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  1. Article ; Online: Europe may bar neighbors from key research.

    Wallace, Nicholas

    Science (New York, N.Y.)

    2021  Volume 371, Issue 6535, Page(s) 1194

    Language English
    Publishing date 2021-03-18
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.371.6535.1194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 27: Show issues Location:
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  2. Article ; Online: Brexit deal secures U.K. access to research funds.

    Wallace, Nicholas

    Science (New York, N.Y.)

    2021  Volume 371, Issue 6525, Page(s) 110–111

    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.371.6525.110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Europe ramps up defense R&D.

    Wallace, Nicholas

    Science (New York, N.Y.)

    2020  Volume 370, Issue 6522, Page(s) 1259–1260

    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.370.6522.1259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Europe bets R&D spending will bring jobs to battered economy.

    Wallace, Nicholas

    Science (New York, N.Y.)

    2020  Volume 368, Issue 6495, Page(s) 1044

    Keywords covid19
    Language English
    Publishing date 2020-06-04
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.368.6495.1044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: European Union gets in the venture capital game.

    Wallace, Nicholas

    Science (New York, N.Y.)

    2020  Volume 368, Issue 6487, Page(s) 120–121

    MeSH term(s) European Union ; Humans ; Investments ; Patient Isolation/economics ; Patient Isolation/instrumentation ; Stretchers/economics
    Keywords covid19
    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.368.6487.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Top EU scientist ousted over plans for coronavirus research.

    Wallace, Nicholas

    Science (New York, N.Y.)

    2020  Volume 368, Issue 6488, Page(s) 223

    MeSH term(s) Biomedical Research/economics ; COVID-19 ; Capital Financing ; Coronavirus Infections/economics ; European Union/economics ; Humans ; Laboratory Personnel/economics ; Pandemics/economics ; Pneumonia, Viral/economics
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type News
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.368.6488.223
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Interactions among human papillomavirus proteins and host DNA repair factors differ during the viral life cycle and virus-induced tumorigenesis.

    Wendel, Sebastian / Wallace, Nicholas A

    mSphere

    2023  Volume 8, Issue 6, Page(s) e0042723

    Abstract: This review focuses on the impact of human papillomavirus (HPV) oncogenes on DNA repair pathways with a particular focus on how these relationships change as productive HPV infections transition to malignant lesions. We made specific efforts to ... ...

    Abstract This review focuses on the impact of human papillomavirus (HPV) oncogenes on DNA repair pathways with a particular focus on how these relationships change as productive HPV infections transition to malignant lesions. We made specific efforts to incorporate advances in the understanding of HPV and DNA damage repair over the last 4 years. We apologize for any articles that we missed in compiling this report.
    MeSH term(s) Humans ; Animals ; Human Papillomavirus Viruses ; Papillomavirus Infections/genetics ; DNA Repair ; Papillomaviridae/genetics ; Carcinogenesis/genetics ; Life Cycle Stages
    Language English
    Publishing date 2023-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00427-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Beta HPV Deregulates Double-Strand Break Repair.

    Hu, Changkun / Wallace, Nicholas

    Viruses

    2022  Volume 14, Issue 5

    Abstract: Beta human papillomavirus (beta HPV) infections are common in adults. Certain types of beta HPVs are associated with nonmelanoma skin cancer (NMSC) in immunocompromised individuals. However, whether beta HPV infections promote NMSC in the immunocompetent ...

    Abstract Beta human papillomavirus (beta HPV) infections are common in adults. Certain types of beta HPVs are associated with nonmelanoma skin cancer (NMSC) in immunocompromised individuals. However, whether beta HPV infections promote NMSC in the immunocompetent population is unclear. They have been hypothesized to increase genomic instability stemming from ultraviolet light exposure by disrupting DNA damage responses. Implicit in this hypothesis is that the virus encodes one or more proteins that impair DNA repair signaling. Fluorescence-based reporters, next-generation sequencing, and animal models have been used to test this primarily in cells expressing beta HPV E6/E7. Of the two, beta HPV E6 appears to have the greatest ability to increase UV mutagenesis, by attenuating two major double-strand break (DSB) repair pathways, homologous recombination, and non-homologous end-joining. Here, we review this dysregulation of DSB repair and emerging approaches that can be used to further these efforts.
    MeSH term(s) Alphapapillomavirus ; Animals ; DNA Repair ; Homologous Recombination ; Papillomaviridae/genetics ; Papillomavirus Infections ; Skin Neoplasms
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14050948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: mSphere of Influence: the Value of Simplicity in Experiments and Solidarity among Lab Members.

    Wallace, Nicholas A

    mSphere

    2019  Volume 4, Issue 3

    Abstract: Nicholas Wallace studies how human papillomaviruses cause cancer throughout the genital and ...

    Abstract Nicholas Wallace studies how human papillomaviruses cause cancer throughout the genital and oropharyngeal tracts as well as in the skin. These viruses inhibit host DNA repair to promote their life style and in doing increase the risk of oncogenic mutations. In this mSphere of Influence article, he reflects on how two papers influenced him. "Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation" by C. A. Moody and L. Laimins (PLoS Pathog 5:e10000605, 2009, https://doi.org/10.1371/journal.ppat.1000605) reminded him of the power of straightforward approaches, while "Forty-Five Years of Cell-Cycle Genetics" by B. Reid et al. (B. J. Reid, J. G. Culotti, R. S. Nash, and J. R. Pringle, Mol Biol Cell 26:4307-4312, 2015, https://doi.org/10.1091/mbc.E14-10-1484) gave him the inspiration for his lab management style.
    MeSH term(s) Genome, Viral ; Host-Pathogen Interactions ; Humans ; Interpersonal Relations ; Laboratory Personnel ; Papillomaviridae/genetics ; Research ; Virus Replication
    Language English
    Publishing date 2019-06-19
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00172-19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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