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Article ; Online: In Vitro

Gupta, Aanchal / Malik, Saquib / Kaminski, Monica / Landman, David / Quale, John M

Microbial drug resistance (Larchmont, N.Y.)

2022 Volume 28, Issue 4, Page(s) 419–424

Abstract: Infections due to extended-spectrum β-lactamase (ESBL)-producing Enterobacterales are an increasingly common problem. For many of these infections, no oral treatment options are available. The activity of amoxicillin-clavulanate combined with ceftibuten ... ...

Abstract	Infections due to extended-spectrum β-lactamase (ESBL)-producing Enterobacterales are an increasingly common problem. For many of these infections, no oral treatment options are available. The activity of amoxicillin-clavulanate combined with ceftibuten or cefpodoxime was evaluated against a group of
MeSH term(s)	Amoxicillin-Potassium Clavulanate Combination/pharmacology ; Amoxicillin-Potassium Clavulanate Combination/therapeutic use ; Anti-Bacterial Agents/pharmacology ; Ceftibuten ; Ceftizoxime/analogs & derivatives ; Escherichia coli ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; beta-Lactamases/genetics ; Cefpodoxime
Chemical Substances	Anti-Bacterial Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Ceftizoxime (C43C467DPE) ; beta-Lactamases (EC 3.5.2.6) ; Ceftibuten (IW71N46B4Y)
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1290490-9
ISSN	1931-8448 ; 1076-6294
ISSN (online)	1931-8448
ISSN	1076-6294
DOI	10.1089/mdr.2021.0025
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Article ; Online: High-dimensional Mass Cytometry identified circulating Natural Killer T-cell subsets associated with protection from Cytomegalovirus infection in kidney transplant recipients.

Donadeu, Laura / Jouve, Thomas / Bin, Sofia / Hartzell, Susan / Crespo, Elena / Torija, Alba / Jarque, Marta / Kevella, Delphine / Zúñiga, José / Zhang, Weijia / Sun, Zeguo / Verlato, Alberto / Martínez-Gallo, Mónica / Font-Miñarro, Cristina / Meneghini, Maria / Toapanta, Nestor / Torres, Irina B / Sellarés, Joana / Perelló, Manel /

Kaminski, Hannah / Couzi, Lionel / Loupy, Alexandre / La Manna, Gaetano / Moreso, Francesc / Cravedi, Paolo / Bestard, Oriol

Kidney international

2024

Abstract: Cytomegalovirus (CMV) infection is associated with poor kidney transplant outcomes. While innate and adaptive immune cells have been implicated in its prevention, an in-depth characterization of the in vivo kinetics of multiple cell subsets and their ... ...

Abstract	Cytomegalovirus (CMV) infection is associated with poor kidney transplant outcomes. While innate and adaptive immune cells have been implicated in its prevention, an in-depth characterization of the in vivo kinetics of multiple cell subsets and their role in protecting against CMV infection has not been achieved. Here, we performed high-dimensional immune phenotyping by mass cytometry, and functional assays, on 112 serially collected samples from CMV seropositive kidney transplant recipients. Advanced unsupervised deep learning analysis was used to assess immune cell populations that significantly correlated with prevention against CMV infection and anti-viral immune function. Prior to infection, kidney transplant recipients who developed CMV infection showed significantly lower CMV-specific cell-mediated immune (CMI) frequencies than those that did not. A broad diversity of circulating cell subsets within innate and adaptive immune compartments were associated with CMV infection or protective CMV-specific CMI. While percentages of CMV (tetramer-stained)-specific T cells associated with high CMI responses and clinical protection, circulating CD3
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2024.03.027
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Article ; Online: Trends in Healthcare Facility-Onset Clostridioides difficile Infection and the Impact of Testing Schemes in an Acute Care Hospital System in New York City, 2016-2019.

Episcopia, Briana / Gupta, Aanchal / Fornek, Mary / Kaminski, Monica / Malik, Saquib / Sunny, Subin / Landman, David / Xavier, Geralda / Quale, John

American journal of infection control

2021 Volume 49, Issue 10, Page(s) 1262–1266

Abstract: Background: Healthcare facility-onset Clostridioides difficile infection is associated with adverse clinical outcomes and hospital reimbursement. A four-year review involving eleven hospitals of the NYC Health + Hospital system was undertaken.: ... ...

Abstract	Background: Healthcare facility-onset Clostridioides difficile infection is associated with adverse clinical outcomes and hospital reimbursement. A four-year review involving eleven hospitals of the NYC Health + Hospital system was undertaken. Methods: From 2016-2019, infection rates and standardized infection ratios (SIRs) were gathered from National Healthcare Safety Network. The C. difficile testing scheme at each facility was recorded. Results: For the eleven hospitals, declines in rates of C. difficile infection and SIRs were documented. However, this decline was driven by two hospitals that had high rates of infection in 2016; for the remaining nine hospitals, rates of infection and SIRs were at a plateau. Most hospitals used a testing scheme that fell into the nucleic acid amplification test (NAAT) category for SIR risk adjustment. Hospitals that used the algorithm glutamate dehydrogenase (GDH) and toxin A/B immunoassay (EIA) followed by NAAT for discrepant results had significantly lower rates of C. difficile infection but similar SIRs. Conclusions: For most hospitals in this system, rates of C. difficile remained level. Within the NAAT test categories, SIRs may not correlate with infection rates. Given the controversies regarding testing and calculation of SIRs, alternatives to C. difficile infection should be sought as a hospital quality measurement.
MeSH term(s)	Bacterial Toxins ; Clostridioides ; Clostridioides difficile ; Clostridium Infections/diagnosis ; Clostridium Infections/epidemiology ; Delivery of Health Care ; Hospitals ; Humans ; New York City/epidemiology
Chemical Substances	Bacterial Toxins
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2021.03.003
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Article ; Online: Tocilizumab therapy for COVID-19: A comparison of subcutaneous and intravenous therapies.

Kaminski, Monica A / Sunny, Subin / Balabayova, Khayala / Kaur, Avneet / Gupta, Aanchal / Abdallah, Marie / Quale, John

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 101, Page(s) 59–64

Abstract: Background: The release of pro-inflammatory cytokines, resulting in cytokine storm syndrome, contributes to the morbidity and mortality associated with COVID-19 disease. This study aimed to compare the effects of intravenous (IV) and subcutaneous (SC) ... ...

Abstract	Background: The release of pro-inflammatory cytokines, resulting in cytokine storm syndrome, contributes to the morbidity and mortality associated with COVID-19 disease. This study aimed to compare the effects of intravenous (IV) and subcutaneous (SC) tocilizumab, an IL-6 receptor antagonist, on respiratory parameters and clinical outcome in patients with COVID 19. Methods: We performed a retrospective cohort study of hospitalized patients with COVID-19 treated with either IV or SC tocilizumab from March 26, 2020, to May 18, 2020. Respiratory parameters seven days after receiving tocilizumab therapy were compared to baseline measurements. All patients were assessed until discharged from the hospital. Results: Tocilizumab was administered to 125 patients: 65 received IV, and 60 received SC therapy. At day seven, 52% of the IV group patients demonstrated improvement in respiratory parameters, compared to 28% in the SC group (P = 0.01). Mortality rates at days seven and 28 were 15% and 37%, respectively, in the IV group and 17% and 50%, respectively, in the SC group (PNS). The in-hospital mortality rate was 38% for the IV group versus 57% for the SC group (P = 0.04). More than 90% of patients in each group received corticosteroids; however, significantly more patients received convalescent plasma in the IV group. Conclusions: At the doses used in this study, IV tocilizumab is preferred over SC therapy to treat cytokine storm syndrome due to COVID-19.
MeSH term(s)	Administration, Intravenous ; Adult ; Aged ; Antibodies, Monoclonal, Humanized/administration & dosage ; COVID-19/mortality ; Cytokine Release Syndrome/drug therapy ; Female ; Hospital Mortality ; Humans ; Injections, Subcutaneous ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Monoclonal, Humanized ; tocilizumab (I031V2H011)
Keywords	covid19
Language	English
Publishing date	2020-09-28
Publishing country	Canada
Document type	Comparative Study ; Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.09.1447
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Article: Influence of Ion Nitriding on Microstructure and Properties of Haynes 282 Nickel Superalloy Specimens Produced Using DMLS Technique.

Sitek, Ryszard / Kulikowski, Krzysztof / Paradowski, Krystian / Gancarczyk, Kamil / Losertová, Monika / Kobayashi, Akira / Moneta, Joanna / Kamiński, Janusz

Materials (Basel, Switzerland)

2023 Volume 16, Issue 14

Abstract: The paper investigates the influence of the ion-nitriding process on the microstructure, corrosion resistance, and tensile strength at elevated temperatures of Haynes 282 nickel superalloy specimens produced by the Direct Metal Laser Sintering (DMLS) ... ...

Abstract	The paper investigates the influence of the ion-nitriding process on the microstructure, corrosion resistance, and tensile strength at elevated temperatures of Haynes 282 nickel superalloy specimens produced by the Direct Metal Laser Sintering (DMLS) technique. The study was performed for two conditions, i.e., as-built by DMLS method and as-built by DMLS method + covered by a layer containing CrN + Cr
Language	English
Publishing date	2023-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16145020
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Article ; Online: Trends in central-line-associated bloodstream infections and catheter-associated urinary tract infections in a large acute-care hospital system in New York City, 2016-2019.

Kaminski, Monica A / Episcopia, Briana / Malik, Saquib / Fornek, Mary / Landman, David / Xavier, Geralda / Quale, John

Infection control and hospital epidemiology

2020 Volume 42, Issue 7, Page(s) 842–846

Abstract: Background: Central-line bloodstream infections (CLABSIs) and catheter-associated urinary tract infections (CAUTIs) negatively impact clinical outcomes and hospital reimbursement. In this report, 4 year trends involving 11 hospitals in New York City ... ...

Abstract	Background: Central-line bloodstream infections (CLABSIs) and catheter-associated urinary tract infections (CAUTIs) negatively impact clinical outcomes and hospital reimbursement. In this report, 4 year trends involving 11 hospitals in New York City were examined. Methods: Data from the National Healthcare Safety Network (NHSN) were extracted for 11 acute-care hospitals belonging to the NYC Health + Hospital system from 2016 through 2019. Trends in device infections per 1,000 patient days, device utilization ratios, and standardized infection ratios (SIRs) were examined for the 11 hospitals and for the entire system. Results: Over the 4-year period, there were progressive declines in central-line days, infections per 1,000 central-line days, and device utilization ratios for the system. The average annual SIRs for the system also declined: 1.40 in 2016, 1.09 in 2017, 1.04 in 2018, and 0.82 in 2019. Case-mix indices correlated with SIRs for CLABSIs. Level 1 trauma centers had higher SIRs and a disproportionately greater number of CLABSIs in patients located in NHSN-defined surgical intensive care units. Similar trends with CAUTIs were noted, with progressive declines in catheter days, infections per 1,000 patient days, device utilization ratios, and SIRs (1.42 in 2016, 0.93 in 2017, 1.18 in 2018, and 0.78 in 2019) over the 4-year period. Conclusions: Across an 11-hospital system, continuing efforts to reduce device utilization and infection rates resulted in declining SIRs for CLABSIs and CAUTIs. Hospitals with higher case-mix indices, and particularly level 1 trauma centers, had significantly higher central-line infection rates and SIRs.
MeSH term(s)	Catheter-Related Infections/epidemiology ; Central Venous Catheters ; Cross Infection/epidemiology ; Hospitals ; Humans ; Intensive Care Units ; New York City/epidemiology ; Pneumonia, Ventilator-Associated ; Sepsis/epidemiology ; Sepsis/etiology ; Urinary Tract Infections/epidemiology
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	639378-0
ISSN	1559-6834 ; 0195-9417 ; 0899-823X
ISSN (online)	1559-6834
ISSN	0195-9417 ; 0899-823X
DOI	10.1017/ice.2020.1293
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Article ; Online: Demand for Continuous and Long-Term Care in Transplant Recipients: Data From the Organ Transplantation Registry-Poltransplant Activity.

Czerwiński, Jarosław / Danek, Teresa / Hermanowicz, Małgorzata / Łęczycka, Anna / Nestorowicz-Kałużna, Klaudia / Parulski, Adam / Szemis, Łukasz / Trujnara, Monika / Woderska-Jasińska, Aleksandra / Kamiński, Artur

Transplantation proceedings

2024

Abstract: Background: This study aimed to determine the number of recipients with active transplants under the care of transplant centers in 2022 and the current volume and needs for continuous and long-term care in this group of transplant recipients. Data came ... ...

Abstract	Background: This study aimed to determine the number of recipients with active transplants under the care of transplant centers in 2022 and the current volume and needs for continuous and long-term care in this group of transplant recipients. Data came from the organ transplant registry, one of the registries maintained by the Polish Transplant Coordinating Center Poltransplant. We included recipients of individual organs who, on January 1, 2022, were living with an active transplant performed in previous years and recipients who received a transplant in 2022. The number of recipients under the care of transplant centers in 2022 was 20,994 (55% of all transplants performed in Poland since the beginning of activity in 1966).
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2024.03.009
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Article ; Online: Why do Polish patients use vitamin drip services? Results of a preliminary cross-sectional survey.

Kamiński, Mikołaj / Kręgielska-Narożna, Matylda / Soczewka, Monika / Bogdański, Paweł

Polish archives of internal medicine

2020 Volume 130, Issue 11, Page(s) 1007–1009

MeSH term(s)	Cross-Sectional Studies ; Humans ; Poland ; Vitamin D ; Vitamins
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2020-09-15
Publishing country	Poland
Document type	Letter
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.15602
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Article ; Online: Tocilizumab therapy for COVID-19

Kaminski, Monica A. / Sunny, Subin / Balabayova, Khayala / Kaur, Avneet / Gupta, Aanchal / Abdallah, Marie / Quale, John

International Journal of Infectious Diseases

A comparison of subcutaneous and intravenous therapies

2020 Volume 101, Page(s) 59–64

Keywords	Microbiology (medical) ; Infectious Diseases ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.09.1447
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Article ; Online: Tocilizumab therapy for COVID-19

Monica A. Kaminski / Subin Sunny / Khayala Balabayova / Avneet Kaur / Aanchal Gupta / Marie Abdallah / John Quale

International Journal of Infectious Diseases, Vol 101, Iss , Pp 59-

A comparison of subcutaneous and intravenous therapies

2020 Volume 64

Abstract	Background: The release of pro-inflammatory cytokines, resulting in cytokine storm syndrome, contributes to the morbidity and mortality associated with COVID-19 disease. This study aimed to compare the effects of intravenous (IV) and subcutaneous (SC) tocilizumab, an IL-6 receptor antagonist, on respiratory parameters and clinical outcome in patients with COVID 19. Methods: We performed a retrospective cohort study of hospitalized patients with COVID-19 treated with either IV or SC tocilizumab from March 26, 2020, to May 18, 2020. Respiratory parameters seven days after receiving tocilizumab therapy were compared to baseline measurements. All patients were assessed until discharged from the hospital. Results: Tocilizumab was administered to 125 patients: 65 received IV, and 60 received SC therapy. At day seven, 52% of the IV group patients demonstrated improvement in respiratory parameters, compared to 28% in the SC group (P = 0.01). Mortality rates at days seven and 28 were 15% and 37%, respectively, in the IV group and 17% and 50%, respectively, in the SC group (PNS). The in-hospital mortality rate was 38% for the IV group versus 57% for the SC group (P = 0.04). More than 90% of patients in each group received corticosteroids; however, significantly more patients received convalescent plasma in the IV group. Conclusions: At the doses used in this study, IV tocilizumab is preferred over SC therapy to treat cytokine storm syndrome due to COVID-19.
Keywords	COVID-19 ; Cytokine storm ; Tocilizumab ; Infectious and parasitic diseases ; RC109-216 ; covid19
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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