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  1. Article ; Online: [No title information]

    Lamontagne, Francois

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2024  Volume 196, Issue 8, Page(s) E274–E275

    Title translation Établir la confiance: communication transparente et prise de décision partagée.
    MeSH term(s) Humans ; Trust ; Decision Making, Shared
    Language French
    Publishing date 2024-03-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.231583-f
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  2. Article ; Online: Establishing trust through clear communication and shared decision-making.

    Lamontagne, Francois

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2023  Volume 195, Issue 49, Page(s) E1725–E1726

    MeSH term(s) Humans ; Trust ; Decision Making, Shared ; Communication ; Decision Making ; Physician-Patient Relations ; Patient Participation
    Language English
    Publishing date 2023-12-17
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.231583
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Vitamin C for Patients Hospitalized With COVID-19-Reply.

    Adhikari, Neill K J / Lamontagne, Francois

    JAMA

    2024  Volume 331, Issue 10, Page(s) 886–887

    MeSH term(s) Humans ; Ascorbic Acid/therapeutic use ; COVID-19/therapy ; COVID-19 Drug Treatment ; Hospitalization ; Vitamins/therapeutic use
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.0455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  4. Article ; Online: Coronavirus disease 2019.

    Arabi, Yaseen M / Diaz, Janet / Lamontagne, François

    Intensive care medicine

    2023  Volume 49, Issue 9, Page(s) 1103–1106

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07168-8
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  5. Article ; Online: Toward Universal Deployable Guidelines for the Care of Patients With COVID-19.

    Lamontagne, Francois / Angus, Derek C

    JAMA

    2020  Volume 323, Issue 18, Page(s) 1786–1787

    Keywords covid19
    Language English
    Publishing date 2020-03-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.5110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The authors reply.

    Angriman, Federico / Muttalib, Fiona / Lamontagne, François / Adhikari, Neill K J

    Critical care medicine

    2023  Volume 51, Issue 12, Page(s) e283–e284

    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000006054
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  7. Article ; Online: Social participation experiences of older adults with an early-onset physical disability: a systematic review protocol.

    Turcotte, Samuel / Simard, Pascale / Levasseur, Mélanie / Raymond, Émilie / Routhier, François / Lamontagne, Marie-Ève

    JBI evidence synthesis

    2024  Volume 22, Issue 2, Page(s) 298–304

    Abstract: Objective: The objective of this review is to assess and synthesize the available qualitative evidence on the experiences of social participation of older adults with an early-onset physical disability.: Introduction: Understanding the experiences of ...

    Abstract Objective: The objective of this review is to assess and synthesize the available qualitative evidence on the experiences of social participation of older adults with an early-onset physical disability.
    Introduction: Understanding the experiences of social participation among older adults with a physical disability acquired earlier in life can guide the development of interventions and policies. It will also help with fostering meaningful community participation and aid in improving the quality of their social participation.
    Inclusion criteria: This review will consider primary studies that explore the experiences of social participation of older adults with an early-onset physical disability. The review will focus on qualitative data, including methods such as phenomenology, grounded theory, ethnography, action research, and feminist research. Studies in French or English will be considered for inclusion, and there will be no limitation on publication dates.
    Methods: A keyword search strategy will be carried out in MEDLINE (Ovid), PsycINFO (Ovid), CINAHL (EBSCOhost), Web of Science, and the Cochrane Library. ProQuest Dissertations and Theses (ProQuest) will be searched for unpublished articles. Two independent reviewers will perform the screening and inclusion process, assess the quality of the evidence, and complete data extraction. The JBI approach to critical appraisal, study selection, data extraction, and data synthesis (meta-aggregation) will be used. The ConQual approach will be used to establish confidence in the synthesized findings.
    Review registration: PROSPERO CRD42022371027.
    MeSH term(s) Humans ; Aged ; Qualitative Research ; Social Participation ; Systematic Reviews as Topic ; Anthropology, Cultural ; Review Literature as Topic
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ISSN 2689-8381
    ISSN (online) 2689-8381
    DOI 10.11124/JBIES-23-00018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Rethinking the pros and cons of randomized controlled trials and observational studies in the era of big data and advanced methods: a panel discussion.

    Fernainy, Pamela / Cohen, Alan A / Murray, Eleanor / Losina, Elena / Lamontagne, Francois / Sourial, Nadia

    BMC proceedings

    2024  Volume 18, Issue Suppl 2, Page(s) 1

    Abstract: Randomized controlled trials (RCTs) have traditionally been considered the gold standard for medical evidence. However, in light of emerging methodologies in data science, many experts question the role of RCTs. Within this context, experts in the USA ... ...

    Abstract Randomized controlled trials (RCTs) have traditionally been considered the gold standard for medical evidence. However, in light of emerging methodologies in data science, many experts question the role of RCTs. Within this context, experts in the USA and Canada came together to debate whether the primacy of RCTs as the gold standard for medical evidence, still holds in light of recent methodological advances in data science and in the era of big data. The purpose of this manuscript, aims to raise awareness of the pros and cons of RCTs and observational studies in order to help guide clinicians, researchers, students, and decision-makers in making informed decisions on the quality of medical evidence to support their work. In particular, new and underappreciated advantages and disadvantages of both designs are contrasted. Innovations taking place in both of these research methodologies, which can blur the lines between the two, are also discussed. Finally, practical guidance for clinicians and future directions in assessing the quality of evidence is offered.
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2411867-9
    ISSN 1753-6561
    ISSN 1753-6561
    DOI 10.1186/s12919-023-00285-8
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  9. Article ; Online: Vitamin C in sepsis.

    Young, Paul J / Lamontagne, François / Fujii, Tomoko

    Intensive care medicine

    2022  Volume 48, Issue 11, Page(s) 1621–1624

    MeSH term(s) Humans ; Ascorbic Acid/therapeutic use ; Vitamins ; Sepsis/drug therapy
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06822-x
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  10. Article ; Online: IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial.

    Angriman, Federico / Muttalib, Fiona / Lamontagne, François / Adhikari, Neill K J

    Critical care medicine

    2023  Volume 51, Issue 8, Page(s) e152–e156

    Abstract: Objectives: The Lessening Organ Dysfunction with Vitamin C trial showed a harmful effect of vitamin C on 28-day death or persistent organ dysfunction. To maximize interpretation, we present a post hoc Bayesian reanalysis.: Design: Bayesian reanalysis ...

    Abstract Objectives: The Lessening Organ Dysfunction with Vitamin C trial showed a harmful effect of vitamin C on 28-day death or persistent organ dysfunction. To maximize interpretation, we present a post hoc Bayesian reanalysis.
    Design: Bayesian reanalysis of a randomized placebo-controlled trial.
    Setting: Thirty-five ICUs.
    Patients: Adults with proven or suspected infection, vasopressor support, and no more than 24 hours of ICU admission.
    Interventions: Patients were allocated to receive either vitamin C (50 mg/kg of body weight) or placebo every 6 hours for up to 96 hours.
    Measurements and main results: The primary outcome was the composite of death or persistent organ dysfunction (i.e., vasopressor use, invasive mechanical ventilation, or new renal replacement therapy) at 28 days. We used Bayesian log-binomial models with random effects for hospital site and varying informative prior beliefs for the effect of vitamin C to estimate risk ratios (RRs) with 95% credible intervals (Crls) in the intention to treat population (vitamin C, 435 patients; placebo, 437 patients). Using weakly neutral priors, patients allocated to vitamin C had a higher risk of death or persistent organ dysfunction at 28 days (RR, 1.20; 95% Crl, 1.04-1.39; probability of harm, 99%). This effect was consistent when using optimistic (RR, 1.14; 95% Crl, 1.00-1.31; probability of harm, 98%) and empiric (RR, 1.09; 95% Crl, 0.97-1.22; probability of harm, 92%) priors. Patients allocated to vitamin C also had a higher risk of death at 28 days under weakly neutral (RR, 1.17; 95% Crl, 0.98-1.40; probability of harm, 96%), optimistic (RR, 1.10; 95% Crl, 0.94-1.30; probability of harm, 88%), and empiric (RR, 1.05; 95% Crl, 0.92-1.19; probability of harm, 76%) priors.
    Conclusions: The use of vitamin C in adult patients with proven or suspected infection and vasopressor support is associated with high probability of harm.
    MeSH term(s) Humans ; Adult ; Vitamins ; Ascorbic Acid/therapeutic use ; Multiple Organ Failure/complications ; Bayes Theorem ; Sepsis/drug therapy ; Sepsis/complications
    Chemical Substances Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005871
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