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Article ; Online: Relationship between reaction time variability on go/no go tasks and neuropsychological functioning in younger and older adults.

Kimura, Naotoshi / Hirano, Daisuke / Yano, Hana / Taniguchi, Keita / Taniguchi, Takamichi

Journal of clinical and experimental neuropsychology

2024 Volume 45, Issue 9, Page(s) 905–914

Abstract: Introduction: Early detection of cognitive impairment in older adults is important for the prevention of dementia. Intra-individual variability in reaction time (IIV-RT) during go/no-go tasks can be used for the early detection of cognitive impairment ... ...

Abstract	Introduction: Early detection of cognitive impairment in older adults is important for the prevention of dementia. Intra-individual variability in reaction time (IIV-RT) during go/no-go tasks can be used for the early detection of cognitive impairment in older adults living in the community. This study aimed to determine the relationship between IIV-RT and cognitive function during go/no-go tasks and the cutoff values for determining the risk of cognitive impairment in community-dwelling older adults. Methods: This study included 31 older adults without cognitive impairment, 15 community-dwelling older adults with cognitive impairment, and 34 healthy young adults. All participants performed a go/no-go task to assess the IIV-RT. Additionally, older adults underwent neuropsychological testing. Based on the results of the Japanese version of the Montreal Test of Cognitive Abilities (MoCA-J), older adults were divided into those with normal cognition and those with cognitive impairment. Results: There were significant differences in the IIV-RT among groups, including a higher IIV in the cognitively impaired group than in young adults and cognitively normal older adults. Moreover, the IIV-RT was correlated with the MoCA-J ( Conclusions: These findings indicate that the IIV-RT during go/no-go tasks is a useful early indicator of cognitive impairment in community-dwelling older adults.
MeSH term(s)	Humans ; Aged ; Reaction Time ; Cognitive Dysfunction/psychology ; Cognition ; Neuropsychological Tests ; Trail Making Test
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	605982-x
ISSN	1744-411X ; 0168-8634 ; 1380-3395
ISSN (online)	1744-411X
ISSN	0168-8634 ; 1380-3395
DOI	10.1080/13803395.2024.2319266
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Zs.B 2393: Show issues

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Article: [Recurrent Breast Cancer with Bone Metastasis Effectively Treated with Abemaciclib plus Endocrine Therapy-A Case Report].

Adachi, Keita / Nagae, Junko / Kubota, Hitomi / Suzuki, Shuhei / Hirano, Tomohiro / Sakurai, Kenichi

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1845–1847

Abstract: We report a case of recurrent breast cancer with bone metastasis in a premenopausal woman. A 46-year-old woman underwent mastectomy for right breast cancer 6 years ago. Histopathological diagnosis was invasive ductal carcinoma, T2N3aM0, stage ⅢC. She ... ...

Abstract	We report a case of recurrent breast cancer with bone metastasis in a premenopausal woman. A 46-year-old woman underwent mastectomy for right breast cancer 6 years ago. Histopathological diagnosis was invasive ductal carcinoma, T2N3aM0, stage ⅢC. She received adjuvant chemotherapy and irradiation followed by tamoxifen. Four and a half years after surgery, serum tumor marker levels elevated, and bone metastasis in the sacral region was revealed by PET-CT scan. After suppressing ovarian function with LH-RH agonist, we switched the endocrine therapy from tamoxifen to letrozole with a CDK4/6 inhibitor. Five months after starting administration of abemaciclib, the bone metastasis disappeared on PET-CT. The elevated tumor markers normalized and have continued to decrease. Abemaciclib combined with endocrine therapy was significantly effective as first-line treatment for premenopausal women with metastatic breast cancer.
MeSH term(s)	Female ; Humans ; Middle Aged ; Breast Neoplasms/surgery ; Antineoplastic Agents, Hormonal/therapeutic use ; Positron Emission Tomography Computed Tomography ; Mastectomy ; Neoplasm Recurrence, Local/surgery ; Tamoxifen/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Aminopyridines ; Benzimidazoles
Chemical Substances	abemaciclib (60UAB198HK) ; Antineoplastic Agents, Hormonal ; Tamoxifen (094ZI81Y45) ; Aminopyridines ; Benzimidazoles
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Zs.B 2573: Show issues

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Article: [Elderly Advanced Breast Cancer Effectively Treated with Locoregional Therapy-A Case Report].

Adachi, Keita / Nagae, Junko / Kubota, Hitomi / Suzuki, Shuhei / Hirano, Tomohiro / Sakurai, Kenichi

Gan to kagaku ryoho. Cancer & chemotherapy

2024 Volume 50, Issue 13, Page(s) 1834–1836

Abstract: We report a case of advanced breast cancer in an elderly patient effectively treated with locoregional therapy. The patient was an 81-year-old woman who presented with an increasing right breast lump. The tumor was 55 mm in diameter, accompanied by ... ...

Abstract	We report a case of advanced breast cancer in an elderly patient effectively treated with locoregional therapy. The patient was an 81-year-old woman who presented with an increasing right breast lump. The tumor was 55 mm in diameter, accompanied by fixation to pectoral muscle. A core needle biopsy for right breast tumor led to a diagnosis of mucinous carcinoma, positive for estrogen receptor(ER)and progesterone receptor(PgR), negative for HER2/neu. The Ki-67 positive cell index was 10%. A bone scintigraphy revealed multiple bone metastases, so, we confirmed the diagnosis as T4cN2aM1, Stage Ⅳ. She initiated endocrine therapy by letrozole. By changing the endocrine therapy to toremifene followed by fulvestrant, the therapy achieved a partial response. However, the size of the primary tumor increased accompanied by bleeding, and surgical resection of the right breast was performed for local control. The locoregional surgery was effective, improving the patient's quality of life. She was administered lapatinib as anti-HER2 therapy in addition to the endocrine therapy. Two years and 6 months after surgery, there has been no worsening of bone metastasis or appearance of visceral metastasis.
MeSH term(s)	Aged, 80 and over ; Female ; Humans ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Breast Neoplasms/drug therapy ; Breast Neoplasms/diagnosis ; Fulvestrant ; Letrozole ; Quality of Life ; Toremifene
Chemical Substances	Fulvestrant (22X328QOC4) ; Letrozole (7LKK855W8I) ; Toremifene (7NFE54O27T)
Language	Japanese
Publishing date	2024-02-01
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	604842-0
ISSN	0385-0684
ISSN	0385-0684
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Article ; Online: Corrigendum to "Oncostatin M mediates cardioprotection via angiogenesis in ischemic heart disease" [Am. Heart J. Plus Cardiol. Res. Pract. vol. 35, 2023, 100331].

Ikeda, Shohei / Sato, Koichi / Takeda, Morihiko / Shinozaki, Mariko / Miki, Keita / Hirano, Michinori / Fukuda, Koji / Shiba, Nobuyuki

American heart journal plus : cardiology research and practice

2024 Volume 40, Page(s) 100385

Abstract: This corrects the article DOI: 10.1016/j.ahjo.2023.100331.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.ahjo.2023.100331.].
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Published Erratum
ISSN	2666-6022
ISSN (online)	2666-6022
DOI	10.1016/j.ahjo.2024.100385
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Article ; Online: Impact of a continuous quality improvement program on contrast-induced nephropathy in outpatients with chronic kidney disease: an interrupted time-series study.

Hirano, Keita / Kobayashi, Daiki / Shimbo, Takuro / Komatsu, Yasuhiro

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2022 Volume 38, Issue 5, Page(s) 1249–1259

Abstract: Background: Contrast-induced nephropathy (CIN) caused by exposure to radioactive contrast media can cause acute kidney injury in patients with chronic kidney disease (CKD). We developed a multifaceted approach in a CIN-quality improvement (QI) program ... ...

Abstract	Background: Contrast-induced nephropathy (CIN) caused by exposure to radioactive contrast media can cause acute kidney injury in patients with chronic kidney disease (CKD). We developed a multifaceted approach in a CIN-quality improvement (QI) program based on a shorter saline hydration protocol for the prevention of CIN in outpatients and assessed the effect of our CIN-QI program on decreasing both the incidence rate of CIN and overall use of contrast agents in patients undergoing contrast-enhanced computed tomography (CT). Methods: We conducted a multi-center prospective interrupted time-series study from 2006 to 2018 investigating the efficacy of a CIN-QI program in preventing CIN among outpatients with CKD. An automatic medical record system alert was implemented to instruct physicians to consult a nephrologist and administer prophylactic hydration and follow-up when ordering contrast-enhanced imaging in patients with an estimated glomerular filtration rate (eGFR) <45 mL/min/1.73 m2. The primary outcomes were the rates of prophylactic hydration and follow-up kidney function assessment, and the incidence of CIN for eligible patients. The usage rate of contrast-enhanced CT was also examined. Results: A total of 95 594 patients who underwent contrast-enhanced CT were included in the study. The annual prophylactic hydration rate before the CIN-QI program ranged from 2.0% to 23.2% but increased to 59.2%-75.2% during the CIN-QI program (P < .001). The annual rate of follow-up kidney function testing also improved from 18.6%-25.8% to 34.1%-42.5% after implementation of the CIN-QI program (P < .001). The rate of CIN significantly declined in level by 10.0% at the start of the CIN-QI program (P = .002) and in trend by 2.9%/year (P < .001). The number of contrast-enhanced CT orders showed a positive level change in patients with advanced CKD, who were the CIN-QI program target group of patients with eGFR <45 mL/min/1.73 m2, at the start of the implementation of the CIN-QI program. After implementing the CIN-QI program, the number of contrast-enhanced CT orders showed a negative trend change across all patients, which decreased from -1.4%/year to -10.0%/year for patients with advanced CKD. Conclusion: The multifaceted approach in the CIN-QI program may be associated with the decreased incidence of CIN and increased rates of prophylactic hydration and follow-up kidney function testing.
MeSH term(s)	Humans ; Contrast Media/adverse effects ; Prospective Studies ; Outpatients ; Quality Improvement ; Risk Factors ; Renal Insufficiency, Chronic/epidemiology ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/prevention & control ; Acute Kidney Injury/epidemiology ; Glomerular Filtration Rate
Chemical Substances	Contrast Media
Language	English
Publishing date	2022-09-12
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfac268
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Zs.A 2198: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Prognostic value of combined psoas muscle mass and controlling nutritional status in patients with pancreatic ductal adenocarcinoma: a retrospective cohort study.

Kuwabara, Shota / Takeuchi, Yuta / Sato, Osamu / Mizota, Tomoko / Ichinokawa, Masaomi / Murakawa, Katsuhiko / Aoki, Yuma / Ishido, Keita / Ono, Koichi / Hirano, Satoshi

BMC surgery

2024 Volume 24, Issue 1, Page(s) 116

Abstract: Background: Pancreatic ductal carcinoma (PDAC) is an extremely poor prognostic disease. Even though multidisciplinary treatment for PDAC has developed, supportive therapies, such as nutritional therapy or perioperative rehabilitation to sustain and ... ...

Abstract	Background: Pancreatic ductal carcinoma (PDAC) is an extremely poor prognostic disease. Even though multidisciplinary treatment for PDAC has developed, supportive therapies, such as nutritional therapy or perioperative rehabilitation to sustain and complete aggressive treatment, have not yet been well-established in PDAC. The aim of this study was to elucidate the relationship between the combined index using psoas muscle mass index (PMI) values and controlling nutritional status (CONUT) score and prognosis. Methods: We included 101 patients diagnosed with PDAC who underwent radical pancreatectomy with regional lymphadenectomy. The cut-off value was set at the first quartile (male, 6.3 cm Results: In the poor general condition group, the proportion of elderly people over 70 years of age was significantly higher than that in the other groups (p < 0.001). The poor general condition group had a significantly worse prognosis than the good and moderate general condition groups (p = 0.012 and p = 0.037). The 5-year survival rates were 10.9%, 22.3%, and 36.1% in the poor, moderate, and good general condition groups, respectively. In multivariate analysis, poor general condition, with both low PMI and malnutrition status, was an independent poor prognostic factor for postoperative OS (hazard ratio 2.161, p = 0.031). Conclusions: The combination of PMI and CONUT scores may be useful for predicting the prognosis of patients with PDAC after radical surgery.
MeSH term(s)	Humans ; Male ; Female ; Aged ; Aged, 80 and over ; Nutritional Status ; Prognosis ; Carcinoma, Pancreatic Ductal/complications ; Carcinoma, Pancreatic Ductal/surgery ; Carcinoma, Pancreatic Ductal/pathology ; Psoas Muscles ; Retrospective Studies ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/surgery ; Pancreatic Neoplasms/pathology
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2050442-1
ISSN	1471-2482 ; 1471-2482
ISSN (online)	1471-2482
ISSN	1471-2482
DOI	10.1186/s12893-024-02395-2
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Article ; Online: Importance of Management of Lifestyle-Related Diseases After Kidney Donation to Living Donors.

Hirano, Hajime / Fujiwara, Yuya / Okabe, Tomota / Nakamori, Keita / Minami, Koichiro / Uehara, Hirofumi / Nomi, Hayahito / Komura, Kazumasa / Inamoto, Teruo / Azuma, Haruhito

Transplantation proceedings

2024 Volume 56, Issue 3, Page(s) 479–481

Abstract: Background: Living kidney transplant donors are classified as stage 3 chronic kidney disease after kidney donation. For this reason, we provide daily lifestyle guidance, such as blood pressure and weight management before surgery, and dietary counseling ...

Abstract	Background: Living kidney transplant donors are classified as stage 3 chronic kidney disease after kidney donation. For this reason, we provide daily lifestyle guidance, such as blood pressure and weight management before surgery, and dietary counseling focused on salt restriction. We emphasize providing lifestyle guidance after kidney donation. Method: At Osaka Medical and Pharmaceutical University Hospital, living kidney donors are scheduled for their first postoperative visit 1 month after kidney donation, followed by regular checkups every 6 months after that, starting 3 months after the initial visit. When living kidney donors come to the Renal Replacement Therapy Selection Outpatient Clinic before kidney transplantation, we provide sufficient explanations of the potential risks that may arise after kidney donation and ensure that they understand the importance of regular postoperative checkups. Apart from cases where patients reside far away, and we ask another hospital to provide postoperative follow-up, we can achieve regular checkups for almost all cases. Results: Eighty-four living kidney transplant donors are being followed up at Osaka Medical and Pharmaceutical University Hospital. The average age is 59.8 ± 11.8 years, showing a trend of aging. Among the donors under follow-up, 7 developed hyperlipidemia, 2 developed hypertension, and 1 developed diabetes as new-onset lifestyle diseases after kidney donation. Conclusion: The ability to empathize with and support the anxieties associated with kidney donation and build a strong relationship of trust with the donors has become a significant factor in achieving a high rate of regular checkups after kidney donation. As a result, it has led to early detection and intervention for donor diseases, contributing to the maintenance of their health. Managing lifestyle-related diseases after kidney donation is essential for living kidney donors.
MeSH term(s)	Humans ; Living Donors ; Kidney Transplantation ; Middle Aged ; Life Style ; Male ; Female ; Aged ; Nephrectomy ; Hypertension
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2024.01.027
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Zs.A 835: Show issues

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Article: Undifferentiated high-grade pleomorphic sarcoma of the mediastinum.

Nakayama, Takashin / Numasawa, Yohei / Hashimoto, Kohei / Hirano, Keita

Oxford medical case reports

2019 Volume 2019, Issue 9, Page(s) omz086

Language	English
Publishing date	2019-09-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2766251-2
ISSN	2053-8855
ISSN	2053-8855
DOI	10.1093/omcr/omz086
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Article ; Online: Warning from constricted and wrinkled internal jugular vein.

Ogawa, Kyohei / Hirano, Keita

Clinical and experimental nephrology

2018 Volume 23, Issue 2, Page(s) 285–286

MeSH term(s)	Aged ; Catheterization, Central Venous/instrumentation ; Catheters, Indwelling ; Central Venous Catheters ; Humans ; Jugular Veins/diagnostic imaging ; Male ; Phlebography ; Predictive Value of Tests ; Punctures ; Ultrasonography, Interventional
Language	English
Publishing date	2018-07-16
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1338768-6
ISSN	1437-7799 ; 1342-1751
ISSN (online)	1437-7799
ISSN	1342-1751
DOI	10.1007/s10157-018-1616-9
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Zs.A 4922: Show issues

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Article: Longitudinal relationship between long sleep duration and future kidney function decline.

Hirano, Keita / Komatsu, Yasuhiro / Shimbo, Takuro / Nakata, Hirosuke / Kobayashi, Daiki

Clinical kidney journal

2022 Volume 15, Issue 9, Page(s) 1763–1769

Abstract: Background: Evidence linking chronic kidney disease (CKD) and sleep duration is inconsistent. This study examined whether sleep duration is associated with a long-term risk of kidney function decline.: Methods: This retrospective, longitudinal cohort ...

Abstract	Background: Evidence linking chronic kidney disease (CKD) and sleep duration is inconsistent. This study examined whether sleep duration is associated with a long-term risk of kidney function decline. Methods: This retrospective, longitudinal cohort study included 82 001 participants who visited a primary care centre in Japan. Participants were categorized into CKD risk groups and sleep duration categories according to their self-reported average nightly sleep duration. The relationship between average nightly sleep duration and the incidence of composite renal outcome comprised a ≥40% reduction in estimated glomerular filtration rate (eGFR) from baseline and a decline in eGFR to <15 mL/min/1.73 m² was evaluated. Results: The mean age and eGFR (±standard deviation) of the patient cohort were 45.8 (±12.4) years and 81.8 (±15.4) mL/min/1.73 m², respectively. A total of 41 891 participants (51.1%) were women. During the median follow-up of 5.1 years [interquartile range 2.2-9.6], 4214 (5.1%) participants achieved the composite renal outcome. Only the long and very long sleep durations (≥8 h/night) were associated with an increased incidence of the composite renal outcome compared with the reference duration (7 h/night) [adjusted odds ratio (OR) 1.22 and 1.44; 95% confidence interval (CI) 1.09-1.36 and 1.13-1.84, for long and very long sleep durations, respectively]. Furthermore, this association was significant for both long and very long sleep durations in the low CKD risk group but only for long sleep duration in the intermediate CKD risk group. The results of the sex-specific analysis showed that men had a decreased risk of achieving the composite renal outcome (OR 0.91; 95% CI 0.79-1.06), while there was an increased risk for women (OR 1.14; 95% CI 1.02-1.28). Conclusions: Average sleep durations ≥8 h/night were associated with an increased incidence of poor renal outcomes over time. However, a longitudinal cohort study is required to confirm whether sleep duration can prevent poor renal outcomes.
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfac107
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