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Article ; Online: BET 2: Pre-hospital finger thoracostomy in patients with chest trauma.

Jodie, Pritchard / Kerstin, Hogg

2017 Volume 34, Issue 6, Page(s) 419

Abstract: A short cut review was carried out to see if 'finger' thoracostomy is a safe and effective method of treating a tension pneumothorax in a pre-hospital setting. Five relevant papers were found looking at this technique in the pre-hospital setting. The ... ...

Abstract	A short cut review was carried out to see if 'finger' thoracostomy is a safe and effective method of treating a tension pneumothorax in a pre-hospital setting. Five relevant papers were found looking at this technique in the pre-hospital setting. The author, date and country of publication, patient group studied, study type, relevant outcomes, results study weaknesses of these papers are tabulated. This technique appears to be safe and effective when performed by trained physicians in a pre-hospital setting.
Language	English
Publishing date	2017-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2017-206808.2
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Article ; Online: BET1: Pre-hospital finger thoracostomy in patients with traumatic cardiac arrest.

Jodie, Pritchard / Kerstin, Hogg

Emergency medicine journal : EMJ

2017 Volume 34, Issue 6, Page(s) 417–418

Abstract: A short cut review was carried out to see if 'finger' thoracostomy was a safe and effective procedure to use in the pre-hospital setting in patients with traumatic cardiac arrest. Three relevant papers were found describing the use of this technique in ... ...

Abstract	A short cut review was carried out to see if 'finger' thoracostomy was a safe and effective procedure to use in the pre-hospital setting in patients with traumatic cardiac arrest. Three relevant papers were found describing the use of this technique in the pre-hospital setting. The author, date and country of publication, patient group studied, study type, relevant outcomes, results study weaknesses of these papers are tabulated. Finger thoracostomy appears to be an acceptable and effective technique for trained physicians in the pre-hospital setting.
Language	English
Publishing date	2017-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2017-206808.1
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Article ; Online: BET 2: Acupuncture and fibromyalgia.

Goldie, Laura / Hogg, Kerstin

Emergency medicine journal : EMJ

2016 Volume 33, Issue 10, Page(s) 743–744

Abstract: A shortcut review was carried out to see if acupuncture is an effective pain treatment in fibromyalgia. One Cochrane review and five subsequent papers and conference abstracts were identified. There are no large studies addressing this question and ... ...

Abstract	A shortcut review was carried out to see if acupuncture is an effective pain treatment in fibromyalgia. One Cochrane review and five subsequent papers and conference abstracts were identified. There are no large studies addressing this question and acupuncture has been compared with many different treatment modalities. Acupuncture may be a valid treatment for pain in fibromyalgia, but more research is required to validate this.
MeSH term(s)	Acupuncture Therapy ; Adult ; Fibromyalgia/therapy ; Humans ; Pain Management
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2016-206204.2
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Article ; Online: Obstacle course runs: review of acquired injuries and illnesses at a series of Canadian events (RACE).

Hawley, Alana / Mercuri, Mathew / Hogg, Kerstin / Hanel, Erich

Emergency medicine journal : EMJ

2017 Volume 34, Issue 3, Page(s) 170–174

Abstract: Background: The growing popularity of obstacle course runs (OCRs) has led to significant concerns regarding their safety. The influx of injuries and illnesses in rural areas where OCRs are often held can impose a large burden on emergency medical ... ...

Abstract	Background: The growing popularity of obstacle course runs (OCRs) has led to significant concerns regarding their safety. The influx of injuries and illnesses in rural areas where OCRs are often held can impose a large burden on emergency medical services (EMS) and local EDs. Literature concerning the safety of these events is minimal and mostly consists of media reports. We sought to characterise the injury and illness profile of OCRs and the level of medical care required. Methods: This study analysed OCR events occurring in eight locations across Canada from May to August 2015 (total 45 285 participants). Data were extracted from event medical charts of patients presenting to the onsite medical team, including injury or illness type, onsite treatment and disposition. Results: There were 557 race participants treated at eight OCR events (1.2% of all participants). There were 609 medical complaints in total. Three quarters of injuries were musculoskeletal in nature. Eighty-nine per cent returned to the event with no need for further medical care. The majority of treatments were completed with first aid and basic medical equipment. Eleven patients (2% of patients) required transfer to hospital by EMS for presentations including fracture, dislocation, head injury, chest pain, fall from height, and abdominal pain. Conclusions: We found that 1.2% of race participants presented to onsite medical services. The majority of complaints were minor and musculoskeletal in nature. Only 2% of those treated were transferred to hospital through EMS. This is consistent with other types of mass gathering events.
MeSH term(s)	Adolescent ; Adult ; Athletic Injuries/epidemiology ; Canada ; Female ; Humans ; Male ; Middle Aged ; Running/injuries ; Running/statistics & numerical data ; Sports/statistics & numerical data ; Sports/trends
Language	English
Publishing date	2017-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2016-206012
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Article ; Online: Concentrations, Stability, and Isolation of the Furan Fatty Acid 9-(3-Methyl-5-pentylfuran-2-yl)-nonanoic Acid from Disposable Latex Gloves.

Müller, Marco / Hogg, Melanie / Ulms, Kerstin / Vetter, Walter

Journal of agricultural and food chemistry

2017 Volume 65, Issue 36, Page(s) 7919–7925

Abstract: Because of their antioxidant properties, furan fatty acids (furan-FAs) are valuable minor compounds with a widespread occurrence in all living matter. Unfortunately, pure standards are not readily available, because they usually contribute only 1% to the ...

Abstract	Because of their antioxidant properties, furan fatty acids (furan-FAs) are valuable minor compounds with a widespread occurrence in all living matter. Unfortunately, pure standards are not readily available, because they usually contribute only 1% to the lipid fraction. A known exception of this is the milky fluid of Hevea brasiliensis, commonly known as latex, in which the furan-FA 9-(3-methyl-5-pentylfuran-2-yl)-nonanoic acid (9M5) contributes about 90% to the triacylglycerides. In this study, we investigated the content of 9M5 in 30 different disposable latex gloves, which ranged from 0.7 to 8.2 mg/g of glove. The light degradability of 9M5 in latex gloves was investigated, and different amounts of 9M5 in disposable latex gloves were attributed to varying exposure time to light. Additionally, over 100 mg of the methyl or ethyl ester of 9M5 (purity of >98%) could be extracted from disposable latex gloves, employing cold extraction and silver ion chromatography. With this method, standards for the quantitation of furan-FAs are obtained easily and rapidly in all laboratories.
MeSH term(s)	Fatty Acids/chemistry ; Furans/chemistry ; Gloves, Protective ; Hevea/chemistry ; Latex/chemistry
Chemical Substances	Fatty Acids ; Furans ; Latex ; pelargonic acid (97SEH7577T) ; furan (UC0XV6A8N9)
Language	English
Publishing date	2017-09-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.7b02444
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Zs.A 1172: Show issues

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Article ; Online: Direct oral anticoagulants: a practical guide for the emergency physician.

Hogg, Kerstin / Panag, Ajit / Worster, Andrew / Thachil, Jecko

European journal of emergency medicine : official journal of the European Society for Emergency Medicine

2016 Volume 23, Issue 5, Page(s) 330–336

Abstract: The direct oral anticoagulants (DOACs) are the mainstay for stroke prophylaxis in nonvalvular atrial fibrillation and treatment of acute venous thrombosis. They are attractive alternatives to warfarin because of their efficacy, ease of prescription and ... ...

Abstract	The direct oral anticoagulants (DOACs) are the mainstay for stroke prophylaxis in nonvalvular atrial fibrillation and treatment of acute venous thrombosis. They are attractive alternatives to warfarin because of their efficacy, ease of prescription and safety profile. The emergency department has gained expertise in the management of DOAC bleeding complications, but has been slower to adopt prescription decisions. Emergency clinicians are in a unique position to identify patients who are prescribed DOACs and are at high risk of impending bleeding. This is a practical guide for the emergency clinician on how to prescribe DOACs, the red flags for DOAC patients in the emergency department and advances in the treatment of bleeding.
MeSH term(s)	Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Atrial Fibrillation/complications ; Emergency Service, Hospital ; Hemorrhage/chemically induced ; Hemorrhage/prevention & control ; Humans ; Stroke/etiology ; Stroke/prevention & control
Chemical Substances	Anticoagulants
Language	English
Publishing date	2016-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1233544-7
ISSN	1473-5695 ; 0969-9546
ISSN (online)	1473-5695
ISSN	0969-9546
DOI	10.1097/MEJ.0000000000000400
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Zs.A 4264: Show issues

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Article: Prevention and treatment of venous thromboembolism in patients with cancer.

Hogg, Kerstin / Carrier, Marc

Therapeutic advances in hematology

2013 Volume 3, Issue 1, Page(s) 45–58

Abstract: Venous thromboembolism (VTE) is the second leading cause of death and a major cause of morbidity in patients with cancer. Pharmacologic thromboprophylaxis is recommended in all hospitalized cancer patients without contraindications to anticoagulants. The ...

Abstract	Venous thromboembolism (VTE) is the second leading cause of death and a major cause of morbidity in patients with cancer. Pharmacologic thromboprophylaxis is recommended in all hospitalized cancer patients without contraindications to anticoagulants. The role of thromboprophylaxis in outpatients undergoing chemotherapy is less certain because of the diversity of the tumor types and their associated risks of VTE and bleeding. Thromboprophylaxis should only be considered in patients at high risk for VTE. Cancer patients with a newly diagnosed VTE should be preferably treated with low-molecular-weight heparin for a minimum of 3-6 months. Treatment duration should be individualized based on the clinical status and stage of the cancer, the risk of recurrent VTE, the risk of bleeding, and personal preference of the patient. Further research is required to assess the role of the new oral anticoagulants (direct Xa and thrombin inhibitors) for this high-risk population.
Language	English
Publishing date	2013-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2585183-4
ISSN	2040-6215 ; 2040-6207
ISSN (online)	2040-6215
ISSN	2040-6207
DOI	10.1177/2040620711422590
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: Which form of aspirin is the fastest to inhibit platelet aggregation in emergency department patients with non-ST segment elevation myocardial infarction?

Morris, Niall / Rigg, Kaitlynn / Hogg, Kerstin

Emergency medicine journal : EMJ

2015 Volume 32, Issue 10, Page(s) 823–826

Abstract: A short cut review was carried out to establish whether, in patients with suspected acute coronary syndromes presenting to the emergency department, what form of aspirin has the most rapid onset of action. Papers comparing the speed of onset of chewable ... ...

Abstract	A short cut review was carried out to establish whether, in patients with suspected acute coronary syndromes presenting to the emergency department, what form of aspirin has the most rapid onset of action. Papers comparing the speed of onset of chewable aspirin, or soluble aspirin or solid aspirin were included. This summarises all three parts of a combined best evidence topic report (BET). The clinical bottom line is that chewable aspirin may be faster than soluble aspirin at decreasing the amount of time to achieve platelet inhibition in a patient. Soluble aspirin is faster than whole solid aspirin, which is faster than enteric-coated aspirin.
MeSH term(s)	Acute Coronary Syndrome/drug therapy ; Aspirin/administration & dosage ; Emergency Service, Hospital ; Evidence-Based Emergency Medicine ; Humans ; Myocardial Infarction/drug therapy ; Platelet Aggregation Inhibitors/administration & dosage
Chemical Substances	Platelet Aggregation Inhibitors ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2015-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2015-205240.1
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Article ; Online: Should we be looking for and treating isolated calf vein thrombosis?

Horner, Daniel / Hogg, Kerstin / Body, Richard

Emergency medicine journal : EMJ

2015 Volume 33, Issue 6, Page(s) 431–437

Abstract: Management of isolated calf deep vein thrombosis is an area of significant international debate and variable clinical practice. Both therapeutic anticoagulation and conservative management carry risk. As clinical care of suspected and confirmed venous ... ...

Abstract	Management of isolated calf deep vein thrombosis is an area of significant international debate and variable clinical practice. Both therapeutic anticoagulation and conservative management carry risk. As clinical care of suspected and confirmed venous thromboembolic disease increasingly becomes the remit of emergency medicine, complex decisions are left to practising clinicians at the front door. We aim to provide a contemporary overview of recent evidence on this topic and associated challenges facing clinicians. Given the lack of high-level evidence, we present this work as a narrative review, based on structured literature review and expert opinion. A decision to manage calf thrombosis is principally dependent on the risk of complications without treatment balanced against the risks of therapeutic anticoagulation. Estimates of the former risks taken from systematic review, meta-analysis, observational cohort and recent pilot trial evidence include proximal propagation 7%-10%, pulmonary embolism 2%-3% and death <1%. Fatal bleeding with therapeutic anticoagulation stands at <0.5%, and major bleeding at approximately 2%. Estimates of haemorrhagic risk are based on robust data from large prospective management studies of venous thromboembolic disease; the risks of untreated calf deep vein thrombosis are based on small cohorts and therefore less exact. Pending further trial evidence, these risks should be discussed with patients openly, in the context of personal preference and shared decision-making. Anticoagulation may maximally benefit those patients with extensive and/or symptomatic disease or those with higher risk for complication (unprovoked, cancer-associated or pregnancy).
MeSH term(s)	Anticoagulants/therapeutic use ; Decision Making ; Humans ; Leg/blood supply ; Venous Thrombosis/complications ; Venous Thrombosis/drug therapy
Chemical Substances	Anticoagulants
Language	English
Publishing date	2015-06-22
Publishing country	England
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2014-204230
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Article ; Online: Overview of the new oral anticoagulants: opportunities and challenges.

Yeh, Calvin H / Hogg, Kerstin / Weitz, Jeffrey I

Arteriosclerosis, thrombosis, and vascular biology

2015 Volume 35, Issue 5, Page(s) 1056–1065

Abstract: The non-vitamin K antagonist oral anticoagulants (NOACs) are replacing warfarin for many indications. These agents include dabigatran, which inhibits thrombin, and rivaroxaban, apixaban, and edoxaban, which inhibit factor Xa. All 4 agents are licensed in ...

Abstract	The non-vitamin K antagonist oral anticoagulants (NOACs) are replacing warfarin for many indications. These agents include dabigatran, which inhibits thrombin, and rivaroxaban, apixaban, and edoxaban, which inhibit factor Xa. All 4 agents are licensed in the United States for stroke prevention in atrial fibrillation and for treatment of venous thromboembolism and rivaroxaban and apixaban are approved for thromboprophylaxis after elective hip or knee arthroplasty. The NOACs are at least as effective as warfarin, but are not only more convenient to administer because they can be given in fixed doses without routine coagulation monitoring but also are safer because they are associated with less intracranial bleeding. As part of a theme series on the NOACs, this article (1) compares the pharmacological profiles of the NOACs with that of warfarin, (2) identifies the doses of the NOACs for each approved indication, (3) provides an overview of the completed phase III trials with the NOACs, (4) briefly discusses the ongoing studies with the NOACs for new indications, (5) reviews the emerging real-world data with the NOACs, and (6) highlights the potential opportunities for the NOACs and identifies the remaining challenges.
MeSH term(s)	Administration, Oral ; Anticoagulants/therapeutic use ; Antithrombins/therapeutic use ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/prevention & control ; Benzimidazoles/therapeutic use ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Dabigatran ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Factor Xa Inhibitors/therapeutic use ; Female ; Humans ; Male ; Morpholines/therapeutic use ; Pyrazoles/therapeutic use ; Pyridines/therapeutic use ; Pyridones/therapeutic use ; Rivaroxaban ; Sensitivity and Specificity ; Stroke/prevention & control ; Thiazoles/therapeutic use ; Thiophenes/therapeutic use ; Thromboembolism/drug therapy ; Thromboembolism/prevention & control ; Warfarin/therapeutic use ; beta-Alanine/analogs & derivatives ; beta-Alanine/therapeutic use
Chemical Substances	Anticoagulants ; Antithrombins ; Benzimidazoles ; Factor Xa Inhibitors ; Morpholines ; Pyrazoles ; Pyridines ; Pyridones ; Thiazoles ; Thiophenes ; beta-Alanine (11P2JDE17B) ; apixaban (3Z9Y7UWC1J) ; Warfarin (5Q7ZVV76EI) ; Rivaroxaban (9NDF7JZ4M3) ; Dabigatran (I0VM4M70GC) ; edoxaban (NDU3J18APO)
Language	English
Publishing date	2015-05
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.115.303397
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