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  1. Article ; Online: Sex-Related Outcomes Following Drug Balloon Angioplasty in Patients from the BIOLUX P-III Registry: A Subgroup Analysis.

    Barry, Ian Patrick / Macarulay, Reane / Brodmann, Marianne / Zeller, Thomas / Moscovic, Matej / Dahm, Johannes / Troisi, Nicola / Tepe, Gunnar / Wong, Jacqueline / Mwipatayi, Bibombe Patrice

    Cardiovascular and interventional radiology

    2022  Volume 45, Issue 7, Page(s) 918–928

    Abstract: ... The BIOLUX P-III is a prospective, international, multi-centre, registry of patients with infra-inguinal ...

    Abstract Purpose: To evaluate the use of drug-coated balloons in a real-world patient population with peripheral arterial disease and analyse the impact of sex on mid-term outcomes following their utilisation.
    Methods: The BIOLUX P-III is a prospective, international, multi-centre, registry of patients with infra-inguinal lesions treated using the Passeo-18 Lux, a drug-coated balloon. Our study is a 24-month subgroup analysis of these patients; primary endpoints were freedom from major adverse events and clinically driven target lesion re-vascularisation within 12 months post-intervention.
    Results: Of the 877 patients in the registry, 561 (64.0%) were male and 316 (36.0%) were female. Chronic limb threatening ischaemia (Rutherford class ≥ 4) occurred in 35.7% of males and 40.6% of females. Rates of freedom from major adverse events and clinically driven target lesion re-vascularisation at 12 months were 87.3% (95% confidence interval [CI] 84.2-89.9) and 90.4% (95% CI 86.5-93.3), and 92.3% (95% CI 89.9-94.1) and 92.9% (95% CI 89.7-95.1) in males and females, respectively. All-cause mortality at 24 months was 12.0% (95% CI 9.4-15.3) in males and 11.9% (95% CI 8.6-16.5) in females. The major target limb amputation rate at 24 months was 9.1% (95% CI 6.9-11.9) in males and 4.0% (95% CI 2.3-7.0) in females.
    Conclusion: Treatment with the Passeo-18 Lux DCB demonstrated high efficacy and low complication rates. Despite the greater proportion of chronic limb threatening ischaemia observed in females, males were at a greater risk of ipsilateral major limb amputation and major adverse events following drug-coated balloon utilisation.
    Clinical trial registration: NCT02276313.
    Level of evidence: Level 4.
    MeSH term(s) Angioplasty, Balloon/adverse effects ; Cardiovascular Agents/adverse effects ; Coated Materials, Biocompatible ; Female ; Femoral Artery ; Humans ; Limb Salvage ; Male ; Paclitaxel/adverse effects ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/diagnostic imaging ; Peripheral Arterial Disease/therapy ; Popliteal Artery ; Prospective Studies ; Registries ; Treatment Outcome ; Vascular Patency
    Chemical Substances Cardiovascular Agents ; Coated Materials, Biocompatible ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603082-8
    ISSN 1432-086X ; 0342-7196 ; 0174-1551
    ISSN (online) 1432-086X
    ISSN 0342-7196 ; 0174-1551
    DOI 10.1007/s00270-022-03135-w
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  2. Article ; Online: Konfidenzintervalle und p-Werte in der Urologie : Interpretation und Fehlinterpretation.

    Rink, M / Kluth, L A / Shariat, S F / Dahlem, R / Fisch, M / Dahm, P

    Der Urologe. Ausg. A

    2013  Volume 52, Issue 4, Page(s) 546–548

    Abstract: Confidence intervals and p-values are widely used in the urological literature to describe and ... interpretation of these values. P-values determine statistical significance of data. Confidence intervals ... as common pitfalls in interpretation of p-values and confidence intervals. An accurate assessment ...

    Title translation Confidence intervals and p-values in urology: interpretation and misinterpretation.
    Abstract Confidence intervals and p-values are widely used in the urological literature to describe and interpret outcomes. However, several readers, authors and reviewers are unfamiliar with the true interpretation of these values. P-values determine statistical significance of data. Confidence intervals characterize a range of values in which the true effect size is suggested to be with a given degree of certainty. An independent but complementary interpretation of both values is important in studies with and without statistical significance. Based on a clinical case scenario this article discusses the interpretation as well as common pitfalls in interpretation of p-values and confidence intervals. An accurate assessment of these statistical cornerstones is fundamental for a correct interpretation of the urological literature and thus important aspects of evidence-based urology.
    MeSH term(s) Confidence Intervals ; Data Interpretation, Statistical ; Evidence-Based Medicine/statistics & numerical data ; Humans ; Outcome Assessment, Health Care/methods ; Treatment Outcome ; Urologic Diseases/epidemiology ; Urologic Diseases/therapy
    Language German
    Publishing date 2013-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-013-3148-y
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  3. Article ; Online: Real-World Experience With a Paclitaxel-Coated Balloon in Critical Limb Ischemia: 24-Month Subgroup Outcomes of BIOLUX P-III.

    Brodmann, Marianne / Moscovic, Matej / Wang, John Chaw Chian / Nano, Giovanni / Dahm, Johannes / Zeller, Thomas / Christensen, Johnny Kent / Keirse, Koen / Ghotbi, Reza / Corpataux, Jean-Marc / Tepe, Gunnar

    JACC. Cardiovascular interventions

    2020  Volume 13, Issue 19, Page(s) 2289–2299

    Abstract: Objectives: The aim of the BIOLUX P-III (A Prospective, International, Multi-Centre, Post-Market ... devices.: Methods: BIOLUX P-III is a prospective, post-market, all-comers registry assessing the safety ...

    Abstract Objectives: The aim of the BIOLUX P-III (A Prospective, International, Multi-Centre, Post-Market All-Comers Registry to Assess the Clinical Performance of the Passeo-18 Lux Paclitaxel Releasing Balloon Catheter in Infrainguinal Arteries - III) registry was to collect real-world data on the Passeo-18 Lux paclitaxel-coated balloon.
    Background: Critical limb ischemia (CLI) is a severe condition associated with high morbidity and mortality. Prospective data are needed to provide further insights on drug-eluting devices.
    Methods: BIOLUX P-III is a prospective, post-market, all-comers registry assessing the safety and performance of the Passeo-18 Lux. Clinical information was collected at 6, 12, and 24 months. The authors report 24-month outcomes of the CLI subgroup with patients in Rutherford classes 4 to 6.
    Results: The CLI subgroup included 328 patients with 422 lesions. Patients were 71.1 ± 10.5 years of age, and 61.0% had diabetes. Femoropopliteal lesions were present in 53.8% (n = 227), below-the-knee lesions were present in 27.0% (n = 114), and lesions were moderate or heavily calcified in 45.0% (n = 190). Major adverse events, defined as 30-day device- or procedure-related mortality, major target limb amputation, and clinically driven target lesion revascularization, occurred in 9.8% of patients through 6 months, in 14.9% through 12 months, and in 19.4% through 24 months. Clinically driven target lesion revascularization occurred in 4.4%, 8.5%, and 12.1%, major amputation in 4.9%, 5.2%, and 6.1%, and mortality in 8.1%, 11.1%, and 20.1%, respectively. Predictors of mortality were age ≥75 years and higher Trans-Atlantic Inter-Society Consensus Document on Management of Peripheral Arterial Disease class, and higher Rutherford class was associated with increased mortality and amputation rates.
    Conclusions: In a large, multimorbid patient population with complex lesions and CLI, the safety and performance of the Passeo-18 Lux paclitaxel-coated balloon has been confirmed, with low rates of major amputation and target lesion revascularization.
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2452157-7
    ISSN 1876-7605 ; 1936-8798
    ISSN (online) 1876-7605
    ISSN 1936-8798
    DOI 10.1016/j.jcin.2020.06.059
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  4. Article ; Online: NAD(P)H oxidase isoforms as therapeutic targets for diabetic complications.

    Gray, Stephen P / Jha, Jay C / Di Marco, Elyse / Jandeleit-Dahm, Karin Am

    Expert review of endocrinology & metabolism

    2014  Volume 9, Issue 2, Page(s) 111–122

    Abstract: The development of macro- and microvascular complications is accelerated in diabetic patients. While some therapeutic regimes have helped in delaying progression of complications, none have yet been able to halt the progression and prevent vascular ... ...

    Abstract The development of macro- and microvascular complications is accelerated in diabetic patients. While some therapeutic regimes have helped in delaying progression of complications, none have yet been able to halt the progression and prevent vascular disease, highlighting the need to identify new therapeutic targets. Increased oxidative stress derived from the NADPH oxidase (Nox) family has recently been identified to play an important role in the pathophysiology of vascular disease. In recent years, specific Nox isoforms have been implicated in contributing to the development of atherosclerosis of major vessels, as well as damage of the small vessels within the kidney and the eye. With the use of novel Nox inhibitors, it has been demonstrated that these complications can be attenuated, indicating that targeting Nox derived oxidative stress holds potential as a new therapeutic strategy.
    Language English
    Publishing date 2014-02-10
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/17446651.2014.887984
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  5. Article ; Online: P-wave scattering and the distribution of heterogeneity around Etna volcano

    Toni Zieger / C. Sens-Schönfelder / Joachim R. R. Ritter / B. Lühr / T. Dahm

    Annals of Geophysics

    2016  

    Abstract: ... of the direct P-wave and the energy in a later coda window. This is based on the basic assumption ... that scattering caused by heterogeneity removes energy from the direct P-waves. We show that measurements ... As an independent proxy of the scattering strength along the ray path we measure the peak delay time of the direct P ...

    Abstract Volcanoes and fault zones are areas of increased heterogeneity in the Earth crust that leads to strong scattering of seismic waves. For the understanding of the volcanic structure and the role of attenuation and scattering processes it is important to investigate the distribution of heterogeneity. We used the signals of air-gun shots to investigate the distribution of heterogeneity around Mount Etna. We devise a new methodology that is based on the coda energy ratio which we define as the ratio between the energy of the direct P-wave and the energy in a later coda window. This is based on the basic assumption that scattering caused by heterogeneity removes energy from the direct P-waves. We show that measurements of the energy ratio are stable with respect to changes of the details of the time windows definitions. As an independent proxy of the scattering strength along the ray path we measure the peak delay time of the direct P-wave. The peak delay time is well correlated with the coda energy ratio. We project the observation in the directions of the incident rays at the stations. Most notably is an area with increased wave scattering in the volcano and east of it. The strong heterogeneity found supports earlier observations and confirms the possibility to use P-wave sources for the determination of scattering properties. We interpret the extension of the highly heterogeneous zone towards the east as a potential signature of inelastic deformation processes induced by the eastward sliding of flank of the volcano.
    Subject code 535
    Language English
    Publishing country de
    Document type Article ; Online
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  6. Article ; Online: P-wave scattering and the distribution of heterogeneity around Etna volcano

    Zieger, T. / Sens-Schönfelder, C. / Ritter, J. / Lühr, B. / Dahm, T.

    Annals of Geophysics

    2016  

    Abstract: ... of the direct P-wave and the energy in a later coda window. This is based on the basic assumption ... that scattering caused by heterogeneity removes energy from the direct P-waves. We show that measurements ... As an independent proxy of the scattering strength along the ray path we measure the peak delay time of the direct P ...

    Abstract Volcanoes and fault zones are areas of increased heterogeneity in the Earth crust that leads to strong scattering of seismic waves. For the understanding of the volcanic structure and the role of attenuation and scattering processes it is important to investigate the distribution of heterogeneity. We used the signals of air-gun shots to investigate the distribution of heterogeneity around Mount Etna. We devise a new methodology that is based on the coda energy ratio which we define as the ratio between the energy of the direct P-wave and the energy in a later coda window. This is based on the basic assumption that scattering caused by heterogeneity removes energy from the direct P-waves. We show that measurements of the energy ratio are stable with respect to changes of the details of the time windows definitions. As an independent proxy of the scattering strength along the ray path we measure the peak delay time of the direct P-wave. The peak delay time is well correlated with the coda energy ratio. We project the observation in the directions of the incident rays at the stations. Most notably is an area with increased wave scattering in the volcano and east of it. The strong heterogeneity found supports earlier observations and confirms the possibility to use P-wave sources for the determination of scattering properties. We interpret the extension of the highly heterogeneous zone towards the east as a potential signature of inelastic deformation processes induced by the eastward sliding of flank of the volcano.
    Subject code 535
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Perplexing bodies: The putative roles of P-bodies in neurons.

    Zeitelhofer, Manuel / Macchi, Paolo / Dahm, Ralf

    RNA biology

    2008  Volume 5, Issue 4, Page(s) 244–248

    Abstract: Processing bodies (P-bodies) have recently come to the fore as important cellular sites of mRNA ... the roles of P-bodies have only been characterized in a limited number of cell types and physiological ... elusive. The discovery of P-bodies in neuronal dendrites near synapses and their response to stimuli ...

    Abstract Processing bodies (P-bodies) have recently come to the fore as important cellular sites of mRNA degradation and translational silencing. Despite these central functions in the control of gene expression, the roles of P-bodies have only been characterized in a limited number of cell types and physiological contexts. Neurons are highly plastic cells that undergo dynamic changes as new connections are made or existing ones modified. This neuronal plasticity relies, in part, on the local synthesis of proteins from localized mRNAs. A strict control of the translation and turnover of these localized mRNAs, both in terms of which proteins are synthesized and when and where they are produced, is a key prerequisite for this process to be synapse-specific. Despite recent advances, the molecular mechanisms mediating this control remain largely elusive. The discovery of P-bodies in neuronal dendrites near synapses and their response to stimuli involved in neuronal plasticity raises the interesting hypothesis that P-bodies might be a component of the cellular machinery that controls neuronal plasticity and thereby processes such as learning and memory.
    MeSH term(s) Animals ; Cytoplasmic Granules/metabolism ; Humans ; Neurons/metabolism ; Protein Biosynthesis ; RNA Transport ; Ribonucleoproteins/metabolism
    Chemical Substances Ribonucleoproteins
    Language English
    Publishing date 2008-10-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1555-8584
    ISSN (online) 1555-8584
    DOI 10.4161/rna.6948
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  8. Article ; Online: Evidence-based urology in practice: P-values vs confidence intervals.

    MacDonald, Susan L / Scales, Charles D / Dahm, Philipp

    BJU international

    2010  Volume 106, Issue 6, Page(s) 758–759

    MeSH term(s) Aged ; Anti-Bacterial Agents/administration & dosage ; Confidence Intervals ; Evidence-Based Medicine/statistics & numerical data ; Female ; Humans ; Meta-Analysis as Topic ; Review Literature as Topic ; Secondary Prevention ; Urinary Tract Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2010-09
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/j.1464-410X.2010.09503.x
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  9. Article ; Online: Oceanic lithospheric S wave velocities from the analysis of P wave polarization at the ocean floor

    Katrin Hannemann / Frank Krüger / T. Dahm

    Geophysical Journal International

    2016  

    Publishing country de
    Document type Article ; Online
    DOI 10.1093/gji/ggw342
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  10. Article ; Online: Oceanic lithospheric S wave velocities from the analysis of P wave polarization at the ocean floor

    Hannemann, K. / Krüger, F. / Dahm, T.

    Geophysical Journal International

    2016  

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