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Article ; Online: Contact allergy to olanzapine and saxagliptin in a pharmaceutical industrial worker: A case report.

Azra, Huršidić Radulović / Željka, Babić / Marija, Macan / Jelena, Macan

2024

Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Case Reports
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.14534
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Article ; Online: Incidence and prevalence of occupational contact dermatitis in hairdressing apprentices: A 3-year prospective cohort study.

Franić, Zrinka / Ljubojević Hadžavdić, Suzana / Babić, Željka / Macan, Jelena

Contact dermatitis

2023 Volume 89, Issue 3, Page(s) 153–160

Abstract: Background: It is known that a large number of hairdressing apprentices (HA) develop occupational contact dermatitis (OCD) during schooling, but studies that address prevalence of contact sensitization in HAs with hand eczema are missing.: Objectives!# ...

Abstract	Background: It is known that a large number of hairdressing apprentices (HA) develop occupational contact dermatitis (OCD) during schooling, but studies that address prevalence of contact sensitization in HAs with hand eczema are missing. Objectives: To assess the prevalence, incidence rate and clinical characteristics of OCD, including contact sensitization, in a sample of Croatian HAs. Materials and methods: A total of 408 HAs from 25 Croatian towns were examined at the beginning of education and monitored at the end of each school year. Clinical evaluation of skin changes was performed using the Osnabrueck Hand Eczema Severity Index (OHSI). Standard patch test (PT) with baseline and hairdresser series of contact allergens was performed in 46 HAs with skin changes lasting ≥3 months. Results: The overall incidence rate of OCD was 32.3/100 person-years, and the 3-year prevalence 50.3%. Contact sensitization was found in 14 out of 46 (30.3%) HAs, with 10 of these 14 HAs (71.4%) sensitized to specific hairdressing allergens. The strongest reactions were found to PPD. HAs with positive PT had higher OHSI than HAs with negative patch test (median, IQR: 3, 2-4 vs. 2, 2-4). Conclusions: Contact sensitization to specific hairdressing chemicals was found in 71.4% of HAs with a positive patch test, supporting evidence on the early contact sensitization to occupational allergens among HAs.
MeSH term(s)	Humans ; Incidence ; Dermatitis, Allergic Contact/epidemiology ; Dermatitis, Allergic Contact/etiology ; Prospective Studies ; Prevalence ; Dermatitis, Occupational/etiology ; Dermatitis, Occupational/complications ; Allergens/adverse effects ; Eczema/epidemiology ; Patch Tests/adverse effects
Chemical Substances	Allergens
Language	English
Publishing date	2023-06-04
Publishing country	England
Document type	Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.14355
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Article ; Online: Evaluation of Skin Barrier Condition Among Physicians and Dentists.

Babić, Željka / Japundžić-Rapić, Iva / Lugović Mihić, Liborija / Macan, Jelena

Dermatitis : contact, atopic, occupational, drug

2023 Volume 35, Issue 1, Page(s) 70–76

MeSH term(s)	Humans ; Male ; Female ; Cross-Sectional Studies ; Skin ; Epidermis ; Water ; Physicians ; Dentists
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2144723-8
ISSN	2162-5220 ; 1532-8163 ; 1710-3568
ISSN (online)	2162-5220 ; 1532-8163
ISSN	1710-3568
DOI	10.1089/derm.2023.0266
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Article ; Online: Skin barrier function in nursing apprentices during the coronavirus disease 2019 (COVID-19) pandemic.

Babić, Željka / Šakić, Franka / Franić, Zrinka / Macan, Jelena

Contact dermatitis

2022 Volume 86, Issue 6, Page(s) 507–513

Abstract: Background: Studies investigating simultaneous influence of personal and work-related factors on skin health during the coronavirus disease 2019 (COVID-19) pandemic are missing.: Objectives: To investigate the associations of skin hazards relevant ... ...

Abstract	Background: Studies investigating simultaneous influence of personal and work-related factors on skin health during the coronavirus disease 2019 (COVID-19) pandemic are missing. Objectives: To investigate the associations of skin hazards relevant for nursing apprentices with parameters of skin barrier function. Methods: A total of 238 nursing apprentices attending the final year of education (median age 19 years) from vocational schools in Zagreb, Croatia, were enrolled in this study. We administered a questionnaire based on the Nordic Occupational Skin Questionnaire to the nursing apprentices, performed clinical examination of skin on the hands, and evaluated transepidermal water loss (TEWL) and stratum corneum (SC) pH on the dorsum of the hand. Results: Around half of nursing apprentices had compromised hand skin barrier function, as indicated by TEWL values >25 g/m Conclusions: Measurement of SC pH was shown to be less sensitive to field conditions than TEWL, and should be employed more in the field studies. Strengthening of skin health promotion in healthcare workers and apprentices is needed in pandemic conditions.
MeSH term(s)	Adult ; COVID-19 ; Dermatitis, Allergic Contact/diagnosis ; Female ; Humans ; Pandemics ; Skin ; Surveys and Questionnaires ; Water Loss, Insensible ; Young Adult
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.14069
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Article ; Online: Characteristics of hand eczema in final-year apprentice nurses during the COVID-19 pandemic.

Šakić, Franka / Babić, Željka / Franić, Zrinka / Macan, Jelena

Contact dermatitis

2021 Volume 86, Issue 2, Page(s) 98–106

Abstract: Background: Apprentice nurses are considered at high risk to developing occupational skin diseases.: Objectives: This study assessed the frequency and origin of hand eczema, and work-related risk factors in apprentice nurses.: Methods: The study ... ...

Abstract	Background: Apprentice nurses are considered at high risk to developing occupational skin diseases. Objectives: This study assessed the frequency and origin of hand eczema, and work-related risk factors in apprentice nurses. Methods: The study involved 240 final-year apprentice nurses (females 75%, median age 19 years) from vocational schools in Zagreb, Croatia. The study was performed in 2020/2021 and included a questionnaire and clinical examination by means of the Osnabrück Hand Eczema Severity Index (OHSI). Skin prick test (SPT) with natural rubber latex (NRL) allergen, and patch test with the basic series of allergens, and disinfectants, were performed in 42 apprentice nurses with hand eczema that lasted more than 3 months. Results: Clinically observed and self-reported hand eczema were found in 49% and 46% of apprentice nurses, respectively. Those with observed changes were older and reported more days per month spent on practical work than those with healthy skin (P = .001). Median OHSI was 4 (interquartile range 2-6). There were no positive SPTs to latex, and 11 (26%) apprentice nurses had positive patch test reactions to one or more tested allergens, mostly nickel. Conclusions: Hand eczema was common in final-year apprentice nurses during the COVID-19 pandemic. It was mostly of irritative origin, associated with the duration of practical training, confirming cumulative effect of hazards on skin barrier.
MeSH term(s)	COVID-19/nursing ; Croatia ; Dermatitis, Occupational/etiology ; Eczema/etiology ; Female ; Hand Dermatoses/etiology ; Humans ; Male ; Pandemics ; Patch Tests ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Students, Nursing ; Young Adult
Language	English
Publishing date	2021-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	193121-0
ISSN	1600-0536 ; 0105-1873
ISSN (online)	1600-0536
ISSN	0105-1873
DOI	10.1111/cod.14006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Skin Characteristics of Hairdresser Apprentices at the Beginning of Vocational Training.

Franić, Zrinka / Babić, Željka / Milić, Mirta / Macan, Jelena

Dermatitis : contact, atopic, occupational, drug

2021 Volume 32, Issue 6, Page(s) 437–443

Abstract: Background: Hairdresser apprentices (HAs) are at high risk of developing occupational contact dermatitis.: Objectives: To assess skin characteristics of HAs, using genotyping, clinically observed and self-reported skin symptoms, and skin ... ...

Abstract	Background: Hairdresser apprentices (HAs) are at high risk of developing occupational contact dermatitis. Objectives: To assess skin characteristics of HAs, using genotyping, clinically observed and self-reported skin symptoms, and skin bioengineering methods at the beginning of apprenticeship. Methods: During the screening phase of a prospective cohort study, we recruited 352 HAs in 24 Croatian towns. The protocol included the following: questionnaires with self-reported skin and atopy symptoms evaluation, Osnabrueck Hand Eczema Severity Index (OHSI) for clinical skin assessment, genotyping FLG (filaggrin) gene mutations, skin pH, and transepidermal water loss (TEWL) measurements. Results: Self-reported skin symptoms were reported by 12%, history of dry hands by 29%, and history of atopy by 46% of HAs. Skin changes were found at the clinical examination in 18% of the HA. The OHSI score was positively correlated with hand TEWL and hand skin pH in multiple regression linear models. An FLG gene mutation was found in 1 apprentice. Conclusions: Significant prevalence of clinically observed skin signs on the hands was observed in HAs at the beginning of training. The OHSI score was found to be an independent predictor of higher hand TEWL and skin pH values. The need to ameliorate preventive examinations before the enrolment to hairdressing schools was indicated.
MeSH term(s)	Barbering ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Occupational/diagnosis ; Dermatitis, Occupational/etiology ; Eczema/diagnosis ; Follow-Up Studies ; Hand Dermatoses/diagnosis ; Hand Dermatoses/etiology ; Humans ; Occupational Exposure/adverse effects ; Prospective Studies ; Vocational Education
Language	English
Publishing date	2021-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2144723-8
ISSN	2162-5220 ; 1532-8163 ; 1710-3568
ISSN (online)	2162-5220 ; 1532-8163
ISSN	1710-3568
DOI	10.1097/DER.0000000000000718
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Article ; Online: Toxicological aspects of increased use of surface and hand disinfectants in Croatia during the COVID-19 pandemic: a preliminary report.

Babić, Željka / Turk, Rajka / Macan, Jelena

Arhiv za higijenu rada i toksikologiju

2020 Volume 71, Issue 3, Page(s) 261–264

Abstract: All COVID-19 prevention strategies include regular use of surface disinfectants and hand sanitisers. As these measures took hold in Croatia, the Croatian Poison Control Centre started receiving phone calls from the general public and healthcare workers, ... ...

Abstract	All COVID-19 prevention strategies include regular use of surface disinfectants and hand sanitisers. As these measures took hold in Croatia, the Croatian Poison Control Centre started receiving phone calls from the general public and healthcare workers, which prompted us to investigate whether the risk of suspected/symptomatic poisonings with disinfectants and sanitisers really increased. To that end we compared their frequency and characteristics in the first half of 2019 and 2020. Cases of exposures to disinfectants doubled in the first half of 2020 (41 vs 21 cases in 2019), and exposure to sanitisers increased about nine times (46 vs 5 cases in 2019). In 2020, the most common ingredients of disinfectants and sanitisers involved in poisoning incidents were hypochlorite/glutaraldehyde, and ethanol/isopropyl alcohol, respectively. Exposures to disinfectants were recorded mostly in adults (56 %) as accidental (78 %) through ingestion or inhalation (86 %). Fortunately, most callers were asymptomatic (people called for advice because they were concerned), but nearly half reported mild gastrointestinal or respiratory irritation, and in one case severe symptoms were reported (gastrointestinal corrosive injury). Reports of exposure to hand sanitisers highlighted preschool children as the most vulnerable group. Accidental exposure through ingestion dominated, but, again, only mild symptoms (gastrointestinal or eye irritation) developed in one third of the cases. These preliminary findings, however limited, confirm that increased availability and use of disinfectants and sanitisers significantly increased the risk of poisoning, particularly in preschool children through accidental ingestion of hand sanitisers. We therefore believe that epidemiological recommendations for COVID-19 prevention should include warnings informing the general public of the risks of poisoning with surface and hand disinfectants in particular.
MeSH term(s)	2-Propanol/toxicity ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Croatia/epidemiology ; Disinfectants/toxicity ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Ethanol/toxicity ; Female ; Glutaral/toxicity ; Hand Sanitizers/toxicity ; Humans ; Hypochlorous Acid/toxicity ; Infant ; Infant, Newborn ; Male ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; SARS-CoV-2 ; Young Adult
Chemical Substances	Disinfectants ; Hand Sanitizers ; Ethanol (3K9958V90M) ; Hypochlorous Acid (712K4CDC10) ; 2-Propanol (ND2M416302) ; Glutaral (T3C89M417N)
Keywords	covid19
Language	English
Publishing date	2020-10-06
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2020-71-3470
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Article ; Online: Comparison of beautician and hairdressing apprentices with regard to skin health and skin barrier function.

Babić, Željka / Samardžić, Tea / Macan, Jelena

Arhiv za higijenu rada i toksikologiju

2020 Volume 71, Issue 3, Page(s) 190–196

Abstract: Hairdressing and beautician apprentices are at high risk of occupational skin diseases. Our objective was to compare the prevalence of skin symptoms and the condition of skin barrier between them at the end of vocational training. We recruited 101 ... ...

Abstract	Hairdressing and beautician apprentices are at high risk of occupational skin diseases. Our objective was to compare the prevalence of skin symptoms and the condition of skin barrier between them at the end of vocational training. We recruited 101 hairdressing and 76 beautician apprentices (overall median age 17 years), who reported their history of skin symptoms through the Croatian translation of the Nordic Occupational Skin Questionnaire (NOSQ-2002) and had their hand skin clinically examined and evaluated with the Osnabrück Hand Eczema Severity Index (OHSI). Transepidermal water loss (TEWL) was measured following the standard procedure. Hairdressing apprentices reported significantly higher prevalence of hand/wrist eczema or urticaria than beautician apprentices (35 % vs 25 %, respectively; P=0.041) and higher severity of current hand eczema [median (range) 1.5 (0-8) vs 0.5 (0-4), respectively; P<0.001] and had higher hand TEWL values in those who washed their hands >20 times a day [median (interquartile range): 24.4 (19.7-33.7) vs 18.8 (15.4-23.2) g/ m2/h, respectively; P<0.001). Hairdressing apprentices had more severe clinical symptoms on the hands, and 83 % of those who reported eczema also reported that exacerbation occurred during practical training in comparison to 38 % of beautician apprentices. Our study is the first to report occupational hand and forearm skin issues in the beautician apprentices and also suggests that more effort is needed to improve training about safety at work, which should be specifically tailored for these two trades.
MeSH term(s)	Adolescent ; Humans ; Occupational Diseases ; Prevalence ; Surveys and Questionnaires
Keywords	covid19
Language	English
Publishing date	2020-10-06
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2020-71-3452
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Article ; Online: Characteristics of unintentional ingestion of oral non-steroidal anti-inflammatory drugs and analgesics in preschool children.

Babić, Željka / Kordić, Nikolina Benco / Rešić, Arnes / Turk, Rajka

Arhiv za higijenu rada i toksikologiju

2021 Volume 72, Issue 4, Page(s) 299–304

Abstract: We characterised accidental ingestion of non-steroidal anti-inflammatory drugs and non-opioid analgesics in children aged 0-5 years between 2009 and 2019 by analysing records of telephone consultations with the Croatian Poison Control Centre (CPCC) and ... ...

Abstract	We characterised accidental ingestion of non-steroidal anti-inflammatory drugs and non-opioid analgesics in children aged 0-5 years between 2009 and 2019 by analysing records of telephone consultations with the Croatian Poison Control Centre (CPCC) and cases treated at the Children's Hospital Zagreb (CHZ). Among the total of 466 identified cases (411 from CPPCC records and 55 from CHS hospital records), the most frequently ingested drugs were ibuprofen (47 %), paracetamol (20 %), ketoprofen (15 %), and diclofenac (11 %). In 94 % of the cases unsupervised children ingested the drug left within their reach. The remaining 6 % were dosing errors by parents or caregivers and involved liquid formulations as a rule. Our findings can serve as real-life examples informing preventive measures.
MeSH term(s)	Analgesics ; Anti-Inflammatory Agents, Non-Steroidal ; Child, Preschool ; Eating ; Humans ; Ibuprofen ; Pharmaceutical Preparations
Chemical Substances	Analgesics ; Anti-Inflammatory Agents, Non-Steroidal ; Pharmaceutical Preparations ; Ibuprofen (WK2XYI10QM)
Language	English
Publishing date	2021-12-30
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	127289-5
ISSN	1848-6312 ; 0004-1254
ISSN (online)	1848-6312
ISSN	0004-1254
DOI	10.2478/aiht-2021-72-3596
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Article: Toxicological aspects of increased use of surface and hand disinfectants in Croatia during the COVID-19 pandemic: a preliminary report

Babic, Zeljka / Turk, Rajka / Macan, Jelena

Arh Hig Rada Toksikol

Abstract	All COVID-19 prevention strategies include regular use of surface disinfectants and hand sanitisers. As these measures took hold in Croatia, the Croatian Poison Control Centre started receiving phone calls from the general public and healthcare workers, which prompted us to investigate whether the risk of suspected/symptomatic poisonings with disinfectants and sanitisers really increased. To that end we compared their frequency and characteristics in the first half of 2019 and 2020. Cases of exposures to disinfectants doubled in the first half of 2020 (41 vs 21 cases in 2019), and exposure to sanitisers increased about nine times (46 vs 5 cases in 2019). In 2020, the most common ingredients of disinfectants and sanitisers involved in poisoning incidents were hypochlorite/glutaraldehyde, and ethanol/isopropyl alcohol, respectively. Exposures to disinfectants were recorded mostly in adults (56 %) as accidental (78 %) through ingestion or inhalation (86 %). Fortunately, most callers were asymptomatic (people called for advice because they were concerned), but nearly half reported mild gastrointestinal or respiratory irritation, and in one case severe symptoms were reported (gastrointestinal corrosive injury). Reports of exposure to hand sanitisers highlighted preschool children as the most vulnerable group. Accidental exposure through ingestion dominated, but, again, only mild symptoms (gastrointestinal or eye irritation) developed in one third of the cases. These preliminary findings, however limited, confirm that increased availability and use of disinfectants and sanitisers significantly increased the risk of poisoning, particularly in preschool children through accidental ingestion of hand sanitisers. We therefore believe that epidemiological recommendations for COVID-19 prevention should include warnings informing the general public of the risks of poisoning with surface and hand disinfectants in particular.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #874402
Database	COVID19

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