therapy is crucial for understanding and effectively treating this complex and multi-faced condition.
Language	English
Publishing date	2024-04-15
Publishing country	Poland
Document type	Journal Article
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16728
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Article: The Role and Value of Professional Rapid Testing of Acute Respiratory Infections (ARIs) in Europe: A Special Focus on the Czech Republic, Poland, and Romania.

Drevinek, Pavel / Flisiak, Robert / Nemes, Roxana / Nogales Crespo, Katya A / Tomasiewicz, Krzysztof

Diagnostics (Basel, Switzerland)

2024 Volume 14, Issue 6

Abstract: This review aims to explore the role of professional diagnostic rapid testing of acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management and treatment in Europe, and particularly in Czech Republic, ... ...

Abstract	This review aims to explore the role of professional diagnostic rapid testing of acute respiratory infections (ARIs), especially COVID-19 and influenza, ensuring proper disease management and treatment in Europe, and particularly in Czech Republic, Poland, and Romania. The paper was constructed based on a review of scientific evidence and national and international policies and recommendations, as well as a process of validation by four experts. The development of new testing technologies, treatment options, and increased awareness of the negative multidimensional impact of ARI profiles transformed differential diagnosis into a tangible and desirable reality. This review covers the following topics: (1) the multidimensional impact of ARIs, (2) ARI rapid diagnostic testing platforms and their value, (3) the policy landscape, (4) challenges and barriers to implementation, and (5) a set of recommendations illustrating a path forward. The findings indicate that rapid diagnostic testing, including at the point of care (POC), can have a positive impact on case management, antimicrobial and antibiotic stewardship, epidemiological surveillance, and decision making. Integrating this strategy will require the commitment of governments and the international and academic communities, especially as we identified room for improvement in the access and expansion of POC rapid testing in the focus countries and the inclusion of rapid testing in relevant policies.
Language	English
Publishing date	2024-03-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14060631
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Article: Recommendations for the diagnosis and treatment of Lyme borreliosis of the Polish Society of Epidemiologists and Infectious Disease Physicians.

Moniuszko-Malinowska, Anna / Pancewicz, Sławomir / Czupryna, Piotr / Garlicki, Aleksander / Jaroszewicz, Jerzy / Marczyńska, Magdalena / Pawłowska, Małgorzata / Piekarska, Anna / Sikorska, Katarzyna / Simon, Krzysztof / Tomasiewicz, Krzysztof / Zajkowska, Joanna / Zarębska-Michaluk, Dorota / Flisiak, Robert

Przeglad epidemiologiczny

2024 Volume 77, Issue 3, Page(s) 261–278

MeSH term(s)	Humans ; Communicable Diseases ; Epidemiologists ; Lyme Disease/diagnosis ; Lyme Disease/drug therapy ; Physicians ; Poland
Language	English
Publishing date	2024-02-03
Publishing country	Poland
Document type	Journal Article ; Practice Guideline
ZDB-ID	421782-2
ISSN	0033-2100
ISSN	0033-2100
DOI	10.32394/pe.77.25
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Article: Recommendations for the management of rickettsioses.

Tomasiewicz, Krzysztof

Przeglad epidemiologiczny

2015 Volume 69, Issue 2, Page(s) 299–302, 411–4

MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Antibodies, Bacterial/blood ; Disease Outbreaks/prevention & control ; Female ; Humans ; Immunoglobulin M/blood ; Male ; Poland ; Primary Prevention/methods ; Rickettsia Infections/diagnosis ; Rickettsia Infections/drug therapy ; Rickettsia Infections/prevention & control
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Antibodies, Bacterial ; Immunoglobulin M
Language	Polish
Publishing date	2015
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421782-2
ISSN	0033-2100
ISSN	0033-2100
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Article: Recommendations of the Polish Group of Experts for HCV for the treatment of hepatitis C in 2023.

Tomasiewicz, Krzysztof / Flisiak, Robert / Jaroszewicz, Jerzy / Małkowski, Piotr / Pawłowska, Małgorzata / Piekarska, Anna / Simon, Krzysztof / Zarębska-Michaluk, Dorota

Clinical and experimental hepatology

2023 Volume 9, Issue 1, Page(s) 1–8

Abstract: The recommendations define the principles of diagnosis and treatment of hepatitis C virus (HCV) infection according to the latest knowledge. The main goal of the treatment of HCV infection is to eliminate the virus from the body, which in turn leads to ... ...

Abstract	The recommendations define the principles of diagnosis and treatment of hepatitis C virus (HCV) infection according to the latest knowledge. The main goal of the treatment of HCV infection is to eliminate the virus from the body, which in turn leads to stopping the progression or causes the regression of previously formed changes in the liver. The current version of the guidelines prioritizes pangenotypic regimens and includes guidelines for special patient populations such as children, patients with cirrhosis, human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infection, patients with renal failure, liver failure and lack of response to previous therapies as well as patients in the peri-transplant period.
Language	English
Publishing date	2023-03-24
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2937940-4
ISSN	2449-8238 ; 2392-1099
ISSN (online)	2449-8238
ISSN	2392-1099
DOI	10.5114/ceh.2023.125957
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Article: COVID-19 prophylaxis, diagnostics, and treatment in patients with rheumatic diseases. The Polish experts panel opinion.

Kwiatkowska, Brygida / Krajewska-Włodarczyk, Magdalena / Batko, Bogdan / Maślińska, Maria / Stajszczyk, Marcin / Świerkot, Jerzy / Wiland, Piotr / Żuber, Zbigniew / Tomasiewicz, Krzysztof

Reumatologia

2024 Volume 62, Issue 1, Page(s) 4–17

Abstract: As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves, infection management in vulnerable populations requires formalized guidance. Although low-virulence variants of SARS-CoV-2 remain predominant, they pose an increased risk of severe ... ...

Abstract	As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves, infection management in vulnerable populations requires formalized guidance. Although low-virulence variants of SARS-CoV-2 remain predominant, they pose an increased risk of severe illness in adults with rheumatic and musculoskeletal diseases (RMDs). Several disease-specific (chronic long-grade inflammation, concomitant immunosuppression) and individual (advanced age, multimorbidity, pregnancy, vaccination status) factors contribute to excess risk in RMD populations. Various post-COVID-19 manifestations are also increasingly reported and appear more commonly than in the general population. At a pathogenetic level, complex interplay involving innate and acquired immune dysregulation, viral persistence, and genetic predisposition shapes a unique susceptibility profile. Moreover, incident cases of SARS-CoV-2 infection as a trigger factor for the development of autoimmune conditions have been reported. Vaccination remains a key preventive strategy, and encouraging active education and awareness will be crucial for rheumatologists in the upcoming years. In patients with RMDs, COVID-19 vaccines' benefits outweigh the risks. Derivation of specialized diagnostic and therapeutic protocols within a comprehensive COVID-19 care plan represents an ideal scenario for healthcare system organization. Vigilance for symptoms of infection and rapid diagnosis are key for introducing antiviral treatment in patients with RMDs in a timely manner. This review provides updated guidance on optimal immunization, diagnosis, and antiviral treatment strategies.
Language	English
Publishing date	2024-03-18
Publishing country	Poland
Document type	Journal Article
ZDB-ID	604151-6
ISSN	0034-6233
ISSN	0034-6233
DOI	10.5114/reum/183469
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Article ; Online: A rotablation-resistant lesion: rare and highly challenging to treat percutaneously.

Rakotoarison, Oscar / Ściborski, Krzysztof / Zimoch, Wojciech / Tomasiewicz, Brunon / Reczuch, Krzysztof / Kübler, Piotr

Kardiologia polska

2021 Volume 79, Issue 2, Page(s) 209–210

MeSH term(s)	Angioplasty, Balloon, Coronary ; Atherectomy, Coronary ; Humans
Language	English
Publishing date	2021-01-18
Publishing country	Poland
Document type	Journal Article
ZDB-ID	411492-9
ISSN	1897-4279 ; 0022-9032
ISSN (online)	1897-4279
ISSN	0022-9032
DOI	10.33963/KP.15758
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Article ; Online: Sexual Dysfunction and Quality of Life in Patients with Rheumatoid Arthritis.

Tański, Wojciech / Dudek, Krzysztof / Tomasiewicz, Anna / Świątoniowska-Lonc, Natalia

International journal of environmental research and public health

2022 Volume 19, Issue 5

Abstract: Background: Sexual health is a major component of human well-being. As repeatedly shown in research, satisfaction with sex life and sexual fulfillment correlate positively with quality of life (QoL) in most of its aspects. It is thus true that a reduced ... ...

Abstract	Background: Sexual health is a major component of human well-being. As repeatedly shown in research, satisfaction with sex life and sexual fulfillment correlate positively with quality of life (QoL) in most of its aspects. It is thus true that a reduced quality of one’s sex life and lack of sexual fulfillment can contribute to poorer QoL overall. The aim of this study is to describe an assessment of sexual dysfunction and factors affecting sexual dysfunctions of patients with rheumatoid arthritis (RA). Material and methods: 171 consecutive RA patients (mean age 48.3 ± 14.6) attending the rheumatology outpatient clinic. Standardized questionnaires used in the study were the sexological questionnaire, WHOQOL-BREF to assess QoL level, Disease Acceptance Scale, and VAS scale to assess pain intensity. Results: The mean duration of the disease in the study group was 13 ± 9 years, mean score of subjective assessment of mobility was 6.2 ± 1.6, and the mean score of the DAS-28 was 4.0 ± 1.9. The study group presented a mean level of disease acceptance (AIS 29.6 ± 11.6). The comparative analysis showed significant differences in reaching orgasm and declared sexual dysfunctions. These problems occurred more often in women than in men (34.2% vs. 18% and 43% vs. 40%, respectively). In univariate analysis, factors correlating positively with the frequency of declaring sexual dysfunction were subjective motor score less < 6 points, AIS < 36 points, WHOQOL-BREF < 59 points, disease activity ≥3.5 points, and VAS > 3. In multivariate logistic regression analysis, independent factors positively correlating with frequency of sexual dysfunction declaration were general QoL (β = 1.255; p = 0.035) and pain limiting social life (β = 1.564; p = 0.030). The absence of comorbidities correlated negatively and reduced the prevalence of sexual dysfunction (β = −1.030; p = 0.043). Patients with reduced QoL and patients with pain limiting social life had 3.5 and 4.8 times higher risk of sexual dysfunction than other patients, respectively. In contrast, those without comorbidities were 2.8 times more likely to be free of sexual dysfunction than those diagnosed with other chronic diseases besides RA. Conclusions: Sexual dysfunction is an emerging problem in both men and women with RA. The absence of comorbidities is an independent determinant of sexual dysfunction, whereas poor QoL and pain limiting social life are independent determinants that exacerbate sexual dysfunction in both genders.
MeSH term(s)	Adult ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Pain/epidemiology ; Quality of Life ; Sexual Dysfunction, Physiological/epidemiology ; Sexual Dysfunction, Physiological/etiology ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19053088
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Article ; Online: Sexual Dysfunction and Quality of Life in Patients with Rheumatoid Arthritis

Wojciech Tański / Krzysztof Dudek / Anna Tomasiewicz / Natalia Świątoniowska-Lonc

International Journal of Environmental Research and Public Health, Vol 19, Iss 3088, p

2022 Volume 3088

Abstract	Background: Sexual health is a major component of human well-being. As repeatedly shown in research, satisfaction with sex life and sexual fulfillment correlate positively with quality of life (QoL) in most of its aspects. It is thus true that a reduced quality of one’s sex life and lack of sexual fulfillment can contribute to poorer QoL overall. The aim of this study is to describe an assessment of sexual dysfunction and factors affecting sexual dysfunctions of patients with rheumatoid arthritis (RA). Material and methods: 171 consecutive RA patients (mean age 48.3 ± 14.6) attending the rheumatology outpatient clinic. Standardized questionnaires used in the study were the sexological questionnaire, WHOQOL-BREF to assess QoL level, Disease Acceptance Scale, and VAS scale to assess pain intensity. Results: The mean duration of the disease in the study group was 13 ± 9 years, mean score of subjective assessment of mobility was 6.2 ± 1.6, and the mean score of the DAS-28 was 4.0 ± 1.9. The study group presented a mean level of disease acceptance (AIS 29.6 ± 11.6). The comparative analysis showed significant differences in reaching orgasm and declared sexual dysfunctions. These problems occurred more often in women than in men (34.2% vs. 18% and 43% vs. 40%, respectively). In univariate analysis, factors correlating positively with the frequency of declaring sexual dysfunction were subjective motor score less < 6 points, AIS < 36 points, WHOQOL-BREF < 59 points, disease activity ≥3.5 points, and VAS > 3. In multivariate logistic regression analysis, independent factors positively correlating with frequency of sexual dysfunction declaration were general QoL (β = 1.255; p = 0.035) and pain limiting social life (β = 1.564; p = 0.030). The absence of comorbidities correlated negatively and reduced the prevalence of sexual dysfunction (β = −1.030; p = 0.043). Patients with reduced QoL and patients with pain limiting social life had 3.5 and 4.8 times higher risk of sexual dysfunction than other patients, ...
Keywords	sexual dysfunctions ; quality of life ; rheumatoid arthritis ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Concentration of LDLR, degree of hepatic fibrosis and hepatic steatosis in patients with chronic hepatitis B infection treated with tenofovir disoproxil fumarate.

Pokora-Rodak, Agnieszka / Krzowska-Firych, Joanna / Tomasiewicz, Krzysztof

Annals of agricultural and environmental medicine : AAEM

2020 Volume 28, Issue 3, Page(s) 458–462

Abstract: Introduction: Epidemiological data indicate that one-third of the world's population have serological markers of hepatitis B virus infection. Hepatic steatosis is often observed in patients with chronic liver diseases. The exact mechanisms of hepatic ... ...

Abstract	Introduction: Epidemiological data indicate that one-third of the world's population have serological markers of hepatitis B virus infection. Hepatic steatosis is often observed in patients with chronic liver diseases. The exact mechanisms of hepatic steatosis progression and the efficacy of antiviral therapy in patients with CHB and hepatic steatosis are not yet fully understood. Objective: The aim of the study was to investigate the LDLR concentration and degree of hepatic fibrosis and hepatic steatosis in patients with chronic hepatitis B infection during tenofovir disoproxil fumarate therapy. Material and methods: The study group consisted of 54 patients with CHB. The LDLR concentration, assessment of the degree of hepatic fibrosis, hepatic steatosis, total cholesterol, low density lipoprotein, high density lipoprotein and triglyceride concentrations, were assessed at the beginning of therapy, 6 months later, and 12 months after commencement of therapy. The control group consisted of 18 healthy individuals. Results: The mean LDLR concentration in the studied groups was statistically significantly lower (p<0.05) than in the controls. The antiviral therapy based on TDF had no influence on the LDLR concentration and HBsAg level. Conclusions: The results indicate a statistically significant lower(p<0.05) concentration of LDLR in patients with chronic hepatitis B infection. Negative correlations between HBsAg level and LDLR concentration in patients with chronic HBV, at all stages of the study may indicate, that HBsAg protects hepatocytes from LDL accumulation.
MeSH term(s)	Adult ; Aged ; Antiviral Agents/administration & dosage ; Fatty Liver/blood ; Fatty Liver/etiology ; Fatty Liver/virology ; Female ; Hepatitis B Surface Antigens/blood ; Hepatitis B virus/genetics ; Hepatitis B virus/metabolism ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/virology ; Humans ; Lipoproteins, HDL/blood ; Liver Cirrhosis/blood ; Liver Cirrhosis/etiology ; Liver Cirrhosis/virology ; Male ; Middle Aged ; Receptors, LDL/blood ; Tenofovir/administration & dosage ; Triglycerides/blood
Chemical Substances	Antiviral Agents ; Hepatitis B Surface Antigens ; LDLR protein, human ; Lipoproteins, HDL ; Receptors, LDL ; Triglycerides ; Tenofovir (99YXE507IL)
Language	English
Publishing date	2020-06-10
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1215115-4
ISSN	1898-2263 ; 1232-1966
ISSN (online)	1898-2263
ISSN	1232-1966
DOI	10.26444/aaem/122627
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