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  1. Article ; Online: Revisioning the ENP Among Emergency Workforce Changes: Specialty or Population?

    Dowling Evans, Dian / Hoyt, K Sue / Davis, Wesley D / Wilbeck, Jennifer

    Advanced emergency nursing journal

    2021  Volume 43, Issue 3, Page(s) 171–177

    MeSH term(s) Emergency Nursing ; Emergency Service, Hospital ; Humans ; Workforce
    Language English
    Publishing date 2021-08-17
    Publishing country United States
    Document type Editorial
    ZDB-ID 2257871-7
    ISSN 1931-4493 ; 1931-4485
    ISSN (online) 1931-4493
    ISSN 1931-4485
    DOI 10.1097/TME.0000000000000366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2305: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Impact of Exercise on Immunometabolism in Multiple Sclerosis.

    Afzal, Remsha / Dowling, Jennifer K / McCoy, Claire E

    Journal of clinical medicine

    2020  Volume 9, Issue 9

    Abstract: Multiple Sclerosis (MS) is a chronic, autoimmune condition characterized by demyelinating lesions and axonal degradation. Even though the cause of MS is heterogeneous, it is known that peripheral immune invasion in the central nervous system (CNS) drives ...

    Abstract Multiple Sclerosis (MS) is a chronic, autoimmune condition characterized by demyelinating lesions and axonal degradation. Even though the cause of MS is heterogeneous, it is known that peripheral immune invasion in the central nervous system (CNS) drives pathology at least in the most common form of MS, relapse-remitting MS (RRMS). The more progressive forms' mechanisms of action remain more elusive yet an innate immune dysfunction combined with neurodegeneration are likely drivers. Recently, increasing studies have focused on the influence of metabolism in regulating immune cell function. In this regard, exercise has long been known to regulate metabolism, and has emerged as a promising therapy for management of autoimmune disorders. Hence, in this review, we inspect the role of key immunometabolic pathways specifically dysregulated in MS and highlight potential therapeutic benefits of exercise in modulating those pathways to harness an anti-inflammatory state. Finally, we touch upon current challenges and future directions for the field of exercise and immunometabolism in MS.
    Language English
    Publishing date 2020-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9093038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: United States Congressional COVID-19 Legislation: Recent Laws and Future Topics.

    Dowling, Marisa K / Terry, Aisha T / Kirilichin, Natalie L / Lee, Jennifer S / Blanchard, Janice C

    The western journal of emergency medicine

    2020  Volume 21, Issue 5, Page(s) 1037–1041

    Keywords covid19
    Language English
    Publishing date 2020-08-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-900X
    ISSN (online) 1936-9018
    ISSN 1936-900X
    DOI 10.5811/westjem.2020.7.48891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Toll-Like Receptors: Ligands, Cell-Based Models, and Readouts for Receptor Action.

    Dowling, Jennifer K / Dellacasagrande, Jérome

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1390, Page(s) 3–27

    Abstract: This chapter details Toll-like receptors (TLRs) and the tools available to study their biology in vitro. Key parameters to consider before exploring TLR action such as receptor localization, signaling pathways, nature of ligands and cellular expression ... ...

    Abstract This chapter details Toll-like receptors (TLRs) and the tools available to study their biology in vitro. Key parameters to consider before exploring TLR action such as receptor localization, signaling pathways, nature of ligands and cellular expression are introduced. Cellular models (i.e., host cells and readouts) based on the use of cell lines, primary cells, or whole blood are presented. The use of modified TLRs to circumvent some technical problems is also discussed.
    MeSH term(s) Animals ; Cell Culture Techniques ; Cell Line ; Gene Expression ; Genes, Reporter ; Humans ; Ligands ; Phosphorylation ; Protein Transport ; Signal Transduction ; Toll-Like Receptors/genetics ; Toll-Like Receptors/metabolism ; Transcription Factors
    Chemical Substances Ligands ; Toll-Like Receptors ; Transcription Factors
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3335-8_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers.

    Fitzsimons, Stephen / Muñoz-San Martín, María / Nally, Frances / Dillon, Eugene / Fashina, Ifeolutembi A / Strowitzki, Moritz J / Ramió-Torrentà, Lluís / Dowling, Jennifer K / De Santi, Chiara / McCoy, Claire E

    Molecular therapy. Nucleic acids

    2023  Volume 33, Page(s) 941–959

    Abstract: The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator ...

    Abstract The modulation of macrophage phenotype from a pro-inflammatory to an anti-inflammatory state holds therapeutic potential in the treatment of inflammatory disease. We have previously shown that arginase-2 (Arg2), a mitochondrial enzyme, is a key regulator of the macrophage anti-inflammatory response. Here, we investigate the therapeutic potential of Arg2 enhancement via target site blockers (TSBs) in human macrophages. TSBs are locked nucleic acid antisense oligonucleotides that were specifically designed to protect specific microRNA recognition elements (MREs) in human
    Language English
    Publishing date 2023-08-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.08.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Toll-like receptors: the swiss army knife of immunity and vaccine development.

    Dowling, Jennifer K / Mansell, Ashley

    Clinical & translational immunology

    2016  Volume 5, Issue 5, Page(s) e85

    Abstract: Innate immune cells have a critical role in defense against infection and disease. Central to this is the broad specificity with which they can detect pathogen-associated patterns and danger-associated patterns via the pattern recognition receptors (PRRs) ...

    Abstract Innate immune cells have a critical role in defense against infection and disease. Central to this is the broad specificity with which they can detect pathogen-associated patterns and danger-associated patterns via the pattern recognition receptors (PRRs) they express. Several families of PRRs have been identified including: Toll-like receptors (TLRs), C-type lectin-like receptors, retinoic acid-inducible gene-like receptors and nucleotide-binding oligomerization domain-like receptors. TLRs are one of the most largely studied families of PRRs. The binding of ligands to TLRs on antigen presenting cells (APCs), mainly dendritic cells, leads to APC maturation, induction of inflammatory cytokines and the priming of naive T cells to drive acquired immunity. Therefore, activation of TLRs promotes both innate inflammatory responses and the induction of adaptive immunity. Consequently, in the last two decades mounting evidence has inextricably linked TLR activation with the pathogenesis of immune diseases and cancer. It has become advantageous to harness these aspects of TLR signaling therapeutically to accelerate and enhance the induction of vaccine-specific responses and also target TLRs with the use of biologics and small molecule inhibitors for the treatment of disease. In these respects, TLRs may be considered a 'Swiss Army' knife of the immune system, ready to respond in a multitude of infectious and disease states. Here we describe the latest advances in TLR-targeted therapeutics and the use of TLR ligands as vaccine adjuvants.
    Language English
    Publishing date 2016-05-20
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 2694482-0
    ISSN 2050-0068
    ISSN 2050-0068
    DOI 10.1038/cti.2016.22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Neurological disorders after severe pneumonia are associated with translocation of endogenous bacteria from the lung to the brain.

    Ma, Qingle / Yao, Chenlu / Wu, Yi / Wang, Heng / Fan, Qin / Yang, Qianyu / Xu, Jialu / Dai, Huaxing / Zhang, Yue / Xu, Fang / Lu, Ting / Dowling, Jennifer K / Wang, Chao

    Science advances

    2023  Volume 9, Issue 42, Page(s) eadi0699

    Abstract: Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed ...

    Abstract Neurological disorders are a common feature in patients who recover from severe acute pneumonia. However, the underlying mechanisms remain poorly understood. Here, we show that the neurological syndromes after severe acute pneumonia are partly attributed to the translocation of endogenous bacteria from the lung to the brain during pneumonia. Using principal components analysis, similarities were found between the brain's flora species and those of the lungs, indicating that the bacteria detected in the brain may originate from the lungs. We also observed impairment of both the lung-blood and brain-blood barriers, allowing endogenous lung bacteria to invade the brain during pneumonia. An elevated microglia and astrocyte activation signature via bacterial infection-related pathways was observed, indicating a bacterial-induced disruption of brain homeostasis. Collectively, we identify endogenous lung bacteria that play a role in altering brain homeostasis, which provides insight into the mechanism of neurological syndromes after severe pneumonia.
    MeSH term(s) Humans ; Bacteria ; Brain/microbiology ; Lung/microbiology ; Nervous System Diseases/complications ; Pneumonia/etiology
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi0699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Exercise on Immunometabolism in Multiple Sclerosis

    Remsha Afzal / Jennifer K. Dowling / Claire E. McCoy

    Journal of Clinical Medicine, Vol 9, Iss 3038, p

    2020  Volume 3038

    Abstract: Multiple Sclerosis (MS) is a chronic, autoimmune condition characterized by demyelinating lesions and axonal degradation. Even though the cause of MS is heterogeneous, it is known that peripheral immune invasion in the central nervous system (CNS) drives ...

    Abstract Multiple Sclerosis (MS) is a chronic, autoimmune condition characterized by demyelinating lesions and axonal degradation. Even though the cause of MS is heterogeneous, it is known that peripheral immune invasion in the central nervous system (CNS) drives pathology at least in the most common form of MS, relapse-remitting MS (RRMS). The more progressive forms’ mechanisms of action remain more elusive yet an innate immune dysfunction combined with neurodegeneration are likely drivers. Recently, increasing studies have focused on the influence of metabolism in regulating immune cell function. In this regard, exercise has long been known to regulate metabolism, and has emerged as a promising therapy for management of autoimmune disorders. Hence, in this review, we inspect the role of key immunometabolic pathways specifically dysregulated in MS and highlight potential therapeutic benefits of exercise in modulating those pathways to harness an anti-inflammatory state. Finally, we touch upon current challenges and future directions for the field of exercise and immunometabolism in MS.
    Keywords multiple sclerosis ; EAE ; CNS ; exercise ; immunometabolism ; glycolysis ; Medicine ; R
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype.

    De Santi, Chiara / Nally, Frances K / Afzal, Remsha / Duffy, Conor P / Fitzsimons, Stephen / Annett, Stephanie L / Robson, Tracy / Dowling, Jennifer K / Cryan, Sally-Ann / McCoy, Claire E

    Molecular therapy. Nucleic acids

    2022  Volume 29, Page(s) 643–655

    Abstract: Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strategy ... ...

    Abstract Macrophages are plastic cells playing a crucial role in innate immunity. While fundamental in responding to infections, when persistently maintained in a pro-inflammatory state they can initiate and sustain inflammatory diseases. Therefore, a strategy that reprograms pro-inflammatory macrophages toward an anti-inflammatory phenotype could hold therapeutic potential in that context. We have recently shown that arginase 2 (Arg2), a mitochondrial enzyme involved in arginine metabolism, promotes the resolution of inflammation in macrophages and it is targeted by miR-155. Here, we designed and tested a target site blocker (TSB) that specifically interferes and blocks the interaction between miR-155 and
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2022.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: MicroRNAs in obesity, sarcopenia, and commonalities for sarcopenic obesity: a systematic review.

    Dowling, Lisa / Duseja, Ankita / Vilaca, Tatiane / Walsh, Jennifer S / Goljanek-Whysall, Katarzyna

    Journal of cachexia, sarcopenia and muscle

    2022  Volume 13, Issue 1, Page(s) 68–85

    Abstract: Sarcopenic obesity is a distinct condition of sarcopenia in the context of obesity, with the cumulative health risks of both phenotypes. Differential expression of microRNAs (miRNAs) has been reported separately in people with obesity and sarcopenia and ... ...

    Abstract Sarcopenic obesity is a distinct condition of sarcopenia in the context of obesity, with the cumulative health risks of both phenotypes. Differential expression of microRNAs (miRNAs) has been reported separately in people with obesity and sarcopenia and may play a role in the pathogenesis of sarcopenic obesity. However, this has not been explored to date. This study aimed to identify differentially expressed miRNAs reported in serum, plasma, and skeletal muscle of people with obesity and sarcopenia and whether there are any commonalities between these conditions. We performed a systematic review on Embase and MEDLINE (PROSPERO, CRD42020224486) for differentially expressed miRNAs (fold change >1.5 or P-value <0.05) in (i) sarcopenia or frailty and (ii) obesity or metabolic syndrome. The functions and targets of miRNAs commonly changed in both conditions, in the same direction, were searched using PubMed. Following deduplication, 247 obesity and 42 sarcopenia studies were identified for full-text screening. Screening identified 36 obesity and 6 sarcopenia studies for final inclusion. A total of 351 miRNAs were identified in obesity and 157 in sarcopenia. Fifty-five miRNAs were identified in both obesity and sarcopenia-by sample type, 48 were found in plasma and one each in serum and skeletal muscle. Twenty-four miRNAs were identified from 10 of the included studies as commonly changed in the same direction (22 in plasma and one each in serum and skeletal muscle) in obesity and sarcopenia. The majority of miRNA-validated targets identified in the literature search were members of the phosphoinositide 3-kinase/protein kinase B and transforming growth factor-β signalling pathways. The most common targets identified were insulin-like growth factor 1 (miR-424-5p, miR-483-3p, and miR-18b-5p) and members of the SMAD family (miR-483-3p, miR-92a-3p, and miR-424-5p). The majority of commonly changed miRNAs were involved in protein homeostasis, mitochondrial dynamics, determination of muscle fibre type, insulin resistance, and adipogenesis. Twenty-four miRNAs were identified as commonly dysregulated in obesity and sarcopenia with functions and targets implicated in the pathogenesis of sarcopenic obesity. Given the adverse health outcomes associated with sarcopenic obesity, understanding the pathogenesis underlying this phenotype has the potential to lead to effective screening, monitoring, or treatment strategies. Further research is now required to confirm whether these miRNAs are differentially expressed in older adults with sarcopenic obesity.
    MeSH term(s) Adipogenesis ; Aged ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Obesity/complications ; Obesity/genetics ; Phosphatidylinositol 3-Kinases ; Sarcopenia/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-01-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.12878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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