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  1. Article ; Online: Reply to Leisman and Crowley.

    Russotto, Vincenzo / Bellani, Giacomo / Laffey, John G

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 5, Page(s) 623–624

    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202209-1771LE
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  2. Article ; Online: Capnography use in the critical care setting: why do clinicians fail to implement this safety measure?

    Russotto, Vincenzo / Cook, Tim M

    British journal of anaesthesia

    2021  Volume 127, Issue 5, Page(s) 661–664

    Abstract: Tracheal intubation is among the most frequently performed manoeuvres in the critical care setting, and can be life-saving in critical illness, though also associated with serious adverse events such as oesophageal intubation or tracheal tube obstruction, ...

    Abstract Tracheal intubation is among the most frequently performed manoeuvres in the critical care setting, and can be life-saving in critical illness, though also associated with serious adverse events such as oesophageal intubation or tracheal tube obstruction, displacement, or disconnection from the ventilator. A key finding of the 4th National Audit Project (NAP4) was identification of waveform capnography as the single intervention with the highest potential for reducing morbidity and mortality during tracheal intubation and maintenance of an artificial airway. In the INTUBE study, penetration of capnography into ICUs was low, and was not in use in 70% of the episodes of oesophageal intubation. To reduce harm and avoidable death, there is a need for a global initiative to increase access to and use of capnography in ICUs.
    MeSH term(s) Airway Obstruction/etiology ; Airway Obstruction/prevention & control ; Capnography/methods ; Critical Care/methods ; Health Services Accessibility ; Humans ; Intensive Care Units ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Editorial
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2021.08.010
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  3. Article ; Online: Challenges and outcomes in airway management outside the operating room.

    Jarzebowski, Mary / Estime, Stephen / Russotto, Vincenzo / Karamchandani, Kunal

    Current opinion in anaesthesiology

    2022  Volume 35, Issue 2, Page(s) 109–114

    Abstract: Purpose of review: Airway management outside the operating room poses unique challenges that every clinician should recognize. These include anatomic, physiologic, and logistic challenges, each of which can contribute to complications and lead to poor ... ...

    Abstract Purpose of review: Airway management outside the operating room poses unique challenges that every clinician should recognize. These include anatomic, physiologic, and logistic challenges, each of which can contribute to complications and lead to poor outcomes. Recognizing these challenges and highlighting known outcome data may better prepare the team, making this otherwise daunting procedure safer and potentially improving patient outcomes.
    Recent findings: Newer intubating techniques and devices have made navigating anatomic airway challenges easier. However, physiological challenges during emergency airway management remain a cause of poor patient outcomes. Hemodynamic collapse has been identified as the most common peri-intubation adverse event and a leading cause of morbidity and mortality associated with the procedure.
    Summary: Emergency airway management outside the operating room remains a high-risk procedure, associated with poor outcomes. Pre-intubation hemodynamic optimization may mitigate some of the risks, and future research should focus on identification of best strategies for hemodynamic optimization prior to and during this procedure.
    MeSH term(s) Airway Management/adverse effects ; Airway Management/methods ; Emergency Medical Services ; Hemodynamic Monitoring ; Humans ; Intubation, Intratracheal/adverse effects ; Intubation, Intratracheal/methods
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645203-6
    ISSN 1473-6500 ; 0952-7907
    ISSN (online) 1473-6500
    ISSN 0952-7907
    DOI 10.1097/ACO.0000000000001100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A fluid bolus before tracheal intubation in the critically ill does not prevent peri-intubation cardiovascular collapse: Time to consider alternatives?

    Myatra, Sheila Nainan / Russotto, Vincenzo / Bellani, Giacomo / Divatia, Jigeeshu Vasishtha

    Anaesthesia, critical care & pain medicine

    2022  Volume 41, Issue 6, Page(s) 101158

    MeSH term(s) Humans ; Critical Illness/therapy ; Intubation, Intratracheal ; Shock
    Language English
    Publishing date 2022-09-12
    Publishing country France
    Document type Editorial ; Comment
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2022.101158
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  5. Article ; Online: Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients-Reply.

    Laffey, John / Bellani, Giacomo / Russotto, Vincenzo

    JAMA

    2021  Volume 326, Issue 6, Page(s) 569

    MeSH term(s) Critical Illness ; Humans ; Intubation, Intratracheal/adverse effects ; Respiration, Artificial
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.8532
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  6. Article ; Online: Programmed Cell Death Ligand 1 Immunohistochemical Expression and Cutaneous Melanoma: A Controversial Relationship.

    Fiorentino, Vincenzo / Pizzimenti, Cristina / Franchina, Mariausilia / Pepe, Ludovica / Russotto, Fernanda / Tralongo, Pietro / Micali, Marina Gloria / Militi, Gaetano Basilio / Lentini, Maria

    International journal of molecular sciences

    2024  Volume 25, Issue 1

    Abstract: Cutaneous melanoma (CM) is traditionally considered one of the most "immunogenic" tumors, eliciting a high immune response. However, despite the presence of tumor-infiltrating lymphocytes (TILs), melanoma cells use strategies to suppress antitumor ... ...

    Abstract Cutaneous melanoma (CM) is traditionally considered one of the most "immunogenic" tumors, eliciting a high immune response. However, despite the presence of tumor-infiltrating lymphocytes (TILs), melanoma cells use strategies to suppress antitumor immunity and avoid being eliminated by immune surveillance. The PD-1 (programmed death-1)/PD-L1 (programmed death-ligand 1) axis is a well-known immune escape system adopted by neoplastic cells. Therefore, immunotherapy with PD-1 and PD-L1 inhibitors is quickly becoming the main treatment approach for metastatic melanoma patients. However, the clinical utility of PD-L1 expression assessment in CM is controversial, and the interpretation of PD-L1 scores in clinical practice is still a matter of debate. Nonetheless, the recent literature data show that by adopting specific PD-L1 assessment methods in melanoma samples, a correlation between the expression of such a biomarker and a positive response to PD-1-based immunotherapy can be seen. Our review aims to describe the state-of-the-art knowledge regarding the prognostic and predictive role of PD-L1 expression in CM while also referring to possible biological explanations for the variability in its expressions and related treatment responses.
    MeSH term(s) Humans ; Melanoma ; Skin Neoplasms ; B7-H1 Antigen/genetics ; Ligands ; Programmed Cell Death 1 Receptor/genetics ; Apoptosis
    Chemical Substances B7-H1 Antigen ; Ligands ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010676
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  7. Article ; Online: Preoxygenation of Critically Ill Patients With Acute Hypoxemic Respiratory Failure.

    Russotto, Vincenzo / Myatra, Sheila Nainan / Bellani, Giacomo

    Chest

    2020  Volume 157, Issue 6, Page(s) 1684–1685

    MeSH term(s) Airway Management ; Critical Illness ; Humans ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.12.047
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  8. Article ; Online: Effect of central venous pressure on back-flow and bolus events during vasopressor syringe changeover. Comment on Br J Anaesth 2020; 125: 622-628.

    Russotto, Vincenzo / Elli, Stefano / Rona, Roberto / Lucchini, Alberto

    British journal of anaesthesia

    2020  Volume 125, Issue 6, Page(s) e463–e464

    MeSH term(s) Adult ; Back ; Central Venous Pressure ; Critical Care ; Humans ; Norepinephrine ; Syringes
    Chemical Substances Norepinephrine (X4W3ENH1CV)
    Language English
    Publishing date 2020-09-25
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2020.09.005
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  9. Article ; Online: Programmed Cell Death Ligand 1 Immunohistochemical Expression and Cutaneous Melanoma

    Vincenzo Fiorentino / Cristina Pizzimenti / Mariausilia Franchina / Ludovica Pepe / Fernanda Russotto / Pietro Tralongo / Marina Gloria Micali / Gaetano Basilio Militi / Maria Lentini

    International Journal of Molecular Sciences, Vol 25, Iss 1, p

    A Controversial Relationship

    2024  Volume 676

    Abstract: Cutaneous melanoma (CM) is traditionally considered one of the most “immunogenic” tumors, eliciting a high immune response. However, despite the presence of tumor-infiltrating lymphocytes (TILs), melanoma cells use strategies to suppress antitumor ... ...

    Abstract Cutaneous melanoma (CM) is traditionally considered one of the most “immunogenic” tumors, eliciting a high immune response. However, despite the presence of tumor-infiltrating lymphocytes (TILs), melanoma cells use strategies to suppress antitumor immunity and avoid being eliminated by immune surveillance. The PD-1 (programmed death-1)/PD-L1 (programmed death-ligand 1) axis is a well-known immune escape system adopted by neoplastic cells. Therefore, immunotherapy with PD-1 and PD-L1 inhibitors is quickly becoming the main treatment approach for metastatic melanoma patients. However, the clinical utility of PD-L1 expression assessment in CM is controversial, and the interpretation of PD-L1 scores in clinical practice is still a matter of debate. Nonetheless, the recent literature data show that by adopting specific PD-L1 assessment methods in melanoma samples, a correlation between the expression of such a biomarker and a positive response to PD-1-based immunotherapy can be seen. Our review aims to describe the state-of-the-art knowledge regarding the prognostic and predictive role of PD-L1 expression in CM while also referring to possible biological explanations for the variability in its expressions and related treatment responses.
    Keywords cutaneous melanoma ; immune surveillance ; PD-1/PD-L1 axis ; immunotherapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: What's new in airway management of the critically ill.

    Russotto, Vincenzo / Myatra, Sheila N / Laffey, John G

    Intensive care medicine

    2019  Volume 45, Issue 11, Page(s) 1615–1618

    MeSH term(s) Airway Management/methods ; Airway Management/trends ; Checklist/instrumentation ; Critical Illness/therapy ; Humans ; Intubation, Intratracheal/instrumentation ; Intubation, Intratracheal/methods ; Intubation, Intratracheal/trends
    Language English
    Publishing date 2019-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-019-05757-0
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