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Article ; Online: The Safety of the Volar Intraarticular Extended Window (VIEW) Approach for Intra-articular Distal Radius Fractures.

Kamal, Robin N / Gomez, Giselle I / Schultz, Emily A / Shapiro, Lauren M

2023 , Page(s) 15589447231210926

Abstract: Background: A novel volar approach to intra-articular distal radius fractures has been introduced for treatment of intra-articular distal radius fractures, in which volar extrinsic ligaments are released to create a volar window into the radiocarpal ... ...

Abstract	Background: A novel volar approach to intra-articular distal radius fractures has been introduced for treatment of intra-articular distal radius fractures, in which volar extrinsic ligaments are released to create a volar window into the radiocarpal joint (Volar Intraarticular Extended Window [VIEW] approach). Our purpose was to evaluate the safety of VIEW approach for treatment of intra-articular distal radius fractures. Methods: A retrospective chart review was performed for 13 patients with intra-articular distal radius fractures treated operatively with the VIEW surgical technique using an intra-articular window in the volar capsule to aid in reduction and fixation. Postoperative radiographs were reviewed to assess for ulnocarpal translocation by assessing lunate uncovering and radial-carpal distance. Results: Thirteen patients were treated with the VIEW approach with mean follow-up of 28 weeks (range, 7-67 weeks; SD, 18 weeks). The mean postoperative lunate uncovering was 34.6% (SD, 7.7%) and mean radial-carpal distance was 4.6 mm (SD, 1.5 mm). Postoperatively, mean intra-articular step-off was 0.9 mm (SD, 1.2 mm) and mean intra-articular gap was 1.2 mm (SD, 1.0 mm). No patients reported clinical symptoms of wrist instability. Conclusions: Using the VIEW approach during a volar approach to intra-articular distal radius fractures is safe and does not lead to carpal instability. Surgeons can consider using the approach when direct visualization of the articular surface may be beneficial for reduction or fixation. Level of evidence: Therapeutic IV.
Language	English
Publishing date	2023-11-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2277325-3
ISSN	1558-9455 ; 1558-9447
ISSN (online)	1558-9455
ISSN	1558-9447
DOI	10.1177/15589447231210926
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Article ; Online: Storm Surfing Fatalities.

Alvarez, Armando / Goo, Irene / Shapiro, Lauren T

Southern medical journal

2022 Volume 115, Issue 10, Page(s) 790–793

Abstract: Objectives: Tropical storms and hurricanes often produce ocean wave conditions that attract surfers. The risk for serious injury or death from "storm surfing" has not yet been described in the medical literature. This study aimed to quantify deaths ... ...

Abstract	Objectives: Tropical storms and hurricanes often produce ocean wave conditions that attract surfers. The risk for serious injury or death from "storm surfing" has not yet been described in the medical literature. This study aimed to quantify deaths attributable to storm surfing along the coasts of North America and the Caribbean islands. Methods: This was a retrospective review of cases of surfing-related fatalities reported in the tropical cyclone reports of the National Hurricane Center from 1995 to 2020. Media reports were used to identify additional cases and, when available, to provide supplemental demographic and geographical information. Results: There have been 27 reported storm surfing deaths during this time period. Among those for whom demographic data were available, all of the decedents were male and three were children younger than 18 years old. All but three of the deaths occurred among those surfing Atlantic storms, and one-third of the fatal injuries occurred off the coast of Florida. Eight deaths occurred while surf conditions were affected by tropical storms that did not reach hurricane status. Conclusions: Both tropical storms and hurricanes produce dangerous surf conditions that have resulted in fatal injuries among surfers during the past 25 years.
MeSH term(s)	Adolescent ; Child ; Cyclonic Storms ; Female ; Florida/epidemiology ; Humans ; Male ; Retrospective Studies ; Sports
Language	English
Publishing date	2022-10-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.14423/SMJ.0000000000001446
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Article: ABCD1 Gene Mutations: Mechanisms and Management of Adrenomyeloneuropathy.

Volmrich, Alyssa M / Cuénant, Lauren M / Forghani, Irman / Hsieh, Sharon L / Shapiro, Lauren T

The application of clinical genetics

2022 Volume 15, Page(s) 111–123

Abstract: Pathogenic variants in the ABCD1 gene on the X chromosome may result in widely heterogenous phenotypes, including adrenomyeloneuropathy (AMN). Affected males typically present in their third or fourth decade of life with progressive lower limb weakness ... ...

Abstract	Pathogenic variants in the ABCD1 gene on the X chromosome may result in widely heterogenous phenotypes, including adrenomyeloneuropathy (AMN). Affected males typically present in their third or fourth decade of life with progressive lower limb weakness and spasticity, and may develop signs and symptoms of adrenal insufficiency and/or cerebral demyelination. Heterozygous females may be asymptomatic, but may develop a later-onset and more slowly progressive spastic paraparesis. In this review, we describe the clinical presentation of AMN, as well as its diagnosis and management. The role of rehabilitative therapies and options for management of spasticity are highlighted.
Language	English
Publishing date	2022-08-12
Publishing country	New Zealand
Document type	Journal Article ; Review
ISSN	1178-704X
ISSN	1178-704X
DOI	10.2147/TACG.S359479
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Article: Firearm injury prevention counseling for patients with traumatic brain injury: a survey of brain injury physicians.

Ramsay, Ian / Miranda-Cantellops, Natalia Del Mar / Acosta, Oliver / Shapiro, Lauren T

Frontiers in neurology

2023 Volume 14, Page(s) 1237095

Abstract: Background: Survivors of traumatic brain injury are at increased risk for firearm-related injuries, including suicide.: Aims: To determine current practices of Brain Injury Medicine (BIM) physicians and their rehabilitation teams in assessing ... ...

Abstract	Background: Survivors of traumatic brain injury are at increased risk for firearm-related injuries, including suicide. Aims: To determine current practices of Brain Injury Medicine (BIM) physicians and their rehabilitation teams in assessing patients' access to firearms and in providing firearm safety education, and the impact of having received training on this topic on physicians' likelihood of inquiring about patients' access to firearms. Methods: 14-item web-based cross-sectional survey of 86 U.S. physiatrists board-certified in BIM. Results: 81% of respondents indicated they believe BIM physicians should counsel their patients on firearm safety but only 12.9% reported always doing so. Fifteen percent reported always inquiring about their patients' access to firearms. 88.2% indicated having never received formal training on firearm injury prevention counseling. Physicians who received such training had 7.5 times higher odds of reporting at least sometimes inquiring about patients' access to firearms than those who were not trained [95% confidence interval (1.94, 28.64)]. They also had 5.7 times higher odds for reporting being at least moderately comfortable providing patients firearm safety counseling [95% CI: (1.39, 23.22)]. Conclusion: While most BIM specialists who responded to this survey believe they should counsel patients on firearm safety, few always or usually do so. Moreover, most do not routinely inquire about their patients' access to firearms. The provision of firearm injury prevention training to BIM physicians was strongly associated with an increased likelihood they will inquire about their patients' access to guns and with an improved comfort level in providing counseling on this subject matter.
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1237095
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Article ; Online: Improving Unrelated Donor Equity: Assessing Mismatched Donor Opportunities with Real-World Data in a Minority-Predominant Cohort.

Hammami, M Bakri / Verceles, Jhannine Alyssa / Goldfinger, Mendel / Shah, Nishi / Sica, R Alejandro / Mantzaris, Ioannis / Kornblum, Noah / Konopleva, Marina / Shastri, Aditi / Shapiro, Lauren C / Feldman, Eric J / Gritsman, Kira / Verma, Amit / Cooper, Dennis L

Transplantation and cellular therapy

2024 Volume 30, Issue 5, Page(s) 544.e1–544.e8

Abstract: Recent advances in graft-versus-host disease (GVHD) prophylaxis including post-transplant cyclophosphamide (PTCy) and abatacept have significantly improved outcomes following HLA-mismatched allogenic hematopoietic stem cell transplantation (allo-HSCT) ... ...

Abstract	Recent advances in graft-versus-host disease (GVHD) prophylaxis including post-transplant cyclophosphamide (PTCy) and abatacept have significantly improved outcomes following HLA-mismatched allogenic hematopoietic stem cell transplantation (allo-HSCT) and have tremendous potential for reducing racial disparities in donor availability. A recent small study employing bone marrow as the source of stem cells showed similar outcomes after 5/8 versus 7/8 matches and is currently being tested in a larger study using peripheral blood stem cells. In this study, we examine real-world alternative donor HSCT options for a minority-predominant cohort in the Bronx, NY, focusing on the availability of lesser-matched (5/8 to 7/8) donors. Records of patients who underwent HLA typing at Montefiore Medical Center (2019 to 2022) were reviewed. The National Marrow Donor Program registry was queried to evaluate the availability of donors with at least 99% likelihood of HLA match at various levels (5/8, 6/8, 7/8, 8/8). Two hundred forty-one patients were included, 70% were non-White. Although the availability of ≥7/8 donors was less common in non-White patients, 100% of patients from each group had at least one or more 5/8 and 6/8 HLA-matched donors and more than 80% of these patients had >100 potential 5/8 and 6/8 HLA-matched donors. There was no statistical difference by race or ethnicity in the mean number of donors at 5/8 and 6/8 HLA-match levels. We demonstrate through real-world data that patients from diverse ethnic and racial backgrounds have access to 5/8 and 6/8 HLA-matched donors for allo-HSCT, potentially eliminating disparities in donor availability and allowing prioritization of other donor selection characteristics such as donor age, sex, ABO, and B leader matching. Further work is needed to study whether the use of mismatched donors offers a more potent graft-versus malignancy effect and optimal GVHD prophylaxis.
MeSH term(s)	Humans ; Unrelated Donors ; Female ; Male ; Middle Aged ; Hematopoietic Stem Cell Transplantation/statistics & numerical data ; Adult ; Histocompatibility Testing ; Graft vs Host Disease/prevention & control ; Minority Groups/statistics & numerical data ; Cohort Studies ; HLA Antigens/immunology ; Aged
Chemical Substances	HLA Antigens
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2024.02.020
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Article ; Online: Toward better preparedness for the next pandemic.

Shapiro, Lauren I / Kajita, Grace R / Arnsten, Julia H / Tomer, Yaron

The Journal of clinical investigation

2020 Volume 130, Issue 9, Page(s) 4543–4545

Abstract: New York City has been described as the epicenter of the COVID-19 pandemic in the United States. While health care workers are notably at increased risk for COVID-19 infection, the impact on resident physicians remains unclear. In this issue of the JCI, ... ...

Abstract	New York City has been described as the epicenter of the COVID-19 pandemic in the United States. While health care workers are notably at increased risk for COVID-19 infection, the impact on resident physicians remains unclear. In this issue of the JCI, Breazzano et al. surveyed resident physicians for their exposure to COVID-19 during the exponential phase of the COVID-19 pandemic. The researchers also assessed how personal protective equipment and COVID-19 testing protected health care workers from infection. This study highlights resident physician experiences of the first COVID-19 wave that can inform and improve preparedness for upcoming COVID-19 surges and other future epidemics.
MeSH term(s)	Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Humans ; New York City ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; United States
Keywords	covid19
Language	English
Publishing date	2020-06-23
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI140296
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Article ; Online: Innovation in Upper Extremity Fracture Treatment-Implementation of Advanced Techniques to Improve Outcomes.

Kamal, Robin N / Shapiro, Lauren M

Hand clinics

2023 Volume 39, Issue 4, Page(s) xi

MeSH term(s)	Humans ; Fractures, Bone/surgery ; Arm Injuries ; Upper Extremity/surgery ; Retrospective Studies
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Editorial
ZDB-ID	1315374-2
ISSN	1558-1969 ; 0749-0712
ISSN (online)	1558-1969
ISSN	0749-0712
DOI	10.1016/j.hcl.2023.07.002
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Article ; Online: Genetic modification of flavone biosynthesis in rice enhances biofilm formation of soil diazotrophic bacteria and biological nitrogen fixation.

Yan, Dawei / Tajima, Hiromi / Cline, Lauren C / Fong, Reedmond Y / Ottaviani, Javier I / Shapiro, Howard-Yana / Blumwald, Eduardo

Plant biotechnology journal

2022 Volume 20, Issue 11, Page(s) 2135–2148

Abstract: Improving biological nitrogen fixation (BNF) in cereal crops is a long-sought objective; however, no successful modification of cereal crops showing increased BNF has been reported. Here, we described a novel approach in which rice plants were modified ... ...

Abstract	Improving biological nitrogen fixation (BNF) in cereal crops is a long-sought objective; however, no successful modification of cereal crops showing increased BNF has been reported. Here, we described a novel approach in which rice plants were modified to increase the production of compounds that stimulated biofilm formation in soil diazotrophic bacteria, promoted bacterial colonization of plant tissues and improved BNF with increased grain yield at limiting soil nitrogen contents. We first used a chemical screening to identify plant-produced compounds that induced biofilm formation in nitrogen-fixing bacteria and demonstrated that apigenin and other flavones induced BNF. We then used CRISPR-based gene editing targeting apigenin breakdown in rice, increasing plant apigenin contents and apigenin root exudation. When grown at limiting soil nitrogen conditions, modified rice plants displayed increased grain yield. Biofilm production also modified the root microbiome structure, favouring the enrichment of diazotrophic bacteria recruitment. Our results support the manipulation of the flavone biosynthetic pathway as a feasible strategy for the induction of biological nitrogen fixation in cereals and a reduction in the use of inorganic nitrogen fertilizers.
MeSH term(s)	Nitrogen Fixation/genetics ; Oryza/metabolism ; Soil ; Gene Editing ; Apigenin/metabolism ; Fertilizers ; Crops, Agricultural ; Bacteria/genetics ; Nitrogen/metabolism ; Edible Grain/metabolism ; Biofilms
Chemical Substances	Soil ; Apigenin (7V515PI7F6) ; Fertilizers ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-08-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7652
ISSN (online)	1467-7652
ISSN	1467-7652
DOI	10.1111/pbi.13894
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Article ; Online: Genetic modification of flavone biosynthesis in rice enhances biofilm formation of soil diazotrophic bacteria and biological nitrogen fixation

Yan, Dawei / Tajima, Hiromi / Cline, Lauren C. / Fong, Reedmond Y. / Ottaviani, Javier I. / Shapiro, Howard‐Yana / Blumwald, Eduardo

Plant Biotechnology Journal. 2022 Nov., v. 20, no. 11 p.2135-2148

2022

Abstract: Improving biological nitrogen fixation (BNF) in cereal crops is a long‐sought objective; however, no successful modification of cereal crops showing increased BNF has been reported. Here, we described a novel approach in which rice plants were modified ... ...

Abstract	Improving biological nitrogen fixation (BNF) in cereal crops is a long‐sought objective; however, no successful modification of cereal crops showing increased BNF has been reported. Here, we described a novel approach in which rice plants were modified to increase the production of compounds that stimulated biofilm formation in soil diazotrophic bacteria, promoted bacterial colonization of plant tissues and improved BNF with increased grain yield at limiting soil nitrogen contents. We first used a chemical screening to identify plant‐produced compounds that induced biofilm formation in nitrogen‐fixing bacteria and demonstrated that apigenin and other flavones induced BNF. We then used CRISPR‐based gene editing targeting apigenin breakdown in rice, increasing plant apigenin contents and apigenin root exudation. When grown at limiting soil nitrogen conditions, modified rice plants displayed increased grain yield. Biofilm production also modified the root microbiome structure, favouring the enrichment of diazotrophic bacteria recruitment. Our results support the manipulation of the flavone biosynthetic pathway as a feasible strategy for the induction of biological nitrogen fixation in cereals and a reduction in the use of inorganic nitrogen fertilizers.
Keywords	apigenin ; bacterial colonization ; biofilm ; biosynthesis ; biotechnology ; exudation ; genes ; genetic engineering ; grain yield ; microbiome ; nitrogen ; nitrogen fixation ; rice ; soil
Language	English
Dates of publication	2022-11
Size	p. 2135-2148.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	2136367-5
ISSN	1467-7652 ; 1467-7644
ISSN (online)	1467-7652
ISSN	1467-7644
DOI	10.1111/pbi.13894
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Contextual Determinants of Time to Surgery for Patients With Hip Fracture.

Welch, Jessica M / Gomez, Giselle I / Chatterjee, Maya / Shapiro, Lauren M / Morris, Arden M / Gardner, Michael J / Sox-Harris, Alex H S / Baker, Laurence / Koltsov, Jayme C B / Castillo, Tiffany / Giori, Nicholas / Salyapongse, Aaron / Kamal, Robin N

JAMA network open

2023 Volume 6, Issue 12, Page(s) e2347834

Abstract: Importance: Surgery within 24 hours after a hip fracture improves patient morbidity and mortality, which has led some hospitals to launch quality improvement programs (eg, targeted resource management, documented protocols) to address delays. However, ... ...

Abstract	Importance: Surgery within 24 hours after a hip fracture improves patient morbidity and mortality, which has led some hospitals to launch quality improvement programs (eg, targeted resource management, documented protocols) to address delays. However, these programs have had mixed results in terms of decreased time to surgery (TTS), identifying an opportunity to improve the effectiveness of interventions. Objective: To identify the contextual determinants (site-specific barriers and facilitators) of TTS for patients with hip fracture across diverse hospitals. Design, setting, and participants: This qualitative mixed-methods study used an exploratory sequential design that comprised 2 phases. In phase 1, qualitative semistructured interviews were conducted with stakeholders involved in hip fracture care (orthopedic surgeons or residents, emergency medicine physicians, hospitalists, anesthesiologists, nurses, and clinical or support staff) at 4 hospitals with differing financial, operational, and educational structures. Interviews were completed between May and July 2021. In phase 2, a quantitative survey assessing contextual determinants of TTS within 24 hours for adult patients with hip fracture was completed by orthopedic surgeon leaders representing 23 diverse hospitals across the US between May and July 2022. Data analysis was performed in August 2022. Main outcomes and measures: Thematic analysis of the interviews identified themes of contextual determinants of TTS within 24 hours for patients with hip fracture. The emergent contextual determinants were then measured across multiple hospitals, and frequency and distribution were used to assess associations between determinants and various hospital characteristics (eg, setting, number of beds). Results: A total of 34 stakeholders were interviewed in phase 1, and 23 surveys were completed in phase 2. More than half of respondents in both phases were men (19 [56%] and 18 [78%], respectively). The following 4 themes of contextual determinants of TTS within 24 hours were identified: availability, care coordination, improvement climate, and incentive structure. Within these themes, the most commonly identified determinants across the various hospitals involved operating room availability, a formal comanagement system between orthopedics and medicine or geriatrics, the presence of a physician champion focused on timely surgery, and a program that facilitates improvement work. Conclusions and relevance: In this study, contextual determinants of TTS within 24 hours for patients with hip fracture varied across hospital sites and could not be generalized across various hospital contexts because no 2 sites had identical profiles. As such, these findings suggest that guidance on strategies for improving TTS should be based on the contextual determinants unique to each hospital.
MeSH term(s)	Adult ; Male ; Humans ; Female ; Hip Fractures/surgery ; Hospitals ; Anesthesiologists ; Climate ; Emergency Medicine
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.47834
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