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  1. Article: Tolerization as a tool for generating novel monoclonal antibodies.

    Holbrook, Felicity L / Nicholson, Ian C / Zola, Heddy

    Immunology and cell biology

    2002  Volume 80, Issue 4, Page(s) 319–322

    Abstract: Standard hybridoma production involves the fusion of spleen cells from an immunized mouse with a non-secretory murine myeloma cell line. While this technology has provided numerous reagents that are highly valuable, demand is now increasing for ... ...

    Abstract Standard hybridoma production involves the fusion of spleen cells from an immunized mouse with a non-secretory murine myeloma cell line. While this technology has provided numerous reagents that are highly valuable, demand is now increasing for monoclonal antibodies which can distinguish between closely related antigens. Induction of tolerance towards common antigens enables the recovery of high-specificity reagents that have previously proved elusive. This review details a number of strategies using either complex protein mixtures or purified proteins as tolerogens and subsequent immunization with a closely related immunogen.
    MeSH term(s) Animals ; Animals, Newborn ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; Antigens/immunology ; Humans ; Immune Tolerance ; Mice ; Proteins/immunology ; Rats
    Chemical Substances Antibodies, Monoclonal ; Antigens ; Proteins
    Language English
    Publishing date 2002-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1046/j.1440-1711.2002.01095.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.175: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Cohort Profile: The New South Wales Child Development Study (NSW-CDS)-Wave 2 (child age 13 years).

    Green, Melissa J / Harris, Felicity / Laurens, Kristin R / Kariuki, Maina / Tzoumakis, Stacy / Dean, Kimberlie / Islam, Fakhrul / Rossen, Larissa / Whitten, Tyson / Smith, Maxwell / Holbrook, Allyson / Bore, Miles / Brinkman, Sally / Chilvers, Marilyn / Sprague, Titia / Stevens, Robert / Carr, Vaughan J

    International journal of epidemiology

    2018  Volume 47, Issue 5, Page(s) 1396–1397k

    MeSH term(s) Academic Success ; Adolescent ; Child ; Child Abuse ; Child Development ; Child Health ; Child, Preschool ; Female ; Geography ; Humans ; Intergenerational Relations ; Longitudinal Studies ; Male ; Mental Health ; New South Wales ; Social Class
    Language English
    Publishing date 2018-07-17
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 187909-1
    ISSN 1464-3685 ; 0300-5771
    ISSN (online) 1464-3685
    ISSN 0300-5771
    DOI 10.1093/ije/dyy115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 893: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: New South Wales Child Development Study (NSW-CDS): an Australian multiagency, multigenerational, longitudinal record linkage study.

    Carr, Vaughan J / Harris, Felicity / Raudino, Alessandra / Luo, Luming / Kariuki, Maina / Liu, Enwu / Tzoumakis, Stacy / Smith, Maxwell / Holbrook, Allyson / Bore, Miles / Brinkman, Sally / Lenroot, Rhoshel / Dix, Katherine / Dean, Kimberlie / Laurens, Kristin R / Green, Melissa J

    BMJ open

    2016  Volume 6, Issue 2, Page(s) e009023

    Abstract: Purpose: The initial aim of this multiagency, multigenerational record linkage study is to identify childhood profiles of developmental vulnerability and resilience, and to identify the determinants of these profiles. The eventual aim is to identify ... ...

    Abstract Purpose: The initial aim of this multiagency, multigenerational record linkage study is to identify childhood profiles of developmental vulnerability and resilience, and to identify the determinants of these profiles. The eventual aim is to identify risk and protective factors for later childhood-onset and adolescent-onset mental health problems, and other adverse social outcomes, using subsequent waves of record linkage. The research will assist in informing the development of public policy and intervention guidelines to help prevent or mitigate adverse long-term health and social outcomes.
    Participants: The study comprises a population cohort of 87,026 children in the Australian State of New South Wales (NSW). The cohort was defined by entry into the first year of full-time schooling in NSW in 2009, at which time class teachers completed the Australian Early Development Census (AEDC) on each child (with 99.7% coverage in NSW). The AEDC data have been linked to the children's birth, health, school and child protection records for the period from birth to school entry, and to the health and criminal records of their parents, as well as mortality databases.
    Findings to date: Descriptive data summarising sex, geographic and socioeconomic distributions, and linkage rates for the various administrative databases are presented. Child data are summarised, and the mental health and criminal records data of the children's parents are provided.
    Future plans: In 2015, at age 11 years, a self-report mental health survey was administered to the cohort in collaboration with government, independent and Catholic primary school sectors. A second record linkage, spanning birth to age 11 years, will be undertaken to link this survey data with the aforementioned administrative databases. This will enable a further identification of putative risk and protective factors for adverse mental health and other outcomes in adolescence, which can then be tested in subsequent record linkages.
    MeSH term(s) Child ; Child Development ; Child Health ; Health Status ; Humans ; Literacy ; Longitudinal Studies ; Medical Record Linkage ; Mental Health ; New South Wales ; Parents ; Socioeconomic Factors
    Language English
    Publishing date 2016-02-11
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2015-009023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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