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  1. Article ; Online: Both Ways at Once: Keeping Small Airways Clean.

    Quinton, Paul M

    Physiology (Bethesda, Md.)

    2017  Volume 32, Issue 5, Page(s) 380–390

    Abstract: The small airways of the lungs are under constant assault from the pathogens and debris in the air that they must conduct to alveoli. Although hygiene is of paramount importance for respiratory health, the underlying principles of airway clearance have ... ...

    Abstract The small airways of the lungs are under constant assault from the pathogens and debris in the air that they must conduct to alveoli. Although hygiene is of paramount importance for respiratory health, the underlying principles of airway clearance have not been well integrated or established. Newly emerging concepts of simultaneous absorption and secretion of airway surface liquid (ASL) and the role of [Formula: see text] in the maturation of mucins have advanced from experimental evidence as well as observations from the congenital disease cystic fibrosis (CF) to present a novel model that integrates microanatomy with organ physiology to meet the constant challenge of cleaning small airways.
    MeSH term(s) Animals ; Bronchioles/metabolism ; Bronchioles/physiology ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/physiopathology ; Humans ; Mucins/metabolism ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/physiology
    Chemical Substances Mucins
    Language English
    Publishing date 2017-08-31
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00013.2017
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  2. Article ; Online: A synopsis of methods of sweat tests in pathology.

    Quinton, Paul M

    Clinical biochemistry

    2014  Volume 47, Issue 9, Page(s) 757–758

    MeSH term(s) Chlorides/metabolism ; Clinical Chemistry Tests ; Cystic Fibrosis/diagnosis ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/physiopathology ; Humans ; Sweat/metabolism ; Sweating
    Chemical Substances Chlorides
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2014.05.047
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  3. Article ; Online: Reassessing the Role of Phonomicrosurgery and Smoking Status in the Management of Reinke's Edema.

    Quinton, Brooke A / Arianpour, Khashayar / Yaffe, Noah M / Tierney, William S / Benninger, Michael S / Bryson, Paul C

    The Laryngoscope

    2023  

    Abstract: Objectives: To elucidate recurrence patterns of Reinke's edema (RE) following phonomicrosurgery and compare current and former smokers' outcomes.: Methods: A retrospective chart review was performed for patients who underwent microflap excision for ... ...

    Abstract Objectives: To elucidate recurrence patterns of Reinke's edema (RE) following phonomicrosurgery and compare current and former smokers' outcomes.
    Methods: A retrospective chart review was performed for patients who underwent microflap excision for RE at our institution since 2008. Patient data were collected, including demographics, smoking history, and operative and voice outcomes during the available follow-up period. Descriptive statistics, student's t-tests, Chi-squared analyses, and Fischer's exact tests were used for the appropriate between-group comparisons utilizing JMP statistical software.
    Results: Patients who quit smoking on the day of surgery or continued to smoke postoperatively were included in our group of current smokers (n = 56). Patients who quit smoking within the month of surgery or longer were included in our group of former smokers (n = 22). There was no significant difference in postoperative voice outcomes between groups. Eight patients in the entire cohort experienced recurrence during the available follow-up period. Fischer's exact test revealed no statistically significant association between smoking status and recurrence (two-tailed p > 0.05). The mean time to recurrence for current smokers who did recur was 69 and 54 months for former smokers.
    Conclusion: We report low overall recurrence rates after microflap excision of RE lesions compared with historical data, without any significant difference in recurrence or voice outcomes when comparing current and former smokers. Further prospective trials with larger sample sizes are warranted to guide the surgical management of RE patients and the implications of smoking status.
    Level of evidence: 3 Laryngoscope, 2023.
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31207
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  4. Article ; Online: The Role of Bilateral Superior Laryngeal Nerve Block in Managing Refractory Chronic Cough.

    Quinton, Brooke A / Tierney, William S / Benninger, Michael S / Nelson, Rebecca C / Gau, Victoria L / Hrelec, Candace M / Bryson, Paul C

    The Laryngoscope

    2023  Volume 134, Issue 4, Page(s) 1773–1777

    Abstract: Objective(s): The aim was to investigate the utilization and efficacy of bilateral superior laryngeal nerve block in patients with refractory chronic cough.: Methods: A retrospective chart review of 164 patients with refractory chronic cough who ... ...

    Abstract Objective(s): The aim was to investigate the utilization and efficacy of bilateral superior laryngeal nerve block in patients with refractory chronic cough.
    Methods: A retrospective chart review of 164 patients with refractory chronic cough who underwent bilateral SLN block at a single institution between November 2018 and September 2022 was performed. Demographics, comorbidities, and patient-reported outcomes including pre- and postinjection Leicester Cough Questionnaire (LCQ) scores were collected and analyzed.
    Results: The cohort underwent an average of 2.97 bilateral injections (range 1-22), containing either corticosteroid and local anesthetic or corticosteroid alone. Notably, 116 of 164 of patients reported an average of 67.3% reduction in their symptoms, with the treatment effect lasting 7.60 weeks on average. The average pre- and postinjection LCQ scores were 9.70 and 13.82, respectively. A lower LCQ score represents a greater impairment of health status due to cough, and the minimum important change is 1.3 points between questionnaires. The average improvement on LCQ following bilateral SLN block was 4.11 points for this cohort.
    Conclusion: The use of in-office bilateral SLN block is an effective treatment that can be used alone or in conjunction with oral medications for the treatment of refractory chronic cough.
    Level of evidence: 4 Laryngoscope, 134:1773-1777, 2024.
    MeSH term(s) Humans ; Chronic Disease ; Retrospective Studies ; Chronic Cough ; Adrenal Cortex Hormones/therapeutic use ; Laryngeal Nerves ; Cough/diagnosis ; Surveys and Questionnaires ; Quality of Life
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31061
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  5. Article ; Online: The Application of Superior Laryngeal Nerve Block for Non-Cough Laryngeal Hypersensitivity.

    Benninger, Michael S / Quinton, Brooke A / Tierney, William S / Gau, Victoria L / Nelson, Rebecca C / Hrelec, Candace M / Bryson, Paul C

    The Laryngoscope

    2023  Volume 134, Issue 4, Page(s) 1765–1768

    Abstract: Objective(s): To investigate the effect of superior laryngeal nerve (SLN) block in patients with non-cough complaints relating to laryngeal who have failed conventional medical therapy.: Methods: Retrospective chart review of 46 patients who ... ...

    Abstract Objective(s): To investigate the effect of superior laryngeal nerve (SLN) block in patients with non-cough complaints relating to laryngeal who have failed conventional medical therapy.
    Methods: Retrospective chart review of 46 patients who underwent SLN block for non-cough indications between July 2019 and March 2022 was performed. Demographics, comorbidities, and patient-reported outcomes were collected. The primary diagnoses for this group included: odynophagia, throat pain, cervicalgia, muscle tension dysphonia, globus sensation, hyoid bone syndrome, and Eagle syndrome.
    Results: The cohort underwent an average of 1.24 bilateral injections (range 0-7) and 0.87 unilateral injections (range 0-4). About 35 of 46 patients reported an average of 51.0% improvement in their symptoms, with the treatment effect lasting 7.60 weeks on average. On subgroup analysis, the patients with spasmodic dysphonia, odynophagia, and hyoid bone syndrome had the best percent improvement on average (75%-77.5%). Patients with globus sensation had the lowest percent improvement on average in response to this therapy, reporting only about 25%. Five patients experienced a mild adverse reaction immediately following injection which resolved spontaneously.
    Conclusion: The use of in-office SLN block for non-cough disorders involving the larynx requires further study with larger sample sizes to better delineate the efficacy of these applications.
    Level of evidence: 4 Laryngoscope, 134:1765-1768, 2024.
    MeSH term(s) Humans ; Dysphonia/therapy ; Retrospective Studies ; Larynx/physiology ; Injections ; Deglutition Disorders ; Laryngeal Nerves
    Language English
    Publishing date 2023-09-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31075
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  6. Article ; Online: Concurrent absorption and secretion of airway surface liquids and bicarbonate secretion in human bronchioles.

    Shamsuddin, A K M / Quinton, Paul M

    American journal of physiology. Lung cellular and molecular physiology

    2019  Volume 316, Issue 5, Page(s) L953–L960

    Abstract: Although small airways account for the largest fraction of the total conducting airway surfaces, the epithelial fluid and electrolyte transport in small, native airway epithelia has not been well characterized. Investigations have been limited, no doubt, ...

    Abstract Although small airways account for the largest fraction of the total conducting airway surfaces, the epithelial fluid and electrolyte transport in small, native airway epithelia has not been well characterized. Investigations have been limited, no doubt, by the complex tissue architecture as well as by its inaccessibility, small dimensions, and lack of applicable assays, especially in human tissues. To better understand how the critically thin layer of airway surface liquid (ASL) is maintained, we applied a "capillary"-Ussing chamber (area ≈1 mm
    MeSH term(s) Animals ; Bicarbonates/metabolism ; Bronchioles/metabolism ; Extracellular Fluid/metabolism ; Humans ; Ion Transport ; Respiratory Mucosa/metabolism ; Swine
    Chemical Substances Bicarbonates
    Language English
    Publishing date 2019-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00545.2018
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  7. Article ; Online: Role of epithelial HCO3⁻ transport in mucin secretion: lessons from cystic fibrosis.

    Quinton, Paul M

    American journal of physiology. Cell physiology

    2010  Volume 299, Issue 6, Page(s) C1222–33

    Abstract: The invitation to present the 2010 Hans Ussing lecture for the Epithelial Transport Group of the American Physiological Society offered me a unique, special, and very surprising opportunity to join in saluting a man whom I met only once, but whose work ... ...

    Abstract The invitation to present the 2010 Hans Ussing lecture for the Epithelial Transport Group of the American Physiological Society offered me a unique, special, and very surprising opportunity to join in saluting a man whom I met only once, but whose work was the basis, not only for my career, but also for finding the molecular defect in the inherited disease cystic fibrosis (CF). In this context, I will venture to make the tribute with a new explanation of why a mutation in a single gene that codes for an anion channel can cause devastation of multiple epithelial systems with pathogenic mucus. In so doing, I hope to raise awareness of a new role for that peculiar anion around which so much physiology revolves, HCO(3)(-). I begin by introducing CF pathology as I question the name of the disease as well as the prevalent view of the basis of its pathology by considering: 1) mucus, 2) salt, and 3) HCO(3)(-). I then present recent data showing that HCO(3)(-) is required for normal mucus discharge, and I will close with conjecture as to how HCO(3)(-) may support mucus discharge and why the failure to transport this electrolyte is pathogenic in CF.
    MeSH term(s) Animals ; Bicarbonates/metabolism ; Cystic Fibrosis/genetics ; Cystic Fibrosis/metabolism ; Cystic Fibrosis/pathology ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator/physiology ; Female ; Humans ; Ion Transport/genetics ; Ion Transport/physiology ; Lung/pathology ; Lung/physiopathology ; Male ; Mice ; Mucins/metabolism ; Mucus/metabolism ; Sodium Chloride/metabolism ; Sweat Glands/metabolism ; Sweat Glands/pathology ; Sweat Glands/physiopathology
    Chemical Substances Bicarbonates ; Mucins ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2010-10-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00362.2010
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  8. Article ; Online: Birth of mucus.

    Quinton, Paul M

    American journal of physiology. Lung cellular and molecular physiology

    2009  Volume 298, Issue 1, Page(s) L13–4

    MeSH term(s) Animals ; Bicarbonates/metabolism ; Biological Transport ; Calcium/metabolism ; Cystic Fibrosis/metabolism ; Fetus/embryology ; Fetus/metabolism ; Humans ; Mucins/metabolism ; Mucus/metabolism
    Chemical Substances Bicarbonates ; Mucins ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2009-10-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00358.2009
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  9. Book ; Conference proceedings: FLUID AND ELECTROLYTE ABNORMALITIES IN EXOCRINE GLANDS IN CYSTIC FIBROSIS

    QUINTON, PAUL M.

    (THE CONFERENCE WAS HELD IN SAN DIEGO, CALIF., ON 10 - 12 MARCH 1982)

    1982  

    Author's details PAUL M. QUINTON ... EDS
    Keywords CYSTIC FIBROSIS / CONGRESSES ; EXOCRINE GLANDS / SECRETION / CONGRESSES ; WATER-ELECTROLYTE IMBALANCE / CONGRESSES
    Size VI, 298 S.: ILL., GRAPH. DARST.
    Publisher SAN FRANCISCO PR
    Publishing place SAN FRANCISCO, CALIF
    Document type Book ; Conference proceedings
    HBZ-ID HT002736777
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Cost-effectiveness of testosterone treatment utilising individual patient data from randomised controlled trials in men with low testosterone levels.

    Hernández, Rodolfo / de Silva, Nipun Lakshitha / Hudson, Jemma / Cruickshank, Moira / Quinton, Richard / Manson, Paul / Dhillo, Waljit S / Bhattacharya, Siladitya / Brazzelli, Miriam / Jayasena, Channa N

    Andrology

    2024  Volume 12, Issue 3, Page(s) 477–486

    Abstract: Background: Testosterone is safe and highly effective in men with organic hypogonadism, but worldwide testosterone prescribing has recently shifted towards middle-aged and older men, mostly with low testosterone related to age, diabetes and obesity, for ...

    Abstract Background: Testosterone is safe and highly effective in men with organic hypogonadism, but worldwide testosterone prescribing has recently shifted towards middle-aged and older men, mostly with low testosterone related to age, diabetes and obesity, for whom there is less established evidence of clinical safety and benefit. The value of testosterone treatment in middle-aged and older men with low testosterone is yet to be determined. We therefore evaluated the cost-effectiveness of testosterone treatment in such men with low testosterone compared with no treatment.
    Methods: A cost-utility analysis comparing testosterone with no treatment was conducted following best practices in decision modelling. A cohort Markov model incorporating relevant care pathways for individuals with hypogonadism was developed for a 10-year-time horizon. Clinical outcomes were obtained from an individual patient meta-analysis of placebo-controlled, double-blind randomised studies. Three starting age categories were defined: 40, 60 and 75 years. Cost utility (quality-adjusted life years) accrued and costs of testosterone treatment, monitoring and cardiovascular complications were compared to estimate incremental cost-effectiveness ratios and cost-effectiveness acceptability curves for selected scenarios.
    Results: Ten-year excess treatment costs for testosterone compared with non-treatment ranged between £2306 and £3269 per patient. Quality-adjusted life years results depended on the instruments used to measure health utilities. Using Beck depression index-derived quality-adjusted life years data, testosterone was cost-effective (incremental cost-effectiveness ratio <£20,000) for men aged <75 years, regardless of morbidity and mortality sensitivity analyses. Testosterone was not cost-effective in men aged >75 years in models assuming increased morbidity and/or mortality.
    Conclusions and future research: Our data suggest that testosterone is cost-effective in men <75 years when Beck depression index-derived quality-adjusted life years data are considered; cost-effectiveness in men >75 years is dependent on cardiovascular safety. However, more robust and longer-term cost-utility data are needed to verify our conclusion.
    MeSH term(s) Male ; Middle Aged ; Humans ; Aged ; Cost-Benefit Analysis ; Testosterone/adverse effects ; Hypogonadism/drug therapy ; Randomized Controlled Trials as Topic
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2696108-8
    ISSN 2047-2927 ; 2047-2919
    ISSN (online) 2047-2927
    ISSN 2047-2919
    DOI 10.1111/andr.13597
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