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  1. Book: Überversorgung - eine Spurensuche

    Grote-Westrick, Marion / Volbracht, Eckhard / Deckenbach, Bernd / Nolting, Hans-Dieter / Zich, Karsten

    2019  

    Institution Bertelsmann Stiftung
    Author's details Herausgeber: Bertelsmann Stiftung ; Autoren: Marion Grote Westrick, Eckhard Volbracht, Bernd Deckenbach, Hans-Dieter Nolting, Karsten Zich
    Language German
    Size 107 Seiten, Illustrationen, Diagramme, 30 cm
    Publisher Bertelsmann Stiftung
    Publishing place Gütersloh
    Publishing country Germany
    Document type Book
    HBZ-ID HT020653764
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1421 available for loan (reading room) Lesesaal EG

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  2. Article: Cellular and Systemic Effects of Micro- and Nanoplastics in Mammals-What We Know So Far.

    Grote, Karsten / Brüstle, Fabian / Vlacil, Ann-Kathrin

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 8

    Abstract: Microplastics (MP) and nanoplastics (NP) are accumulating more and more in our environment and have been frequently detected in water and soil, but also in a variety of mainly marine organisms. Polymers such as polyethylene, polypropylene, and ... ...

    Abstract Microplastics (MP) and nanoplastics (NP) are accumulating more and more in our environment and have been frequently detected in water and soil, but also in a variety of mainly marine organisms. Polymers such as polyethylene, polypropylene, and polystyrene are those most commonly found. Once in the environment, MP/NP are carriers for many other substances, which often convey toxic effects. Even though intuitively it is thought that ingesting MP/NP cannot be healthy, little is known about their effects on mammalian cells and organisms so far. To better understand the potential hazards of MP/NP on humans and to offer an overview of the already associated pathological effects, we conducted a comprehensive literature review on cellular effects, as well as experimental animal studies on MP/NP in mammals.
    Language English
    Publishing date 2023-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16083123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cathelicidin Antimicrobial Peptide Levels in Atherosclerosis and Myocardial Infarction in Mice and Human.

    Höpfinger, Alexandra / Schmid, Andreas / Karrasch, Thomas / Pankuweit, Sabine / Schäffler, Andreas / Grote, Karsten

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Obesity represents a worldwide health challenge, and the condition is accompanied by elevated risk of cardiovascular diseases caused by metabolic dysfunction and proinflammatory adipokines. Among those, the immune-modulatory cathelicidin antimicrobial ... ...

    Abstract Obesity represents a worldwide health challenge, and the condition is accompanied by elevated risk of cardiovascular diseases caused by metabolic dysfunction and proinflammatory adipokines. Among those, the immune-modulatory cathelicidin antimicrobial peptide (human: CAMP; murine: CRAMP) might contribute to the interaction of the innate immune system and metabolism in these settings. We investigated systemic CAMP/CRAMP levels in experimental murine models of atherosclerosis, myocardial infarction and cardiovascular patients. Atherosclerosis was induced in low-density lipoprotein receptor-deficient (Ldlr
    MeSH term(s) Adult ; Animals ; Humans ; Mice ; Antimicrobial Cationic Peptides/metabolism ; Atherosclerosis ; Cathelicidins ; Coronary Artery Disease ; Mice, Inbred C57BL ; Mice, Knockout ; Myocardial Infarction
    Chemical Substances Antimicrobial Cationic Peptides ; Cathelicidins ; CAMP protein, human ; Camp protein, mouse
    Language English
    Publishing date 2024-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Rolle des NOD-Signalings innerhalb des Makrophagen Lipidmetabolismus

    Shahin, Kinan [Verfasser] / Grote, Karsten [Akademischer Betreuer]

    2022  

    Author's details Kinan Shahin ; Betreuer: Karsten Grote
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Book ; Online ; Thesis: Bedeutung des Adipokins CTRP3 für das Fettgewebe und die Entwicklung der Atherosklerose

    Koch, Sören [Verfasser] / Grote, Karsten [Akademischer Betreuer]

    2022  

    Author's details Sören Koch ; Betreuer: Karsten Grote
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book: Das Lexikon der prominenten Selbstmörder

    Grote, Gerald / Völkel, Michael / Weyershausen, Karsten

    [mehr als 300 dramatische Lebensläufe: Van Gogh und Hemingway, Kurt Cobain und Rex Gildo, Ulrich Wildgruber und Stefan Zweig]

    2000  

    Author's details von Gerald Grote, Michael Völkel und Karsten Weyershausen
    Keywords Suizid ; Berühmte Persönlichkeit
    Subject Prominenter ; VIP ; Bekannte Persönlichkeit ; Prominenz ; Berühmtheit ; Selbstmord ; Freitod ; Selbsttötung
    Language German
    Size 345 S. : Ill.
    Publisher Lexikon-Imprint-Verl
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    HBZ-ID HT012763860
    ISBN 3-89602-265-2 ; 978-3-89602-265-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    A 439 B 5 order for loan Magazin

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  7. Article ; Online: Targeting the High-Density Lipoprotein Proteome for the Treatment of Post-Acute Sequelae of SARS-CoV-2.

    Grote, Karsten / Schaefer, Ann-Christin / Soufi, Muhidien / Ruppert, Volker / Linne, Uwe / Mukund Bhagwat, Aditya / Szymanski, Witold / Graumann, Johannes / Gercke, Yana / Aldudak, Sümeya / Hilfiker-Kleiner, Denise / Schieffer, Elisabeth / Schieffer, Bernhard

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Here, we target the high-density lipoprotein (HDL) proteome in a case series of 16 patients with post-COVID-19 symptoms treated with HMG-Co-A reductase inhibitors (statin) plus angiotensin II type 1 receptor blockers (ARBs) for 6 weeks. Patients ... ...

    Abstract Here, we target the high-density lipoprotein (HDL) proteome in a case series of 16 patients with post-COVID-19 symptoms treated with HMG-Co-A reductase inhibitors (statin) plus angiotensin II type 1 receptor blockers (ARBs) for 6 weeks. Patients suffering from persistent symptoms (post-acute sequelae) after serologically confirmed SARS-CoV-2 infection (post-COVID-19 syndrome, PCS, n = 8) or following SARS-CoV-2 vaccination (PVS, n = 8) were included. Asymptomatic subjects with corresponding serological findings served as healthy controls (n = 8/8). HDL was isolated using dextran sulfate precipitation and the HDL proteome of all study participants was analyzed quantitatively by mass spectrometry. Clinical symptoms were assessed using questionnaires before and after therapy. The inflammatory potential of the patients' HDL proteome was addressed in human endothelial cells. The HDL proteome of patients with PCS and PVS showed no significant differences; however, compared to controls, the HDL from PVS/PCS patients displayed significant alterations involving hemoglobin, cytoskeletal proteins (MYL6, TLN1, PARVB, TPM4, FLNA), and amyloid precursor protein. Gene Ontology Biological Process (GOBP) enrichment analysis identified hemostasis, peptidase, and lipoprotein regulation pathways to be involved. Treatment of PVS/PCS patients with statins plus ARBs improved the patients' clinical symptoms. After therapy, three proteins were significantly increased (FAM3C, AT6AP2, ADAM10; FDR < 0.05) in the HDL proteome from patients with PVS/PCS. Exposure of human endothelial cells with the HDL proteome from treated PVS/PCS patients revealed reduced inflammatory cytokine and adhesion molecule expression. Thus, HDL proteome analysis from PVS/PCS patients enables a deeper insight into the underlying disease mechanisms, pointing to significant involvement in metabolic and signaling disturbances. Treatment with statins plus ARBs improved clinical symptoms and reduced the inflammatory potential of the HDL proteome. These observations may guide future therapeutic strategies for PVS/PCS patients.
    MeSH term(s) Humans ; Proteome/metabolism ; Male ; COVID-19/blood ; COVID-19/virology ; COVID-19/complications ; Female ; Lipoproteins, HDL/blood ; Lipoproteins, HDL/metabolism ; Middle Aged ; SARS-CoV-2/drug effects ; Aged ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Post-Acute COVID-19 Syndrome ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; COVID-19 Drug Treatment ; Adult
    Chemical Substances Proteome ; Lipoproteins, HDL ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Angiotensin II Type 1 Receptor Blockers
    Language English
    Publishing date 2024-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients.

    Schmid, Andreas / Pankuweit, Sabine / Vlacil, Ann-Kathrin / Koch, Sören / Berge, Benedikt / Gajawada, Praveen / Richter, Manfred / Troidl, Kerstin / Schieffer, Bernhard / Schäffler, Andreas / Grote, Karsten

    Journal of molecular medicine (Berlin, Germany)

    2024  Volume 102, Issue 5, Page(s) 667–677

    Abstract: C1q/TNF-related protein 3 (CTRP3) represents an adipokine with various metabolic and immune-regulatory functions. While circulating CTRP3 has been proposed as a potential biomarker for cardiovascular disease (CVD), current data on CTRP3 regarding ... ...

    Abstract C1q/TNF-related protein 3 (CTRP3) represents an adipokine with various metabolic and immune-regulatory functions. While circulating CTRP3 has been proposed as a potential biomarker for cardiovascular disease (CVD), current data on CTRP3 regarding coronary artery disease (CAD) remains partially contradictory. This study aimed to investigate CTRP3 levels in chronic and acute settings such as chronic coronary syndrome (CCS) and acute coronary syndrome (ACS). A total of 206 patients were classified into three groups: CCS (n = 64), ACS having a first acute event (ACS-1, n = 75), and ACS having a recurrent acute event (ACS-2, n = 67). The control group consisted of 49 healthy individuals. ELISA measurement in peripheral blood revealed decreased CTRP3 levels in all patient groups (p < 0.001) without significant differences between the groups. This effect was exclusively observed in male patients. Females generally exhibited significantly higher CTRP3 plasma levels than males. ROC curve analysis in male patients revealed a valuable predictive potency of plasma CTRP3 in order to identify CAD patients, with a proposed cut-off value of 51.25 ng/mL. The sensitivity and specificity of prediction by CTRP3 were congruent for the subgroups of CCS, ACS-1, and ACS-2 patients. Regulation of circulating CTRP3 levels in murine models of cardiovascular pathophysiology was found to be partly opposite to the clinical findings, with male mice exhibiting higher circulating CTRP3 levels than females. We conclude that circulating CTRP3 levels are decreased in both male CCS and ACS patients. Therefore, CTRP3 might be useful as a biomarker for CAD but not for distinguishing an acute from a chronic setting. KEY MESSAGES: CTRP3 levels were found to be decreased in both male CCS and ACS patients compared to healthy controls. Plasma CTRP3 has a valuable predictive potency in order to identify CAD patients among men and is therefore proposed as a biomarker for CAD but not for distinguishing between acute and chronic settings. Regulation of circulating CTRP3 levels in murine models of cardiovascular pathophysiology was found to be partly opposite to the clinical findings in men.
    MeSH term(s) Humans ; Male ; Female ; Middle Aged ; Aged ; Biomarkers/blood ; Animals ; Acute Coronary Syndrome/blood ; Acute Coronary Syndrome/diagnosis ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/diagnosis ; Mice ; Adipokines/blood ; Chronic Disease ; ROC Curve ; Tumor Necrosis Factors/blood ; Case-Control Studies
    Chemical Substances Biomarkers ; C1QTNF3 protein, human ; Adipokines ; Tumor Necrosis Factors
    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-024-02426-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Extracellular Ribosomal RNA Acts Synergistically with Toll-like Receptor 2 Agonists to Promote Inflammation.

    Grote, Karsten / Nicolai, Marina / Schubert, Uwe / Schieffer, Bernhard / Troidl, Christian / Preissner, Klaus T / Bauer, Stefan / Fischer, Silvia

    Cells

    2022  Volume 11, Issue 9

    Abstract: Self-extracellular RNA (eRNA), which is released under pathological conditions from damaged tissue, has recently been identified as a new alarmin and synergistic agent together with toll-like receptor (TLR)2 ligands to induce proinflammatory activities ... ...

    Abstract Self-extracellular RNA (eRNA), which is released under pathological conditions from damaged tissue, has recently been identified as a new alarmin and synergistic agent together with toll-like receptor (TLR)2 ligands to induce proinflammatory activities of immune cells. In this study, a detailed investigation of these interactions is reported. The macrophage cell line J774 A.1 or C57 BL/6 J wild-type mice were treated with 18S rRNA and different TLR2 agonists. Gene and protein expression of tumor necrosis factor
    MeSH term(s) Alarmins ; Animals ; Inflammation ; Interleukin-6/genetics ; Mice ; Mice, Inbred C57BL ; Oligopeptides ; RNA, Ribosomal, 18S ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 2/metabolism ; Toll-Like Receptor 9/agonists ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances Alarmins ; Interleukin-6 ; Oligopeptides ; RNA, Ribosomal, 18S ; Toll-Like Receptor 2 ; Toll-Like Receptor 9 ; Tumor Necrosis Factor-alpha ; PAM2-CSK4 (L33ZW7BO91)
    Language English
    Publishing date 2022-04-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11091440
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: NOD1 and NOD2 in microRNA-regulated vascular inflammation, cholesterol metabolism and atherogenesis

    Vlacil, Ann-Kathrin [Verfasser] / Grote, Karsten [Akademischer Betreuer]

    2019  

    Author's details Ann-Kathrin Vlacil ; Betreuer: Karsten Grote
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Philipps-Universität Marburg
    Publishing place Marburg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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