LIVIVO - Search results -

Search results

Result 1 - 10 of total 187

Article ; Online: Cardiac Na

Watanabe, Yasuhide

The journal of physiological sciences : JPS

2019 Volume 69, Issue 6, Page(s) 837–849

Abstract: We previously reviewed our study of the pharmacological properties of cardiac ... ...

Abstract	We previously reviewed our study of the pharmacological properties of cardiac Na
MeSH term(s)	Animals ; Cardiotonic Agents/pharmacology ; Cyclic GMP/metabolism ; Cyclic GMP-Dependent Protein Kinases/metabolism ; Humans ; Nitric Oxide/metabolism ; Signal Transduction/drug effects ; Sodium-Calcium Exchanger/agonists
Chemical Substances	Cardiotonic Agents ; Sodium-Calcium Exchanger ; Nitric Oxide (31C4KY9ESH) ; Cyclic GMP-Dependent Protein Kinases (EC 2.7.11.12) ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2019-10-29
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2234472-X
ISSN	1880-6562 ; 1880-6546
ISSN (online)	1880-6562
ISSN	1880-6546
DOI	10.1007/s12576-019-00721-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Observing an expert's action swapped with an observer's face increases corticospinal excitability during combined action observation and motor imagery.

Watanabe, Hironori / Washino, Sohei / Ogoh, Shigehiko / Miyamoto, Naokazu / Kanehisa, Hiroaki / Kato, Hirokazu / Yoshitake, Yasuhide

The European journal of neuroscience

2024 Volume 59, Issue 5, Page(s) 1016–1028

Abstract: This study aimed to examine whether observing an expert's action swapped with an observer's face increases corticospinal excitability during combined action observation and motor imagery (AOMI). Twelve young males performed motor imagery of motor tasks ... ...

Abstract	This study aimed to examine whether observing an expert's action swapped with an observer's face increases corticospinal excitability during combined action observation and motor imagery (AOMI). Twelve young males performed motor imagery of motor tasks with different difficulties while observing the actions of an expert performer and an expert performer with a swapped face. Motor tasks included bilateral wrist dorsiflexion (EASY) and unilateral two-ball rotating motions (DIFF). During the AOMI of EASY and DIFF, single-pulse transcranial magnetic stimulation was delivered to the left primary motor cortex, and motor-evoked potentials (MEPs) were obtained from the extensor carpi ulnaris and first dorsal interosseous muscles of the right upper limb, respectively. Visual analogue scale (VAS) assessed the subjective similarity of the expert performer with the swapped face in the EASY and DIFF to the participants themselves. The MEP amplitude in DIFF was larger in the observation of the expert performer with the swapped face than that of the expert performer (P = 0.012); however, the corresponding difference was not observed in EASY (P = 1.000). The relative change in the MEP amplitude from observing the action of the expert performer to that of the expert performer with the swapped face was positively correlated with VAS only in DIFF (r = 0.644, P = 0.024). These results indicate that observing the action of an expert performer with the observer's face enhances corticospinal excitability during AOMI, depending on the task difficulty and subjective similarity between the expert performer being observed and the observer.
MeSH term(s)	Male ; Humans ; Imagination/physiology ; Muscle, Skeletal/physiology ; Hand ; Evoked Potentials, Motor/physiology ; Motor Cortex/physiology ; Transcranial Magnetic Stimulation/methods ; Pyramidal Tracts/physiology ; Electromyography/methods
Language	English
Publishing date	2024-01-26
Publishing country	France
Document type	Journal Article
ZDB-ID	645180-9
ISSN	1460-9568 ; 0953-816X
ISSN (online)	1460-9568
ISSN	0953-816X
DOI	10.1111/ejn.16257
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2548: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Greater task difficulty during unilateral motor tasks changes intracortical inhibition and facilitation in the ipsilateral primary motor cortex in young men.

Watanabe, Hironori / Ogoh, Shigehiko / Miyamoto, Naokazu / Kanehisa, Hiroaki / Yoshitake, Yasuhide

Neuroscience letters

2023 Volume 808, Page(s) 137293

Abstract: This study aimed to clarify the changes in short-interval intracortical inhibition (SICI) and facilitation (ICF) in the ipsilateral primary motor cortex (iM1) when the task difficulty during unilateral force-matching tasks was manipulated. Twelve young ... ...

Abstract	This study aimed to clarify the changes in short-interval intracortical inhibition (SICI) and facilitation (ICF) in the ipsilateral primary motor cortex (iM1) when the task difficulty during unilateral force-matching tasks was manipulated. Twelve young male adults matched their left index finger abduction force to a displayed target force. Task difficulty was manipulated by varying the acceptable force range of the mean target force (5% MVC). Briefly, unilateral force-matching tasks with lesser and greater task difficulty (EASY and DIFF, respectively) were assigned acceptable force ranges of ± 7% and ± 0% of the target force, respectively. To evaluate SICI and ICF in iM1, paired-pulse transcranial magnetic stimulation with 2-ms and 10-ms interstimulus intervals was applied to correct motor-evoked potentials (MEPs) from the first dorsal interosseous muscle during each task. Test stimulus intensity to evoke the MEP with a peak-to-peak amplitude of approximately 0.5-1.5 mV for each task was lower in DIFF than in EASY (P = 0.001), indicating that DIFF increased corticospinal excitability of the ipsilateral hemisphere compared with EASY. The MEPs in SICI and ICF were significantly larger in DIFF than in EASY (P < 0.050). These results suggest that greater corticospinal excitability in the ipsilateral hemisphere during DIFF is associated with reduced SICI and increased ICF.
MeSH term(s)	Adult ; Humans ; Male ; Electromyography/methods ; Motor Cortex/physiology ; Neural Inhibition/physiology ; Fingers ; Evoked Potentials, Motor/physiology ; Transcranial Magnetic Stimulation/methods ; Muscle, Skeletal/physiology
Language	English
Publishing date	2023-05-09
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2023.137293
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clarification of generation mechanism of volatilization flux based on detailed analysis of transport phenomena near the ground surface and quantitative evaluation of influencing factors.

Kondo, Monami / Sakamoto, Yasuhide / Hara, Junko / Komai, Takeshi / Watanabe, Noriaki

Journal of hazardous materials

2023 Volume 465, Page(s) 133356

Abstract: Assessing human health risks associated with inhalation exposure of volatile chemical substances (VCSs) volatilized from contaminated soil requires quantitative evaluation of volatilization fluxes (VFs) and an understanding of how environmental factors ... ...

Abstract	Assessing human health risks associated with inhalation exposure of volatile chemical substances (VCSs) volatilized from contaminated soil requires quantitative evaluation of volatilization fluxes (VFs) and an understanding of how environmental factors impact VF generation. We developed a numerical model that considers advection-dispersion and VCSs volatilization in unsaturated soil, enabling VF prediction through parameter optimization using soil column tests. We conducted parametric analyses to assess how key parameters, such as soil particle size, contamination depth, temperature, and surface soil thickness affect VF generation. By analyzing VCS transport near the ground surface, we uncovered the mechanisms underlying VF generation. We also identified characteristic differences in VF generation behavior linked to soil particle size and gas saturation at the ground surface. Under specific soil particle size conditions, significant VF generation occurred even when contamination was deep underground. This was primarily observed when capillary effect was pronounced, and VCSs continued to be supplied to the ground surface through upward advection. Considering the significant impact of VF generation on human health, our parametric study provides valuable insights into relationships between different parameters and VF behavior, especially under varying ground surface temperatures and surface soil thicknesses. This study contributes to developing effective remediation and risk-reduction strategies. ENVIRONMENTAL IMPLICATION: This research examines the environmental implications of volatile chemical substances (VCSs), including hazardous materials like benzene and trichloroethylene, in contaminated soil. VCSs pose health risks when they volatilize from soil. The study quantifies volatilization fluxes (VF) and elucidates the environmental factors affecting VF generation. These findings are vital for effective environmental management. By comprehending the mechanisms governing VF generation, particularly regarding soil properties like particle size, this research enhances the effectiveness of soil contamination remediation and risk reduction. It emphasizes the essential need for a comprehensive VCS assessment in contaminated soils to protect both human health and the environment.
MeSH term(s)	Humans ; Volatilization ; Trichloroethylene ; Benzene/analysis ; Soil/chemistry ; Soil Pollutants/analysis
Chemical Substances	Trichloroethylene (290YE8AR51) ; Benzene (J64922108F) ; Soil ; Soil Pollutants
Language	English
Publishing date	2023-12-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.133356
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Drug-drug conjugates of MEK and Akt inhibitors for RAS-mutant cancers.

Fujita, Hikaru / Arai, Sachiko / Arakawa, Hiroshi / Hamamoto, Kana / Kato, Toshiyuki / Arai, Tsubasa / Nitta, Nanaka / Hotta, Kazuki / Hosokawa, Natsuko / Ohbayashi, Takako / Takahashi, Chiaki / Inokuma, Yasuhide / Tamai, Ikumi / Yano, Seiji / Kunishima, Munetaka / Watanabe, Yoshihiro

Bioorganic & medicinal chemistry

2024 Volume 102, Page(s) 117674

Abstract: Controlling RAS mutant cancer progression remains a significant challenge in developing anticancer drugs. Whereas Ras G12C-covalent binders have received clinical approval, the emergence of further mutations, along with the activation of Ras-related ... ...

Abstract	Controlling RAS mutant cancer progression remains a significant challenge in developing anticancer drugs. Whereas Ras G12C-covalent binders have received clinical approval, the emergence of further mutations, along with the activation of Ras-related proteins and signals, has led to resistance to Ras binders. To discover novel compounds to overcome this bottleneck, we focused on the concurrent and sustained blocking of two major signaling pathways downstream of Ras. To this end, we synthesized 25 drug-drug conjugates (DDCs) by combining the MEK inhibitor trametinib with Akt inhibitors using seven types of linkers with structural diversity. The DDCs were evaluated for their cell permeability/accumulation and ability to inhibit proliferation in RAS-mutant cell lines. A representative DDC was further evaluated for its effects on signaling proteins, induction of apoptosis-related proteins, and the stability of hepatic metabolic enzymes. These in vitro studies identified a series of DDCs, especially those containing a furan-based linker, with promising properties as agents for treating RAS-mutant cancers. Additionally, in vivo experiments in mice using the two selected DDCs revealed prolonged half-lives and anticancer efficacies comparable to those of trametinib. The PK profiles of trametinib and the Akt inhibitor were unified through the DDC formation. The DDCs developed in this study have potential as drug candidates for the broad inhibition of RAS-mutant cancers.
MeSH term(s)	Animals ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Signal Transduction ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Mutation ; Angiogenesis Inhibitors/pharmacology ; Mitogen-Activated Protein Kinase Kinases/metabolism ; Cell Line, Tumor
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Antineoplastic Agents ; Protein Kinase Inhibitors ; Angiogenesis Inhibitors ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2)
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2024.117674
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3815: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Development of a Model for Predicting the Volatilization Flux from Unsaturated Soil Contaminated by Volatile Chemical Substances

Kondo, Monami / Sakamoto, Yasuhide / Kawabe, Yoshishige / Nakamura, Kengo / Watanabe, Noriaki / Komai, Takeshi

Environmental modeling and assessment. 2022 Apr., v. 27, no. 2

2022

Abstract: This work developed a model for predicting the volatilization flux from the unsaturated soil contaminated by volatile chemical substances (VCSs) such as mercury and benzene. The model considers a series of phenomena under the unsaturated condition such ... ...

Abstract	This work developed a model for predicting the volatilization flux from the unsaturated soil contaminated by volatile chemical substances (VCSs) such as mercury and benzene. The model considers a series of phenomena under the unsaturated condition such as multi-phase flow consisting of a non-aqueous phase liquid, water, and gases together with the permeation of rainfall into the surface soil, the volatilization/condensation of VCSs, and the adsorption/desorption of VCSs. On this basis, this work clarified a mechanism for the generation of a volatilization flux at the ground surface. In addition, the effects of various transport phenomena in the surface soil on the magnitude and seasonal changes in this flux due to variations in weather factors such as rainfall level, temperature, and air pressure were quantitatively evaluated. This newly developed prediction model can be utilized to estimate dynamic variations in the flux under real-environmental conditions.
Keywords	adsorption ; atmospheric pressure ; benzene ; desorption ; mercury ; nonaqueous phase liquids ; permeability ; rain ; temperature ; volatile compounds ; volatilization
Language	English
Dates of publication	2022-04
Size	p. 251-273.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	2000915-X
ISSN	1573-2967 ; 1420-2026
ISSN (online)	1573-2967
ISSN	1420-2026
DOI	10.1007/s10666-021-09796-0
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Tissue-Engineered Hepatocyte Sheets Supplemented with Adipose-Derived Stem Cells.

Suzushino, Seiko / Sato, Naoya / Ishigame, Teruhide / Okada, Ryo / Kofunato, Yasuhide / Watanabe, Junichiro / Muto, Makoto / Tsukida, Shigeyuki / Nishimagi, Atsushi / Kimura, Takashi / Kenjo, Akira / Waguri, Satoshi / Marubashi, Shigeru

Tissue engineering. Part A

2023 Volume 29, Issue 13-14, Page(s) 384–396

Abstract: The ability to engineer biologically viable hepatocytes and tissue matrices with long-term functional maintenance has attracted considerable interest in the fields of hepatocyte transplantation and liver tissue engineering. Here, newly developed ... ...

Abstract	The ability to engineer biologically viable hepatocytes and tissue matrices with long-term functional maintenance has attracted considerable interest in the fields of hepatocyte transplantation and liver tissue engineering. Here, newly developed hepatocyte sheets supplemented with adipose-derived stem cells (ADSCs) were evaluated to assess the effects of ADSCs on hepatocyte function and engraftment into the subcutaneous space. Eight-week-old male C57BL/6J mice were used as donors, and 6-week-old male C.B-17/Icr-scid/scid mice were used as recipients. Hepatocyte-ADSC composite sheets were developed using temperature-responsive culture dishes. Hepatocyte viability in the hepatocyte-ADSC composite sheets was evaluated in an
MeSH term(s)	Mice ; Animals ; Male ; Adipose Tissue ; Tissue Engineering ; Mice, Inbred C57BL ; Hepatocytes ; Stem Cells
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2420582-5
ISSN	1937-335X ; 1937-3341
ISSN (online)	1937-335X
ISSN	1937-3341
DOI	10.1089/ten.TEA.2022.0197
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5500/A: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Can digital health technologies exacerbate the health gap? A clustering analysis of mothers' opinions toward digitizing the maternal and child health handbook.

Goto, Ryunosuke / Watanabe, Yoko / Yamazaki, Ako / Sugita, Masatoshi / Takeda, Satoru / Nakabayashi, Masao / Nakamura, Yasuhide

SSM - population health

2021 Volume 16, Page(s) 100935

Abstract: Background: The use of mobile health has increased worldwide, but along with its increased utilization comes the risk of the digital divide, inequity in access to information and communications technologies, exerting greater influence on health inequity ...

Abstract	Background: The use of mobile health has increased worldwide, but along with its increased utilization comes the risk of the digital divide, inequity in access to information and communications technologies, exerting greater influence on health inequity caused by socioeconomic determinants of health. There is a growing need to investigate whether the digitization of existing health interventions has a risk of worsening the health gap. Methods: We investigated the attitudes of mothers and pregnant women toward digitization of the Maternal and Child Health Handbook (MCHH), a popular personal health record (PHR) used by almost every pregnant woman or mother in Japan, using a cross-sectional survey. We determined sociodemographic factors associated with favorable opinions toward digitization using a multivariate regression model. We then grouped the participants using partitioning around medoids clustering, a machine-learning approach, to interpret their varying attitudes toward digitization in light of their sociodemographic characteristics as well as their affinity toward the paper MCHH. Findings: Higher income and educational level, older age, and less reliance on the MCHH were significantly associated with favorable opinion toward digitization. Clustering analysis identified four latent clusters. The cluster with the highest socioeconomic status (SES) was the most favorable toward digitization, while two clusters with the lowest SES, one of which relied heavily on the paper MCHH, were less favorable of digitization compared to the high SES cluster. The final cluster was comprised of mothers with the experience of raising multiple children and did not rely heavily on the MCHH. Interpretation: Our study identified a socioeconomic divide in opinions toward digitization of an existing health intervention. A hasty digitization may result in an unbalanced uptake of the digitized health intervention among different social classes.
Language	English
Publishing date	2021-10-01
Publishing country	England
Document type	Journal Article
ISSN	2352-8273
ISSN	2352-8273
DOI	10.1016/j.ssmph.2021.100935
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Reconstruction of net force fluctuations from surface EMGs of multiple muscles in steady isometric plantarflexion.

Suzuki, Ryosei / Kanehisa, Hiroaki / Washino, Sohei / Watanabe, Hironori / Shinohara, Minoru / Yoshitake, Yasuhide

Experimental brain research

2021 Volume 239, Issue 2, Page(s) 601–612

Abstract: The purposes of this study were to clarify if force fluctuations during steady multi-muscle contractions have a temporal correlation with a low-frequency component of rectified surface EMG (rEMG) in the involved muscles and collection of that component ... ...

Abstract	The purposes of this study were to clarify if force fluctuations during steady multi-muscle contractions have a temporal correlation with a low-frequency component of rectified surface EMG (rEMG) in the involved muscles and collection of that component across muscles allows for the reconstruction of force fluctuations across a wide range of contraction intensities. Healthy young men (n = 15) exerted steady isometric plantarflexion force at 5-60% of maximal force. Surface EMG was recorded from the medial and lateral gastrocnemii, soleus, peroneus longus, abductor hallucis, and tibialis anterior muscles. The cross-correlation function (CCF) between plantarflexion force fluctuations and low-pass filtered rEMG in each muscle was calculated for 8 s. To reconstruct force fluctuations from rEMGs, the product of rEMG and an identified constant factor were summed across muscles with time-lag compensation for electro-mechanical delay. A distinct peak of the CCF was found between plantarflexion force fluctuations and rEMG in most cases except for the tibialis anterior. The CCF peak was greatest in the medial gastrocnemius and soleus. Reconstructed force from rEMGs was temporally correlated with measured force fluctuations across contraction intensities (average CCF peak: r = 0.65). The results indicate that individual surface rEMG has a low-frequency component that is temporally correlated with net force fluctuations during steady multi-muscle contractions and contributes to the reconstruction of force fluctuations across a wide range of contraction intensities. It suggests a potential applicability of individual surface EMGs for identifying the contributing muscles to controlling or disturbing isometric steady force in multi-muscle contractions.
MeSH term(s)	Electromyography ; Humans ; Isometric Contraction ; Leg ; Male ; Muscle Contraction ; Muscle, Skeletal
Language	English
Publishing date	2021-01-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1201-4
ISSN	1432-1106 ; 0014-4819
ISSN (online)	1432-1106
ISSN	0014-4819
DOI	10.1007/s00221-020-05987-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 278: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Can digital health technologies exacerbate the health gap? A clustering analysis of mothers’ opinions toward digitizing the maternal and child health handbook

Ryunosuke Goto / Yoko Watanabe / Ako Yamazaki / Masatoshi Sugita / Satoru Takeda / Masao Nakabayashi / Yasuhide Nakamura

SSM: Population Health, Vol 16, Iss , Pp 100935- (2021)

2021

Abstract	Background: The use of mobile health has increased worldwide, but along with its increased utilization comes the risk of the digital divide, inequity in access to information and communications technologies, exerting greater influence on health inequity caused by socioeconomic determinants of health. There is a growing need to investigate whether the digitization of existing health interventions has a risk of worsening the health gap. Methods: We investigated the attitudes of mothers and pregnant women toward digitization of the Maternal and Child Health Handbook (MCHH), a popular personal health record (PHR) used by almost every pregnant woman or mother in Japan, using a cross-sectional survey. We determined sociodemographic factors associated with favorable opinions toward digitization using a multivariate regression model. We then grouped the participants using partitioning around medoids clustering, a machine-learning approach, to interpret their varying attitudes toward digitization in light of their sociodemographic characteristics as well as their affinity toward the paper MCHH. Findings: Higher income and educational level, older age, and less reliance on the MCHH were significantly associated with favorable opinion toward digitization. Clustering analysis identified four latent clusters. The cluster with the highest socioeconomic status (SES) was the most favorable toward digitization, while two clusters with the lowest SES, one of which relied heavily on the paper MCHH, were less favorable of digitization compared to the high SES cluster. The final cluster was comprised of mothers with the experience of raising multiple children and did not rely heavily on the MCHH. Interpretation: Our study identified a socioeconomic divide in opinions toward digitization of an existing health intervention. A hasty digitization may result in an unbalanced uptake of the digitized health intervention among different social classes.
Keywords	Social determinants of health ; Maternal and child health ; Health inequity ; Digital ; Health ; Digital divide ; Public aspects of medicine ; RA1-1270 ; Social sciences (General) ; H1-99
Subject code	360
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED