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  1. Article ; Online: Oxa-Michael/Ugi-Smiles cascade reaction with α,β-unsaturated aldehydes

    Aubrey Thessing / Robert Ayres / Joshua Jones / Haleigh Bauer / Maryam Zangi / Sarah B. Luesse

    Results in Chemistry, Vol 4, Iss , Pp 100416- (2022)

    2022  

    Abstract: ... event involving an oxa-Michael conjugate addition and an Ugi-Smiles multicomponent reaction. Five bonds ...

    Abstract Use of α,β-unsaturated aldehydes as components in Ugi-Smiles couplings of 2-nitrophenol with alkyl isocyanides and primary amines provides ready access to γ-alkoxy substituted amides when performed in the presence of alcoholic solvents. The observed five component coupling forms these adducts via a cascade event involving an oxa-Michael conjugate addition and an Ugi-Smiles multicomponent reaction. Five bonds and two stereocenters are generated in this diastereoselective formation of γ-alkoxy substituted amides in moderate to good yields.
    Keywords Ugi-Smiles ; Oxa-Michael ; Multicomponent reaction ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Thesis ; Online: Investigation of the Reaction Pathway for an oxy-Michael Ugi-Smiles Process

    Bauer, Haleigh

    2019  

    Abstract: ... Michael Ugi-Smiles process. The observed coupling occurs in competition with the expected Ugi-Smiles ...

    Abstract Multicomponent coupling reactions (MCRs) are highly atom-efficient, one-pot reactions that combine three or more starting materials to produce several new bonds. The use of MCRs shortens the number of linear steps in synthetic routes to complex, biologically-active molecules for pharmaceutical development and drug discovery efforts. To identify and refine a drug candidate, libraries of related molecules are often prepared and structure activity relationships (SARs) are examined; when MCRs are included in the synthetic plan, they provide built-in component variation opportunities for diversification. The Ugi-Smiles reaction is a four-component coupling (4CC) that utilizes an amine, isocyanide, phenol, and aldehyde in a one-pot process. It was recently discovered that utilizing a conjugated aldehyde and an alcohol solvent in this reaction resulted in a five-component coupling, which can formally be described as an oxy-Michael Ugi-Smiles process. The observed coupling occurs in competition with the expected Ugi-Smiles reaction. This work describes efforts focused on modifying reaction temperature, alcohol and isocyanide components, and exploring the reaction pathway to discover when the alcoholic solvent participates in the reaction and adds to the Ugi-Smiles scaffold.
    Keywords Organic chemistry|Chemistry
    Subject code 540
    Language ENG
    Publishing date 2019-01-01 00:00:01.0
    Publisher Southern Illinois University at Edwardsville
    Publishing country us
    Document type Thesis ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: "Für die Erforschung psychischer Störungen bedarf es konzentrierter und vernetzter Forschungsanstrengungen". Interview mit Professor Michael Bauer, Sprecher des Forschungsnetzes zu psychischen Erkrankungen

    Bauer, Michael

    Aktuelle Ergebnisse der Gesundheitsforschung

    2015  Volume 74, Issue -, Page(s) 5

    Language German
    Document type Article
    ZDB-ID 2629461-8
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6360: Show issues Location:
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  4. Book ; Conference proceedings: Johann Michael Fischer

    Bauer, Anna / Dischinger, Gabriele / Fischer, Johann Michael

    : 1692 - 1766

    1997  

    Event/congress Johann-Michael-Fischer-Ausstellung (1995, Burglengenfeld)
    Author's details hrsg. von Gabriele Dischinger
    Keywords Architektur
    Language German
    Size 366 S, Ill., graph. Darst
    Publisher Wasmuth
    Publishing place Tübingen
    Document type Book ; Conference proceedings
    Note Literaturverz. S. 354 - 355
    ISBN 3803001757 ; 3803001765 ; 9783803001757 ; 9783803001764
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book ; Conference proceedings: Johann Michael Fischer

    Bauer, Anna / Dischinger, Gabriele / Fischer, Johann Michael

    : 1692 - 1766

    1997  

    Event/congress Johann-Michael-Fischer-Ausstellung (1995, Burglengenfeld)
    Author's details hrsg. von Gabriele Dischinger
    Keywords Architektur
    Language German
    Size 366 S, Ill., graph. Darst
    Publisher Wasmuth
    Publishing place Tübingen
    Document type Book ; Conference proceedings
    Note Literaturverz. S. 354 - 355
    ISBN 3803001757 ; 3803001765 ; 9783803001757 ; 9783803001764
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  6. Book: Geriatrie

    Bauer, Jürgen M. / Becker, Clemens / Denkinger, Michael D. / Wirth, Rainer

    das gesamte Spektrum der Altersmedizin für Klinik und Praxis

    2024  

    Author's details Jürgen M. Bauer, Clemens Becker, Michael Denkinger, Rainer Wirth (Hrsg.)
    Keywords Alterskrankheit ; Geriatrie
    Subject Altersmedizin ; Altersheilkunde ; Alter ; Alterserkrankung
    Language German
    Size 942 Seiten, Illustrationen, Diagramme
    Publisher Kohlhammer
    Publishing place Stuttgart
    Publishing country Germany
    Document type Book
    HBZ-ID HT030725012
    ISBN 978-3-17-041794-6 ; 9783170417953 ; 9783170417960 ; 3-17-041794-0 ; 3170417959 ; 3170417967
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    not available for loan Bestellt

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  7. Article: Bipolare Störungen - bestehende Grenzen überwinden. Interview mit Prof. Michael Bauer und Prof. Peter Brieger

    Bauer, Michael / Brieger, Peter

    Der Neurologe & Psychiater

    2010  Volume 11, Issue 9, Page(s) 12

    Language German
    Document type Article
    ZDB-ID 2036795-8
    ISSN 1616-2455
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5588: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Thesis: Histopathologische und immunhistochemische Untersuchungen zum Vorkommen melanozytärer Proliferate in Lymphknoten und deren klinische Bedeutung

    Bauer, Ortrun / Tronnier, Michael

    2022  

    Institution Medizinische Hochschule Hannover
    HELIOS Klinikum Hildesheim
    Author's details vorgelegt von Ortrun Bauer ; aus der Klinik für Dermatologie und Venerologie des Helios Klinikum Hildesheim, Akademisches Lehrkrankenhaus der Medizinischen Hochschule Hannover ; Betreuer der Arbeit: Prof. Dr. med. Michael Hagen Tronnier
    Language German
    Size 92 Blätter, Illustrationen, Diagramme
    Publishing place Hannover
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Medizinische Hochschule Hannover, 2023
    HBZ-ID HT030666800
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2024 E 444 order for loan Magazin

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  9. Article: Investigations into the metal species of the homogeneous iron(III) catalyzed Michael addition reactions.

    Bauer, Matthias / Kauf, Thomas / Christoffers, Jens / Bertagnolli, Helmut

    Physical chemistry chemical physics : PCCP

    2005  Volume 7, Issue 13, Page(s) 2664–2670

    Abstract: An investigation into the species formed in the first step of the solvent free homogeneous Michael ...

    Abstract An investigation into the species formed in the first step of the solvent free homogeneous Michael reaction of alpha,beta-unsaturated ketones with 2-oxocyclopentanecarboxylate (1) is presented. This reaction is catalyzed by FeCl(3).6H(2)O (2) and Fe(ClO(4))(3).9H(2)O (3). EXAFS, XANES, Raman and UV-Vis studies were carried out to explain the experimentally found higher catalytic activity of Fe(ClO(4))(3).9H(2)O (3) compared to FeCl(3).6H(2)O (2). A very intense pre-edge peak is found for a 1.6 mol% solution of FeCl(3).6H(2)O (2) in 1, suggesting a tetrachloroferrate(III) compound to be present in this solution. This is proved by UV-Vis and Raman spectroscopy. The counterion of this anionic complex is an octahedral [Fe(III)(1-H)(2)(H2O2)](+) complex with two deprotonated 2-oxocyclopentanecarboxylate (1) as the chelating ligand, (1-H)(-), as suggested by the examination of the XANES region, the obtained coordination numbers from the EXAFS analysis and by UV-Vis and Raman spectroscopies. In summary, the anion-cation species [Fe(III)Cl(4)](-)[Fe(III)(-H)(2)(H2O2)](+) is formed with FeCl(3).6H(2)O (2), whereas in the case of Fe(ClO(4))(3).9H(2)O (3) XAFS, Raman and UV-Vis investigations suggest the presence of a complex of the form [Fe(III)(1-H)(2)(H2O2)](+)[ClO(4)](-). The obtained results are discussed to explain the reduced catalytic activity of FeCl(3).6H(2)O (2) in comparison to Fe(ClO(4))(3).9H(2)O (3).
    MeSH term(s) Catalysis ; Cyclopentanes/chemical synthesis ; Cyclopentanes/chemistry ; Esters/chemical synthesis ; Esters/chemistry ; Ferric Compounds/chemistry ; Ketones/chemical synthesis ; Ketones/chemistry ; Molecular Structure ; Spectrum Analysis/methods ; Surface Properties ; X-Rays
    Chemical Substances Cyclopentanes ; Esters ; Ferric Compounds ; Ketones ; ethyl 2-oxocyclopentanecarboxylate
    Language English
    Publishing date 2005-07-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/b501204j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Conference proceedings: Michael Schoenholtz

    Bauer, Uwe / Krimmel, Bernd / Schoenholtz, Michael

    Plastik, Zeichnung, Graphik ; Mathildenhöhe, Darmstadt, 20.3. - 1.5.77 ; Wilhelm-Lehmbruck-Museum, Duisburg, 19.7. - 4.9.77

    1977  

    Institution Institut Mathildenhöhe
    Wilhelm-Lehmbruck-Museum
    Event/congress Ausstellung Michael Schoenholtz (1977.03.20-05.01, Darmstadt) ; Ausstellung Michael Schoenholtz (1977.07.19-09.04, Duisburg)
    Author's details [Katalog u. Plakat: Bernd Krimmel. Bearb.: Uwe Bauer ...]
    Language German
    Size XXVIII, 142 S., überw. Ill.
    Publisher Mathildenhöhe u.a.
    Publishing place Darmstadt
    Document type Book ; Conference proceedings
    Database Former special subject collection: coastal and deep sea fishing

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