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  1. Article: Topical Silicone Sheet Application in the Treatment of Hypertrophic Scars and Keloids.

    Westra, Iris / Pham, Hth / Niessen, Frank B

    The Journal of clinical and aesthetic dermatology

    2016  Volume 9, Issue 10, Page(s) 28–35

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2016-10-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2571623-2
    ISSN 1941-2789
    ISSN 1941-2789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The interpersonal context of client motivational language in cognitive-behavioral therapy.

    Sijercic, Iris / Button, Melissa L / Westra, Henny A / Hara, Kimberley M

    Psychotherapy (Chicago, Ill.)

    2016  Volume 53, Issue 1, Page(s) 13–21

    Abstract: Previous research has found that client motivational language (especially arguments against change or counterchange talk; CCT) in early therapy sessions is a reliable predictor of therapy process and outcomes across a broad range of treatments including ... ...

    Abstract Previous research has found that client motivational language (especially arguments against change or counterchange talk; CCT) in early therapy sessions is a reliable predictor of therapy process and outcomes across a broad range of treatments including cognitive-behavioral therapy (CBT). Existing studies have considered the general occurrence of CCT, but the present study differentiated 2 types of CCT in early CBT sessions for 37 clients with generalized anxiety disorder: (a) statements that are uttered to express ambivalence regarding change versus (b) statements that are intended to oppose the therapist or therapy. Two process coding systems were used to accomplish this differentiation. Findings indicated that a higher number of CCT statements that occurred in the presence of resistance (opposition to the therapist or therapy) were a substantive and consistent predictor of lower homework compliance and poorer outcomes, up to 1 year posttreatment. Moreover, when both types of CCT were considered together, only opposition CCT was related to outcomes, and ambivalent CCT was not significantly predictive of proximal and distal outcomes. These findings suggest that the interpersonal context in which CCT statements occur may be critically important to their predictive capacity. More broadly, the findings of this study have implications for the future study of client motivational language and underscore the clinical importance of detecting opposition CCT.
    MeSH term(s) Adult ; Anxiety Disorders/psychology ; Anxiety Disorders/therapy ; Canada ; Cognitive Therapy/methods ; Female ; Humans ; Interpersonal Relations ; Language ; Male ; Motivation ; Professional-Patient Relations ; Treatment Outcome
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 281564-3
    ISSN 1939-1536 ; 0033-3204
    ISSN (online) 1939-1536
    ISSN 0033-3204
    DOI 10.1037/pst0000017
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  3. Article: A torsional eye movement calculation algorithm for low contrast images in video-oculography.

    Jansen, S H / Kingma, H / Peeters, R M / Westra, R L

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2010  Volume 2010, Page(s) 5628–5631

    Abstract: ... iris textures are almost invisible, making them unsuited for direct application of standard matching ...

    Abstract Video-oculography (VOG) is a frequently used clinical technique to detect eye movements. In this research, head mounted small video-cameras and IR-illumination are employed to image the eye. Many algorithms have been developed to extract horizontal and vertical eye movements from the video images. Designing a method to determine torsional eye movements is a more complex task. The use of IR-wavelengths required for illumination in certain clinical tests results in a very low image contrast. In such images, iris textures are almost invisible, making them unsuited for direct application of standard matching algorithms, which are used to calculate torsional eye movements. This research presents the design and implementation of a robust torsional eye movement detection algorithm for VOG. This algorithm uses a new approach to measure the torsional eye movement and is suitable for low contrast videos. The algorithm is implemented in a clinical device and its performance is compared to that of alternative techniques.
    MeSH term(s) Algorithms ; Contrast Sensitivity ; Eye Movement Measurements ; Eye Movements/physiology ; Humans ; Image Processing, Computer-Assisted/methods ; Iris/physiology ; Torsion, Mechanical ; Video Recording/methods
    Language English
    Publishing date 2010-10-27
    Publishing country United States
    Document type Journal Article
    ISSN 2375-7477
    ISSN 2375-7477
    DOI 10.1109/IEMBS.2010.5628040
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  4. Article ; Online: New genetic loci link adipose and insulin biology to body fat distribution.

    Shungin, Dmitry / Winkler, Thomas W / Croteau-Chonka, Damien C / Ferreira, Teresa / Locke, Adam E / Mägi, Reedik / Strawbridge, Rona J / Pers, Tune H / Fischer, Krista / Justice, Anne E / Workalemahu, Tsegaselassie / Wu, Joseph M W / Buchkovich, Martin L / Heard-Costa, Nancy L / Roman, Tamara S / Drong, Alexander W / Song, Ci / Gustafsson, Stefan / Day, Felix R /
    Esko, Tonu / Fall, Tove / Kutalik, Zoltán / Luan, Jian'an / Randall, Joshua C / Scherag, André / Vedantam, Sailaja / Wood, Andrew R / Chen, Jin / Fehrmann, Rudolf / Karjalainen, Juha / Kahali, Bratati / Liu, Ching-Ti / Schmidt, Ellen M / Absher, Devin / Amin, Najaf / Anderson, Denise / Beekman, Marian / Bragg-Gresham, Jennifer L / Buyske, Steven / Demirkan, Ayse / Ehret, Georg B / Feitosa, Mary F / Goel, Anuj / Jackson, Anne U / Johnson, Toby / Kleber, Marcus E / Kristiansson, Kati / Mangino, Massimo / Leach, Irene Mateo / Medina-Gomez, Carolina / Palmer, Cameron D / Pasko, Dorota / Pechlivanis, Sonali / Peters, Marjolein J / Prokopenko, Inga / Stančáková, Alena / Sung, Yun Ju / Tanaka, Toshiko / Teumer, Alexander / Van Vliet-Ostaptchouk, Jana V / Yengo, Loïc / Zhang, Weihua / Albrecht, Eva / Ärnlöv, Johan / Arscott, Gillian M / Bandinelli, Stefania / Barrett, Amy / Bellis, Claire / Bennett, Amanda J / Berne, Christian / Blüher, Matthias / Böhringer, Stefan / Bonnet, Fabrice / Böttcher, Yvonne / Bruinenberg, Marcel / Carba, Delia B / Caspersen, Ida H / Clarke, Robert / Daw, E Warwick / Deelen, Joris / Deelman, Ewa / Delgado, Graciela / Doney, Alex Sf / Eklund, Niina / Erdos, Michael R / Estrada, Karol / Eury, Elodie / Friedrich, Nele / Garcia, Melissa E / Giedraitis, Vilmantas / Gigante, Bruna / Go, Alan S / Golay, Alain / Grallert, Harald / Grammer, Tanja B / Gräßler, Jürgen / Grewal, Jagvir / Groves, Christopher J / Haller, Toomas / Hallmans, Goran / Hartman, Catharina A / Hassinen, Maija / Hayward, Caroline / Heikkilä, Kauko / Herzig, Karl-Heinz / Helmer, Quinta / Hillege, Hans L / Holmen, Oddgeir / Hunt, Steven C / Isaacs, Aaron / Ittermann, Till / James, Alan L / Johansson, Ingegerd / Juliusdottir, Thorhildur / Kalafati, Ioanna-Panagiota / Kinnunen, Leena / Koenig, Wolfgang / Kooner, Ishminder K / Kratzer, Wolfgang / Lamina, Claudia / Leander, Karin / Lee, Nanette R / Lichtner, Peter / Lind, Lars / Lindström, Jaana / Lobbens, Stéphane / Lorentzon, Mattias / Mach, François / Magnusson, Patrik Ke / Mahajan, Anubha / McArdle, Wendy L / Menni, Cristina / Merger, Sigrun / Mihailov, Evelin / Milani, Lili / Mills, Rebecca / Moayyeri, Alireza / Monda, Keri L / Mooijaart, Simon P / Mühleisen, Thomas W / Mulas, Antonella / Müller, Gabriele / Müller-Nurasyid, Martina / Nagaraja, Ramaiah / Nalls, Michael A / Narisu, Narisu / Glorioso, Nicola / Nolte, Ilja M / Olden, Matthias / Rayner, Nigel W / Renstrom, Frida / Ried, Janina S / Robertson, Neil R / Rose, Lynda M / Sanna, Serena / Scharnagl, Hubert / Scholtens, Salome / Sennblad, Bengt / Seufferlein, Thomas / Sitlani, Colleen M / Smith, Albert Vernon / Stirrups, Kathleen / Stringham, Heather M / Sundström, Johan / Swertz, Morris A / Swift, Amy J / Syvänen, Ann-Christine / Tayo, Bamidele O / Thorand, Barbara / Thorleifsson, Gudmar / Tomaschitz, Andreas / Troffa, Chiara / van Oort, Floor Va / Verweij, Niek / Vonk, Judith M / Waite, Lindsay L / Wennauer, Roman / Wilsgaard, Tom / Wojczynski, Mary K / Wong, Andrew / Zhang, Qunyuan / Zhao, Jing Hua / Brennan, Eoin P / Choi, Murim / Eriksson, Per / Folkersen, Lasse / Franco-Cereceda, Anders / Gharavi, Ali G / Hedman, Åsa K / Hivert, Marie-France / Huang, Jinyan / Kanoni, Stavroula / Karpe, Fredrik / Keildson, Sarah / Kiryluk, Krzysztof / Liang, Liming / Lifton, Richard P / Ma, Baoshan / McKnight, Amy J / McPherson, Ruth / Metspalu, Andres / Min, Josine L / Moffatt, Miriam F / Montgomery, Grant W / Murabito, Joanne M / Nicholson, George / Nyholt, Dale R / Olsson, Christian / Perry, John Rb / Reinmaa, Eva / Salem, Rany M / Sandholm, Niina / Schadt, Eric E / Scott, Robert A / Stolk, Lisette / Vallejo, Edgar E / Westra, Harm-Jan / Zondervan, Krina T / Amouyel, Philippe / Arveiler, Dominique / Bakker, Stephan Jl / Beilby, John / Bergman, Richard N / Blangero, John / Brown, Morris J / Burnier, Michel / Campbell, Harry / Chakravarti, Aravinda / Chines, Peter S / Claudi-Boehm, Simone / Collins, Francis S / Crawford, Dana C / Danesh, John / de Faire, Ulf / de Geus, Eco Jc / Dörr, Marcus / Erbel, Raimund / Eriksson, Johan G / Farrall, Martin / Ferrannini, Ele / Ferrières, Jean / Forouhi, Nita G / Forrester, Terrence / Franco, Oscar H / Gansevoort, Ron T / Gieger, Christian / Gudnason, Vilmundur / Haiman, Christopher A / Harris, Tamara B / Hattersley, Andrew T / Heliövaara, Markku / Hicks, Andrew A / Hingorani, Aroon D / Hoffmann, Wolfgang / Hofman, Albert / Homuth, Georg / Humphries, Steve E / Hyppönen, Elina / Illig, Thomas / Jarvelin, Marjo-Riitta / Johansen, Berit / Jousilahti, Pekka / Jula, Antti M / Kaprio, Jaakko / Kee, Frank / Keinanen-Kiukaanniemi, Sirkka M / Kooner, Jaspal S / Kooperberg, Charles / Kovacs, Peter / Kraja, Aldi T / Kumari, Meena / Kuulasmaa, Kari / Kuusisto, Johanna / Lakka, Timo A / Langenberg, Claudia / Le Marchand, Loic / Lehtimäki, Terho / Lyssenko, Valeriya / Männistö, Satu / Marette, André / Matise, Tara C / McKenzie, Colin A / McKnight, Barbara / Musk, Arthur W / Möhlenkamp, Stefan / Morris, Andrew D / Nelis, Mari / Ohlsson, Claes / Oldehinkel, Albertine J / Ong, Ken K / Palmer, Lyle J / Penninx, Brenda W / Peters, Annette / Pramstaller, Peter P / Raitakari, Olli T / Rankinen, Tuomo / Rao, D C / Rice, Treva K / Ridker, Paul M / Ritchie, Marylyn D / Rudan, Igor / Salomaa, Veikko / Samani, Nilesh J / Saramies, Jouko / Sarzynski, Mark A / Schwarz, Peter Eh / Shuldiner, Alan R / Staessen, Jan A / Steinthorsdottir, Valgerdur / Stolk, Ronald P / Strauch, Konstantin / Tönjes, Anke / Tremblay, Angelo / Tremoli, Elena / Vohl, Marie-Claude / Völker, Uwe / Vollenweider, Peter / Wilson, James F / Witteman, Jacqueline C / Adair, Linda S / Bochud, Murielle / Boehm, Bernhard O / Bornstein, Stefan R / Bouchard, Claude / Cauchi, Stéphane / Caulfield, Mark J / Chambers, John C / Chasman, Daniel I / Cooper, Richard S / Dedoussis, George / Ferrucci, Luigi / Froguel, Philippe / Grabe, Hans-Jörgen / Hamsten, Anders / Hui, Jennie / Hveem, Kristian / Jöckel, Karl-Heinz / Kivimaki, Mika / Kuh, Diana / Laakso, Markku / Liu, Yongmei / März, Winfried / Munroe, Patricia B / Njølstad, Inger / Oostra, Ben A / Palmer, Colin Na / Pedersen, Nancy L / Perola, Markus / Pérusse, Louis / Peters, Ulrike / Power, Chris / Quertermous, Thomas / Rauramaa, Rainer / Rivadeneira, Fernando / Saaristo, Timo E / Saleheen, Danish / Sinisalo, Juha / Slagboom, P Eline / Snieder, Harold / Spector, Tim D / Stefansson, Kari / Stumvoll, Michael / Tuomilehto, Jaakko / Uitterlinden, André G / Uusitupa, Matti / van der Harst, Pim / Veronesi, Giovanni / Walker, Mark / Wareham, Nicholas J / Watkins, Hugh / Wichmann, H-Erich / Abecasis, Goncalo R / Assimes, Themistocles L / Berndt, Sonja I / Boehnke, Michael / Borecki, Ingrid B / Deloukas, Panos / Franke, Lude / Frayling, Timothy M / Groop, Leif C / Hunter, David J / Kaplan, Robert C / O'Connell, Jeffrey R / Qi, Lu / Schlessinger, David / Strachan, David P / Thorsteinsdottir, Unnur / van Duijn, Cornelia M / Willer, Cristen J / Visscher, Peter M / Yang, Jian / Hirschhorn, Joel N / Zillikens, M Carola / McCarthy, Mark I / Speliotes, Elizabeth K / North, Kari E / Fox, Caroline S / Barroso, Inês / Franks, Paul W / Ingelsson, Erik / Heid, Iris M / Loos, Ruth Jf / Cupples, L Adrienne / Morris, Andrew P / Lindgren, Cecilia M / Mohlke, Karen L

    Nature

    2016  Volume 518, Issue 7538, Page(s) 187–196

    Abstract: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to ... ...

    Abstract Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
    MeSH term(s) Adipocytes/metabolism ; Adipogenesis/genetics ; Adipose Tissue/metabolism ; Age Factors ; Body Fat Distribution ; Body Mass Index ; Epigenesis, Genetic ; Europe/ethnology ; Female ; Genome, Human/genetics ; Genome-Wide Association Study ; Humans ; Insulin/metabolism ; Insulin Resistance/genetics ; Male ; Models, Biological ; Neovascularization, Physiologic/genetics ; Obesity/genetics ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Racial Groups/genetics ; Sex Characteristics ; Transcription, Genetic/genetics ; Waist-Hip Ratio
    Chemical Substances Insulin
    Language English
    Publishing date 2016-02-08
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature14132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

    Winkler, Thomas W / Justice, Anne E / Graff, Mariaelisa / Barata, Llilda / Feitosa, Mary F / Chu, Su / Czajkowski, Jacek / Esko, Tõnu / Fall, Tove / Kilpeläinen, Tuomas O / Lu, Yingchang / Mägi, Reedik / Mihailov, Evelin / Pers, Tune H / Rüeger, Sina / Teumer, Alexander / Ehret, Georg B / Ferreira, Teresa / Heard-Costa, Nancy L /
    Karjalainen, Juha / Lagou, Vasiliki / Mahajan, Anubha / Neinast, Michael D / Prokopenko, Inga / Simino, Jeannette / Teslovich, Tanya M / Jansen, Rick / Westra, Harm-Jan / White, Charles C / Absher, Devin / Ahluwalia, Tarunveer S / Ahmad, Shafqat / Albrecht, Eva / Alves, Alexessander Couto / Bragg-Gresham, Jennifer L / de Craen, Anton J M / Bis, Joshua C / Bonnefond, Amélie / Boucher, Gabrielle / Cadby, Gemma / Cheng, Yu-Ching / Chiang, Charleston W K / Delgado, Graciela / Demirkan, Ayse / Dueker, Nicole / Eklund, Niina / Eiriksdottir, Gudny / Eriksson, Joel / Feenstra, Bjarke / Fischer, Krista / Frau, Francesca / Galesloot, Tessel E / Geller, Frank / Goel, Anuj / Gorski, Mathias / Grammer, Tanja B / Gustafsson, Stefan / Haitjema, Saskia / Hottenga, Jouke-Jan / Huffman, Jennifer E / Jackson, Anne U / Jacobs, Kevin B / Johansson, Åsa / Kaakinen, Marika / Kleber, Marcus E / Lahti, Jari / Mateo Leach, Irene / Lehne, Benjamin / Liu, Youfang / Lo, Ken Sin / Lorentzon, Mattias / Luan, Jian'an / Madden, Pamela A F / Mangino, Massimo / McKnight, Barbara / Medina-Gomez, Carolina / Monda, Keri L / Montasser, May E / Müller, Gabriele / Müller-Nurasyid, Martina / Nolte, Ilja M / Panoutsopoulou, Kalliope / Pascoe, Laura / Paternoster, Lavinia / Rayner, Nigel W / Renström, Frida / Rizzi, Federica / Rose, Lynda M / Ryan, Kathy A / Salo, Perttu / Sanna, Serena / Scharnagl, Hubert / Shi, Jianxin / Smith, Albert Vernon / Southam, Lorraine / Stančáková, Alena / Steinthorsdottir, Valgerdur / Strawbridge, Rona J / Sung, Yun Ju / Tachmazidou, Ioanna / Tanaka, Toshiko / Thorleifsson, Gudmar / Trompet, Stella / Pervjakova, Natalia / Tyrer, Jonathan P / Vandenput, Liesbeth / van der Laan, Sander W / van der Velde, Nathalie / van Setten, Jessica / van Vliet-Ostaptchouk, Jana V / Verweij, Niek / Vlachopoulou, Efthymia / Waite, Lindsay L / Wang, Sophie R / Wang, Zhaoming / Wild, Sarah H / Willenborg, Christina / Wilson, James F / Wong, Andrew / Yang, Jian / Yengo, Loïc / Yerges-Armstrong, Laura M / Yu, Lei / Zhang, Weihua / Zhao, Jing Hua / Andersson, Ehm A / Bakker, Stephan J L / Baldassarre, Damiano / Banasik, Karina / Barcella, Matteo / Barlassina, Cristina / Bellis, Claire / Benaglio, Paola / Blangero, John / Blüher, Matthias / Bonnet, Fabrice / Bonnycastle, Lori L / Boyd, Heather A / Bruinenberg, Marcel / Buchman, Aron S / Campbell, Harry / Chen, Yii-Der Ida / Chines, Peter S / Claudi-Boehm, Simone / Cole, John / Collins, Francis S / de Geus, Eco J C / de Groot, Lisette C P G M / Dimitriou, Maria / Duan, Jubao / Enroth, Stefan / Eury, Elodie / Farmaki, Aliki-Eleni / Forouhi, Nita G / Friedrich, Nele / Gejman, Pablo V / Gigante, Bruna / Glorioso, Nicola / Go, Alan S / Gottesman, Omri / Gräßler, Jürgen / Grallert, Harald / Grarup, Niels / Gu, Yu-Mei / Broer, Linda / Ham, Annelies C / Hansen, Torben / Harris, Tamara B / Hartman, Catharina A / Hassinen, Maija / Hastie, Nicholas / Hattersley, Andrew T / Heath, Andrew C / Henders, Anjali K / Hernandez, Dena / Hillege, Hans / Holmen, Oddgeir / Hovingh, Kees G / Hui, Jennie / Husemoen, Lise L / Hutri-Kähönen, Nina / Hysi, Pirro G / Illig, Thomas / De Jager, Philip L / Jalilzadeh, Shapour / Jørgensen, Torben / Jukema, J Wouter / Juonala, Markus / Kanoni, Stavroula / Karaleftheri, Maria / Khaw, Kay Tee / Kinnunen, Leena / Kittner, Steven J / Koenig, Wolfgang / Kolcic, Ivana / Kovacs, Peter / Krarup, Nikolaj T / Kratzer, Wolfgang / Krüger, Janine / Kuh, Diana / Kumari, Meena / Kyriakou, Theodosios / Langenberg, Claudia / Lannfelt, Lars / Lanzani, Chiara / Lotay, Vaneet / Launer, Lenore J / Leander, Karin / Lindström, Jaana / Linneberg, Allan / Liu, Yan-Ping / Lobbens, Stéphane / Luben, Robert / Lyssenko, Valeriya / Männistö, Satu / Magnusson, Patrik K / McArdle, Wendy L / Menni, Cristina / Merger, Sigrun / Milani, Lili / Montgomery, Grant W / Morris, Andrew P / Narisu, Narisu / Nelis, Mari / Ong, Ken K / Palotie, Aarno / Pérusse, Louis / Pichler, Irene / Pilia, Maria G / Pouta, Anneli / Rheinberger, Myriam / Ribel-Madsen, Rasmus / Richards, Marcus / Rice, Kenneth M / Rice, Treva K / Rivolta, Carlo / Salomaa, Veikko / Sanders, Alan R / Sarzynski, Mark A / Scholtens, Salome / Scott, Robert A / Scott, William R / Sebert, Sylvain / Sengupta, Sebanti / Sennblad, Bengt / Seufferlein, Thomas / Silveira, Angela / Slagboom, P Eline / Smit, Jan H / Sparsø, Thomas H / Stirrups, Kathleen / Stolk, Ronald P / Stringham, Heather M / Swertz, Morris A / Swift, Amy J / Syvänen, Ann-Christine / Tan, Sian-Tsung / Thorand, Barbara / Tönjes, Anke / Tremblay, Angelo / Tsafantakis, Emmanouil / van der Most, Peter J / Völker, Uwe / Vohl, Marie-Claude / Vonk, Judith M / Waldenberger, Melanie / Walker, Ryan W / Wennauer, Roman / Widén, Elisabeth / Willemsen, Gonneke / Wilsgaard, Tom / Wright, Alan F / Zillikens, M Carola / van Dijk, Suzanne C / van Schoor, Natasja M / Asselbergs, Folkert W / de Bakker, Paul I W / Beckmann, Jacques S / Beilby, John / Bennett, David A / Bergman, Richard N / Bergmann, Sven / Böger, Carsten A / Boehm, Bernhard O / Boerwinkle, Eric / Boomsma, Dorret I / Bornstein, Stefan R / Bottinger, Erwin P / Bouchard, Claude / Chambers, John C / Chanock, Stephen J / Chasman, Daniel I / Cucca, Francesco / Cusi, Daniele / Dedoussis, George / Erdmann, Jeanette / Eriksson, Johan G / Evans, Denis A / de Faire, Ulf / Farrall, Martin / Ferrucci, Luigi / Ford, Ian / Franke, Lude / Franks, Paul W / Froguel, Philippe / Gansevoort, Ron T / Gieger, Christian / Grönberg, Henrik / Gudnason, Vilmundur / Gyllensten, Ulf / Hall, Per / Hamsten, Anders / van der Harst, Pim / Hayward, Caroline / Heliövaara, Markku / Hengstenberg, Christian / Hicks, Andrew A / Hingorani, Aroon / Hofman, Albert / Hu, Frank / Huikuri, Heikki V / Hveem, Kristian / James, Alan L / Jordan, Joanne M / Jula, Antti / Kähönen, Mika / Kajantie, Eero / Kathiresan, Sekar / Kiemeney, Lambertus A L M / Kivimaki, Mika / Knekt, Paul B / Koistinen, Heikki A / Kooner, Jaspal S / Koskinen, Seppo / Kuusisto, Johanna / Maerz, Winfried / Martin, Nicholas G / Laakso, Markku / Lakka, Timo A / Lehtimäki, Terho / Lettre, Guillaume / Levinson, Douglas F / Lind, Lars / Lokki, Marja-Liisa / Mäntyselkä, Pekka / Melbye, Mads / Metspalu, Andres / Mitchell, Braxton D / Moll, Frans L / Murray, Jeffrey C / Musk, Arthur W / Nieminen, Markku S / Njølstad, Inger / Ohlsson, Claes / Oldehinkel, Albertine J / Oostra, Ben A / Palmer, Lyle J / Pankow, James S / Pasterkamp, Gerard / Pedersen, Nancy L / Pedersen, Oluf / Penninx, Brenda W / Perola, Markus / Peters, Annette / Polašek, Ozren / Pramstaller, Peter P / Psaty, Bruce M / Qi, Lu / Quertermous, Thomas / Raitakari, Olli T / Rankinen, Tuomo / Rauramaa, Rainer / Ridker, Paul M / Rioux, John D / Rivadeneira, Fernando / Rotter, Jerome I / Rudan, Igor / den Ruijter, Hester M / Saltevo, Juha / Sattar, Naveed / Schunkert, Heribert / Schwarz, Peter E H / Shuldiner, Alan R / Sinisalo, Juha / Snieder, Harold / Sørensen, Thorkild I A / Spector, Tim D / Staessen, Jan A / Stefania, Bandinelli / Thorsteinsdottir, Unnur / Stumvoll, Michael / Tardif, Jean-Claude / Tremoli, Elena / Tuomilehto, Jaakko / Uitterlinden, André G / Uusitupa, Matti / Verbeek, André L M / Vermeulen, Sita H / Viikari, Jorma S / Vitart, Veronique / Völzke, Henry / Vollenweider, Peter / Waeber, Gérard / Walker, Mark / Wallaschofski, Henri / Wareham, Nicholas J / Watkins, Hugh / Zeggini, Eleftheria / Chakravarti, Aravinda / Clegg, Deborah J / Cupples, L Adrienne / Gordon-Larsen, Penny / Jaquish, Cashell E / Rao, D C / Abecasis, Goncalo R / Assimes, Themistocles L / Barroso, Inês / Berndt, Sonja I / Boehnke, Michael / Deloukas, Panos / Fox, Caroline S / Groop, Leif C / Hunter, David J / Ingelsson, Erik / Kaplan, Robert C / McCarthy, Mark I / Mohlke, Karen L / O'Connell, Jeffrey R / Schlessinger, David / Strachan, David P / Stefansson, Kari / van Duijn, Cornelia M / Hirschhorn, Joel N / Lindgren, Cecilia M / Heid, Iris M / North, Kari E / Borecki, Ingrid B / Kutalik, Zoltán / Loos, Ruth J F

    PLoS genetics

    2016  Volume 12, Issue 6, Page(s) e1006166

    Abstract: This corrects the article DOI: 10.1371/journal.pgen.1005378.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pgen.1005378.].
    Language English
    Publishing date 2016-06-29
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1006166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Genetic studies of body mass index yield new insights for obesity biology.

    Locke, Adam E / Kahali, Bratati / Berndt, Sonja I / Justice, Anne E / Pers, Tune H / Day, Felix R / Powell, Corey / Vedantam, Sailaja / Buchkovich, Martin L / Yang, Jian / Croteau-Chonka, Damien C / Esko, Tonu / Fall, Tove / Ferreira, Teresa / Gustafsson, Stefan / Kutalik, Zoltán / Luan, Jian'an / Mägi, Reedik / Randall, Joshua C /
    Winkler, Thomas W / Wood, Andrew R / Workalemahu, Tsegaselassie / Faul, Jessica D / Smith, Jennifer A / Zhao, Jing Hua / Zhao, Wei / Chen, Jin / Fehrmann, Rudolf / Hedman, Åsa K / Karjalainen, Juha / Schmidt, Ellen M / Absher, Devin / Amin, Najaf / Anderson, Denise / Beekman, Marian / Bolton, Jennifer L / Bragg-Gresham, Jennifer L / Buyske, Steven / Demirkan, Ayse / Deng, Guohong / Ehret, Georg B / Feenstra, Bjarke / Feitosa, Mary F / Fischer, Krista / Goel, Anuj / Gong, Jian / Jackson, Anne U / Kanoni, Stavroula / Kleber, Marcus E / Kristiansson, Kati / Lim, Unhee / Lotay, Vaneet / Mangino, Massimo / Leach, Irene Mateo / Medina-Gomez, Carolina / Medland, Sarah E / Nalls, Michael A / Palmer, Cameron D / Pasko, Dorota / Pechlivanis, Sonali / Peters, Marjolein J / Prokopenko, Inga / Shungin, Dmitry / Stančáková, Alena / Strawbridge, Rona J / Sung, Yun Ju / Tanaka, Toshiko / Teumer, Alexander / Trompet, Stella / van der Laan, Sander W / van Setten, Jessica / Van Vliet-Ostaptchouk, Jana V / Wang, Zhaoming / Yengo, Loïc / Zhang, Weihua / Isaacs, Aaron / Albrecht, Eva / Ärnlöv, Johan / Arscott, Gillian M / Attwood, Antony P / Bandinelli, Stefania / Barrett, Amy / Bas, Isabelita N / Bellis, Claire / Bennett, Amanda J / Berne, Christian / Blagieva, Roza / Blüher, Matthias / Böhringer, Stefan / Bonnycastle, Lori L / Böttcher, Yvonne / Boyd, Heather A / Bruinenberg, Marcel / Caspersen, Ida H / Chen, Yii-Der Ida / Clarke, Robert / Daw, E Warwick / de Craen, Anton J M / Delgado, Graciela / Dimitriou, Maria / Doney, Alex S F / Eklund, Niina / Estrada, Karol / Eury, Elodie / Folkersen, Lasse / Fraser, Ross M / Garcia, Melissa E / Geller, Frank / Giedraitis, Vilmantas / Gigante, Bruna / Go, Alan S / Golay, Alain / Goodall, Alison H / Gordon, Scott D / Gorski, Mathias / Grabe, Hans-Jörgen / Grallert, Harald / Grammer, Tanja B / Gräßler, Jürgen / Grönberg, Henrik / Groves, Christopher J / Gusto, Gaëlle / Haessler, Jeffrey / Hall, Per / Haller, Toomas / Hallmans, Goran / Hartman, Catharina A / Hassinen, Maija / Hayward, Caroline / Heard-Costa, Nancy L / Helmer, Quinta / Hengstenberg, Christian / Holmen, Oddgeir / Hottenga, Jouke-Jan / James, Alan L / Jeff, Janina M / Johansson, Åsa / Jolley, Jennifer / Juliusdottir, Thorhildur / Kinnunen, Leena / Koenig, Wolfgang / Koskenvuo, Markku / Kratzer, Wolfgang / Laitinen, Jaana / Lamina, Claudia / Leander, Karin / Lee, Nanette R / Lichtner, Peter / Lind, Lars / Lindström, Jaana / Lo, Ken Sin / Lobbens, Stéphane / Lorbeer, Roberto / Lu, Yingchang / Mach, François / Magnusson, Patrik K E / Mahajan, Anubha / McArdle, Wendy L / McLachlan, Stela / Menni, Cristina / Merger, Sigrun / Mihailov, Evelin / Milani, Lili / Moayyeri, Alireza / Monda, Keri L / Morken, Mario A / Mulas, Antonella / Müller, Gabriele / Müller-Nurasyid, Martina / Musk, Arthur W / Nagaraja, Ramaiah / Nöthen, Markus M / Nolte, Ilja M / Pilz, Stefan / Rayner, Nigel W / Renstrom, Frida / Rettig, Rainer / Ried, Janina S / Ripke, Stephan / Robertson, Neil R / Rose, Lynda M / Sanna, Serena / Scharnagl, Hubert / Scholtens, Salome / Schumacher, Fredrick R / Scott, William R / Seufferlein, Thomas / Shi, Jianxin / Smith, Albert Vernon / Smolonska, Joanna / Stanton, Alice V / Steinthorsdottir, Valgerdur / Stirrups, Kathleen / Stringham, Heather M / Sundström, Johan / Swertz, Morris A / Swift, Amy J / Syvänen, Ann-Christine / Tan, Sian-Tsung / Tayo, Bamidele O / Thorand, Barbara / Thorleifsson, Gudmar / Tyrer, Jonathan P / Uh, Hae-Won / Vandenput, Liesbeth / Verhulst, Frank C / Vermeulen, Sita H / Verweij, Niek / Vonk, Judith M / Waite, Lindsay L / Warren, Helen R / Waterworth, Dawn / Weedon, Michael N / Wilkens, Lynne R / Willenborg, Christina / Wilsgaard, Tom / Wojczynski, Mary K / Wong, Andrew / Wright, Alan F / Zhang, Qunyuan / Brennan, Eoin P / Choi, Murim / Dastani, Zari / Drong, Alexander W / Eriksson, Per / Franco-Cereceda, Anders / Gådin, Jesper R / Gharavi, Ali G / Goddard, Michael E / Handsaker, Robert E / Huang, Jinyan / Karpe, Fredrik / Kathiresan, Sekar / Keildson, Sarah / Kiryluk, Krzysztof / Kubo, Michiaki / Lee, Jong-Young / Liang, Liming / Lifton, Richard P / Ma, Baoshan / McCarroll, Steven A / McKnight, Amy J / Min, Josine L / Moffatt, Miriam F / Montgomery, Grant W / Murabito, Joanne M / Nicholson, George / Nyholt, Dale R / Okada, Yukinori / Perry, John R B / Dorajoo, Rajkumar / Reinmaa, Eva / Salem, Rany M / Sandholm, Niina / Scott, Robert A / Stolk, Lisette / Takahashi, Atsushi / Tanaka, Toshihiro / van 't Hooft, Ferdinand M / Vinkhuyzen, Anna A E / Westra, Harm-Jan / Zheng, Wei / Zondervan, Krina T / Heath, Andrew C / Arveiler, Dominique / Bakker, Stephan J L / Beilby, John / Bergman, Richard N / Blangero, John / Bovet, Pascal / Campbell, Harry / Caulfield, Mark J / Cesana, Giancarlo / Chakravarti, Aravinda / Chasman, Daniel I / Chines, Peter S / Collins, Francis S / Crawford, Dana C / Cupples, L Adrienne / Cusi, Daniele / Danesh, John / de Faire, Ulf / den Ruijter, Hester M / Dominiczak, Anna F / Erbel, Raimund / Erdmann, Jeanette / Eriksson, Johan G / Farrall, Martin / Felix, Stephan B / Ferrannini, Ele / Ferrières, Jean / Ford, Ian / Forouhi, Nita G / Forrester, Terrence / Franco, Oscar H / Gansevoort, Ron T / Gejman, Pablo V / Gieger, Christian / Gottesman, Omri / Gudnason, Vilmundur / Gyllensten, Ulf / Hall, Alistair S / Harris, Tamara B / Hattersley, Andrew T / Hicks, Andrew A / Hindorff, Lucia A / Hingorani, Aroon D / Hofman, Albert / Homuth, Georg / Hovingh, G Kees / Humphries, Steve E / Hunt, Steven C / Hyppönen, Elina / Illig, Thomas / Jacobs, Kevin B / Jarvelin, Marjo-Riitta / Jöckel, Karl-Heinz / Johansen, Berit / Jousilahti, Pekka / Jukema, J Wouter / Jula, Antti M / Kaprio, Jaakko / Kastelein, John J P / Keinanen-Kiukaanniemi, Sirkka M / Kiemeney, Lambertus A / Knekt, Paul / Kooner, Jaspal S / Kooperberg, Charles / Kovacs, Peter / Kraja, Aldi T / Kumari, Meena / Kuusisto, Johanna / Lakka, Timo A / Langenberg, Claudia / Marchand, Loic Le / Lehtimäki, Terho / Lyssenko, Valeriya / Männistö, Satu / Marette, André / Matise, Tara C / McKenzie, Colin A / McKnight, Barbara / Moll, Frans L / Morris, Andrew D / Morris, Andrew P / Murray, Jeffrey C / Nelis, Mari / Ohlsson, Claes / Oldehinkel, Albertine J / Ong, Ken K / Madden, Pamela A F / Pasterkamp, Gerard / Peden, John F / Peters, Annette / Postma, Dirkje S / Pramstaller, Peter P / Price, Jackie F / Qi, Lu / Raitakari, Olli T / Rankinen, Tuomo / Rao, D C / Rice, Treva K / Ridker, Paul M / Rioux, John D / Ritchie, Marylyn D / Rudan, Igor / Salomaa, Veikko / Samani, Nilesh J / Saramies, Jouko / Sarzynski, Mark A / Schunkert, Heribert / Schwarz, Peter E H / Sever, Peter / Shuldiner, Alan R / Sinisalo, Juha / Stolk, Ronald P / Strauch, Konstantin / Tönjes, Anke / Trégouët, David-Alexandre / Tremblay, Angelo / Tremoli, Elena / Virtamo, Jarmo / Vohl, Marie-Claude / Völker, Uwe / Waeber, Gérard / Willemsen, Gonneke / Witteman, Jacqueline C / Zillikens, M Carola / Adair, Linda S / Amouyel, Philippe / Asselbergs, Folkert W / Assimes, Themistocles L / Bochud, Murielle / Boehm, Bernhard O / Boerwinkle, Eric / Bornstein, Stefan R / Bottinger, Erwin P / Bouchard, Claude / Cauchi, Stéphane / Chambers, John C / Chanock, Stephen J / Cooper, Richard S / de Bakker, Paul I W / Dedoussis, George / Ferrucci, Luigi / Franks, Paul W / Froguel, Philippe / Groop, Leif C / Haiman, Christopher A / Hamsten, Anders / Hui, Jennie / Hunter, David J / Hveem, Kristian / Kaplan, Robert C / Kivimaki, Mika / Kuh, Diana / Laakso, Markku / Liu, Yongmei / Martin, Nicholas G / März, Winfried / Melbye, Mads / Metspalu, Andres / Moebus, Susanne / Munroe, Patricia B / Njølstad, Inger / Oostra, Ben A / Palmer, Colin N A / Pedersen, Nancy L / Perola, Markus / Pérusse, Louis / Peters, Ulrike / Power, Chris / Quertermous, Thomas / Rauramaa, Rainer / Rivadeneira, Fernando / Saaristo, Timo E / Saleheen, Danish / Sattar, Naveed / Schadt, Eric E / Schlessinger, David / Slagboom, P Eline / Snieder, Harold / Spector, Tim D / Thorsteinsdottir, Unnur / Stumvoll, Michael / Tuomilehto, Jaakko / Uitterlinden, André G / Uusitupa, Matti / van der Harst, Pim / Walker, Mark / Wallaschofski, Henri / Wareham, Nicholas J / Watkins, Hugh / Weir, David R / Wichmann, H-Erich / Wilson, James F / Zanen, Pieter / Borecki, Ingrid B / Deloukas, Panos / Fox, Caroline S / Heid, Iris M / O'Connell, Jeffrey R / Strachan, David P / Stefansson, Kari / van Duijn, Cornelia M / Abecasis, Gonçalo R / Franke, Lude / Frayling, Timothy M / McCarthy, Mark I / Visscher, Peter M / Scherag, André / Willer, Cristen J / Boehnke, Michael / Mohlke, Karen L / Lindgren, Cecilia M / Beckmann, Jacques S / Barroso, Inês / North, Kari E / Ingelsson, Erik / Hirschhorn, Joel N / Loos, Ruth J F / Speliotes, Elizabeth K

    Nature

    2016  Volume 518, Issue 7538, Page(s) 197–206

    Abstract: Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and ...

    Abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
    MeSH term(s) Adipogenesis/genetics ; Adiposity/genetics ; Age Factors ; Body Mass Index ; Energy Metabolism/genetics ; Europe/ethnology ; Female ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Glutamic Acid/metabolism ; Humans ; Insulin/metabolism ; Insulin Secretion ; Male ; Obesity/genetics ; Obesity/metabolism ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Racial Groups/genetics ; Synapses/metabolism
    Chemical Substances Insulin ; Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2016-02-08
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature14177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.

    Winkler, Thomas W / Justice, Anne E / Graff, Mariaelisa / Barata, Llilda / Feitosa, Mary F / Chu, Su / Czajkowski, Jacek / Esko, Tõnu / Fall, Tove / Kilpeläinen, Tuomas O / Lu, Yingchang / Mägi, Reedik / Mihailov, Evelin / Pers, Tune H / Rüeger, Sina / Teumer, Alexander / Ehret, Georg B / Ferreira, Teresa / Heard-Costa, Nancy L /
    Karjalainen, Juha / Lagou, Vasiliki / Mahajan, Anubha / Neinast, Michael D / Prokopenko, Inga / Simino, Jeannette / Teslovich, Tanya M / Jansen, Rick / Westra, Harm-Jan / White, Charles C / Absher, Devin / Ahluwalia, Tarunveer S / Ahmad, Shafqat / Albrecht, Eva / Alves, Alexessander Couto / Bragg-Gresham, Jennifer L / de Craen, Anton J M / Bis, Joshua C / Bonnefond, Amélie / Boucher, Gabrielle / Cadby, Gemma / Cheng, Yu-Ching / Chiang, Charleston W K / Delgado, Graciela / Demirkan, Ayse / Dueker, Nicole / Eklund, Niina / Eiriksdottir, Gudny / Eriksson, Joel / Feenstra, Bjarke / Fischer, Krista / Frau, Francesca / Galesloot, Tessel E / Geller, Frank / Goel, Anuj / Gorski, Mathias / Grammer, Tanja B / Gustafsson, Stefan / Haitjema, Saskia / Hottenga, Jouke-Jan / Huffman, Jennifer E / Jackson, Anne U / Jacobs, Kevin B / Johansson, Åsa / Kaakinen, Marika / Kleber, Marcus E / Lahti, Jari / Mateo Leach, Irene / Lehne, Benjamin / Liu, Youfang / Lo, Ken Sin / Lorentzon, Mattias / Luan, Jian'an / Madden, Pamela A F / Mangino, Massimo / McKnight, Barbara / Medina-Gomez, Carolina / Monda, Keri L / Montasser, May E / Müller, Gabriele / Müller-Nurasyid, Martina / Nolte, Ilja M / Panoutsopoulou, Kalliope / Pascoe, Laura / Paternoster, Lavinia / Rayner, Nigel W / Renström, Frida / Rizzi, Federica / Rose, Lynda M / Ryan, Kathy A / Salo, Perttu / Sanna, Serena / Scharnagl, Hubert / Shi, Jianxin / Smith, Albert Vernon / Southam, Lorraine / Stančáková, Alena / Steinthorsdottir, Valgerdur / Strawbridge, Rona J / Sung, Yun Ju / Tachmazidou, Ioanna / Tanaka, Toshiko / Thorleifsson, Gudmar / Trompet, Stella / Pervjakova, Natalia / Tyrer, Jonathan P / Vandenput, Liesbeth / van der Laan, Sander W / van der Velde, Nathalie / van Setten, Jessica / van Vliet-Ostaptchouk, Jana V / Verweij, Niek / Vlachopoulou, Efthymia / Waite, Lindsay L / Wang, Sophie R / Wang, Zhaoming / Wild, Sarah H / Willenborg, Christina / Wilson, James F / Wong, Andrew / Yang, Jian / Yengo, Loïc / Yerges-Armstrong, Laura M / Yu, Lei / Zhang, Weihua / Zhao, Jing Hua / Andersson, Ehm A / Bakker, Stephan J L / Baldassarre, Damiano / Banasik, Karina / Barcella, Matteo / Barlassina, Cristina / Bellis, Claire / Benaglio, Paola / Blangero, John / Blüher, Matthias / Bonnet, Fabrice / Bonnycastle, Lori L / Boyd, Heather A / Bruinenberg, Marcel / Buchman, Aron S / Campbell, Harry / Chen, Yii-Der Ida / Chines, Peter S / Claudi-Boehm, Simone / Cole, John / Collins, Francis S / de Geus, Eco J C / de Groot, Lisette C P G M / Dimitriou, Maria / Duan, Jubao / Enroth, Stefan / Eury, Elodie / Farmaki, Aliki-Eleni / Forouhi, Nita G / Friedrich, Nele / Gejman, Pablo V / Gigante, Bruna / Glorioso, Nicola / Go, Alan S / Gottesman, Omri / Gräßler, Jürgen / Grallert, Harald / Grarup, Niels / Gu, Yu-Mei / Broer, Linda / Ham, Annelies C / Hansen, Torben / Harris, Tamara B / Hartman, Catharina A / Hassinen, Maija / Hastie, Nicholas / Hattersley, Andrew T / Heath, Andrew C / Henders, Anjali K / Hernandez, Dena / Hillege, Hans / Holmen, Oddgeir / Hovingh, Kees G / Hui, Jennie / Husemoen, Lise L / Hutri-Kähönen, Nina / Hysi, Pirro G / Illig, Thomas / De Jager, Philip L / Jalilzadeh, Shapour / Jørgensen, Torben / Jukema, J Wouter / Juonala, Markus / Kanoni, Stavroula / Karaleftheri, Maria / Khaw, Kay Tee / Kinnunen, Leena / Kittner, Steven J / Koenig, Wolfgang / Kolcic, Ivana / Kovacs, Peter / Krarup, Nikolaj T / Kratzer, Wolfgang / Krüger, Janine / Kuh, Diana / Kumari, Meena / Kyriakou, Theodosios / Langenberg, Claudia / Lannfelt, Lars / Lanzani, Chiara / Lotay, Vaneet / Launer, Lenore J / Leander, Karin / Lindström, Jaana / Linneberg, Allan / Liu, Yan-Ping / Lobbens, Stéphane / Luben, Robert / Lyssenko, Valeriya / Männistö, Satu / Magnusson, Patrik K / McArdle, Wendy L / Menni, Cristina / Merger, Sigrun / Milani, Lili / Montgomery, Grant W / Morris, Andrew P / Narisu, Narisu / Nelis, Mari / Ong, Ken K / Palotie, Aarno / Pérusse, Louis / Pichler, Irene / Pilia, Maria G / Pouta, Anneli / Rheinberger, Myriam / Ribel-Madsen, Rasmus / Richards, Marcus / Rice, Kenneth M / Rice, Treva K / Rivolta, Carlo / Salomaa, Veikko / Sanders, Alan R / Sarzynski, Mark A / Scholtens, Salome / Scott, Robert A / Scott, William R / Sebert, Sylvain / Sengupta, Sebanti / Sennblad, Bengt / Seufferlein, Thomas / Silveira, Angela / Slagboom, P Eline / Smit, Jan H / Sparsø, Thomas H / Stirrups, Kathleen / Stolk, Ronald P / Stringham, Heather M / Swertz, Morris A / Swift, Amy J / Syvänen, Ann-Christine / Tan, Sian-Tsung / Thorand, Barbara / Tönjes, Anke / Tremblay, Angelo / Tsafantakis, Emmanouil / van der Most, Peter J / Völker, Uwe / Vohl, Marie-Claude / Vonk, Judith M / Waldenberger, Melanie / Walker, Ryan W / Wennauer, Roman / Widén, Elisabeth / Willemsen, Gonneke / Wilsgaard, Tom / Wright, Alan F / Zillikens, M Carola / van Dijk, Suzanne C / van Schoor, Natasja M / Asselbergs, Folkert W / de Bakker, Paul I W / Beckmann, Jacques S / Beilby, John / Bennett, David A / Bergman, Richard N / Bergmann, Sven / Böger, Carsten A / Boehm, Bernhard O / Boerwinkle, Eric / Boomsma, Dorret I / Bornstein, Stefan R / Bottinger, Erwin P / Bouchard, Claude / Chambers, John C / Chanock, Stephen J / Chasman, Daniel I / Cucca, Francesco / Cusi, Daniele / Dedoussis, George / Erdmann, Jeanette / Eriksson, Johan G / Evans, Denis A / de Faire, Ulf / Farrall, Martin / Ferrucci, Luigi / Ford, Ian / Franke, Lude / Franks, Paul W / Froguel, Philippe / Gansevoort, Ron T / Gieger, Christian / Grönberg, Henrik / Gudnason, Vilmundur / Gyllensten, Ulf / Hall, Per / Hamsten, Anders / van der Harst, Pim / Hayward, Caroline / Heliövaara, Markku / Hengstenberg, Christian / Hicks, Andrew A / Hingorani, Aroon / Hofman, Albert / Hu, Frank / Huikuri, Heikki V / Hveem, Kristian / James, Alan L / Jordan, Joanne M / Jula, Antti / Kähönen, Mika / Kajantie, Eero / Kathiresan, Sekar / Kiemeney, Lambertus A L M / Kivimaki, Mika / Knekt, Paul B / Koistinen, Heikki A / Kooner, Jaspal S / Koskinen, Seppo / Kuusisto, Johanna / Maerz, Winfried / Martin, Nicholas G / Laakso, Markku / Lakka, Timo A / Lehtimäki, Terho / Lettre, Guillaume / Levinson, Douglas F / Lind, Lars / Lokki, Marja-Liisa / Mäntyselkä, Pekka / Melbye, Mads / Metspalu, Andres / Mitchell, Braxton D / Moll, Frans L / Murray, Jeffrey C / Musk, Arthur W / Nieminen, Markku S / Njølstad, Inger / Ohlsson, Claes / Oldehinkel, Albertine J / Oostra, Ben A / Palmer, Lyle J / Pankow, James S / Pasterkamp, Gerard / Pedersen, Nancy L / Pedersen, Oluf / Penninx, Brenda W / Perola, Markus / Peters, Annette / Polašek, Ozren / Pramstaller, Peter P / Psaty, Bruce M / Qi, Lu / Quertermous, Thomas / Raitakari, Olli T / Rankinen, Tuomo / Rauramaa, Rainer / Ridker, Paul M / Rioux, John D / Rivadeneira, Fernando / Rotter, Jerome I / Rudan, Igor / den Ruijter, Hester M / Saltevo, Juha / Sattar, Naveed / Schunkert, Heribert / Schwarz, Peter E H / Shuldiner, Alan R / Sinisalo, Juha / Snieder, Harold / Sørensen, Thorkild I A / Spector, Tim D / Staessen, Jan A / Stefania, Bandinelli / Thorsteinsdottir, Unnur / Stumvoll, Michael / Tardif, Jean-Claude / Tremoli, Elena / Tuomilehto, Jaakko / Uitterlinden, André G / Uusitupa, Matti / Verbeek, André L M / Vermeulen, Sita H / Viikari, Jorma S / Vitart, Veronique / Völzke, Henry / Vollenweider, Peter / Waeber, Gérard / Walker, Mark / Wallaschofski, Henri / Wareham, Nicholas J / Watkins, Hugh / Zeggini, Eleftheria / Chakravarti, Aravinda / Clegg, Deborah J / Cupples, L Adrienne / Gordon-Larsen, Penny / Jaquish, Cashell E / Rao, D C / Abecasis, Goncalo R / Assimes, Themistocles L / Barroso, Inês / Berndt, Sonja I / Boehnke, Michael / Deloukas, Panos / Fox, Caroline S / Groop, Leif C / Hunter, David J / Ingelsson, Erik / Kaplan, Robert C / McCarthy, Mark I / Mohlke, Karen L / O'Connell, Jeffrey R / Schlessinger, David / Strachan, David P / Stefansson, Kari / van Duijn, Cornelia M / Hirschhorn, Joel N / Lindgren, Cecilia M / Heid, Iris M / North, Kari E / Borecki, Ingrid B / Kutalik, Zoltán / Loos, Ruth J F

    PLoS genetics

    2015  Volume 11, Issue 10, Page(s) e1005378

    Abstract: Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow ... ...

    Abstract Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<5%) age-specific effects, of which 11 had larger effects in younger (<50y) than in older adults (≥50y). No sex-dependent effects were identified for BMI. For WHRadjBMI, we identified 44 loci (27 previously established for main effects, 17 novel) with sex-specific effects, of which 28 showed larger effects in women than in men, five showed larger effects in men than in women, and 11 showed opposite effects between sexes. No age-dependent effects were identified for WHRadjBMI. This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI. In addition, we confirm the sex-specificity of genetic effects on WHRadjBMI. These results may provide further insights into the biology that underlies weight change with age or the sexually dimorphism of body shape.
    MeSH term(s) Adult ; Age Factors ; Aged ; Body Mass Index ; Body Size/genetics ; Chromosome Mapping ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Sex Characteristics ; Waist-Hip Ratio ; Whites
    Language English
    Publishing date 2015-10-01
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1005378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Defining the role of common variation in the genomic and biological architecture of adult human height.

    Wood, Andrew R / Esko, Tonu / Yang, Jian / Vedantam, Sailaja / Pers, Tune H / Gustafsson, Stefan / Chu, Audrey Y / Estrada, Karol / Luan, Jian'an / Kutalik, Zoltán / Amin, Najaf / Buchkovich, Martin L / Croteau-Chonka, Damien C / Day, Felix R / Duan, Yanan / Fall, Tove / Fehrmann, Rudolf / Ferreira, Teresa / Jackson, Anne U /
    Karjalainen, Juha / Lo, Ken Sin / Locke, Adam E / Mägi, Reedik / Mihailov, Evelin / Porcu, Eleonora / Randall, Joshua C / Scherag, André / Vinkhuyzen, Anna A E / Westra, Harm-Jan / Winkler, Thomas W / Workalemahu, Tsegaselassie / Zhao, Jing Hua / Absher, Devin / Albrecht, Eva / Anderson, Denise / Baron, Jeffrey / Beekman, Marian / Demirkan, Ayse / Ehret, Georg B / Feenstra, Bjarke / Feitosa, Mary F / Fischer, Krista / Fraser, Ross M / Goel, Anuj / Gong, Jian / Justice, Anne E / Kanoni, Stavroula / Kleber, Marcus E / Kristiansson, Kati / Lim, Unhee / Lotay, Vaneet / Lui, Julian C / Mangino, Massimo / Mateo Leach, Irene / Medina-Gomez, Carolina / Nalls, Michael A / Nyholt, Dale R / Palmer, Cameron D / Pasko, Dorota / Pechlivanis, Sonali / Prokopenko, Inga / Ried, Janina S / Ripke, Stephan / Shungin, Dmitry / Stancáková, Alena / Strawbridge, Rona J / Sung, Yun Ju / Tanaka, Toshiko / Teumer, Alexander / Trompet, Stella / van der Laan, Sander W / van Setten, Jessica / Van Vliet-Ostaptchouk, Jana V / Wang, Zhaoming / Yengo, Loïc / Zhang, Weihua / Afzal, Uzma / Arnlöv, Johan / Arscott, Gillian M / Bandinelli, Stefania / Barrett, Amy / Bellis, Claire / Bennett, Amanda J / Berne, Christian / Blüher, Matthias / Bolton, Jennifer L / Böttcher, Yvonne / Boyd, Heather A / Bruinenberg, Marcel / Buckley, Brendan M / Buyske, Steven / Caspersen, Ida H / Chines, Peter S / Clarke, Robert / Claudi-Boehm, Simone / Cooper, Matthew / Daw, E Warwick / De Jong, Pim A / Deelen, Joris / Delgado, Graciela / Denny, Josh C / Dhonukshe-Rutten, Rosalie / Dimitriou, Maria / Doney, Alex S F / Dörr, Marcus / Eklund, Niina / Eury, Elodie / Folkersen, Lasse / Garcia, Melissa E / Geller, Frank / Giedraitis, Vilmantas / Go, Alan S / Grallert, Harald / Grammer, Tanja B / Gräßler, Jürgen / Grönberg, Henrik / de Groot, Lisette C P G M / Groves, Christopher J / Haessler, Jeffrey / Hall, Per / Haller, Toomas / Hallmans, Goran / Hannemann, Anke / Hartman, Catharina A / Hassinen, Maija / Hayward, Caroline / Heard-Costa, Nancy L / Helmer, Quinta / Hemani, Gibran / Henders, Anjali K / Hillege, Hans L / Hlatky, Mark A / Hoffmann, Wolfgang / Hoffmann, Per / Holmen, Oddgeir / Houwing-Duistermaat, Jeanine J / Illig, Thomas / Isaacs, Aaron / James, Alan L / Jeff, Janina / Johansen, Berit / Johansson, Åsa / Jolley, Jennifer / Juliusdottir, Thorhildur / Junttila, Juhani / Kho, Abel N / Kinnunen, Leena / Klopp, Norman / Kocher, Thomas / Kratzer, Wolfgang / Lichtner, Peter / Lind, Lars / Lindström, Jaana / Lobbens, Stéphane / Lorentzon, Mattias / Lu, Yingchang / Lyssenko, Valeriya / Magnusson, Patrik K E / Mahajan, Anubha / Maillard, Marc / McArdle, Wendy L / McKenzie, Colin A / McLachlan, Stela / McLaren, Paul J / Menni, Cristina / Merger, Sigrun / Milani, Lili / Moayyeri, Alireza / Monda, Keri L / Morken, Mario A / Müller, Gabriele / Müller-Nurasyid, Martina / Musk, Arthur W / Narisu, Narisu / Nauck, Matthias / Nolte, Ilja M / Nöthen, Markus M / Oozageer, Laticia / Pilz, Stefan / Rayner, Nigel W / Renstrom, Frida / Robertson, Neil R / Rose, Lynda M / Roussel, Ronan / Sanna, Serena / Scharnagl, Hubert / Scholtens, Salome / Schumacher, Fredrick R / Schunkert, Heribert / Scott, Robert A / Sehmi, Joban / Seufferlein, Thomas / Shi, Jianxin / Silventoinen, Karri / Smit, Johannes H / Smith, Albert Vernon / Smolonska, Joanna / Stanton, Alice V / Stirrups, Kathleen / Stott, David J / Stringham, Heather M / Sundström, Johan / Swertz, Morris A / Syvänen, Ann-Christine / Tayo, Bamidele O / Thorleifsson, Gudmar / Tyrer, Jonathan P / van Dijk, Suzanne / van Schoor, Natasja M / van der Velde, Nathalie / van Heemst, Diana / van Oort, Floor V A / Vermeulen, Sita H / Verweij, Niek / Vonk, Judith M / Waite, Lindsay L / Waldenberger, Melanie / Wennauer, Roman / Wilkens, Lynne R / Willenborg, Christina / Wilsgaard, Tom / Wojczynski, Mary K / Wong, Andrew / Wright, Alan F / Zhang, Qunyuan / Arveiler, Dominique / Bakker, Stephan J L / Beilby, John / Bergman, Richard N / Bergmann, Sven / Biffar, Reiner / Blangero, John / Boomsma, Dorret I / Bornstein, Stefan R / Bovet, Pascal / Brambilla, Paolo / Brown, Morris J / Campbell, Harry / Caulfield, Mark J / Chakravarti, Aravinda / Collins, Rory / Collins, Francis S / Crawford, Dana C / Cupples, L Adrienne / Danesh, John / de Faire, Ulf / den Ruijter, Hester M / Erbel, Raimund / Erdmann, Jeanette / Eriksson, Johan G / Farrall, Martin / Ferrannini, Ele / Ferrières, Jean / Ford, Ian / Forouhi, Nita G / Forrester, Terrence / Gansevoort, Ron T / Gejman, Pablo V / Gieger, Christian / Golay, Alain / Gottesman, Omri / Gudnason, Vilmundur / Gyllensten, Ulf / Haas, David W / Hall, Alistair S / Harris, Tamara B / Hattersley, Andrew T / Heath, Andrew C / Hengstenberg, Christian / Hicks, Andrew A / Hindorff, Lucia A / Hingorani, Aroon D / Hofman, Albert / Hovingh, G Kees / Humphries, Steve E / Hunt, Steven C / Hypponen, Elina / Jacobs, Kevin B / Jarvelin, Marjo-Riitta / Jousilahti, Pekka / Jula, Antti M / Kaprio, Jaakko / Kastelein, John J P / Kayser, Manfred / Kee, Frank / Keinanen-Kiukaanniemi, Sirkka M / Kiemeney, Lambertus A / Kooner, Jaspal S / Kooperberg, Charles / Koskinen, Seppo / Kovacs, Peter / Kraja, Aldi T / Kumari, Meena / Kuusisto, Johanna / Lakka, Timo A / Langenberg, Claudia / Le Marchand, Loic / Lehtimäki, Terho / Lupoli, Sara / Madden, Pamela A F / Männistö, Satu / Manunta, Paolo / Marette, André / Matise, Tara C / McKnight, Barbara / Meitinger, Thomas / Moll, Frans L / Montgomery, Grant W / Morris, Andrew D / Morris, Andrew P / Murray, Jeffrey C / Nelis, Mari / Ohlsson, Claes / Oldehinkel, Albertine J / Ong, Ken K / Ouwehand, Willem H / Pasterkamp, Gerard / Peters, Annette / Pramstaller, Peter P / Price, Jackie F / Qi, Lu / Raitakari, Olli T / Rankinen, Tuomo / Rao, D C / Rice, Treva K / Ritchie, Marylyn / Rudan, Igor / Salomaa, Veikko / Samani, Nilesh J / Saramies, Jouko / Sarzynski, Mark A / Schwarz, Peter E H / Sebert, Sylvain / Sever, Peter / Shuldiner, Alan R / Sinisalo, Juha / Steinthorsdottir, Valgerdur / Stolk, Ronald P / Tardif, Jean-Claude / Tönjes, Anke / Tremblay, Angelo / Tremoli, Elena / Virtamo, Jarmo / Vohl, Marie-Claude / Amouyel, Philippe / Asselbergs, Folkert W / Assimes, Themistocles L / Bochud, Murielle / Boehm, Bernhard O / Boerwinkle, Eric / Bottinger, Erwin P / Bouchard, Claude / Cauchi, Stéphane / Chambers, John C / Chanock, Stephen J / Cooper, Richard S / de Bakker, Paul I W / Dedoussis, George / Ferrucci, Luigi / Franks, Paul W / Froguel, Philippe / Groop, Leif C / Haiman, Christopher A / Hamsten, Anders / Hayes, M Geoffrey / Hui, Jennie / Hunter, David J / Hveem, Kristian / Jukema, J Wouter / Kaplan, Robert C / Kivimaki, Mika / Kuh, Diana / Laakso, Markku / Liu, Yongmei / Martin, Nicholas G / März, Winfried / Melbye, Mads / Moebus, Susanne / Munroe, Patricia B / Njølstad, Inger / Oostra, Ben A / Palmer, Colin N A / Pedersen, Nancy L / Perola, Markus / Pérusse, Louis / Peters, Ulrike / Powell, Joseph E / Power, Chris / Quertermous, Thomas / Rauramaa, Rainer / Reinmaa, Eva / Ridker, Paul M / Rivadeneira, Fernando / Rotter, Jerome I / Saaristo, Timo E / Saleheen, Danish / Schlessinger, David / Slagboom, P Eline / Snieder, Harold / Spector, Tim D / Strauch, Konstantin / Stumvoll, Michael / Tuomilehto, Jaakko / Uusitupa, Matti / van der Harst, Pim / Völzke, Henry / Walker, Mark / Wareham, Nicholas J / Watkins, Hugh / Wichmann, H-Erich / Wilson, James F / Zanen, Pieter / Deloukas, Panos / Heid, Iris M / Lindgren, Cecilia M / Mohlke, Karen L / Speliotes, Elizabeth K / Thorsteinsdottir, Unnur / Barroso, Inês / Fox, Caroline S / North, Kari E / Strachan, David P / Beckmann, Jacques S / Berndt, Sonja I / Boehnke, Michael / Borecki, Ingrid B / McCarthy, Mark I / Metspalu, Andres / Stefansson, Kari / Uitterlinden, André G / van Duijn, Cornelia M / Franke, Lude / Willer, Cristen J / Price, Alkes L / Lettre, Guillaume / Loos, Ruth J F / Weedon, Michael N / Ingelsson, Erik / O'Connell, Jeffrey R / Abecasis, Goncalo R / Chasman, Daniel I / Goddard, Michael E / Visscher, Peter M / Hirschhorn, Joel N / Frayling, Timothy M

    Nature genetics

    2014  Volume 46, Issue 11, Page(s) 1173–1186

    Abstract: Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that ... ...

    Abstract Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explained one-fifth of the heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ∼2,000, ∼3,700 and ∼9,500 SNPs explained ∼21%, ∼24% and ∼29% of phenotypic variance. Furthermore, all common variants together captured 60% of heritability. The 697 variants clustered in 423 loci were enriched for genes, pathways and tissue types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/β-catenin and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
    MeSH term(s) Adult ; Analysis of Variance ; Body Height/genetics ; Genetic Variation/genetics ; Genetics, Population ; Genome-Wide Association Study/methods ; Humans ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide/genetics ; White People/genetics
    Language English
    Publishing date 2014-10-05
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/ng.3097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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