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  1. Article: Decreased incidence of Kawasaki disease in South Korea during the SARS-CoV-2 pandemic.

    Oh, Kyung Jin / Lee, Sang-Yun

    Frontiers in pediatrics

    2024  Volume 12, Page(s) 1307931

    Abstract: Purpose: Analyzing Kawasaki disease epidemiology during the SARS-CoV-2 pandemic in South Korea using 2012-2020 National Health Insurance Service data.: Methods: The incidence of Kawasaki disease for 2012-2020 was investigated to identify changes in ... ...

    Abstract Purpose: Analyzing Kawasaki disease epidemiology during the SARS-CoV-2 pandemic in South Korea using 2012-2020 National Health Insurance Service data.
    Methods: The incidence of Kawasaki disease for 2012-2020 was investigated to identify changes in incidence after the start of the pandemic. National Health Insurance Service data from the Republic of Korea were used. Kawasaki disease was defined based on the International Statistical Classification of Diseases and Related Health Problems, the Tenth Revision diagnostic code (M30.3), and the intravenous immunoglobulin prescription code. Prescription history was collected for the following medications: intravenous immunoglobulin, aspirin, corticosteroids, tumor necrosis factor-α antagonist, clopidogrel, and anticoagulation drugs.
    Results: The Kawasaki disease incidence per 100,000 individuals younger than 5 years was 238.9, 230.0, and 141.2 in 2018, 2019, and 2020, respectively. Regarding the incidence from 2012 to 2020, it was the highest in 2018 and decreased to 141.2 (
    Conclusion: After the start of the pandemic, the Kawasaki disease incidence decreased, and the percentage of patients with Kawasaki disease aged <1 year increased. These findings provide support for the hypothesis suggesting an infectious trigger in Kawasaki disease.
    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2024.1307931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Author Correction: Optimization of 3D-aggregated spheroid model (3D-ASM) for selecting high efficacy drugs.

    Lee, Sang-Yun / Hwang, Hyun Ju / Lee, Dong Woo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 5519

    Language English
    Publishing date 2023-04-04
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-32198-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Author Correction

    Sang‑Yun Lee / Hyun Ju Hwang / Dong Woo Lee

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    Optimization of 3D-aggregated spheroid model (3D-ASM) for selecting high efficacy drugs

    2023  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction to Cell Proliferation Receptor-Enhanced 3D High-Throughput Screening Model for Optimized Drug Efficacy Evaluation in Breast Cancer Cells.

    Lee, Sang-Yun / Hwang, Hyun Ju / Ku, Bosung / Lee, Dong Woo

    Analytical chemistry

    2023  Volume 95, Issue 15, Page(s) 6476

    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c00706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: WITHDRAWN: In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models.

    Lee, Sang-Yun / Koo, In-Seong / Hwang, Hyun Ju / Lee, Dong Woo

    SLAS discovery : advancing life sciences R & D

    2023  Volume 29, Issue 1F, Page(s) 131

    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Retraction of Publication
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1016/j.slasd.2023.12.003
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  6. Article: Facile Fabrication of TiO

    Lee, Jin-Hyoek / Jeong, Sang-Yun / Son, Young-Don / Lee, Sang-Wha

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 9

    Abstract: TiO₂ semiconductors exhibit a low catalytic activity level under visible light because of their large band gap and fast recombination of electron-hole pairs. This paper reports the simple fabrication of a 0D/2D heterojunction photocatalyst by anchoring ... ...

    Abstract TiO₂ semiconductors exhibit a low catalytic activity level under visible light because of their large band gap and fast recombination of electron-hole pairs. This paper reports the simple fabrication of a 0D/2D heterojunction photocatalyst by anchoring TiO₂ quantum dots (QDs) on graphite-like C₃N₄ (g-C₃N₄) nanosheets (NSs); the photocatalyst is denoted as TiO₂ QDs@g-C₃N₄. The nanocomposite was characterized via analytical instruments, such as powder X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, t orange (MO) under solar light were compared. The TiO₂ QDs@g-C₃N₄ photocatalyst exhibited 95.57% MO degradation efficiency and ~3.3-fold and 5.7-fold higher activity level than those of TiO₂ QDs and g-C₃N₄ NSs, respectively. Zero-dimensional/two-dimensional heterojunction formation with a staggered electronic structure leads to the efficient separation of photogenerated charge carriers via a Z-scheme pathway, which significantly accelerates photocatalysis under solar light. This study provides a facile synthetic method for the rational design of 0D/2D heterojunction nanocomposites with enhanced solar-driven catalytic activity.
    Language English
    Publishing date 2023-05-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13091565
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  7. Article ; Online: In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models.

    Lee, Sang-Yun / Koo, In-Seong / Hwang, Hyun Ju / Lee, Dong Woo

    SLAS discovery : advancing life sciences R & D

    2023  Volume 28, Issue 4, Page(s) 119–137

    Abstract: Three-dimensional (3D) cell culture technology has been steadily studied since the 1990's due to its superior biocompatibility compared to the conventional two-dimensional (2D) cell culture technology, and has recently developed into an organoid culture ... ...

    Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the 1990's due to its superior biocompatibility compared to the conventional two-dimensional (2D) cell culture technology, and has recently developed into an organoid culture technology that further improved biocompatibility. Since the 3D culture of human cell lines in artificial scaffolds was demonstrated in the early 90's, 3D cell culture technology has been actively developed owing to various needs in the areas of disease research, precision medicine, new drug development, and some of these technologies have been commercialized. In particular, 3D cell culture technology is actively being applied and utilized in drug development and cancer-related precision medicine research. Drug development is a long and expensive process that involves multiple steps-from target identification to lead discovery and optimization, preclinical studies, and clinical trials for approval for clinical use. Cancer ranks first among life-threatening diseases owing to intra-tumoral heterogeneity associated with metastasis, recurrence, and treatment resistance, ultimately contributing to treatment failure and adverse prognoses. Therefore, there is an urgent need for the development of efficient drugs using 3D cell culture techniques that can closely mimic in vivo cellular environments and customized tumor models that faithfully represent the tumor heterogeneity of individual patients. This review discusses 3D cell culture technology focusing on research trends, commercialization status, and expected effects developed until recently. We aim to summarize the great potential of 3D cell culture technology and contribute to expanding the base of this technology.
    MeSH term(s) Humans ; Cell Culture Techniques/methods ; Neoplasms/drug therapy ; Neoplasms/pathology ; Organoids ; Cell Line
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2885123-7
    ISSN 2472-5560 ; 2472-5552
    ISSN (online) 2472-5560
    ISSN 2472-5552
    DOI 10.1016/j.slasd.2023.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4911: Show issues Location:
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  8. Article ; Online: Cardiogenic shock

    Sungkyu Cho / Sang-Yun Lee

    Pediatric Emergency Medicine Journal, Vol 7, Iss 2, Pp 61-

    2020  Volume 69

    Abstract: Cardiogenic shock is an acute circulatory failure due to compromised myocardial contractility associated with congenital heart diseases and cardiomyopathies, such as myocarditis. In this article, the authors present a 3-step overview of cardiogenic shock ...

    Abstract Cardiogenic shock is an acute circulatory failure due to compromised myocardial contractility associated with congenital heart diseases and cardiomyopathies, such as myocarditis. In this article, the authors present a 3-step overview of cardiogenic shock diagnosis and management to restore tissue oxygen delivery. The first step is early recognition of nonspecific signs of the shock. The second step is medical management, monitoring, and repeated assessment. In addition to conventional parameters, biomarkers may be useful to monitor the shock. The final step is mechanical circulatory support, such as ventricular assist devices, for children with the refractory shock. We also briefly describe the shock in multisystem inflammatory syndrome in children with coronavirus disease 2019.
    Keywords cardiovascular system ; child ; extracorporeal membrane oxygenation ; heart-assist devices ; shock ; cardiogenic ; Medicine ; R
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Korean Society of Pediatric Emergency Medicine
    Document type Article ; Online
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  9. Article ; Online: Optimization of 3D-aggregated spheroid model (3D-ASM) for selecting high efficacy drugs.

    Lee, Sang-Yun / Hwang, Hyun Ju / Lee, Dong Woo

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 18937

    Abstract: Various three-dimensional (3D) cell culture methods have been developed to implement tumor models similar to in vivo. However, the conventional 3D cell culture method has limitations such as difficulty in using an extracellular matrix (ECM), low ... ...

    Abstract Various three-dimensional (3D) cell culture methods have been developed to implement tumor models similar to in vivo. However, the conventional 3D cell culture method has limitations such as difficulty in using an extracellular matrix (ECM), low experimental reproducibility, complex 3D cell culture protocol, and difficulty in applying to high array plates such as 96- or 384-plates. Therefore, detailed protocols related to robust 3D-aggregated spheroid model (3D-ASM) production were optimized and proposed. A specially designed wet chamber was used to implement 3D-ASM using the hepatocellular carcinoma (HCC) cell lines, and the conditions were established for the icing step to aggregate the cells in one place and optimized ECM gelation step. Immunofluorescence (IF) staining is mainly used to simultaneously analyze drug efficacy and changes in drug-target biomarkers. By applying the IF staining method to the 3D-ASM model, confocal microscopy imaging and 3D deconvolution image analysis were also successfully performed. Through a comparative study of drug response with conventional 2D-high throughput screening (HTS), the 3D-HTS showed a more comprehensive range of drug efficacy analyses for HCC cell lines and enabled selective drug efficacy analysis for the FDA-approved drug sorafenib. This suggests that increased drug resistance under 3D-HTS conditions does not reduce the analytical discrimination of drug efficacy, also drug efficacy can be analyzed more selectively compared to the conventional 2D-HTS assay. Therefore, the 3D-HTS-based drug efficacy analysis method using an automated 3D-cell spotter/scanner, 384-pillar plate/wet chamber, and the proposed 3D-ASM fabrication protocol is a very suitable platform for analyzing target drug efficacy in HCC cells.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Reproducibility of Results ; Liver Neoplasms/drug therapy ; High-Throughput Screening Assays/methods ; Cell Culture Techniques/methods ; Spheroids, Cellular ; Cell Line, Tumor
    Language English
    Publishing date 2022-11-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-23474-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Effects of Fermented

    Kim, Young-Seon / Han, Ji-Hye / Lim, Chang-Hoon / Fang, Xue-Quan / Jang, Hyeock-Soon / Lee, Sang-Yun / Yim, Woo-Jong / Lim, Ji-Hong

    Nutrients

    2024  Volume 16, Issue 2

    Abstract: Plant extract fermentation is widely employed to enhance the nutritional and pharmaceutical value of functional foods. ...

    Abstract Plant extract fermentation is widely employed to enhance the nutritional and pharmaceutical value of functional foods.
    MeSH term(s) Mice ; Animals ; Fallopia japonica ; Emodin/metabolism ; Resveratrol/pharmacology ; Resveratrol/metabolism ; Anthraquinones ; Muscle, Skeletal/metabolism
    Chemical Substances Emodin (KA46RNI6HN) ; Resveratrol (Q369O8926L) ; Anthraquinones
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16020305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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