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Article ; Online: DeepFlood

A. Emily Jenifer / Sudha Natarajan

Journal of Universal Computer Science, Vol 28, Iss 3, Pp 329-

A deep learning based flood detection framework using feature-level fusion of multi-sensor remote sensing images

2022 Volume 343

Abstract: Flooding is the most common natural disaster in many countries. Remote sensing images are very much useful in disaster monitoring. The different image modalities from different satellites provide varied information about the earth. The synergistic use of ...

Abstract	Flooding is the most common natural disaster in many countries. Remote sensing images are very much useful in disaster monitoring. The different image modalities from different satellites provide varied information about the earth. The synergistic use of optical and radar data helps in precise flood detection. The central focus of this paper is to identify the flooded regions using a dual patch-based Fully Convolutional Network (FCN) for performing deep learning-based feature fusion. The learned features of FCNs trained independently with Synthetic Aperture Radar (SAR) and Multispectral (MS) images are concatenated to represent the flooding better. A random forest classifier is employed to identify the flood from the fused features. The information retrieved is very much valuable in undertaking necessary rescue efforts in flood-affected areas. The proposed network shows superior performance in flood detection on the images from the SEN12-FLOOD dataset with an accuracy as high as 94.17%.
Keywords	flood detection ; synthetic aperture radar ; multisp ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	006
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Graz University of Technology
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Predominant factors influencing reactive oxygen species in cancer stem cells.

Soundararajan, Loshini / Warrier, Sudha / Dharmarajan, Arun / Bhaskaran, Natarajan

Journal of cellular biochemistry

2023 Volume 125, Issue 1, Page(s) 3–21

Abstract: Reactive oxygen species (ROS) and its related signaling pathways and regulating molecules play a major role in the growth and development of cancer stem cells. The concept of ROS and cancer stem cells (CSCs) has been gaining much attention since the past ...

Abstract	Reactive oxygen species (ROS) and its related signaling pathways and regulating molecules play a major role in the growth and development of cancer stem cells. The concept of ROS and cancer stem cells (CSCs) has been gaining much attention since the past decade and the evidence show that these CSCs possess robust self-renewal and tumorigenic potential and are resistant to conventional chemo- and radiotherapy and believed to be responsible for tumor progression, metastasis, and recurrence. It seems reasonable to say that cancer can be cured only if the CSCs are eradicated. ROS are Janus-faced molecules that can regulate cellular physiology as well as induce cytotoxicity, depending on the magnitude, duration, and site of generation. Unlike normal cancer cells, CSCs expel ROS efficiently by upregulating ROS scavengers. This unique redox regulation in CSCs protects them from ROS-mediated cell death and nullifies the effect of radiation, leading to chemoresistance and radioresistance. However, how these CSCs control ROS production by scavenging free radicals and how they maintain low levels of ROS is a challenging to understand and these attributes make CSCs as prime therapeutic targets. Here, we summarize the mechanisms of redox regulation in CSCs, with a focus on therapy resistance, its various pathways and microRNAs regulation, and the potential therapeutic implications of manipulating the ROS levels to eradicate CSCs. A better understanding of these molecules, their interactions in the CSCs may help us to adopt proper control and treatment measures.
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Neoplasms/metabolism ; MicroRNAs/metabolism ; Oxidation-Reduction ; Neoplastic Stem Cells/metabolism
Chemical Substances	Reactive Oxygen Species ; MicroRNAs
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.30506
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Article ; Online: Evaluation of Antibacterial Efficacy of Two Commercially Available Probiotics as Intracanal Medicament against

Ravi, Sudha / Ananthan, Hemasathya Bahavathi / Reddy, Bharath Naga / Sankar, Sriram / Natarajan, Senthil Nathan / Sankar, Sathish

The journal of contemporary dental practice

2023 Volume 24, Issue 3, Page(s) 157–161

Abstract: Aim: This study was performed to evaluate the antibacterial efficacy of two commercially available probiotics (BIFILAC and VSL 3) as intracanal medicament against : Materials and methods: Microorganisms from commercially available probiotics (BIFILAC ...

Abstract	Aim: This study was performed to evaluate the antibacterial efficacy of two commercially available probiotics (BIFILAC and VSL 3) as intracanal medicament against Materials and methods: Microorganisms from commercially available probiotics (BIFILAC and VSL 3) were extracted via the manufacturer's recommendations and mixed by weight. About 30 microliters were then placed on sterile discs. The pathogenic test organism was Results: The results of phase-1 showed that probiotics Lactobacillus rhamnosus and Bifidobacterium species are effective in fighting against Conclusion: Commercially available probiotics can be used effectively as an intracanal medicament to fight against Clinical significance: If probiotics are proved to be an effective intracanal medicament against
MeSH term(s)	Enterococcus faecalis ; Poloxamer/pharmacology ; Anti-Bacterial Agents/pharmacology ; Root Canal Therapy ; Probiotics/pharmacology ; Calcium Hydroxide/pharmacology
Chemical Substances	Poloxamer (106392-12-5) ; Anti-Bacterial Agents ; Calcium Hydroxide (PF5DZW74VN)
Language	English
Publishing date	2023-03-01
Publishing country	India
Document type	Journal Article
ISSN	1526-3711
ISSN (online)	1526-3711
DOI	10.5005/jp-journals-10024-3466
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Article ; Online: Study on the

Natarajan, Aishwarya / Sudha Bandla, Shaile / Damodaran, Mohan / Sundaram, Sandhya / Venkatesan, Vettriselvi

Journal of genetics

2021 Volume 99

Abstract: Prostate cancer is a heterogeneous disease and considered to be the most commonly diagnosed cancer. ...

Abstract	Prostate cancer is a heterogeneous disease and considered to be the most commonly diagnosed cancer.
MeSH term(s)	Aged ; Aged, 80 and over ; Alleles ; Gene Expression Regulation, Neoplastic ; Gene Frequency ; Genotype ; Humans ; India ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prostatic Neoplasms/genetics ; Proto-Oncogene Proteins/genetics ; Risk Factors
Chemical Substances	Proto-Oncogene Proteins ; SFRP4 protein, human
Language	English
Publishing date	2021-02-11
Publishing country	India
Document type	Journal Article
ZDB-ID	3039-9
ISSN	0973-7731 ; 0958-8361 ; 0022-1333
ISSN (online)	0973-7731
ISSN	0958-8361 ; 0022-1333
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Article ; Online: The Tween Years: Thriving as a Mid-Career Academic Hospice and Palliative Medicine Clinician.

Daubman, Bethany-Rose / Lawton, Andrew J / Zehm, April / Rosenberg, Leah B / Natarajan, Sudha

Journal of palliative medicine

2023 Volume 26, Issue 3, Page(s) 321–326

Abstract: In the young and rapidly evolving field of hospice and palliative medicine (HPM), the transition from early to mid-career can be a precarious time. The high rates of burnout and low rates of work-life balance and satisfaction found in mid-career ... ...

Abstract	In the young and rapidly evolving field of hospice and palliative medicine (HPM), the transition from early to mid-career can be a precarious time. The high rates of burnout and low rates of work-life balance and satisfaction found in mid-career jeopardize our field's ability to maintain a healthy workforce. In this series, we present three cases that highlight common issues encountered during the early to mid-career transition in academic HPM and present several strategies for navigating challenges. A web of mentors/connections, academic map, and continuing education to enhance teaching skills are several concrete tools explored. To sustain a robust HPM workforce, such practical and structured supports during the particularly challenging mid-career transition are crucial.
MeSH term(s)	Humans ; Palliative Medicine/education ; Polysorbates ; Hospices ; Hospice Care ; Workforce ; Mentors
Chemical Substances	Polysorbates
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	1427361-5
ISSN	1557-7740 ; 1096-6218
ISSN (online)	1557-7740
ISSN	1096-6218
DOI	10.1089/jpm.2022.0285
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Article: Glycemic index of a nutritional supplement designed for people with chronic kidney disease.

Rachana, Bhoite / Shobana, Shanmugam / Lalithya, Pratti Varalakshmi / Sudha, Vasudevan / Vinita, Satyavrat / Gayathri, Rajagopal / Kalpana, Natarajan / Ranjit, Mohan Anjana / Viswanathan, Mohan

Food science & nutrition

2023 Volume 11, Issue 9, Page(s) 5379–5387

Abstract: The study was carried out to measure the glycemic index (GI) of an oral food supplement for people with CKD as well as on patients on maintenance dialysis. The study was conducted as per international protocols for testing GI, was approved by the local ... ...

Abstract	The study was carried out to measure the glycemic index (GI) of an oral food supplement for people with CKD as well as on patients on maintenance dialysis. The study was conducted as per international protocols for testing GI, was approved by the local institutional ethics committee, and was registered with the Clinical Trial Registry of India (CTRI). This was a crossover randomized controlled study which enrolled 15 participants between the ages of 18 and 45 years. The participants were randomly allotted to one group that consumed either the reference food (27.5 g of glucose monohydrate) or 118 g of the nutritional supplement which contained 25 g of available carbohydrates. Fasting capillary blood samples as well as blood samples at different time intervals as per the GI protocol, after consumption of either the supplement or the reference food were taken from the participants. Each testing day was separated by a 3-day washout period. GI was calculated from the incremental area under the blood glucose response elicited by the nutritional supplement as a percentage of the response after the consumption of 25 g of glucose (27.5 g of glucose monohydrate) by the same participant using a standard formula. The GI of the nutritional supplement was calculated to be 10.3 ± 2.0 which is considered to be low as per international GI testing standards. The product was created to supplement the diet of people with CKD at different stages and to help prevent the progression from CKD to ESRD as well as the risk for CVD. This product was found to have a low GI which is desirable for people with CKD as well as diabetics in general who are at risk for developing CKD.
Language	English
Publishing date	2023-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3495
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Article ; Online: Datasets comprising the quality validations of simulated protein-ligand complexes and SYBYL docking scores of bioactive natural compounds as inhibitors of

Miryala, Sravan Kumar / Basu, Soumya / Naha, Aniket / Debroy, Reetika / Ramaiah, Sudha / Anbarasu, Anand / Natarajan, Saravanan

Data in brief

2022 Volume 42, Page(s) 108146

Abstract: Docking scores and simulation parameters to study the potency of natural compounds against protein targets ... ...

Abstract	Docking scores and simulation parameters to study the potency of natural compounds against protein targets in
Language	English
Publishing date	2022-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108146
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Article ; Online: Patterns of risk for diabetic retinopathy in the Mumbai slums

Radhika Krishnan / Astha Jain / Siddhita Nare / Rajkumar Sankaranarayanan / Jacquelaine Bartlett / Sudha K. Iyengar / Scott M. Williams / Natarajan Sundaram

PLOS Global Public Health, Vol 3, Iss

The Aditya Jyot Diabetic Retinopathy in Urban Mumbai Slums Study (AJ-DRUMSS) Report 3

2023 Volume 4

Abstract: Diabetes onset precedes diabetic retinopathy (DR) by 5–10 years, but many people with diabetes remain free of this microvascular complication. Our aim was to identify risk factors for DR progression in a unique and diverse population, the slums of Mumbai. ...

Abstract	Diabetes onset precedes diabetic retinopathy (DR) by 5–10 years, but many people with diabetes remain free of this microvascular complication. Our aim was to identify risk factors for DR progression in a unique and diverse population, the slums of Mumbai. We performed a nested case-control study of 1163 diabetics over 40 years of age from slums in 18 wards of Mumbai. Data was collected on 33 variables and assessed for association with DR using both univariate and multivariate analyses. Stratified analyses were also performed on males and females, separately. Among hypertensive individuals we also assessed whether duration of hypertension associated with DR. Of 31 non-correlated variables analysed as risk factors for DR, 15 showed evidence of significant association. The most prominent included sex, where being a female associated with decreased odds of DR, while longer duration of diabetes and poor glycaemic control associated with increased odds. The duration of diabetes effect was partially, but significantly, mediated by age of diabetes diagnoses (8.6% of variance explained, p = 0.012). Obesity as measured by several measures, including body mass index (BMI) and measures of central obesity had a negative association with DR; increased measures of obesity consistently reduced odds of DR. As in most earlier studies, DR was associated with the duration of diabetes and glycaemic control. However, other factors, especially obesity related measures were associated with DR, in ways that contrast with most prior studies. These results indicated that the overall pattern of association in the Mumbai slums was novel. Thus, in previously uncharacterized populations, such as the slums that we examined, it is important to evaluate all risk factors de novo to appropriately assess patterns of association as the patterns of association with DR can be complex and population specific.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Patterns of risk for diabetic retinopathy in the Mumbai slums

Radhika Krishnan / Astha Jain / Siddhita Nare / Rajkumar Sankaranarayanan / Jacquelaine Bartlett / Sudha K Iyengar / Scott M Williams / Natarajan Sundaram

PLOS Global Public Health, Vol 3, Iss 4, p e

The Aditya Jyot Diabetic Retinopathy in Urban Mumbai Slums Study (AJ-DRUMSS) Report 3.

2023 Volume 0000351

Abstract: Diabetes onset precedes diabetic retinopathy (DR) by 5-10 years, but many people with diabetes remain free of this microvascular complication. Our aim was to identify risk factors for DR progression in a unique and diverse population, the slums of Mumbai. ...

Abstract	Diabetes onset precedes diabetic retinopathy (DR) by 5-10 years, but many people with diabetes remain free of this microvascular complication. Our aim was to identify risk factors for DR progression in a unique and diverse population, the slums of Mumbai. We performed a nested case-control study of 1163 diabetics over 40 years of age from slums in 18 wards of Mumbai. Data was collected on 33 variables and assessed for association with DR using both univariate and multivariate analyses. Stratified analyses were also performed on males and females, separately. Among hypertensive individuals we also assessed whether duration of hypertension associated with DR. Of 31 non-correlated variables analysed as risk factors for DR, 15 showed evidence of significant association. The most prominent included sex, where being a female associated with decreased odds of DR, while longer duration of diabetes and poor glycaemic control associated with increased odds. The duration of diabetes effect was partially, but significantly, mediated by age of diabetes diagnoses (8.6% of variance explained, p = 0.012). Obesity as measured by several measures, including body mass index (BMI) and measures of central obesity had a negative association with DR; increased measures of obesity consistently reduced odds of DR. As in most earlier studies, DR was associated with the duration of diabetes and glycaemic control. However, other factors, especially obesity related measures were associated with DR, in ways that contrast with most prior studies. These results indicated that the overall pattern of association in the Mumbai slums was novel. Thus, in previously uncharacterized populations, such as the slums that we examined, it is important to evaluate all risk factors de novo to appropriately assess patterns of association as the patterns of association with DR can be complex and population specific.
Keywords	Public aspects of medicine ; RA1-1270
Subject code	616
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Patterns of risk for diabetic retinopathy in the Mumbai slums: The Aditya Jyot Diabetic Retinopathy in Urban Mumbai Slums Study (AJ-DRUMSS) Report 3.

Krishnan, Radhika / Jain, Astha / Nare, Siddhita / Sankaranarayanan, Rajkumar / Bartlett, Jacquelaine / Iyengar, Sudha K / Williams, Scott M / Sundaram, Natarajan

PLOS global public health

2023 Volume 3, Issue 4, Page(s) e0000351

Abstract	Diabetes onset precedes diabetic retinopathy (DR) by 5-10 years, but many people with diabetes remain free of this microvascular complication. Our aim was to identify risk factors for DR progression in a unique and diverse population, the slums of Mumbai. We performed a nested case-control study of 1163 diabetics over 40 years of age from slums in 18 wards of Mumbai. Data was collected on 33 variables and assessed for association with DR using both univariate and multivariate analyses. Stratified analyses were also performed on males and females, separately. Among hypertensive individuals we also assessed whether duration of hypertension associated with DR. Of 31 non-correlated variables analysed as risk factors for DR, 15 showed evidence of significant association. The most prominent included sex, where being a female associated with decreased odds of DR, while longer duration of diabetes and poor glycaemic control associated with increased odds. The duration of diabetes effect was partially, but significantly, mediated by age of diabetes diagnoses (8.6% of variance explained, p = 0.012). Obesity as measured by several measures, including body mass index (BMI) and measures of central obesity had a negative association with DR; increased measures of obesity consistently reduced odds of DR. As in most earlier studies, DR was associated with the duration of diabetes and glycaemic control. However, other factors, especially obesity related measures were associated with DR, in ways that contrast with most prior studies. These results indicated that the overall pattern of association in the Mumbai slums was novel. Thus, in previously uncharacterized populations, such as the slums that we examined, it is important to evaluate all risk factors de novo to appropriately assess patterns of association as the patterns of association with DR can be complex and population specific.
Language	English
Publishing date	2023-04-12
Publishing country	United States
Document type	Journal Article
ISSN	2767-3375
ISSN (online)	2767-3375
DOI	10.1371/journal.pgph.0000351
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