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Article ; Online: Coordination-Controlled C-C Coupling Products via ortho-Site C-H Activation.

Zhang, Xue / Xue, Na / Li, Chao / Li, Na / Wang, Hao / Kocić, Nemanja / Beniwal, Sumit / Palotás, Krisztián / Li, Ruoning / Xue, Qiang / Maier, Sabine / Hou, Shimin / Wang, Yongfeng

ACS nano

2019 Volume 13, Issue 2, Page(s) 1385–1393

Abstract: The coordination-restricted ortho-site C-H bond activation and dehydrogenative homocoupling of 4,4' ...

Abstract	The coordination-restricted ortho-site C-H bond activation and dehydrogenative homocoupling of 4,4'-(1,3-phenylene)dipyridine (1,3-BPyB) and 4,4'-(1,4-phenylene)dipyridine (1,4-BPyB) on different metal surfaces were studied by a combination of scanning tunneling microscopy, noncontact atomic force microscopy, and density functional theory calculations. The coupling products on Cu(111) exhibited certain configurations subject to the spatial restriction of robust two-fold Cu-N coordination bonds. Compared to the V-shaped 1,3-BPyB, the straight backbone of 1,4-BPyB helped to further reduce the variety of reactive products. By utilizing the three-fold coordination of Fe atoms with 1,4-BPyB molecules on Au(111), a large-scale network containing single products was constructed. Our results offer a promising protocol for controllable on-surface synthesis with the aid of robust coordination interactions.
Language	English
Publishing date	2019-02-11
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.8b06885
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Book ; Online ; Thesis: Studies on C–H-Activation, Organocatalysis, and Synthesis of Amphidinolide Q

Mishra, Vivek K. [Verfasser] / Maier, Martin E. [Akademischer Betreuer]

2017

Author's details	Vivek Kumar Mishra ; Betreuer: Martin E. Maier
Keywords	Naturwissenschaften ; Science
Subject code	sg500
Language	English
Publisher	Universitätsbibliothek Tübingen
Publishing place	Tübingen
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Article ; Online: Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.

Maier, Dieter / Praxenthaler, Heiko / Schulz, Adriana / Preiss, Anette

PloS one

2013 Volume 8, Issue 11, Page(s) e81578

Abstract: ... of Hairless [Su(H)]. Together with the intracellular domain of the activated Notch receptor ICN, Su(H ... H) and several co-repressors. Su(H) is characterized by three domains, the N-terminal domain NTD ... the beta-trefoil domain BTD and the C-terminal domain CTD. NTD and BTD bind to the DNA, whereas BTD and CTD ...

Abstract	The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch receptor are transduced by CSL-type DNA-binding proteins. In Drosophila, this protein is named Suppressor of Hairless [Su(H)]. Together with the intracellular domain of the activated Notch receptor ICN, Su(H) assembles a transcriptional activator complex on Notch target genes. Hairless acts as the major antagonist of the Notch signaling pathway in Drosophila by means of the formation of a repressor complex together with Su(H) and several co-repressors. Su(H) is characterized by three domains, the N-terminal domain NTD, the beta-trefoil domain BTD and the C-terminal domain CTD. NTD and BTD bind to the DNA, whereas BTD and CTD bind to ICN. Hairless binds to the CTD, however, to sites different from ICN. In this work, we have addressed the question of competition and availability of Su(H) for ICN and Hairless binding in vivo. To this end, we overexpressed the CTD during fly development. We observed a strong activation of Notch signaling processes in various tissues, which may be explained by an interference of CTD with Hairless corepressor activity. Accordingly, a combined overexpression of CTD together with Hairless ameliorated the effects, unlike Su(H) which strongly enhances repression when overexpressed concomitantly with Hairless. Interestingly, in the combined overexpression CTD accumulated in the nucleus together with Hairless, whereas it is predominantly cytoplasmic on its own.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Cell Line ; Drosophila ; Drosophila Proteins/chemistry ; Drosophila Proteins/genetics ; Drosophila Proteins/physiology ; Larva/genetics ; Phenotype ; Receptors, Notch/chemistry ; Receptors, Notch/genetics ; Receptors, Notch/physiology ; Transcription Factors/chemistry ; Transcription Factors/genetics ; Transcription Factors/physiology ; Wings, Animal
Chemical Substances	Drosophila Proteins ; N protein, Drosophila ; Receptors, Notch ; Transcription Factors ; H protein, Drosophila (148349-66-0)
Language	English
Publishing date	2013-11-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0081578
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Article: Infrared spectra of C(3)H(3)(+)-N(2) dimers: identification of proton-bound c-C(3)H(3)(+)-N(2) and H(2)CCCH(+)-N(2) isomers.

Dopfer, Otto / Roth, Doris / Maier, John P

Journal of the American Chemical Society

2002 Volume 124, Issue 3, Page(s) 494–502

Abstract: Mid-infrared photodissociation spectra of mass selected C(3)H(3)(+)-N(2) ionic complexes are ... obtained in the vicinity of the C-H stretch fundamentals (2970-3370 cm(-1)). The C(3)H(3)(+)-N(2) dimers ... of allene, N(2), and Ar. Rovibrational analysis of the spectra demonstrates that (at least) two C(3)H(3 ...

Abstract	Mid-infrared photodissociation spectra of mass selected C(3)H(3)(+)-N(2) ionic complexes are obtained in the vicinity of the C-H stretch fundamentals (2970-3370 cm(-1)). The C(3)H(3)(+)-N(2) dimers are produced in an electron impact cluster ion source by supersonically expanding a gas mixture of allene, N(2), and Ar. Rovibrational analysis of the spectra demonstrates that (at least) two C(3)H(3)(+) isomers are produced in the employed ion source, namely the cyclopropenyl (c-C(3)H(3)(+)) and the propargyl (H(2)CCCH(+)) cations. This observation is the first spectroscopic detection of the important c-C(3)H(3)(+) ion in the gas phase. Both C(3)H(3)(+) cations form intermolecular proton bonds to the N(2) ligand with a linear -C-H...N-N configuration, leading to planar C(3)H(3)(+)-N(2) structures with C(2v) symmetry. The strongest absorption of the H(2)CCCH(+)-N(2) dimer in the spectral range investigated corresponds to the acetylenic C-H stretch fundamental (v(1) = 3139 cm(-1)), which experiences a large red shift upon N(2) complexation (Delta(v1) approximately -180 cm(-1)). For c-C(3)H(3)(+)-N(2), the strongly IR active degenerate antisymmetric stretch vibration (v4)) of c-C(3)H(3)(+) is split into two components upon complexation with N(2): v4)(a(1)) = 3094 cm(-1) and v4)(b(2)) = 3129 cm(-1). These values bracket the yet unknown v4) frequency of free c-C(3)H(3)(+) in the gas phase, which is estimated as 3125 +/- 4 cm(-1) by comparison with theoretical data. Analysis of the nuclear spin statistical weights and A rotational constants of H(2)CCCH(+)-N(2) and c-C(3)H(3)(+)-N(2) provide for the first time high-resolution spectroscopic evidence that H(2)CCCH(+) and c-C(3)H(3)(+) are planar ions with C(2v) and D(3h) symmetry, respectively. Ab initio calculations at the MP2(full)/6-311G(2df,2pd) level confirm the given assignments and predict intermolecular separations of R(e) = 2.1772 and 2.0916 A and binding energies of D(e) = 1227 and 1373 cm(-1) for the H-bound c-C(3)H(3)(+)-N(2) and H(2)CCCH(+)-N(2) dimers, respectively.
Language	English
Publishing date	2002-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja012004p
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Article ; Online: Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.

Dieter Maier / Heiko Praxenthaler / Adriana Schulz / Anette Preiss

PLoS ONE, Vol 8, Iss 11, p e

2013 Volume 81578

Abstract	The Notch signaling pathway is instrumental for cell fate decisions. Signals from the Notch receptor are transduced by CSL-type DNA-binding proteins. In Drosophila, this protein is named Suppressor of Hairless [Su(H)]. Together with the intracellular domain of the activated Notch receptor ICN, Su(H) assembles a transcriptional activator complex on Notch target genes. Hairless acts as the major antagonist of the Notch signaling pathway in Drosophila by means of the formation of a repressor complex together with Su(H) and several co-repressors. Su(H) is characterized by three domains, the N-terminal domain NTD, the beta-trefoil domain BTD and the C-terminal domain CTD. NTD and BTD bind to the DNA, whereas BTD and CTD bind to ICN. Hairless binds to the CTD, however, to sites different from ICN. In this work, we have addressed the question of competition and availability of Su(H) for ICN and Hairless binding in vivo. To this end, we overexpressed the CTD during fly development. We observed a strong activation of Notch signaling processes in various tissues, which may be explained by an interference of CTD with Hairless corepressor activity. Accordingly, a combined overexpression of CTD together with Hairless ameliorated the effects, unlike Su(H) which strongly enhances repression when overexpressed concomitantly with Hairless. Interestingly, in the combined overexpression CTD accumulated in the nucleus together with Hairless, whereas it is predominantly cytoplasmic on its own.
Keywords	Medicine ; R ; Science ; Q
Subject code	570
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Electronic Ground and Excited State Spectroscopy of C(6)H and C(6)D.

Linnartz / Motylewski / Vaizert / Maier / Apponi / McCarthy / Gottlieb / Thaddeus

Journal of molecular spectroscopy

1999 Volume 197, Issue 1, Page(s) 1–11

Abstract: Rotational transitions in the X(2)Pi ground state of C(6)H and C(6)D have been measured by Fourier ...

Abstract	Rotational transitions in the X(2)Pi ground state of C(6)H and C(6)D have been measured by Fourier transform microwave and millimeter-wave absorption spectroscopy. More than 150 rotational lines in the ground (2)Pi(3/2) and (2)Pi(1/2) ladders have been observed, allowing an accurate determination of the rotational, fine structure, lambda-doubling, and hyperfine coupling constants using a standard effective Hamiltonian for a molecule in an isolated (2)Pi electronic state. The molecular ground state constants are used to characterize the rotationally resolved origin band of the (2)Pi <-- X(2)Pi electronic transition observed by cavity ring-down laser absorption spectroscopy in a pulsed supersonic slit-jet discharge source. From these data, spectroscopic constants for the excited electronic state are determined. Copyright 1999 Academic Press.
Language	English
Publishing date	1999-09
Publishing country	United States
Document type	Journal Article
ISSN	0022-2852
ISSN	0022-2852
DOI	10.1006/jmsp.1999.7885
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Article: Synthesis of novel 3'-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides.

An, H / Wang, T / Maier, M A / Manoharan, M / Ross, B S / Cook, P D

The Journal of organic chemistry

2001 Volume 66, Issue 8, Page(s) 2789–2801

Abstract: ... directly provided the desired 5'-O-DMT- and/or MMT-protected 3'-C-methylene-modified H-phosphonates 1-6 ... to the corresponding 4-N-(N-methylpyrrolidin-2-ylidene)-protected H-phosphonate monomer 7. 5'-O-MMT-protected 3'-C ... Novel 5'-O-DMT- and MMT-protected 3'-C-methylene-modified thymidine, 5-methyluridine, and 5 ...

Abstract	Novel 5'-O-DMT- and MMT-protected 3'-C-methylene-modified thymidine, 5-methyluridine, and 5-methylcytidine H-phosphonates 1-7 with O-methyl, fluoro, hydrogen, and O-(2-methoxyethyl) substituents at the 2'-position have been synthesized by a new effective strategy from the corresponding key intermediates 3'-C-iodomethyl nucleosides and intermediate BTSP, prepared in situ through the Arbuzov reaction. The modified reaction conditions for the Arbuzov reaction prevented the loss of DMT- and MMT-protecting groups, and directly provided the desired 5'-O-DMT- and/or MMT-protected 3'-C-methylene-modified H-phosphonates 1-6 although some of them were also prepared through the manipulation of protecting groups after the P-C bond formation. The modified Arbuzov reaction of 3'-C-iodomethyl-5-methylcytidine 53, prepared from its 5-methyluridine derivative 42, with BTSP provided the 5-methylcytidine H-phosphonate 54, which was further transferred to the corresponding 4-N-(N-methylpyrrolidin-2-ylidene)-protected H-phosphonate monomer 7. 5'-O-MMT-protected 3'-C-methylene-modified H-phosphonates 5, 3, and 7 were converted to the corresponding cyanoethyl H-phosphonates 50, 51, and 56 using DCC as a coupling reagent. One-pot three-step reactions of 50, 51, and 56 provided the desired 3'-C-methylene-modified phosphonamidite monomers 8-10. Some of these new 3'-methylene-modified monomers 1-10 have been successfully utilized for the synthesis of 3'-methylene-modified oligonucleotides, which have shown superior antisense properties including nuclease resistance and binding affinity to the target RNA.
MeSH term(s)	Anti-Infective Agents/chemical synthesis ; Antineoplastic Agents/chemical synthesis ; Cytidine/analogs & derivatives ; Cytidine/chemical synthesis ; Oligonucleotides/chemical synthesis ; Oligonucleotides, Antisense/chemical synthesis ; Organophosphonates ; Thymidine/analogs & derivatives ; Thymidine/chemical synthesis ; Uridine/analogs & derivatives ; Uridine/chemical synthesis
Chemical Substances	3'-C-methylene thymidine ; Anti-Infective Agents ; Antineoplastic Agents ; Oligonucleotides ; Oligonucleotides, Antisense ; Organophosphonates ; ribothymidine (1463-10-1) ; Cytidine (5CSZ8459RP) ; 5-methylcytidine (TL9PB228DC) ; Thymidine (VC2W18DGKR) ; Uridine (WHI7HQ7H85)
Language	English
Publishing date	2001-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/jo001699u
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Article ; Online: Advances in management strategies for large and persistent macular hole: An update.

Arda, Helin / Maier, Mathias / Schultheiß, Maximilian / Haritoglou, Christos

Survey of ophthalmology

2024

Abstract: The standard of care to treat small- and medium-sized macular holes (<400 µm diameter) consists of a conventional transconjunctival sutureless pars plana vitrectomy followed by ILM peeling and endotamponade, mainly with gas or in some cases with silicone ...

Abstract	The standard of care to treat small- and medium-sized macular holes (<400 µm diameter) consists of a conventional transconjunctival sutureless pars plana vitrectomy followed by ILM peeling and endotamponade, mainly with gas or in some cases with silicone oil, resulting in closure rates of over 90% and good functional results. Large (>400 µm diameter), chronic and persistent macular holes remain a surgical challenge since closure rates and functional results decrease with larger macular hole diameters. Various modifications of the conventional surgical technique were introduced to improve anatomic and functional success in refractory cases not suitable for conventional macular hole surgery. These techniques comprise the positioning of tissue at the top of the hole to improve closure as performed by an inner limiting membrane flap and free flap preparation or the transplantation of autologous retinal tissue, lens capsule or amniotic membrane. For the treatment of very large and persistent macular holes, the induction of a localized retinal detachment at the posterior pole by subretinal injection of balanced salt solution and a subsequent attenuation of the rim of the hole during fluid-air exchange has been suggested as a promising surgical technique. In particular, accurate patient education about the expected surgical outcome in this specific group of patients appears important.
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	391346-6
ISSN	1879-3304 ; 0039-6257
ISSN (online)	1879-3304
ISSN	0039-6257
DOI	10.1016/j.survophthal.2024.03.010
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Article: Anläßlich des 75. Geburtstages von Herrn Professor Dr. med., Dr. med. h.c. Fritz Rehbein

Holschneider, Alexander M. / Maier, Wolfgang A.

Zeitschrift für Kinderchirurgie

1986 Volume 41, Issue 02, Page(s) 69–70

Language	German
Publishing date	1986-04-01
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1065043-x
ISSN	1439-359X ; 0939-7248 ; 0939-6764 ; 0930-7249
ISSN (online)	1439-359X
ISSN	0939-7248 ; 0939-6764 ; 0930-7249
DOI	10.1055/s-2008-1043312
Database	Thieme publisher's database

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Article ; Online: Mixed-methods Exploration of Telehealth-supported Long-acting Reversible Contraceptive Services in School-based Health Centers: How Much Added Value?

Maier, Malia C / Gold, Melanie A / Vacca, Susan H / Garbers, Samantha

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2023 Volume 37, Issue 6, Page(s) 599–608

Abstract: Introduction: This study explored adolescent and young adult preferences and experiences with telehealth-supported long-acting reversible contraceptive (LARC) services in New York City school-based health centers (SBHCs) during COVID-19.: Method: ... ...

Abstract	Introduction: This study explored adolescent and young adult preferences and experiences with telehealth-supported long-acting reversible contraceptive (LARC) services in New York City school-based health centers (SBHCs) during COVID-19. Method: Sequential mixed methods included post-LARC insertion surveys and in-depth interviews. Results: Survey respondents (n = 45) were aged 14-21 years and predominantly Hispanic (53.3%). Only four respondents completed a postinsertion visit via telehealth. Most (82.2%) preferred in-person for future LARC visits; none preferred telehealth. Four themes emerged in interviews (n = 15): LARC self-efficacy and autonomy; SBHC convenience and accessibility; comfort with SBHC providers; and preference for in-person visits despite telehealth benefits. Discussion: Although telehealth theoretically adds value to LARC service delivery, uptake and preference for telehealth in the SBHC context were low. Despite the perceived acceptability of telehealth, adolescents and young adults prefer in-person SBHC visits, suggesting SBHC access may eliminate barriers to care that telehealth seeks to overcome.
MeSH term(s)	Adolescent ; Young Adult ; Humans ; Contraceptive Agents ; School Health Services ; COVID-19/epidemiology ; Telemedicine ; New York City/epidemiology
Chemical Substances	Contraceptive Agents
Language	English
Publishing date	2023-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1036356-7
ISSN	1532-656X ; 0891-5245
ISSN (online)	1532-656X
ISSN	0891-5245
DOI	10.1016/j.pedhc.2023.05.004
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