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Article: Can Micro RNA-24 Affect the Cardiovascular Morbidity in Systemic Lupus Erythematosus by Targeting YKL-40?

Alhelf, Maha / Rashed, Laila / Ahmed, Sahar / Mady, Mohamed / Abdelgwad, Marwa

Reports of biochemistry & molecular biology

2023 Volume 11, Issue 3, Page(s) 511–523

Abstract: Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with inflammatory nature. One of the leading causes of death in SLE patients is cardiovascular (CVS) morbidity. MiRNA-24 is highly expressed in vascular endothelial cells (VECs). ... ...

Abstract	Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with inflammatory nature. One of the leading causes of death in SLE patients is cardiovascular (CVS) morbidity. MiRNA-24 is highly expressed in vascular endothelial cells (VECs). This dysregulated expression pattern is associated with dysfunction or even damage of VECs and leads to the occurrence of cardiovascular diseases. YKL- 40 is an inflammatory glycoprotein involved in the pathogenesis of endothelial dysfunction and thereby atherosclerosis. In this work, we aimed at illustrating the possible role of miR-24 and its target YKL-40 in the pathogenesis of the CVS morbidity associated with SLE. Methods: This work was conducted on 40 SLE patients and 40 healthy controls. Quantitative real-time PCR (qPCR) was done to estimate the expression level of miRNA-24 in serum. In addition, we measured the serum level of YKL-40 using ELISA. Results: miR-24-fold change was found to be down-regulated, whereas serum YKL- 40 was up-regulated among SLE patients with observed significant and negative correlation between the two parameters. Conclusion: Our study provided an insight about the role of miR-24 and its target serum YKL-40 protein in the development of SLE-related inflammation and atherosclerosis.
Language	English
Publishing date	2023-01-30
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2743890-9
ISSN	2322-3480
ISSN	2322-3480
DOI	10.52547/rbmb.11.3.511
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Article ; Online: Influence of gamma irradiation on rosin properties and its antimicrobial activity.

Badr, Magd M / Awadallah-F, Ahmed / Azzam, Ahmed M / Mady, A H

Scientific reports

2023 Volume 13, Issue 1, Page(s) 4500

Abstract: The main component of rosin natural gum is abietic acid, which has an interesting chemical structure to be studied with the influence of gamma-ray and the antimicrobial activity on the properties of a cheap abundant solid state natural material of rosin. ...

Abstract	The main component of rosin natural gum is abietic acid, which has an interesting chemical structure to be studied with the influence of gamma-ray and the antimicrobial activity on the properties of a cheap abundant solid state natural material of rosin. Rosin is exposed to a wide scale of gamma-ray ranges from 0 to 100 kGy. The changes in the properties are tracked by various techniques of FTIR, XRD, TGA, GPC, and SEM. The molecular weight of rosin changes from 370 g/mol to higher and the morphological properties were investigated. The irradiated rosin acid (IRA) at different irradiation doses exploited antimicrobial effect versus Gram-positive and Gram-negative as well. The inhibition zone enhanced from 15 to 33, 14 to 28, 14 to 20, and 9 to 14 mm for Gram-positive and Gram-negative, respectively. Moreover, bioactive behavior for irradiated rosin of 40 kGy recorded the highest antibacterial activity against both types of bacteria. The outcome data of antimicrobial activity are good and confirm that there is a significant effect of irradiation dose on the biocidal activity of rosin.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bacteria ; Resins, Plant/chemistry ; Molecular Weight
Chemical Substances	rosin (88S87KL877) ; Anti-Bacterial Agents ; Resins, Plant
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-31372-7
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Article: Correction: Elsherbeny et al. 2-(3-Bromophenyl)-8-fluoroquinazoline-4-carboxylic Acid as a Novel and Selective Aurora A Kinase Inhibitory Lead with Apoptosis Properties: Design, Synthesis, In Vitro and In Silico Biological Evaluation.

Elsherbeny, Mohamed H / Ammar, Usama M / Abdellattif, Magda H / Abourehab, Mohammed A S / Abdeen, Ahmed / Ibrahim, Samah F / Abdelrahaman, Doaa / Mady, Wessam / Roh, Eun Joo / Elkamhawy, Ahmed

Life (Basel, Switzerland)

2024 Volume 14, Issue 4

Abstract: In the original publication [ ... ]. ...

Abstract	In the original publication [...].
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14040423
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Article: Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering.

El-Husseiny, Hussein M / Mady, Eman A / El-Dakroury, Walaa A / Doghish, Ahmed S / Tanaka, Ryou

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1174075

Abstract: Biomedicine and tissue regeneration have made significant advancements recently, positively affecting the whole healthcare spectrum. This opened the way for them to develop their applications for revitalizing damaged tissues. Thus, their functionality ... ...

Abstract	Biomedicine and tissue regeneration have made significant advancements recently, positively affecting the whole healthcare spectrum. This opened the way for them to develop their applications for revitalizing damaged tissues. Thus, their functionality will be restored. Cardiac tissue engineering (CTE) using curative procedures that combine biomolecules, biomimetic scaffolds, and cells plays a critical part in this path. Stimuli-responsive hydrogels (SRHs) are excellent three-dimensional (3D) biomaterials for tissue engineering (TE) and various biomedical applications. They can mimic the intrinsic tissues' physicochemical, mechanical, and biological characteristics in a variety of ways. They also provide for 3D setup, adequate aqueous conditions, and the mechanical consistency required for cell development. Furthermore, they function as competent delivery platforms for various biomolecules. Many natural and synthetic polymers were used to fabricate these intelligent platforms with innovative enhanced features and specialized capabilities that are appropriate for CTE applications. In the present review, different strategies employed for CTE were outlined. The light was shed on the limitations of the use of conventional hydrogels in CTE. Moreover, diverse types of SRHs, their characteristics, assembly and exploitation for CTE were discussed. To summarize, recent development in the construction of SRHs increases their potential to operate as intelligent, sophisticated systems in the reconstruction of degenerated cardiac tissues.
Language	English
Publishing date	2023-06-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1174075
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Article: Off-Pump Versus On-Pump Coronary Artery Bypass Grafting In Patients With Chronic Obstructive Pulmonary Disease.

Mady, Karim Mohamed / Abdou Ettish, Amr Ahmed / Elfeky, Wael Mohamed / Mostafa, Mohamed Mostafa

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73Suppl 4, Issue 4, Page(s) S34–S38

Abstract: Objectives: To compare the outcome of coronary artery bypass grafting with and without cardiopulmonary bypassin patients of chronic obstructive pulmonary disease.: Method: The prospective randomised multicentre study was conducted in 2020 at ... ...

Abstract	Objectives: To compare the outcome of coronary artery bypass grafting with and without cardiopulmonary bypassin patients of chronic obstructive pulmonary disease. Method: The prospective randomised multicentre study was conducted in 2020 at Kafrelsheikh University Hospital, International Cardiac Centre and Alexandria New Medical Centre, Egypt. Patients regardless of age and gender who had ischaemic heart disease and chronic obstructive pulmonary disease were enrolled, and randomised into on-pump procedure group 1 and off-pump procedure group II. All patients were assessed preoperatively for pulmonary function tests and postoperatively for duration of mechanical ventilation, respiratory failure, pneumonia, atrial fibrillation, acute respiratory distresssyndrome, pleural effusion, lung atelectasis, sternal dehiscence, intensive care unit stay and overall hospital stay. Data was analysed using SPSS ver 25 Armonk, NY: IBM Corp.; Released 2017. Results: Of the 60 patients, 30(50%) were in each of the two groups. Overall, there were 20(33.3%) women and 40(66.6%) men with mean age 56.5±6.05 years. The mean duration of mechanical ventilation in group I was 12.07±5.18 minutes compared to 6.97±2.25 minutes in group II (p<0.001). The mean duration of stay in intensive care unit in group I was 4.17±1.64 days compared to 3.03±1.03 days in group II (p<0.001). The mean hospital stay was 7.40±1.90 days in group I and 5.93±1.17 days in group II (p<0.001). There was no significant difference between the groups regarding the frequency of respiratory failure, pneumonia, atrial fibrillation, acute respiratory distresssyndrome, pleural effusion, lung atelectasis and sternal dehiscence (p=1.000). Conclusions: Off-pump coronary artery bypass grafting wasfound to be efficient and had a faster postoperative course than on-pump procedure in patients with chronic obstructive pulmonary disease.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Prospective Studies ; Atrial Fibrillation/epidemiology ; Coronary Artery Bypass ; Pulmonary Disease, Chronic Obstructive/complications ; Coronary Artery Disease/surgery ; Pleural Effusion ; Pulmonary Atelectasis ; Respiratory Insufficiency ; Postoperative Complications/epidemiology ; Length of Stay ; Treatment Outcome ; Cardiopulmonary Bypass
Language	English
Publishing date	2023-07-24
Publishing country	Pakistan
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.EGY-S4-11
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Article: Off-Pump Versus On-Pump Coronary Artery Bypass Grafting In Patients With Left Main Coronary Artery Disease: A Randomized Controlled Trial.

Mady, Karim Mohamed / Abdou Ettish, Amr Ahmed / Elfeky, Wael Mohamed / Abdelaal, Mohamed Mostafa

JPMA. The Journal of the Pakistan Medical Association

2023 Volume 73Suppl 4, Issue 4, Page(s) S22–S25

Abstract: Objectives: To compare the outcome of off-pump and on-pump coronary artery bypass graftsurgery in patients with left main coronary artery disease.: Methods: The randomised, controlled, prospective, multicentric study was conducted in 2020 during the ... ...

Abstract	Objectives: To compare the outcome of off-pump and on-pump coronary artery bypass graftsurgery in patients with left main coronary artery disease. Methods: The randomised, controlled, prospective, multicentric study was conducted in 2020 during the period from January 2020 to December 2020 at Kafrelsheikh University Hospital, International Cardiac Centre and Alexandria New Medical Centre, Egypt, and comprised patients with left main coronary artery disease who underwent coronary artery bypass graftsurgery. The patients were randomised to on-pump surgery group I (Control Group) and off-pump surgery group II(Interventional Group). All patients were assessed pre-operatively for the presence of comorbid conditions and post-operatively for myocardial infarction, acute kidney injury, pneumonia, sternal dehiscence and 3-month mortality. Data was analysed using SPSS 20. Results: Of the 60 patients, 44(73.3%) were men and 16(26.6%) were women. The overall mean age was 66.4±9.2 years. There were 30(50%) patients in each of the two groups. There were 2(6.7%) cases of myocardial infarction in group I and 1(3.3%) in group II. There was 1(3.3%) case of acute kidney injury in group I and none in group II. There were 3(10%) cases of pneumonia in group 1 compared to 1(3.3%) in group II. There was 1(3.3%) case of sternal dehiscence in group I and none in group II. Mortality at 3 months was 2(6.7%) in group I and 1(3.3%) in group II. There was no significant difference with respect to outcome between the groups (p>0.05). Conclusions: Off-pump coronary artery bypass graft surgery was found to be efficient and non-inferior to on-pump procedure in patients with left main coronary artery disease. Rct registration: The RCT was registered retrospectively at the Pan African Clinical Trials Registry (PACTR) (Trial #: PACTR202301506140749 Date of Approval: 06/01/2023). Link: https://pactr.samrc.ac.za/Search.aspx.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Coronary Artery Disease/complications ; Coronary Artery Disease/surgery ; Retrospective Studies ; Prospective Studies ; Treatment Outcome ; Coronary Artery Bypass ; Myocardial Infarction/epidemiology ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Pneumonia/epidemiology ; Postoperative Complications/epidemiology
Language	English
Publishing date	2023-07-23
Publishing country	Pakistan
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	603873-6
ISSN	0030-9982
ISSN	0030-9982
DOI	10.47391/JPMA.EGY-S4-5
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Article ; Online: Mortality Rates in Early versus Late Intensive Care Unit Readmission.

Mady, Ahmed Fouad / Al-Odat, Mohammed Ali / Alshaya, Rayan / Hussien, Sahar / Aletreby, Ahmed / Hamido, Hend Mohammed / Aletreby, Waleed Tharwat

Saudi journal of medicine & medical sciences

2023 Volume 11, Issue 2, Page(s) 143–149

Abstract: Background: ICU readmission is associated with poor outcomes. Few studies have directly compared the outcomes of early versus late readmissions, especially in Saudi Arabia.: Objective: To compare the outcomes between early and late ICU readmissions, ... ...

Abstract	Background: ICU readmission is associated with poor outcomes. Few studies have directly compared the outcomes of early versus late readmissions, especially in Saudi Arabia. Objective: To compare the outcomes between early and late ICU readmissions, mainly with regards to hospital mortality. Methods: This retrospective study included unique patients who, within the same hospitalization, were admitted to the ICU, discharged to the general wards, and then readmitted to the ICU of King Saud Medical City, Riyadh, Saudi Arabia, between January 01, 2015, and June 30, 2022. Patients readmitted within 2 calendar days were grouped into the Early readmission group, while those readmitted after 2 calendar days were in the Late readmission group. Results: A total of 997 patients were included, of which 753 (75.5%) belonged to the Late group. The mortality rate in the Late group was significantly higher than that in the Early group (37.6% vs. 29.5%, respectively; 95% CI: 1%-14.8%; Conclusion: Compared with late readmission, early readmission was associated with lower mortality, but not with lower LOS or severity score.
Language	English
Publishing date	2023-04-12
Publishing country	India
Document type	Journal Article
ZDB-ID	2734896-9
ISSN	2321-4856 ; 2321-4856
ISSN (online)	2321-4856
ISSN	2321-4856
DOI	10.4103/sjmms.sjmms_634_22
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Article ; Online: Pseudoaneurysm of the left ventricular free wall occurring after cardiac surgery of endocarditis affecting mitral and aortic valves: a case report.

El Hadj Sidi, Chighaly / Isselmou, Varha / Mohamed Ahmed, Mohamed Feissal / Diop, El Hadj Abdelaziz / Argueina, Taleb Ekhyar / Mady, Haimouda / Boye, Khaled

The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology

2023 Volume 75, Issue 1, Page(s) 6

Abstract: Background: Infective endocarditis remains a serious condition. Left ventricular pseudoaneurysm may complicate the clinical course of infective endocarditis or occur postoperatively.: Case presentation: We describe a case of a pseudoaneurysm of the ... ...

Abstract	Background: Infective endocarditis remains a serious condition. Left ventricular pseudoaneurysm may complicate the clinical course of infective endocarditis or occur postoperatively. Case presentation: We describe a case of a pseudoaneurysm of the left ventricular lateral wall which developed one month following cardiac surgery of active endocarditis affecting aortic and mitral valves. The diagnosis was established by transthoracic echocardiography and computed tomography angiography of the chest. Urgent cardiac surgery is performed with excision of the pseudoaneurysm and direct closure of the defect. The patient had a complete recovery and was discharged on the twelfth postoperative day. Conclusions: Left ventricular pseudoaneurysms are rare but potentially fatal. The symptoms revealing such complications are very diverse. Surgical treatment can be offered to younger patients.
Language	English
Publishing date	2023-01-24
Publishing country	Germany
Document type	Journal Article
ISSN	2090-911X
ISSN (online)	2090-911X
DOI	10.1186/s43044-023-00334-9
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Article ; Online: The relationship between asymptomatic atherosclerosis and hepcidin-25 in chronic kidney disease patients.

Mohamed, Osama Nady / Mady, Ahmed Mohamed / Sedik, Mohamed Mamdouh / Issa, Ahmed S / Mohamed, Omima M / Abdelhameed, Nadia Ismail

Annals of Saudi medicine

2023 Volume 43, Issue 5, Page(s) 298–308

Abstract: Background: The most common and lethal consequence of chronic kidney disease (CKD) is atherosclerotic cardiovascular disease. The persistent inflammation present in CKD increases hepcidin levels. Iron accumulates in the arterial wall in atherosclerosis. ...

Abstract	Background: The most common and lethal consequence of chronic kidney disease (CKD) is atherosclerotic cardiovascular disease. The persistent inflammation present in CKD increases hepcidin levels. Iron accumulates in the arterial wall in atherosclerosis. Hepcidin-25 was thought to accelerate the development of atherosclerotic plaques by blocking iron release from macrophages. Therefore, we sought to determine the relationship between hepcidin-25 and asymptomatic atherosclerosis in non-dialysis CKD patients. Objectives: Investigate the relationship between hepcidin-25 and subclinical atherosclerosis in non-dialysis CKD patients. Design: Cross-sectional SETTINGS: Outpatient clinic for urology and nephrology at a university hospital SUBJECTS AND METHODS: Participants above the age of 18 years included a group of healthy controls and a group of CKD patients who were not routinely maintained on hemodialysis. The latter group was further divided according to eGFR into CKD-3, CKD-4 and CKD-5 subgroups. We excluded patients with comorbidities, patients with chronic liver disease, and other conditions or habits. CBC, kidney function tests, and serum levels of hepcidin-25 (SH-25), TNF-α, IL-6, high-sensitivity C-reactive protein (hs-CRP), TC, TG, LDL-C and HDL-C were assessed. To measure carotid intima media thickness (CIMT) and determine presence of plaques, carotid ultrasonography was performed. The near or far walls of common carotid artery, bulb, and internal carotid artery were used to measure CIMT. Main outcome measures: SH-25 association and indicators of subclinical atherosclerosis. Sample size: 128 participants, the control group (n=25) and the non-hemodialysis CKD patients (n=103) RESULTS: The CKD patients had significantly higher serum levels of markers of inflammation including IL-6, TNF-α, and hs-CRP ( Conclusions: SH-25 and CIMT had a positive relationship in CKD patients. The ROC curve showed that SH-25 is a reliable predictor of carotid atherosclerosis. Therefore, we suggest that SH-25 is a vital biomarker of asymptomatic atherosclerosis. Limitations: Single-center.
MeSH term(s)	Humans ; Adolescent ; Carotid Intima-Media Thickness ; C-Reactive Protein/metabolism ; Hepcidins ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Cross-Sectional Studies ; Cholesterol, LDL ; Atherosclerosis/etiology ; Renal Insufficiency, Chronic/complications ; Inflammation ; Iron ; Risk Factors
Chemical Substances	C-Reactive Protein (9007-41-4) ; Hepcidins ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Cholesterol, LDL ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-10-05
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	639014-6
ISSN	0975-4466 ; 0256-4947
ISSN (online)	0975-4466
ISSN	0256-4947
DOI	10.5144/0256-4947.2023.298
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Article ; Online: Green Synthesis, Characterization, Antimicrobial and Anticancer Screening of New Metal Complexes Incorporating Schiff Base.

Hassan, Ali M / Said, Ahmed O / Heakal, Bassem H / Younis, Ahmed / Aboulthana, Wael M / Mady, Mohamed F

ACS omega

2022 Volume 7, Issue 36, Page(s) 32418–32431

Abstract: A Schiff base ligand ... ...

Abstract	A Schiff base ligand of
Language	English
Publishing date	2022-08-26
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.2c03911
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