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  1. Article ; Online: Long-term results of first-generation S-ICD systems: strong from the start and through the threats of time.

    Cappato, Riccardo

    European heart journal

    2021  Volume 43, Issue 21, Page(s) 2051–2053

    MeSH term(s) Death, Sudden, Cardiac ; Defibrillators, Implantable ; Electric Countershock ; Humans
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehac137
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    Zs.A 1563: Show issues Location:
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  2. Article ; Online: Implementation of Guidelines on Atrial Fibrillation Management in the Global Arena: So Many Actors on Stage!

    Cappato, Riccardo

    European journal of internal medicine

    2021  Volume 86, Page(s) 22–24

    MeSH term(s) Anticoagulants/therapeutic use ; Atrial Fibrillation/therapy ; Humans ; Stroke
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2021-04-08
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2021.03.013
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    Zs.A 2608: Show issues Location:
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  3. Article ; Online: Treatment of inappropriate sinus tachycardia: Still a long way to go.

    Cappato, Riccardo

    Journal of cardiovascular electrophysiology

    2021  Volume 32, Issue 4, Page(s) 1062–1064

    MeSH term(s) Humans ; Ivabradine ; Sinoatrial Node ; Tachycardia, Sinus/diagnosis
    Chemical Substances Ivabradine (3H48L0LPZQ)
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.14940
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  4. Article ; Online: Catheter Ablation of Atrial Fibrillation: Are We Getting Better in Preservation From Periprocedural Cardiac Tamponade?

    Cappato, Riccardo

    JACC. Clinical electrophysiology

    2020  Volume 6, Issue 6, Page(s) 646–648

    MeSH term(s) Anticoagulants ; Atrial Fibrillation/surgery ; Cardiac Tamponade ; Catheter Ablation ; Humans
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2020.02.015
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  5. Article ; Online: Light anti-thrombotic regimen after interatrial shunt device closure: A strategy for all patients?

    Cappato, Riccardo

    European journal of internal medicine

    2020  Volume 74, Page(s) 35–36

    MeSH term(s) Heart Septal Defects, Atrial ; Humans ; Septal Occluder Device ; Thrombosis
    Language English
    Publishing date 2020-01-21
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2020.01.007
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  6. Article ; Online: Irregular Rhythm in a Middle-Aged Man Presenting With New-Onset Heart Failure.

    Ali, Hussam / Passarelli, Ilaria / Cappato, Riccardo

    JAMA cardiology

    2024  Volume 9, Issue 1, Page(s) 91–92

    MeSH term(s) Male ; Middle Aged ; Humans ; Heart Failure/diagnosis ; Heart Failure/etiology ; Electrocardiography
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6591
    ISSN (online) 2380-6591
    DOI 10.1001/jamacardio.2023.4249
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  7. Article ; Online: Open Issues in the Management of Otcagerian Patients with Atrial Fibrillation and Chronic Kidney Disease: Are we Ready for Left Atrial Appendage Occlusion (LAAO) as First-Line Therapy for Thromboembolic Risk Prevention?

    Condello, Francesco / Cersosimo, Angelica / Cappato, Riccardo / Pagnotta, Paolo

    Cardiovascular drugs and therapy

    2024  

    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-024-07554-4
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    Zs.B 3057: Show issues Location:
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  8. Article: How much does the presentation pattern of atrial fibrillation affect thrombo-embolic risk and mortality?

    Turturiello, Dario / Cappato, Riccardo

    European heart journal supplements : journal of the European Society of Cardiology

    2023  Volume 25, Issue Suppl B, Page(s) B46–B49

    Abstract: Atrial fibrillation (AF) is associated with a substantial increase in mortality and morbidity. Systemic thrombo-embolism is the most serious complication associated with this arrhythmia. The use of anticoagulant drugs is the cornerstone of therapy for ... ...

    Abstract Atrial fibrillation (AF) is associated with a substantial increase in mortality and morbidity. Systemic thrombo-embolism is the most serious complication associated with this arrhythmia. The use of anticoagulant drugs is the cornerstone of therapy for the prophylaxis of stroke and peripheral ischaemia in these patients. The current guidelines recommend the use of anticoagulant drugs based on the thrombo-embolic risk profile of each individual patient calculated by SCORE based on the presence or absence of clinical risk factors and regardless of the presentation pattern of AF. A review of literature data investigating the effect of AF presentation pattern on thrombo-embolic risk and mortality showed an increased risk of both thrombo-embolic events and death in patients with non-paroxysmal AF compared to patients with paroxysmal AF. Most of these studies, however, consist of post-hoc analyses of large trials or observational studies and meta-analyses derived from these, resulting in an important limitation in the interpretation of data derived from such studies. At the same time, these data suggest the need for both new therapies to prevent AF progression and for further studies to explore the integration of AF presentation pattern into models of thrombo-embolic risk.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suad066
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    Zs.A 1563 -Suppl.-: Show issues Location:
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  9. Article ; Online: Lessons derived from post authorisation safety studies (ETNA-AF and XANTUS) on once daily direct oral anticoagulants for atrial fibrillation.

    Cemin, Roberto / Cappato, Riccardo

    International journal of cardiology

    2023  Volume 398, Page(s) 131618

    Abstract: Background: Phase III trials should be integrated by post authorisation safety studies (PASS) to confirm their conclusions in real life. In this setting, comorbidities are commonly more prevalent, decisions about drugs and regimens are left to the ... ...

    Abstract Background: Phase III trials should be integrated by post authorisation safety studies (PASS) to confirm their conclusions in real life. In this setting, comorbidities are commonly more prevalent, decisions about drugs and regimens are left to the attending physicians and therapy monitoring is not usually as strict as in pivotal trials.
    Aims and methods: To evaluate real life safety and effectiveness of edoxaban and rivaroxaban, ETNA-AF Europe (ETNA-AF-Eu) and XANTUS studies were reviewed and compared. A further comparison between data collected in these studies and in the pivotal studies ENGAGE AF-TIMI 48 and ROCKET-AF was also performed.
    Results: ETNA-AF-Eu and XANTUS showed lower bleeding, stroke, cardiovascular- and all-cause mortality rates as compared to those observed in Phase 3 trials, even when including subgroups with lower comorbidities. Patients in ETNA-AF-Eu were older, with a larger proportion of octogenarians (≥85 years in 10.5%) and patients with impaired renal function as compared to patients in XANTUS (CrCl <50 ml/min in 18.2% vs 12.2%) and in ENGAGE AF-TIMI 48 and ROCKET-AF, without paying any excess tribute in terms of safety. Therapy persistence was very high in the two real life studies (91.9% in ETNA-AF-Eu and 79.9% in XANTUS), thus showing that edoxaban and rivaroxaban are well tolerated in real life.
    Conclusion: The ETNA-AF-Eu and XANTUS confirmed the safety and effectiveness of edoxaban and rivaroxaban in real life.
    MeSH term(s) Aged, 80 and over ; Humans ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/chemically induced ; Rivaroxaban/adverse effects ; Factor Xa Inhibitors ; Anticoagulants ; Stroke/drug therapy ; Pyridines ; Thiazoles
    Chemical Substances edoxaban (NDU3J18APO) ; Rivaroxaban (9NDF7JZ4M3) ; Factor Xa Inhibitors ; Anticoagulants ; Pyridines ; Thiazoles
    Language English
    Publishing date 2023-11-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131618
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    Zs.A 1673: Show issues Location:
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  10. Article ; Online: Ten years of subcutaneous defibrillator therapy: Consolidated clinical evidence and future perspectives.

    Magnani, Silvia / Ali, Hussam / Cappato, Riccardo

    Journal of cardiovascular electrophysiology

    2024  Volume 35, Issue 3, Page(s) 601–607

    Abstract: The subcutaneous implantable cardioverter defibrillator (S-ICD) was developed as an alternative to the traditional transvenous implantable cardioverter defibrillator (TV-ICD), aiming to provide easier implantation, simplified detection algorithm of ... ...

    Abstract The subcutaneous implantable cardioverter defibrillator (S-ICD) was developed as an alternative to the traditional transvenous implantable cardioverter defibrillator (TV-ICD), aiming to provide easier implantation, simplified detection algorithm of malignant ventricular arrhythmias and prevention from placing components in the cardiovascular system. The S-ICD is implanted subcutaneously or intramuscularly with the generator placed in the left midaxillary line and the lead tunneled subcutaneously in the left para-sternal region. Preimplant electrocardiogram screening is recommended to prevent implantation in patients at high risk of T wave over-sensing. Currently, the S-ICD is unsuitable for patients requiring pacing or cardiac resynchronization. Since the beginning, the S-ICD underwent extensive preclinical investigation until the first prospective multicentre trial demonstrating high efficacy and safety led to market release. While earlier studies focused on younger patients with higher ejection fraction, more recent studies showed favorable outcomes even in patients with comorbidities similar to those typically observed in patients receiving TV-ICD. The development of second and third generation devices has contributed to reduce inappropriate shocks and overcome previous limitations. The aim of this paper is to review the evidence in the literature over the past decade supporting S-ICD as a valid alternative to TV-ICD in terms of safety and efficacy, highlighting the improvements in technology, as well as outcomes.
    MeSH term(s) Humans ; Death, Sudden, Cardiac/prevention & control ; Prospective Studies ; Treatment Outcome ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/therapy ; Arrhythmias, Cardiac/etiology ; Defibrillators, Implantable/adverse effects ; Multicenter Studies as Topic
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.16171
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