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Article ; Online: Gordon Mathews, Gustavo Lins Ribeiro y Carlos Alba Vega (dirs.), Globalization from Below

Pierre Salama

Foro Internacional, Vol 54, Iss

The World’s other Economy

2014 Volume 2

Keywords	Political science ; J ; International relations ; JZ2-6530
Language	Spanish
Publishing date	2014-04-01T00:00:00Z
Publisher	El Colegio de México
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia. Reply.

Salama, Carlos / Mohan, Shalini V

The New England journal of medicine

2021 Volume 384, Issue 15, Page(s) 1473–1474

MeSH term(s)	Antibodies, Monoclonal, Humanized ; COVID-19/drug therapy ; Humans ; SARS-CoV-2
Chemical Substances	Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2100217
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Article: Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis.

Blanc, Romeo S / Shah, Nidhi / Salama, Noah A S / Meng, Fanju W / Mousaei, Alireza / Yang, Benjamin A / Aguilar, Carlos A / Chakkalakal, Joe V / Onukwufor, John O / Murphy, Patrick J / Calvi, Laura / Dirksen, Robert

Research square

2024

Abstract: Aging is associated with a decline in stem cell functionality and number across the organism. In this study, we aimed to further unravel Muscle Stem Cells (MuSCs) aging by assessing how systemic factors influence MuSC fate decisions through long-term ... ...

Abstract	Aging is associated with a decline in stem cell functionality and number across the organism. In this study, we aimed to further unravel Muscle Stem Cells (MuSCs) aging by assessing how systemic factors influence MuSC fate decisions through long-term epigenetic landscape remodelling. As aging is intricately linked to a pro-inflammatory shift, we studied the epigenetic effects of inflammatory signals in MuSCs and measured decreased H4K20me1 levels. This loss disrupts MuSC quiescence, largely through epigenetic silencing of Notch target genes. In the setting of inflammatory signals or aging, the lack of Kmt5a and the subsequent absence of
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3937628/v2
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Article: Tocilizumab for Severe and Critical COVID-19 Pneumonia in Queens, NYC.

Salama, Carlos / Kaplan-Lewis, Emma / Durrance, Richard / Wong, Linda / Arumugam, Vasanthi / Fabbri, Marilyn

Infectious diseases in clinical practice (Baltimore, Md.)

2021 Volume 29, Issue 4, Page(s) e215–e220

Abstract: New York City was hard hit by COVID-19. Elmhurst Hospital is a public hospital in Queens where more than 1500 patients were hospitalized with COVID. During the pandemic, various treatments were used with hopes of reducing the need for mechanical ... ...

Abstract	New York City was hard hit by COVID-19. Elmhurst Hospital is a public hospital in Queens where more than 1500 patients were hospitalized with COVID. During the pandemic, various treatments were used with hopes of reducing the need for mechanical ventilation and death. Methods: We retrospectively reviewed charts of patients admitted from March 25 to April 3 with severe or critical COVID-19 pneumonia who received tocilizumab compared with a similar cohort who did not. Analyses were performed to determine differences in outcomes. Results: There was no observed difference in need for mechanical ventilation, length of stay, or mortality rate. In the tocilizumab-treated group, mechanical ventilation rate was 55%, and 49% of patients died. In the control group, 54% required mechanical ventilation and 46% died. Tocilizumab was overall well tolerated, although alanine aminotransferase elevation was more common in the tocilizumab-treated group. Conclusions: Tocilizumab failed to show short-term benefits in clinical outcomes in patients with hypoxic COVID pneumonia at our institution.
Language	English
Publishing date	2021-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1162378-0
ISSN	1056-9103
ISSN	1056-9103
DOI	10.1097/IPC.0000000000000988
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Article: Analysis of ABO and Rh Blood Type Association With Acute COVID-19 Infection in Hospitalized Patients: A Superficial Association Among a Multitude of Established Confounders.

Bhandari, Priyanka / Durrance, Richard Jesse / Bhuti, Penpa / Salama, Carlos

Journal of clinical medicine research

2020 Volume 12, Issue 12, Page(s) 809–815

Abstract: Background: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and considerable effort is focused on identifying certain populations at increased risk. ABO blood types have been associated with disease susceptibility; however, ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) has affected millions of people worldwide, and considerable effort is focused on identifying certain populations at increased risk. ABO blood types have been associated with disease susceptibility; however, evidence remains limited. Our aim was to determine the association between ABO/Rh blood type with disease susceptibility and mortality among admitted COVID-19 patients. Methods: A retrospective analysis of patients with COVID-19 requiring admission was undertaken. Demographics and pertinent medical history were analyzed with respect to ABO/Rh blood type: between the cases and a control population; as well as with respect to mortality in the COVID-19 population in univariate analysis. Potential confounding factors were evaluated by multivariate models. The main outcomes were disease susceptibility by comparison of blood type prevalence between populations, and mortality within the COVID-19 population. Results: A total of 825 cases (admitted with confirmed COVID-19 infection by reverse transcriptase-polymerase chain reaction (RT-PCR)) and 396 controls (seen at the same institution during the calendar year of 2019) were included. The COVID-19 population was older with male predominance. It was heavily represented by blood types O-positive (53%) and A-positive (23%), while lower representation was observed in groups B-positive (odds ratio (OR): 0.61, P = 0.013) and AB-positive (OR: 0.46, P = 0.014). Neither relationship remained significant in pairwise analysis. Within the COVID-19 population, no mortality difference was appreciated between ABO groups (P = 0.312), but higher mortality was observed in Rh negative group (P = 0.01). The latter of which was significantly confounded by age (P < 0.001), sex (P = 0.022), body mass index (BMI) (P = 0.001), and hemoglobin A1c (HbA1c) (P < 0.001) in multivariate analysis. Conclusions: While type A blood appears to be weakly more prevalent with respect to B and AB types in hospitalized patients, strong confounders of age and sex dilute this significance. Rh-negative patients appear to have a higher mortality, although this too is strongly confounded. Overall, ABO and Rh blood types do not have a significant relationship with susceptibility and mortality with COVID-19 infection in our population.
Language	English
Publishing date	2020-12-18
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2548987-2
ISSN	1918-3011 ; 1918-3003
ISSN (online)	1918-3011
ISSN	1918-3003
DOI	10.14740/jocmr4382
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Article: Evaluation of Characteristics and Outcomes for Patients with Diabetic Ketoacidosis (DKA) With and Without COVID-19 in Elmhurst Queens During Similar Three-Month Periods in 2019 and 2020.

Patel, Urja / Deluxe, Linda / Salama, Carlos / Jimenez, Aaron Ross / Whiting, Adrian / Lubin, Cedrick / Tarlin, Nancy

Cureus

2021 Volume 13, Issue 7, Page(s) e16427

Abstract: Aim There are reports of COVID-19 patients presenting with new onset diabetes, diabetic ketoacidosis (DKA), and hyperosmolar hyperglycemic syndrome (HHS). We compared the characteristics of patients with DKA with and without COVID-19 and their effect on ... ...

Abstract	Aim There are reports of COVID-19 patients presenting with new onset diabetes, diabetic ketoacidosis (DKA), and hyperosmolar hyperglycemic syndrome (HHS). We compared the characteristics of patients with DKA with and without COVID-19 and their effect on mortality. Research design and methods A retrospective study at Elmhurst Hospital Center in Queens, New York was performed using ICD-10 codes to identify patients with DKA from March 1 to May 31 in 2019 and 2020. Results While comparing COVID-19 patients with DKA to the DKA patients without COVID-19 in both 2019 and 2020, hispanic patients, males, and type 2 diabetes predominated. COVID-19 patients were older (p=0.010), had more hypertension (p=0.002), and severe lactic acidosis (p=0.006). Mortality for DKA patients with COVID-19 was 57%, for DKA patients without COVID-19 it was 2.1% (p=0.0001), and for diabetic patients (no DKA) with COVID-19 it was 39% (p=0.035). Within the COVID-19 group, older age (mean age 65), (p=0.014), elevated CRP (p=0.012), low O
Language	English
Publishing date	2021-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.16427
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Article: Too much of a good thing: Immune reconstitution inflammatory syndrome in a patient with Still's disease.

Batool, Nuzhat / Song, David / Almas, Talal / Alsubai, Abdulla K / Thakur, Tushar / Ismail, Hebatalla / Alsufyani, Majid / Hadeed, Sebastian / Huang, Helen / Kotait, Farida / Aldhaheri, Khaled Saeed Obaid / Sindi, Atif Bakr / Chan, Emilie / Salama, Carlos

Annals of medicine and surgery (2012)

2022 Volume 82, Page(s) 104590

Abstract: Immune Reconstitution Inflammatory Syndrome (IRIS) is a potential complication when treating non HIV immunosuppressed patients with opportunistic infections. We present a case of a 49-year-old female with Adult-onset Still's disease on prednisone 40 mg ... ...

Abstract	Immune Reconstitution Inflammatory Syndrome (IRIS) is a potential complication when treating non HIV immunosuppressed patients with opportunistic infections. We present a case of a 49-year-old female with Adult-onset Still's disease on prednisone 40 mg daily who came to ED with right leg weakness and intractable headache for one week. She was diagnosed with Cryptococcus meningitis. Patient completed the induction phase of antifungal therapy and the steroids were tapered over four weeks. One month after discharge, a patient was brought in to ED, minimally responsive to verbal stimuli and had new left hemiparesis with persistent right leg weakness was noted on exam. An MRI of the brain was consistent with diffuse leptomeningeal enhancement compatible with meningoencephalitis. LP was notable for elevated opening pressure of 36cmH2O and CSF studies were negative for recurrence of cryptococcal infection. Given the timeline of patients presentation one month after discontinuation of steroids, and workup consistent with sterile meningitis, immune reconstitution inflammatory syndrome was identified as the likely diagnosis. The patient was started on 50 mg of Prednisone daily. Six weeks after presentation, the patient's mental status returned to baseline, left hemiparesis resolved, and right lower extremity strength significantly improved. Clinicians should have a high index of suspicion for CNS IRIS in patients presenting with new neurologic findings in the setting of rapid discontinuation of steroids due to infection. IRIS in HIV patients with cryptococcal meningitis is a well-established entity; the purpose of this case report is to bring attention to similar inflammatory syndrome in non-HIV patients with cryptococcal meningitis.
Language	English
Publishing date	2022-09-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2022.104590
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Article ; Online: A New Collaborative Multi-Agent Monte Carlo Simulation Model for Spatial Correlation of Air Pollution Global Risk Assessment

Mustafa Hamid Hassan / Salama A. Mostafa / Aida Mustapha / Mohd Zainuri Saringat / Bander Ali Saleh Al-rimy / Faisal Saeed / A.E.M. Eljialy / Mohammed Ahmed Jubair

Sustainability, Vol 14, Iss 510, p

2022 Volume 510

Abstract: ... ARIMA), a Monte Carlo simulation, a collaborative multi-agent system, and a prediction algorithm ...

Abstract	Air pollution risk assessment is complex due to dynamic data change and pollution source distribution. Air quality index concentration level prediction is an effective method of protecting public health by providing the means for an early warning against harmful air pollution. However, air quality index-based prediction is challenging as it depends on several complicated factors resulting from dynamic nonlinear air quality time-series data, such as dynamic weather patterns and the verity and distribution of air pollution sources. Subsequently, some minimal models have incorporated a time series-based predicting air quality index at a global level (for a particular city or various cities). These models require interaction between the multiple air pollution sensing sources and additional parameters like wind direction and wind speed. The existing methods in predicting air quality index cannot handle short-term dependencies. These methods also mostly neglect the spatial correlations between the different parameters. Moreover, the assumption of selecting the most recent part of the air quality time series is not valid considering that pollution is cyclic behavior according to various events and conditions due to the high possibility of falling into the trap of local minimum and poor generalization. Therefore, this paper proposes a new air pollution global risk assessment (APGRA) prediction model for an air quality index of spatial correlations to address these issues. The APGRA model incorporates an autoregressive integrated moving average (ARIMA), a Monte Carlo simulation, a collaborative multi-agent system, and a prediction algorithm for reducing air quality index prediction error and processing time. The proposed APGRA model is evaluated based on Malaysia and China real-world air quality datasets. The proposed APGRA model improves the average root mean squared error by 41%, mean and absolute error by 47.10% compared with the conventional ARIMA and ANFIS models.
Keywords	air quality index ; air pollution ; risk assessment ; autoregressive integrated moving average ; Monte Carlo simulation ; multi-agent system ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	690
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: HIV Diagnosis and the Clinical Course of COVID-19 Among Patients Seeking Care Within the New York City Public Hospital System During the Initial Pandemic Peak.

Kaplan-Lewis, Emma / Banga, Jaspreet / Khan, Maria / Casey, Eunice / Mazumdar, Medha / Bratu, Simona / Abdallah, Marie / Pitts, Robert / Leider, Jason / Hennessey, Karen / Cohen, Gabriel M / Cleland, Charles M / Salama, Carlos

AIDS patient care and STDs

2021 Volume 35, Issue 12, Page(s) 457–466

Abstract: Reports conflict on how HIV infection influences the clinical course of COVID-19. The New York City (NYC) public hospital system provides care for over 14,000 people with HIV, was central in responding to the COVID-19 pandemic, and is therefore in a ... ...

Abstract	Reports conflict on how HIV infection influences the clinical course of COVID-19. The New York City (NYC) public hospital system provides care for over 14,000 people with HIV, was central in responding to the COVID-19 pandemic, and is therefore in a unique position to evaluate the intersection of these concurrent infections. Retrospective chart review of patients presenting to NYC Health and Hospitals (NYC H+H) diagnosed with COVID-19 infection from March 1, 2020, through April 28, 2020, compared people living with HIV (PLWH) and a propensity-matched (PM) control group of patients without HIV to evaluate associations between HIV status and COVID-19 outcomes. Two hundred thirty-four PLWH presented for COVID-19 testing and 110 (47%) were diagnosed with COVID-19. Among 17,413 patients with COVID-19 and without HIV, 1:n nearest neighbor propensity score matching identified 194 patients matched on age, sex, race, and any comorbidity. In the sample with COVID-19 (
MeSH term(s)	COVID-19 ; COVID-19 Testing ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Hospitalization ; Hospitals, Public ; Humans ; New York City/epidemiology ; Pandemics ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1326868-5
ISSN	1557-7449 ; 0893-5068 ; 1087-2914
ISSN (online)	1557-7449
ISSN	0893-5068 ; 1087-2914
DOI	10.1089/apc.2021.0124
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Article ; Online: Pseudo-Pelger-Huët anomaly and granulocytic dysplasia associated with human granulocytic anaplasmosis.

Lee, Sunyoung / Khankhanian, Pouya / Salama, Carlos / Brown, Maritza / Lieber, Joseph

International journal of hematology

2015 Volume 102, Issue 1, Page(s) 129–133

Abstract: Pseudo-Pelger-Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or hematological malignancies including myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). ... ...

Abstract	Pseudo-Pelger-Huët anomaly (PHA) refers to mono- or bi-lobed granulocytes, reportedly observed in patients with severe infections and inflammation or hematological malignancies including myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Dysplastic changes in granulocytes are typical manifestations in MDS and granulocytic leukemias. Here, we report the unique case of a patient found to have human granulocytic anaplasmosis (HGA), a tick-borne disease caused by Anaplasma phagocytophilum, a Gram-negative coccobacillus. This patient showed striking hematological manifestations including a large number of pseudo-PHA, a severe degree of left shift, and dysplastic granulocytes. These hematological presentations on the peripheral smear all resolved with doxycycline treatment, implying that the changes were most likely reactive manifestations secondary to HGA, rather than underlying hematological malignancies such as MDS or AML.
MeSH term(s)	Adult ; Anaplasma phagocytophilum ; Anaplasmosis/diagnosis ; Anaplasmosis/drug therapy ; Anaplasmosis/microbiology ; Diagnosis, Differential ; Granulocytes/pathology ; Humans ; Male ; Neutrophils/pathology ; Pelger-Huet Anomaly/diagnosis
Language	English
Publishing date	2015-03-07
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-015-1769-1
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