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Article ; Online: Tocilizumab in patients infected by SARS-CoV2.

Sancho, Milagros / Muñiz, Javier / Cardinal-Fernández, Pablo

Medicina clinica (English ed.)

2021 Volume 156, Issue 8, Page(s) 402–406

Language	English
Publishing date	2021-03-19
Publishing country	Spain
Document type	Journal Article
ISSN	2387-0206
ISSN (online)	2387-0206
DOI	10.1016/j.medcle.2020.12.010
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Article ; Online: Tocilizumab en el paciente con COVID-19.

Sancho, Milagros / Muñiz, Javier / Cardinal-Fernández, Pablo

Medicina clinica

2021 Volume 156, Issue 8, Page(s) 402–406

Title translation	Tocilizumab in patients infected by SARS-CoV2.
MeSH term(s)	Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; RNA, Viral ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Monoclonal, Humanized ; RNA, Viral ; tocilizumab (I031V2H011)
Language	Spanish
Publishing date	2021-01-28
Publishing country	Spain
Document type	Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2020.12.003
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Article ; Online: Multicentre study of cefiderocol for treatment of Gram-negative bacteria infections in critically ill patients.

Balandín, Bárbara / Pintado, Vicente / Pérez-Pedrero, María José / Martínez-Sagasti, Fernando / Sancho-González, Milagros / Soriano-Cuesta, Cruz / Gesso, Cristina Martín-Dal / Chicot, Marta / de Luna, Rafael Ruiz / Asensio-Martín, María José / Catalan, Mercedes / Díaz-Díaz, Juan José / Carbonell, Nieves / Iranzo, Reyes / Royuela, Ana / Ballesteros, Daniel

International journal of antimicrobial agents

2024 Volume 63, Issue 5, Page(s) 107121

Language	English
Publishing date	2024-02-24
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2024.107121
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Donación en asistolia controlada en el paciente pediátrico.

Butragueño Laiseca, Laura / Sancho González, Milagros / López-Herce Cid, Jesús / Mencía Bartolomé, Santiago

Anales de pediatria

2019 Volume 92, Issue 5, Page(s) 299–300

Title translation	Controlled asystole donation in the paediatric patient.
MeSH term(s)	Female ; Heart Arrest ; Humans ; Infant ; Tissue and Organ Harvesting/methods ; Tissue and Organ Procurement/methods
Language	Spanish
Publishing date	2019-07-21
Publishing country	Netherlands
Document type	Case Reports ; Letter
ZDB-ID	2830901-7
ISSN	2341-2879 ; 2341-2879
ISSN (online)	2341-2879
ISSN	2341-2879
DOI	10.1016/j.anpedi.2019.06.006
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Article ; Online: Redox- and Ligand Binding-Dependent Conformational Ensembles in the Human Apoptosis-Inducing Factor Regulate Its Pro-Life and Cell Death Functions.

Villanueva, Raquel / Romero-Tamayo, Silvia / Laplaza, Ruben / Martínez-Olivan, Juan / Velázquez-Campoy, Adrián / Sancho, Javier / Ferreira, Patricia / Medina, Milagros

Antioxidants & redox signaling

2019 Volume 30, Issue 18, Page(s) 2013–2029

Abstract: Aims: ...

Abstract	Aims:
MeSH term(s)	Apoptosis Inducing Factor/chemistry ; Apoptosis Inducing Factor/genetics ; Apoptosis Inducing Factor/metabolism ; Cell Death ; Humans ; Hydrogen-Ion Concentration ; Mitochondria/metabolism ; Models, Molecular ; Mutation ; NAD/metabolism ; Oxidation-Reduction ; Protein Binding ; Protein Conformation ; Protein Multimerization
Chemical Substances	AIFM1 protein, human ; Apoptosis Inducing Factor ; NAD (0U46U6E8UK)
Language	English
Publishing date	2019-01-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2018.7658
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Zs.A 5488: Show issues

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Article: Hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS) following treatment with tisagenlecleucel.

Martín-Rojas, Reyes Maria / Gómez-Centurión, Ignacio / Bailén, Rebeca / Bastos, Mariana / Diaz-Crespo, Francisco / Carbonell, Diego / Correa-Rocha, Rafael / Pion, Marjorie / Muñoz, Cristina / Sancho, Milagros / Gómez Fernández, Isabel / Oarbeascoa, Gillen / Pérez-Corral, Ana / Martínez-Laperche, Carolina / Anguita, Javier / Buño, Ismael / Menárguez, Javier / Díez-Martín, Jose Luis / Kwon, Mi

Clinical case reports

2022 Volume 10, Issue 1, Page(s) e05209

Abstract: Chimeric antigen receptor (CAR) T cell-related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the ... ...

Abstract	Chimeric antigen receptor (CAR) T cell-related HLH/MAS is an unusual manifestation of severe cytokine release syndrome (CRS) with poor prognosis and a challenging diagnosis. The establishment of specific diagnosis criteria is essential, and the combination of several techniques for CAR T-cell follow-up, allows a more precise management of this complication.
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.5209
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Article ; Online: Mid-Regional Pro-Adrenomedullin, Methemoglobin and Carboxyhemoglobin as Prognosis Biomarkers in Critically Ill Patients with COVID-19: An Observational Prospective Study.

Oblitas, Crhistian-Mario / Galeano-Valle, Francisco / Ramírez-Navarro, Jesús / López-Cano, Jorge / Monterrubio-Manrique, Ángel / García-Gámiz, Mercedes / Sancho-González, Milagros / Arenal-López, Sara / Álvarez-Sala Walther, Luis-Antonio / Demelo-Rodríguez, Pablo

Viruses

2021 Volume 13, Issue 12

Abstract: Mid-regional pro-adrenomedullin (MR-proADM), methemoglobin (MetHb), and carboxyhemoglobin (COHb) levels have been associated with sepsis. In this study, we assessed the role of this potential biomarkers in critically ill COVID-19 patients. Outcomes were ... ...

Abstract	Mid-regional pro-adrenomedullin (MR-proADM), methemoglobin (MetHb), and carboxyhemoglobin (COHb) levels have been associated with sepsis. In this study, we assessed the role of this potential biomarkers in critically ill COVID-19 patients. Outcomes were mortality and a combined event (mortality, venous or arterial thrombosis, and orotracheal intubation (OTI)) during a 30-day follow-up. A total of 95 consecutive patients were included, 51.6% required OTI, 12.6% patients died, 8.4% developed VTE, and 3.1% developed arterial thrombosis. MetHb and COHb levels were not associated with mortality nor combined event. Higher MR-proADM levels were found in patients with mortality (median of 1.21 [interquartile range-IQR-0.84;2.33] nmol/L vs. 0.76 [IQR 0.60;1.03] nmol/L,
MeSH term(s)	Adrenomedullin ; Aged ; Biomarkers ; COVID-19/mortality ; COVID-19 Testing ; Carboxyhemoglobin ; Critical Illness ; Female ; Humans ; Male ; Methemoglobin ; Middle Aged ; Prognosis ; Prospective Studies ; SARS-CoV-2 ; Sepsis ; Thrombosis
Chemical Substances	ADM protein, human ; Biomarkers ; Adrenomedullin (148498-78-6) ; Methemoglobin (9008-37-1) ; Carboxyhemoglobin (9061-29-4)
Language	English
Publishing date	2021-12-06
Publishing country	Switzerland
Document type	Journal Article ; Observational Study
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13122445
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Article ; Online: A mild deficiency of ADAMTS13 is associated with severity in COVID-19: comparison of the coagulation profile in critically and noncritically ill patients.

Martín-Rojas, Reyes María / Chasco-Ganuza, Maite / Casanova-Prieto, Sara / Delgado-Pinos, Valeria Estefanía / Pérez-Rus, Gloria / Duque-González, Patricia / Sancho, Milagros / Díez-Martín, José Luis / Pascual-Izquierdo, Cristina

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2021 Volume 32, Issue 7, Page(s) 458–467

Abstract: Early descriptions of COVID-19 associated coagulopathy identified it as a disseminated intravascular coagulation (DIC). However, recent studies have highlighted the potential role of endothelial cell injury in its pathogenesis, and other possible ... ...

Abstract	Early descriptions of COVID-19 associated coagulopathy identified it as a disseminated intravascular coagulation (DIC). However, recent studies have highlighted the potential role of endothelial cell injury in its pathogenesis, and other possible underlying mechanisms are being explored. This study aimed to analyse the coagulation parameters of critically and noncritically ill patients with COVID-19 bilateral pneumonia, determine if coagulation factors consumption occurs and explore other potential mechanisms of COVID-19 coagulopathy. Critically and noncritically ill patients with a diagnosis of COVID-19 bilateral pneumonia were recruited. For each patient, we performed basic coagulation tests, quantification of coagulation factors and physiological inhibitor proteins, an evaluation of the fibrinolytic system and determination of von Willebrand Factor (vWF) and ADAMTS13. Laboratory data were compared with clinical data and outcomes. The study involved 62 patients (31 ICU, 31 non-ICU). The coagulation parameters assessment demonstrated normal median prothrombin time (PT), international normalized ratio (INR) and activated partial thromboplastin time (APTT) in our cohort and all coagulation factors were within normal range. PAI-1 median levels were elevated (median 52.6 ng/ml; IQR 37.2-85.7), as well as vWF activity (median 216%; IQR 196-439) and antigen (median 174%; IQR 153.5-174.1). A mild reduction of ADAMTS13 was observed in critically ill patients and nonsurvivors. We demonstrated an inverse correlation between ADAMTS13 levels and inflammatory markers, D-dimer and SOFA score in our cohort. Elevated vWF and PAI-1 levels, and a mild reduction of ADAMTS13 in the most severe patients, suggest that COVID-19 coagulopathy is an endotheliopathy that has shared features with thrombotic microangiopathy.
MeSH term(s)	ADAMTS13 Protein/blood ; ADAMTS13 Protein/deficiency ; Adult ; Aged ; Blood Coagulation ; COVID-19/blood ; COVID-19/complications ; Critical Illness/epidemiology ; Disseminated Intravascular Coagulation/blood ; Disseminated Intravascular Coagulation/etiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Chemical Substances	ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
Language	English
Publishing date	2021-07-26
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	1033551-1
ISSN	1473-5733 ; 0957-5235
ISSN (online)	1473-5733
ISSN	0957-5235
DOI	10.1097/MBC.0000000000001068
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Article ; Online: Multicentre study of ceftazidime/avibactam for Gram-negative bacteria infections in critically ill patients.

Balandín, Bárbara / Ballesteros, Daniel / Pintado, Vicente / Soriano-Cuesta, Cruz / Cid-Tovar, Irene / Sancho-González, Milagros / Pérez-Pedrero, María José / Chicot, Marta / Asensio-Martín, María José / Silva, José Alberto / de Luna, Rafael Ruiz / Gesso, Cristina Martín-Dal / Rodríguez-Serrano, Diego Aníbal / Martínez-Sagasti, Fernando / Royuela, Ana

International journal of antimicrobial agents

2022 Volume 59, Issue 3, Page(s) 106536

Abstract: This study aimed to assess the efficacy of ceftazidime/avibactam (C/A) in the treatment of infections due to Gram-negative bacteria (GNB) in critically ill patients. A multicentre, retrospective, observational study was conducted in critically ill ... ...

Abstract	This study aimed to assess the efficacy of ceftazidime/avibactam (C/A) in the treatment of infections due to Gram-negative bacteria (GNB) in critically ill patients. A multicentre, retrospective, observational study was conducted in critically ill patients receiving C/A for GNB infections. We evaluated demographic data, localisation and severity of infection, clinical and microbiological outcomes, and mortality. A total of 68 patients received C/A for serious GNB infections. The main infections were respiratory (33.8%), intra-abdominal (22.1%) and urinary tract infections (10.3%); bacteraemia was found in 22 cases (32.4%). Most infections were complicated by septic shock (58.8%) or sepsis (36.8%) and most of them required life-supporting therapies. Enterobacterales (79.4%) and Pseudomonas aeruginosa (19.1%) were the most frequently isolated bacteria; 84.2% of isolates were carbapenem-resistant. Thirty-four patients (50.0%) received C/A in combination with other antimicrobials. Fifty patients (73.5%) presented a favourable clinical response. Microbiological eradication was documented in 25 cases (36.8%). No significant differences were found in clinical response between patients treated with monotherapy or combined therapy (79.4% vs. 67.6%; P = 0.27). Overall intensive care unit (ICU) mortality was 41.2%. Univariate analysis showed that 30-day all-cause mortality was significantly (P < 0.05) associated with bacteraemia, previous corticosteroid use and the need of life-supporting therapies. C/A appears to be an effective therapy for severe infections due to GNB, including carbapenem-resistant isolates, in critically ill patients. C/A combination therapy was not associated with a higher clinical response. Mortality correlated significantly with the presence of bacteraemia, previous corticosteroid use and the need for life-supporting therapies.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds/therapeutic use ; Ceftazidime/therapeutic use ; Critical Illness ; Drug Combinations ; Drug Resistance, Multiple, Bacterial ; Gram-Negative Bacteria ; Gram-Negative Bacterial Infections/drug therapy ; Gram-Negative Bacterial Infections/microbiology ; Humans ; Microbial Sensitivity Tests ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Azabicyclo Compounds ; Drug Combinations ; avibactam (7352665165) ; Ceftazidime (9M416Z9QNR)
Language	English
Publishing date	2022-01-25
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2022.106536
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Allogeneic CD34-selected stem cell boost as salvage treatment of life-threatening infection and severe cytopenias after CAR-T cell therapy.

de Tena, Pablo Silva / Bailén, Rebeca / Oarbeascoa, Gillen / Gómez-Centurión, Ignacio / Pérez-Corral, Ana / Carbonell, Diego / Martínez-Laperche, Carolina / Sancho, Milagros / Bastos-Oreiro, Mariana / Conde-Royo, Diego / Fernández-Caldas, Paula / Muñoz, Cristina / Sabell, Santiago / Buño, Ismael / Anguita, Javier / Díez-Martín, José Luis / Kwon, Mi

Transfusion

2022 Volume 62, Issue 10, Page(s) 2143–2147

Abstract: Background: A variable incidence of profound cytopenia has been described in patients receiving chimeric antigen receptor T-cell (CAR-T) therapy for relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (ALL). This complication leads to ... ...

Abstract	Background: A variable incidence of profound cytopenia has been described in patients receiving chimeric antigen receptor T-cell (CAR-T) therapy for relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (ALL). This complication leads to severe infection in some cases, especially those who present additional risk factors including prior hematopoietic stem cell transplantation (HSCT). Study design and methods: We report a case of breakthrough invasive fungal infection in a patient with prolonged neutropenia after CAR-T cell therapy administered for relapsed B-cell ALL after allogeneic haploidentical HSCT. Results: After disease progression was discarded, therapy with antifungal agents, G-CSF and thrombopoietin analogue was started. However, no sign of haematological recovery or infection improvement was observed. A fresh mobilized selected CD34-stem cell boost from her haploidentical transplant donor was infused without further conditioning. Within 15 days of mobilized CD34-boost administration the patient showed complete resolution of both the aplasia and fungal infection. Discussion: This case illustrates as proof-of-concept the efficacy and safety of selected CD34-stem cell boost from prior donor as salvage treatment of prolonged cytopenias after CAR-T cell therapy.
MeSH term(s)	Antifungal Agents/therapeutic use ; Antigens, CD34 ; Female ; Granulocyte Colony-Stimulating Factor/therapeutic use ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Immunotherapy, Adoptive/adverse effects ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Receptors, Chimeric Antigen ; Salvage Therapy ; Thrombocytopenia/etiology ; Thrombopoietin
Chemical Substances	Antifungal Agents ; Antigens, CD34 ; Receptors, Chimeric Antigen ; Granulocyte Colony-Stimulating Factor (143011-72-7) ; Thrombopoietin (9014-42-0)
Language	English
Publishing date	2022-08-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.17071
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